ライフサイエンスコーパス: erythroid progenitor

1 d from a common precursor, the megakaryocyte-erythroid progenitor.

2 e expression downstream of the megakaryocyte-erythroid progenitor.

3 yocytes after formation of the megakaryocyte-erythroid progenitor.

4 1 to inhibit commitment to the megakaryocyte-erythroid progenitor.

5 ses >100 PU.1 myelo-lymphoid gene targets in erythroid progenitors.

6 vivo differentiation of Hri(-/-) fetal liver erythroid progenitors.

7 mming and subsequent generation of committed erythroid progenitors.

8 and active histone marks similar to those in erythroid progenitors.

9 is by stimulating the expansion of primitive erythroid progenitors.

10 he (pA)d site during B19V infection of human erythroid progenitors.

11 humans and has an extreme tropism for human erythroid progenitors.

12 ar pathogenesis of B19V in highly permissive erythroid progenitors.

13 apid expansion and differentiation of stress erythroid progenitors.

14 markable tropism of B19V infection for human erythroid progenitors.

15 ng gamma-globin transcription in adult human erythroid progenitors.

16 iking decrease in multipotential myeloid and erythroid progenitors.

17 opoietic stem/progenitor cells and committed erythroid progenitors.

18 the fetal liver contains two populations of erythroid progenitors.

19 oblast, primitive, erythroid, and definitive erythroid progenitors.

20 , and cytokine-independent growth of primary erythroid progenitors.

21 poR in UT7 erythroid cells and primary CD71+ erythroid progenitors.

22 vity, and P4.2 and beta-globin expression in erythroid progenitors.

23 induced erythropoietin receptor signaling in erythroid progenitors.

24 c, and granulocytic cells as well as primary erythroid progenitors.

25 ding Stat5, Akt, and p44/42 MAPK, in primary erythroid progenitors.

26 oid gene such as GATA-2 in the megakaryocyte-erythroid progenitors.

27 ansion of a specialized population of stress erythroid progenitors.

28 , suggesting that IL-7 might directly act on erythroid progenitors.

29 ncostatin-M was found to enhance survival of erythroid progenitors.

30 in the yolk sac with Meg-CFCs and definitive erythroid progenitors.

31 onferred a proliferative signal to primitive erythroid progenitors.

32 creased, with only modest expansion of early erythroid progenitors.

33 in developmental stage-discordant definitive erythroid progenitors.

34 a-globin gene promoter and in cultured human erythroid progenitors.

35 ed Epo-induced signaling pathways in splenic erythroid progenitors.

36 ha- and beta-globins and for the survival of erythroid progenitors.

37 TA-1 impairs the maturation of megakaryocyte-erythroid progenitors.

38 apitulates the in vivo development of stress erythroid progenitors.

39 -3 KO mice, as evidenced by higher levels of erythroid progenitors.

40 myeloid colony formation by Rcor1-deficient erythroid progenitors.

41 also causes Epo hypersensitivity in primary erythroid progenitors.

42 es, we profiled the transcriptome of primary erythroid progenitors.

43 complex and is required for the survival of erythroid progenitors.

44 ajor new EPO/EPOR target for the survival of erythroid progenitors.

45 e clonal expansion of Kit(+) multipotent and erythroid progenitors.

46 monocytic) and erythroid (burst-forming unit-erythroid) progenitors.

47 of Meis1 repressed the development of early erythroid progenitors, acting in vivo at the megakaryocy

48 and betae1-globin, suggesting that both the erythroid progenitor and mature erythrocyte compartments

49 e from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including

50 matopoietic stem cells resulted in a loss of erythroid progenitors and an increase in myeloid cells b

51 ne system, Zbtb46 was expressed in committed erythroid progenitors and endothelial cell populations.

52 osis is driven by increased numbers of early erythroid progenitors and enhanced erythroblast prolifer

53 ilia and thrombocytosis, marked expansion of erythroid progenitors and Epo-independent erythroid colo

54 We found increased numbers of erythroid progenitors and erythroid cells in C/EBPalpha(

55 ranscription of the cdk6 gene in both normal erythroid progenitors and erythroleukemia cells, as well

56 ctions, leading to Epo-independent growth of erythroid progenitors and eventually promoting erythrole

57 at serine 310 (S310) in primary fetal liver erythroid progenitors and in cultured erythroid cells.

58 sion of immature and lineage-committed myelo-erythroid progenitors and ineffective erythropoiesis.

59 9-deficient embryos, deltaNp63 is induced in erythroid progenitors and may contribute to blood defect

60 in Vhl(R/R) spleens, with greater numbers of erythroid progenitors and megakaryocytes and increased e

61 Erythroid progenitors and precursors were increased in h

62 oid differentiation of murine megakaryocytic/erythroid progenitors and primary human CD34(+) progenit

63 in marrow and with emergence of circulating erythroid progenitors and subsequent reestablishment of

64 id differentiation, but only at the stage of erythroid progenitors and very early erythroblasts.

65 it-mediated proliferative expansion of early erythroid progenitors and, ultimately, transient reticul

66 AK is thought to be expressed in myeloid and erythroid progenitors, and its expression is enhanced in

67 ation, a mild anemia with reduced numbers of erythroid progenitors, and significant inhibition of ter

68 Lnk-deficient mice have elevated numbers of erythroid progenitors, and that splenic erythroid colony

69 When K-ras(-/-) erythroid progenitors are cultured in vitro, there is a

70 ority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal

71 r instances of HIFs upregulation, VHL(P138L) erythroid progenitors are hypersensitive to erythropoiet

72 topoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas gr

73 se results demonstrate that V617F-homozygous erythroid progenitors are present in most patients with

74 beta-globin mRNA within the nucleus of early erythroid progenitors are unlikely to account for the co

75 ocyte-monocyte progenitor, and megakaryocyte-erythroid progenitor), as well as the lymphoid-primed mu

76 ence on the fate choice at the megakaryocyte-erythroid progenitor between megakaryocytic and erythroi

77 Burst-forming unit erythroid progenitors (BFU-Es) are so named based on the

78 cifically stimulate self-renewal of an early erythroid progenitor, burst-forming unit erythroid (BFU-

79 (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstrea

80 rolling proliferation and differentiation of erythroid progenitors, but regulatory mechanisms are lar

81 n of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as eryth

82 ed expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other facto

83 t form based on hyperplastic bone marrow and erythroid progenitor cell culture; these cases may subse

84 trate that the 11 kDa protein contributes to erythroid progenitor cell death during B19V infection.

85 ere, we report the establishment of a murine erythroid progenitor cell line, iEBHX1S-4, developmental

86 Erythroid progenitor cell lines have been derived from c

87 eveloped an ex vivo-generated TP composed of erythroid progenitor cells (EPCs) and precursors cells.

88 dvances in generating large numbers of human erythroid progenitor cells (EPCs) ex vivo from hematopoi

89 l role of erythropoietin (Epo) signaling, in erythroid progenitor cells (EPCs) expanded ex vivo from

90 19V) infection has a unique tropism to human erythroid progenitor cells (EPCs) in human bone marrow a

91 2 kinase complexes propagates signals within erythroid progenitor cells (EPCs) that are essential for

92 ythrotropic and preferentially replicates in erythroid progenitor cells (EPCs).

93 eplication, however, is almost restricted to erythroid progenitor cells (ErPCs).

94 red for B19V replication in ex vivo-expanded erythroid progenitor cells after initial virus entry and

95 Expression of these receptors in primary erythroid progenitor cells also demonstrated a functiona

96 onomous B19V replication is limited to human erythroid progenitor cells and in a small number of eryt

97 eq to study the interactome of EKLF in mouse erythroid progenitor cells and more differentiated eryth

98 In accord with this, erythroid progenitor cells and reticulocytes were substa

99 DYRK3 is restricted to erythroid progenitor cells and testes.

100 he antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme

101 Infection of erythroid progenitor cells by Friend spleen focus-formin

102 estoration of the cytosol oxidative state of erythroid progenitor cells by the pro-oxidant Paraquat r

103 ed, and B19V replication in ex vivo-expanded erythroid progenitor cells exposed to Epo (CD36(+)/Epo(+

104 and excessive erythrocytosis is suggested by erythroid progenitor cells from a patient that exhibits

105 group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chrom

106 ion using ex vivo differentiation of CD34(+) erythroid progenitor cells from peripheral blood of heal

107 nduction during the rapid expansion of adult erythroid progenitor cells have not been fully elucidate

108 cks the proliferation and differentiation of erythroid progenitor cells in cultured human CD34(+) cel

109 /Gab2 complex mediates the growth of primary erythroid progenitor cells in response to Friend virus.O

110 Friend erythroleukemia and the expansion of erythroid progenitor cells in response to infection can

111 s PlGF, and its enforced expression in human erythroid progenitor cells induces PlGF mRNA.

112 ocalized NS1 at the protein level in primary erythroid progenitor cells infected with B19V; and inhib

113 Human erythroid progenitor cells lines have been produced from

114 ovirus B19 (B19V) infection is restricted to erythroid progenitor cells of the human bone marrow.

115 ockdown (KD) of PRMT1 by RNA interference in erythroid progenitor cells prevents histone acetylation,

116 pression of these microRNAs in primary human erythroid progenitor cells results in elevated fetal and

117 gonists in stimulating self-renewal of early erythroid progenitor cells suggests that the clinically

118 vitro culture system to expand human stress erythroid progenitor cells that express analogous cell-s

119 tipotent progenitor cells, and megakaryocyte-erythroid progenitor cells that is required under hemato

120 d an accumulation of nuclear p53 staining in erythroid progenitor cells that was not present in contr

121 ata1/GATA1 transcription in murine and human erythroid progenitor cells through an evolutionarily con

122 s by binding to its cell surface receptor on erythroid progenitor cells to stimulate erythrocyte prod

123 is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 trans

124 Genes specific to erythroid progenitor cells were up-regulated by dexameth

125 9 therefore blocks proliferation of immature erythroid progenitor cells, and dexamethasone activates

126 e, we report that, in ex vivo-expanded human erythroid progenitor cells, B19V infection induces a bro

127 Friend virus infects erythroid progenitor cells, followed by an initial polyc

128 in transfection of primary ex vivo-expanded erythroid progenitor cells, in comparison with apoptosis

129 rs the growth and differentiation program of erythroid progenitor cells, leading to malignant leukemi

130 vating the erythropoietin receptor (EPOR) in erythroid progenitor cells, leading to proliferation and

131 latelet c-mpl expression, in vitro assays of erythroid progenitor cells, serum erythropoietin levels,

132 g erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the

133 s were markedly decreased in Eklf(-/-) early erythroid progenitor cells, which showed a delay in the

134 example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and T

135 lentiviral short hairpin RNA transduction of erythroid progenitor cells, with global surface proteomi

136 modimers signal to promote the maturation of erythroid progenitor cells.

137 during B19V infection of permissive CD36(+) erythroid progenitor cells.

138 tress response in K562 cell line and primary erythroid progenitor cells.

139 19V) infection is highly restricted to human erythroid progenitor cells.

140 n of p21 and consequent cell cycle arrest in erythroid progenitor cells.

141 ins to promote the Epo-independent growth of erythroid progenitor cells.

142 or (SCF) stimulation in cultured human adult erythroid progenitor cells.

143 bin gene expression in primary CD71-positive erythroid progenitor cells.

144 tosis significantly during B19V infection of erythroid progenitor cells.

145 with RNA from wild-type and Eklf(-/-) early erythroid progenitor cells.

146 EKLF-dependent DNase I sensitivity in early erythroid progenitor cells.

147 while reducing the numbers of megakaryocyte-erythroid progenitor cells.

148 erminal proliferation and differentiation of erythroid progenitor cells.

149 B19 (B19V) has an extreme tropism for human erythroid progenitor cells.

150 -binding protein family that is expressed in erythroid progenitor cells.

151 globin genes during differentiation of adult erythroid progenitor cells.

152 nt for Epo-induced maturation of fetal liver erythroid progenitor cells.

153 vival, proliferation, and differentiation of erythroid progenitor cells.

154 the initial polyclonal expansion of infected erythroid progenitor cells.

155 were also present in downstream myeloid and erythroid progenitor cells.

156 arly steps in the differentiation of myeloid-erythroid progenitor cells.

157 n in both K562 cells and primary human adult erythroid progenitor cells.

158 nd repressed their transcription in immature erythroid progenitor cells.

159 ietin (Epo), because the colony-forming unit erythroid progenitors (CFU-Es) that respond to Epo are e

160 ns resulted in the preferential expansion of erythroid progenitors characterized by the expression of

161 gs had distinct effects on the production of erythroid progenitor colonies; dexamethasone selectively

162 ltures, INCB018424 preferentially suppressed erythroid progenitor colony formation from JAK2V617F(+)

163 ence with FLVCR display results in a loss of erythroid progenitors (colony-forming units-erythroid, C

164 Abnormality in Meg/E or erythroid progenitors could potentially be considered an

165 Remarkably, Rcor1 null erythroid progenitors cultured in vitro form myeloid col

166 initiates with rapid expansion of late-stage erythroid progenitors-day 3 burst-forming units and colo

167 p53-deficient mice, thereby ameliorating the erythroid progenitor defect.

168 Lowering LMO2 levels in erythroid progenitors delays G1-S progression and arrest

169 P1 knock-in premegakaryocyte/erythroid progenitors demonstrate an erythroid-specifica

170 -globin gene promoters in GM979 cells and in erythroid progenitors demonstrate that RB7 and butyrate

171 Erythroid progenitors derived from fetal or adult mammal

172 rrested GATA1-deficient murine megakaryocyte-erythroid progenitors derived from murine embryonic stem

173 udi resulted in less severe anemia, improved erythroid progenitor development, and increased survival

174 , to a greater extent, CMP and megakaryocyte-erythroid progenitor development, and red blood cell pro

175 oduced during malaria infection may suppress erythroid progenitor development.

176 Erythroid progenitors differentiate in erythroblastic is

177 posttranslational histone modifications when erythroid progenitors differentiate into late erythrobla

178 As erythroid progenitors differentiate into precursors and

179 -macrophage progenitors and as megakaryocyte-erythroid progenitors differentiated to both megakaryocy

180 NUP98-HOXA9 expression inhibited erythroid progenitor differentiation and delayed neutrop

181 phosphorylation that normally occurs during erythroid progenitor differentiation.

182 constitutively active Akt kinase (ca.Akt) in erythroid progenitors does not significantly affect eryt

183 TRPC3 expression increases on normal human erythroid progenitors during differentiation.

184 ydrazine revealed a delay in the recovery of erythroid progenitors, early precursors, and normal hema

185 onogenic assays that quantify early and late erythroid progenitor (EEP and LEP) potential, respective

186 both quantitative and qualitative defects in erythroid progenitor (EP) contribute to defective erythr

187 ctor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus

188 ythroid burst-forming unit [BFU-E]) and late erythroid progenitors (erythroid colony-forming unit [CF

189 s derived from the later colony-forming unit erythroid progenitor erythropoietin (Epo)-dependent prog

190 We show that in primary fetal liver erythroid progenitors, erythropoietin activates all thre

191 last (CD71(+) Ter119(-) cells) stage onward, erythroid progenitors exhibited excess heme content, inc

192 ockdown studies confirmed RHEX regulation of erythroid progenitor expansion and further revealed role

193 hropoiesis, we demonstrate that human stress erythroid progenitors express fetal hemoglobin upon diff

194 FOG-1(R3K5A/R3K5A) megakaryocytes and erythroid progenitors expressed increased levels of GATA

195 in embryos with severely reduced Scl levels, erythroid progenitors expressing gata1 and embryonic glo

196 Erythroid progenitors failed to develop normally, showin

197 neage differentiation model of megakaryocyte/erythroid progenitor formation was insufficient for hema

198 population exhibits the properties of stress erythroid progenitors found in adult spleen.

199 One population resembles the steady state erythroid progenitors found in the adult bone marrow.

200 tocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow.

201 dose-dependent increase in Hb F synthesis in erythroid progenitors from individuals with sickle cell

202 te-macrophage progenitors, and megakaryocyte-erythroid progenitors from marrow during several phases

203 Culture of erythroid progenitors from the patient and his parents r

204 depletion of erythroid cells and a defect in erythroid progenitor function.

205 e that lymphoid progenitors, but not myeloid-erythroid progenitors, give rise to NH cells in vivo.

206 common myeloid progenitor and megakaryocytic-erythroid progenitor, granulocyte-monocyte progenitor an

207 athways were analyzed within Spry1-deficient erythroid progenitors, hyperactivation of not only Erk1,

208 poietic stem cells (HSCs) and megakaryocytic erythroid progenitors identified highly up-regulated gen

209 s prolonged Epo-independent proliferation of erythroid progenitors in addition to a block in differen

210 d reduced myeloid multilineage and committed erythroid progenitors in HIF-1alpha-deficient embryos, a

211 tion of a self-renewing population of stress erythroid progenitors in mice suggests that therapeutic

212 We detected normal numbers of primitive erythroid progenitors in Ncx1-/- versus wild type (WT) Y

213 ion, suggesting distinct mechanisms by which erythroid progenitors in polycythemias with defects of h

214 Friend erythroleukemia and that expansion of erythroid progenitors in response to infection requires

215 he rapid mobilization and differentiation of erythroid progenitors in the adult spleen.

216 nemia despite adequate numbers of clonogenic erythroid progenitors in the bone marrow and expanded sp

217 causes proliferation and differentiation of erythroid progenitors in the bone marrow through inhibit

218 rentially affect the expansion of the stress erythroid progenitors in the fetal liver leading to feta

219 pathway plays a key role in the expansion of erythroid progenitors in the fetal liver.

220 hat can be targeted to elevate both HSCs and erythroid progenitors in the local hematopoietic microen

221 acid receptor antagonist increases gata1(+) erythroid progenitors in the posterior mesoderm of wild-

222 mice harbor significantly higher numbers of erythroid progenitors in the spleen compared with wild-t

223 ansion of a specialized population of stress erythroid progenitors in the spleen during the recovery

224 e B and T cells, monocytes, macrophages, and erythroid progenitors in the spleens of p27Kip1-/-; p130

225 E7.25 along with megakaryocyte and primitive erythroid progenitors, indicating that primitive hematop

226 ing, is the most active caspase in apoptotic erythroid progenitors induced by 11 kDa and NS1 as well

227 p process involving differentiation of early erythroid progenitors into enucleated RBCs.

228 Although initial expansion of late-stage erythroid progenitors is dependent on EPO, this cellular

229 is expression pattern is also seen in stress erythroid progenitors isolated from patients with sickle

230 xpression is essential for megakaryocyte and erythroid progenitors, its down-regulation is required f

231 ematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid an

232 ietic Cbfb-deficient mice also lack CD105(+) erythroid progenitors, leading to severe anemia at 3 to

233 ylinositol 3-kinase/Akt pathway in wild-type erythroid progenitors leads to a delay in erythroid diff

234 In iron deficiency, committed erythroid progenitors lose responsiveness to erythropoie

235 s transcription factors (TFs) in human-mouse erythroid progenitor, lymphoblast and embryonic stem-cel

236 t knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and

237 Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate f

238 Megakaryocytic/erythroid progenitor (MEP) reductions in Hoxa7(-/-) mice

239 mmon myeloid progenitor (CMP), megakaryocyte-erythroid progenitor (MEP), and granulocyte-macrophage p

240 e from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains poorly defined

241 ls that arise from a bipotent megakaryocytic-erythroid progenitor (MEP).

242 d its immediate precursor, the megakaryocyte-erythroid progenitor (MEP).

243 topoietic stem cells (HSC) and megakaryocyte-erythroid progenitors (MEP) than low-risk patients, and

244 ose were decreased in purified megakaryocyte/erythroid progenitors (MEPs) from W41/41 mice and rescue

245 Bipotent megakaryocyte/erythroid progenitors (MEPs) give rise to progeny limite

246 aused by an expansion of fetal megakaryocyte-erythroid progenitors (MEPs) triggered by trisomy of chr

247 yocytic progenitors (MPs) and megakaryocytic/erythroid progenitors (MEPs).

248 s) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs).

249 unctional equivalents known as megakaryocyte/erythroid progenitors (MEPs).

250 romote increased quiescence in megakaryocyte-erythroid progenitors (MEPs).

251 cytic progenitors (GMPs), and megakaryocytic-erythroid progenitors (MEPs).

252 ion, supporting the concept that bone marrow erythroid progenitors migrate to spleen.

253 rrects their hematocrits and deficiencies in erythroid progenitor numbers.

254 roliferation and terminal differentiation of erythroid progenitors occurs in human bone marrow within

255 megakaryocyte and/or bipotent megakaryocyte/erythroid progenitors of bone marrow, hence they are ref

256 tDNA mutations in vivo, we deleted Atg7 from erythroid progenitors of wild-type and mtDNA-mutator mic

257 Culturing erythroid progenitors on recombinant fibronectin fragmen

258 When overexpressed in primary erythroid progenitors, oncogenic Ras leads to the consti

259 s leads to decreased GATA1 expression in the erythroid progenitor population and p53-dependent upregu

260 s characterized by an expanded megakaryocyte erythroid progenitor population that was able to propaga

261 re activated in P1 knock-in premegakaryocyte/erythroid progenitors, presumably accounting for the inc

262 al, and knockdown of ZFP36L2 in transplanted erythroid progenitors prevented expansion of erythroid l

263 leukemias co-opt miR-486 functions in normal erythroid progenitor progrowth and survival activity.

264 hropoiesis is the process by which nucleated erythroid progenitors proliferate and differentiate to g

265 To meet this need, erythroid progenitors rapidly expand in the fetal liver

266 se mice and the precise function of c-Myb in erythroid progenitors remains elusive.

267 down of Mbnl1 in cultured murine fetal liver erythroid progenitors resulted in a strong block in eryt

268 ds to expansion of myeloid cells and reduced erythroid progenitors resulting in anemia, with dysregul

269 CL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of

270 Gene expression profiling of Fog(ki/ki) MK-erythroid progenitors revealed inappropriate expression

271 Commensurately, HSC and megakaryocyte-erythroid progenitors show higher clonogenicity, with in

272 Of importance, p67 recognizes early erythroid progenitors, since sorted p67(+) cells were si

273 enitors, acting in vivo at the megakaryocyte-erythroid progenitor stage to skew development away from

274 crucial functions: (1) at the megakaryocyte-erythroid progenitor stage, where it is involved in eryt

275 entiation of erythrocytes was blocked at the erythroid progenitor stage.

276 oid (CFU-Es) activities and reduced immature erythroid progenitors, suggesting that Cdc42 deficiency

277 thought to arise from bipotent thrombocytic/erythroid progenitors (TEPs).

278 in the spleen of a specialized population of erythroid progenitors termed stress BFU-E.

279 mosaic UPD of the beta-globin locus, more SS erythroid progenitors than AS, but a reverse ratio of er

280 xl1(f/f) (Asxl1(/)) mice had less numbers of erythroid progenitors than Asxl1(f/f) controls.

281 lt in an initial expansion of mutant HSC and erythroid progenitors that are later depleted as more di

282 raction is disrupted (Fog(ki/ki)) produce MK-erythroid progenitors that give rise to significantly fe

283 ntially expand ES cell-derived megakaryocyte-erythroid progenitors that have the capacity to differen

284 BM ALDH(hi) cells were enriched for myelo-erythroid progenitors that produced multipotent hematopo

285 Despite a severe depletion of erythroid progenitors, the erythrocyte and megakaryocyte

286 ia stimulates the proliferation of wild-type erythroid progenitors, the proliferation of progenitors

287 (1) are the principal integrins expressed on erythroid progenitors; their down-regulation during eryt

288 we analyzed the response of normal enriched erythroid progenitors to inducible disruption of a floxe

289 s that involves the differentiation of early erythroid progenitors to mature erythrocytes.

290 as it changes from a poised, silent state in erythroid progenitors, to the fully activated state in l

291 ach anemia model, however, hyperexpansion of erythroid progenitors was observed.

292 By culturing fetal liver erythroid progenitors, we show that fibronectin and Epo

293 Megakaryocyte and late erythroid progenitors were dramatically increased, with

294 nted hypoxia-inducible factor activity whose erythroid progenitors were hypersensitive to EPO.

295 ony activity and numbers of CD71(+)Ter119(+) erythroid progenitors were severely reduced.

296 throblastic islands remained unrecognized as erythroid progenitors were shown to possess an autonomou

297 l relevance of these findings, human primary erythroid progenitors were treated with HDAC9 siRNA; we

298 e development of three populations of stress erythroid progenitors, which expanded in the spleen subs

299 ial of JAK2(V617F)-expressing cell lines and erythroid progenitors while moderately affecting normal

300 ce markers that delineate a series of stress erythroid progenitors with increasing maturity.