ライフサイエンスコーパス: erythrocytic

1 g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinesterase) or nonexisting (synap

2 ncode a multiepitope string fused to the pre-erythrocytic Ag thrombospondin-related adhesion protein.

3 ifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) o

4 ates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens.

5 MBCs and antibodies recognizing pre-erythrocytic and cross-stage antigens were gradually acq

6 The critical involvement of SUB1 in both pre-erythrocytic and erythrocytic developmental phases quali

7 t Plasmodium falciparum parasites in the pre-erythrocytic and erythrocytic stages, with some research

8 falciparum vaccine that targets both the exo-erythrocytic and erythrocytic stages.

9 Numerous pre-erythrocytic and erythrocytic vaccine candidates have be

10 n, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be prefera

11 We report compounds active against both the erythrocytic and exoerythrocytic forms of malaria parasi

12 5p (IC50 values of 54 and 710 nM against the erythrocytic and exoerythrocytic forms), which constitut

13 The erythrocytic and exoerythrocytic protein chimeras descri

14 cytoplasmic foci adjacent to the nucleus in erythrocytic and liver stage parasites, and throughout t

15 tion of lineage-restricted precursors of the erythrocytic and myelopoietic lineages.

16 multistage malaria vaccine targeting the pre-erythrocytic and sexual stages of Plasmodium could effec

17 able of delivering a potent antimalarial pre-erythrocytic and TB response via a single immunization r

18 t to the plasma membrane of aspartate 821 in erythrocytic anion exchanger has been determined by labe

19 Novel pre-erythrocytic antibody (Ab) targets could be key to impro

20 IgG antibodies to pre-erythrocytic antigens are involved in prevention of infe

21 volunteers reacted strongly against the pre-erythrocytic antigens circumsporozoite protein (CSP) and

22 stage antigen 1 (LSA1) is one of several pre-erythrocytic antigens considered for inclusion in a mult

23 ith high levels of IgG antibodies to the pre-erythrocytic antigens CSP, LSA-1, and TRAP have a lower

24 lular immune response to blood-stage and pre-erythrocytic antigens longitudinally from 1 to 3 years o

25 ar sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting

26 ility of eight alternative P. falciparum pre-erythrocytic antigens to induce a high proportion of CD8

27 ia (aHR 0.96, P = .83), but responses to pre-erythrocytic antigens were associated with protection af

28 IFNgamma responses to pre-erythrocytic antigens were infrequent and similar betwee

29 Well classified merozoite and erythrocytic antigens were strongly reactive in semi-imm

30 Responses to pre-erythrocytic antigens were uncommon, not associated with

31 traditionally focused on two well-known pre-erythrocytic antigens, CSP and TRAP, yet thousands of ge

32 semi-immune individuals mainly react against erythrocytic antigens.

33 ight on an important role for PfCDPK7 in the erythrocytic asexual cycle of malaria parasites.

34 tire parasite lifecycle, including the intra-erythrocytic asexual forms responsible for disease, the

35 DNA and expression of only the A gene during erythrocytic asexual growth.

36 The erythrocytic asexual reproduction cycle of Plasmodium fa

37 gens corresponding to the sporozoite, liver, erythrocytic asexual, and sexual stages.

38 . falciparum at three time points during its erythrocytic (asexual) cycle.

39 Binding of erythrocytic beta-actin to ezrin is saturable with a mol

40 HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accurac

41 e membrane surrounding the merozoites is not erythrocytic but rather is derived from the parasitophor

42 RNA levels as parasites progress through the erythrocytic cell cycle and examined this process in two

43 d another red cell disease to the panoply of erythrocytic changes that give rise to resistance to mal

44 Phenotypic whole-cell screening in erythrocytic cocultures of Plasmodium falciparum identif

45 oper targeting of parasite proteins to intra-erythrocytic compartments, including the apicoplast, a p

46 In a synchronized erythrocytic culture of P. falciparum, the PfP2 protein

47 the plastid-like genome is essential for the erythrocytic cycle and presents a novel therapeutic site

48 parum is derived from studies of the asexual erythrocytic cycle of the parasite, the portion of the p

49 sential for the completion of the parasite's erythrocytic cycle that causes disease in humans.

50 of nucleosome occupancy across the parasite erythrocytic cycle using two complementary assays--the f

51 Midway during the erythrocytic cycle, at the highly transcriptionally acti

52 t affect parasite replication throughout the erythrocytic cycle, gametocyte production, mosquito infe

53 pression of probable variant antigens in the erythrocytic cycle, modifies the elicited mammalian immu

54 Within the asexual erythrocytic cycle, responsible for the clinical manifes

55 at every morphological stage of the parasite erythrocytic cycle.

56 ver control massive transcription during the erythrocytic cycle.

57 of four parasite aminopeptidases during the erythrocytic cycle.

58 at a relatively steady level throughout the erythrocytic cycle.

59 DNA that mark the reproductive phase of the erythrocytic cycle.

60 a single active var gene locus through many erythrocytic cycles and also achieve successive switchin

61 Circulating hemoglobin and heme represent erythrocytic danger-associated molecular pattern (eDAMP)

62 Congenital methemoglobinemia caused by an erythrocytic deficiency of cytochrome b5 reductase (b5R;

63 ding both LipDHs, are transcribed during the erythrocytic development of P. falciparum.

64 t roles in regulating gene expression during erythrocytic development of the malaria parasite.

65 fferentially expressed in gametocytes during erythrocytic development of the parasite.

66 P. falciparum and was lethal for their intra-erythrocytic development, corroborating the suggestion t

67 During intra-erythrocytic development, malaria trophozoites digest he

68 n the early and late stages of P. falciparum erythrocytic development.

69 is pathway is not functionally important for erythrocytic development.

70 lvement of SUB1 in both pre-erythrocytic and erythrocytic developmental phases qualifies SUB1 as an a

71 atically digests hemoglobin during its intra-erythrocytic developmental stages in acidic food vacuole

72 -specific transcription factor essential for erythrocytic differentiation at relatively early stages,

73 mosquito-borne transmission depends on intra-erythrocytic differentiation into non-replicating sexual

74 During erythrocytic differentiation of murine erythroleukemia (

75 in iron metabolism, hepatocyte function, and erythrocytic differentiation.

76 e number of megakaryocytes, and an arrest in erythrocytic differentiation.

77 y of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols.

78 of multiple lymph nodes, splenomegaly due to erythrocytic extramedullary hematopoiesis, and lymphoid

79 The evidence for and against a quiescent pre-erythrocytic form of P. malariae is reviewed.

80 alaria (defined as the absence of detectable erythrocytic form parasites) (P = 0.007, chi square) and

81 to the liver where they develop into the exo-erythrocytic forms (EEFs).

82 inst both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium fa

83 ugs active against both erythrocytic and exo-erythrocytic forms would be preferable.

84 esearchers to investigate the biology of exo-erythrocytic forms.

85 oms, the development and maturation of intra-erythrocytic gametocytes that are transmissible to Anoph

86 and 2) compounds with antioxidant activity, erythrocytic glutathione, plasma glutathione peroxidase,

87 efficiency within the time-span of a single erythrocytic growth cycle.

88 cule, ACT-213615, potently inhibits in vitro erythrocytic growth of all tested Plasmodium falciparum

89 sickle cell disease, deoxygenation of intra-erythrocytic hemoglobin S leads to hemoglobin polymeriza

90 iron protoporphyrin IX (FePPIX) derived from erythrocytic hemoglobin.

91 is proposed as an important component of pre-erythrocytic human malaria vaccines.

92 um falciparum (Pf) infection mediated by pre-erythrocytic immunity can be experimentally induced unde

93 nder chloroquine cover does not generate pre-erythrocytic immunity, which is acquired only after immu

94 ytotoxic CD4 and CD8 T-cell responses in pre-erythrocytic immunity.

95 linositol-anchored proteins had no effect on erythrocytic infection by malarial parasite or movement

96 Thus, erythrocytic infection does not preclude the establishme

97 he effects of sporozoite-specific Abs on pre-erythrocytic infection in vivo remain underdeveloped.

98 knockout mice are unable to clear a primary erythrocytic infection of Plasmodium chabaudi chabaudi.

99 development of memory T cells during active erythrocytic infection remains uncharacterized.

100 t this complex with a goal of preventing the erythrocytic invasion of these parasites and to further

101 rtant roles during the Plasmodium falciparum erythrocytic life cycle.

102 ith recognition of antigens expressed in pre-erythrocytic life-cycle stages.

103 e commitment of blood progenitors toward the erythrocytic lineage and link Notch signaling to optimal

104 th bone marrow failure, affecting mostly the erythrocytic lineage.

105 n of human progenitor cells into colonies of erythrocytic lineage.

106 ed in heme biosynthesis, specifically in the erythrocytic lineage.

107 teworthy was the 40% decline in cells of the erythrocytic lineages in the marrow of colitis mice, whi

108 host is thought to be restricted to the pre-erythrocytic liver phase.

109 vaccinia Ankara (MVA) vectors expressing pre-erythrocytic malaria Ags.

110 specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adh

111 CD25 lead to improved protection against pre-erythrocytic malaria challenge.

112 Erythrocytic malaria parasites degrade hemoglobin as a s

113 Erythrocytic malaria parasites degrade hemoglobin in an

114 idic food vacuole to provide amino acids for erythrocytic malaria parasites.

115 Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels o

116 hopoiesis, including a 2- 3-fold increase in erythrocytic markers.

117 During intra-erythrocytic maturation, the infected erythrocyte (iE) m

118 Erythrocytic mechanisms involved in malarial infection a

119 aches the spectrin/actin cytoskeleton to the erythrocytic membrane.

120 y interacting with both the surface of intra-erythrocytic merozoites and the inner aspect of erythroc

121 nt, including maturation into infectious exo-erythrocytic merozoites as well as the formation and per

122 ements and provide evidence that hepatic and erythrocytic merozoites differ.

123 e e1alpha(-) and e3(-) parasites to form exo-erythrocytic merozoites during late liver stage developm

124 e1 alpha(-) and e3(-) parasites to form exo-erythrocytic merozoites during late liver stage developm

125 entify a subset of HbSS patients with higher erythrocytic miR-144 expression and more severe anemia.

126 work we determined whether the primary human erythrocytic nitrite reductase is hemoglobin as opposed

127 suggest that deoxyhemoglobin is the primary erythrocytic nitrite reductase operating under physiolog

128 otal NO-related signal in blood is caused by erythrocytic nitrite, which may partly be bound to hemog

129 e effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes p

130 A variety of defects in either the erythrocytic or microsomal forms of the enzyme have been

131 assified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether

132 rom the fetal state, characterized by robust erythrocytic output that supports prenatal growth in the

133 killed multidrug-resistant strains of intra-erythrocytic P. falciparum parasites at sub to low micro

134 here the essential function of pfht for the erythrocytic parasite growth as it was not possible to k

135 th cell-mediated and humoral immunity to pre-erythrocytic parasite stages can provide protection agai

136 has been traditionally focused on targeting erythrocytic parasite stages that cause clinical symptom

137 ually and very rapidly affects all 3 asexual erythrocytic parasite stages.

138 and is located on the membrane of the intra-erythrocytic parasite's digestive vacuole.

139 unity, in addition to protection against pre-erythrocytic parasites following high dose sporozoite im

140 Accumulation of erythrocytic parasites in bone marrow and the spleen has

141 ed by inoculating humans with irradiated pre-erythrocytic parasites, and a recombinant pre-erythrocyt

142 te that although falcipain-1 is expressed by erythrocytic parasites, it is not essential for normal d

143 tter characterize the role of falcipain-1 in erythrocytic parasites, we disrupted the falcipain-1 gen

144 bition of host haemoglobin uptake into intra-erythrocytic parasites.

145 transition from the pre-erythrocytic to the erythrocytic part of the life cycle.

146 RTS,S targets the pre-erythrocytic phase of the disease and induces high antib

147 develops as wild type throughout the asexual erythrocytic phase of the life cycle.

148 eine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites.

149 nd significantly greater proliferation of an erythrocytic progenitor cell line compared with stromal

150 h PKA activity was known to be necessary for erythrocytic proliferation, we show that uncontrolled in

151 A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malar

152 lations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that

153 on induces stage-specific and long-lived pre-erythrocytic protective anti-malarial immunity, mediated

154 reductase is hemoglobin as opposed to other erythrocytic proteins that have been suggested to be the

155 the respective contributions of hepatic and erythrocytic protoporphyrin to the pathophysiology of EP

156 Hepatocystis parasites lack the intermittent erythrocytic replication cycles, the signature and exclu

157 based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically as

158 nitroso-N-acetylcysteine (SNOAC), decreasing erythrocytic S-nitrosothiol content, both during whole-b

159 36 parasite kinases as likely essential for erythrocytic schizogony.

160 ality of the orthologous gene for P. berghei erythrocytic schizogony.

161 to humans with sickle cell disease in having erythrocytic sickling, vascular ectasia, intravascular h

162 The elevated levels of intra-erythrocytic SNO-Hb fell rapidly, independent of oxygen

163 exhibited selective activity towards the pre-erythrocytic stage (98% of activity against P. gallinace

164 gene is expressed specifically in the sexual erythrocytic stage (gametocytes).

165 e known to be causal prophylactic and potent erythrocytic stage agents in avian models.

166 Vaccines targeting the erythrocytic stage are often viewed as an anti-disease s

167 s and protective capacities against a lethal erythrocytic stage challenge, than those resulting from

168 by a vaccine against the liver stage, a pre-erythrocytic stage during which the parasite multiplies

169 P. falciparum erythrocytic stage growth in vitro is reduced in anaemic

170 completely protected against development of erythrocytic stage infection after sporozoite challenge.

171 known about protective immunity against pre-erythrocytic stage malaria by considering the humoral an

172 itro correlate of protective immunity to exo-erythrocytic stage malaria vaccines.

173 r developing protective immunity against pre-erythrocytic stage malaria.

174 ypeptides designated MSP1a and MSP1b) of the erythrocytic stage of Anaplasma marginale conferred prot

175 fA-M1 and PfA-M17, play crucial roles in the erythrocytic stage of infection and have been validated

176 During the erythrocytic stage of its life cycle, the human malaria

177 emonstrated a rapid rate of clearance of the erythrocytic stage of P. falciparum in the SCID mouse mo

178 lkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7).

179 rticle vaccine, RTS,S, which targets the pre-erythrocytic stage of Plasmodium falciparum infection.

180 e of a protective effect against the asexual erythrocytic stage of the life cycle.

181 ve long-lived sterile immunity targeting pre-erythrocytic stage parasites in mice.

182 on the surface of P. knowlesi sporozoite and erythrocytic stage parasites.

183 ranted for tests in clinical trials as a pre-erythrocytic stage vaccine candidate.

184 Of the erythrocytic stage vaccine candidates, the 19 kDa fragme

185 A highly efficacious pre-erythrocytic stage vaccine would be an important tool fo

186 arum circumsporozoite (CS) protein-based pre-erythrocytic stage vaccine, RTS,S, induces a high level

187 ctive targets in the effort to develop a pre-erythrocytic stage vaccine.

188 culture-derived A. marginale and the bovine erythrocytic stage, currently the source of A. marginale

189 st time on malaria parasites for analysis of erythrocytic stage-specific gene expression.

190 ites and around the rhoptries in the asexual erythrocytic stage.

191 ental phase in the liver, which precedes the erythrocytic stage.

192 promise as a component of a vaccine against erythrocytic-stage falciparum malaria.

193 uced significant protective efficacy against erythrocytic-stage infection in a pre-specified primary

194 nging them with homologous P. falciparum FVO erythrocytic-stage malaria parasites.

195 candidates that target infection by asexual erythrocytic-stage malaria parasites.

196 rovide the foundation for an approach to pre-erythrocytic-stage malaria vaccine development, based on

197 Deltamif parasites grew normally as asexual erythrocytic-stage parasites and showed normal infection

198 ues infected by intravenous inoculation with erythrocytic-stage parasites did not display these same

199 early blood responses in mice infected with erythrocytic-stage Plasmodium chabaudi.

200 s may represent an in vitro correlate of pre-erythrocytic-stage protective immunity.

201 g two preerythrocytic-stage proteins and two erythrocytic-stage proteins from P. knowlesi and combina

202 Data nevertheless suggest that a pre-erythrocytic-stage vaccine should be designed to induce

203 nd protein synthetic capabilities of asexual erythrocytic stages and sexual stages of P. falciparum.

204 hese, 19 induced antibody titers against the erythrocytic stages and three against sporozoite stages.

205 otective immune responses that eliminate pre-erythrocytic stages are paving the way for the developme

206 site that infects human erythrocytes and the erythrocytic stages are responsible for all symptoms and

207 e effect seen on parasite development in the erythrocytic stages is potent.

208 ive stress to which it is exposed during the erythrocytic stages of its life cycle.

209 work on protective immunity against the pre-erythrocytic stages of malaria has focused on induction

210 ajor role in protective immunity against pre-erythrocytic stages of malaria parasites.

211 (MSP-1), a leading vaccine candidate against erythrocytic stages of malaria, was expressed as a fusio

212 1H)-quinolones with nanomolar EC(50) against erythrocytic stages of multidrug resistant W2 and TM90-C

213 uences fused to green fluorescent protein in erythrocytic stages of P. falciparum and by immunofluore

214 chondrial electron transport nonessential in erythrocytic stages of P. falciparum.

215 sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo.

216 The intra-erythrocytic stages of Plasmodium falciparum assemble a

217 RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergo

218 cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium.

219 Here we show that erythrocytic stages of the human malaria parasite Plasmo

220 inhibitors (PIs) exert inhibitory effects on erythrocytic stages of the human-malaria parasite Plasmo

221 roteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypoth

222 Erythrocytic stages of the malaria parasite Plasmodium f

223 essed in the sporozoite, asexual, and sexual erythrocytic stages of the parasite life cycle.

224 rasite Plasmodium falciparum in vitro and on erythrocytic stages of the rodent-malaria parasite Plasm

225 as been drawn to the mosquito stages and pre-erythrocytic stages owing to recognition that these are

226 otection is mediated by immunity against pre-erythrocytic stages, presumably at least partially by cy

227 iparum parasites in the pre-erythrocytic and erythrocytic stages, with some research on transmission-

228 e that targets both the exo-erythrocytic and erythrocytic stages.

229 dy and CD4+ T cells to target Plasmodium pre-erythrocytic stages.

230 reen fluorescent protein fusions in parasite erythrocytic stages.

231 are expressed in sporozoites and hepatic and erythrocytic stages.

232 ve been concerned with asexual and/or sexual erythrocytic stages.

233 the comprehensive transcriptional profile of erythrocytic stages.

234 es induce cross-stage immunity targeting pre-erythrocytic stages.

235 etween Toxoplasma tachyzoites and Plasmodium erythrocytic stages.

236 sential role of the apicoplast in Plasmodium erythrocytic stages.

237 bs were devoid of actin, but proteins of the erythrocytic submembranous cytoskeleton were present.

238 stages, marking the transition from the pre-erythrocytic to the erythrocytic part of the life cycle.

239 ultiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the

240 us merozoites to identify stage-specific pre-erythrocytic transcripts.

241 ovide a physiologically robust mechanism for erythrocytic transport of NO bioactivity allowing for ho

242 as a fusion protein, thereby acting as a pre-erythrocytic vaccine and a TB vaccine, respectively.

243 The leading pre-erythrocytic vaccine candidate is RTS,S, and early resul

244 However, experimental evidence, from pre-erythrocytic vaccine candidates and irradiated sporozoit

245 Numerous pre-erythrocytic and erythrocytic vaccine candidates have been evaluated safe

246 rythrocytic parasites, and a recombinant pre-erythrocytic vaccine partially protects humans from infe

247 We envision that a highly protective pre-erythrocytic vaccine will likely be based upon a heterol

248 vo protective activity and indicate that pre-erythrocytic vaccines against Plasmodium should include

249 e a novel approach in designing CS based pre-erythrocytic vaccines against Plasmodium using the adjuv

250 nd tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G)

251 In Europeans and Asians, erythrocytic variants in aggregate had only modest effec

252 Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at geno

253 nized individuals react strongly against pre-erythrocytic while semi-immune individuals mainly react

254 rtantly, there is limited NO production from erythrocytic xanthine oxidoreductase and nitric-oxide sy