ライフサイエンスコーパス: erythropoietin receptor

1 tions between transferrin receptor-2 and the erythropoietin receptor.

2 ivated JAK2 to induce phosphorylation of the erythropoietin receptor.

3 0(5) units/ml on cells that also express the erythropoietin receptor.

4 ge-restricted genes, including Klf1/Eklf and Erythropoietin receptor.

5 replaced with the cytoplasmic domain of the erythropoietin receptor.

6 lls engineered to coexpress Mpl receptor and erythropoietin receptor.

7 mutations of the SHP-1 binding domain of the erythropoietin receptor.

8 ch as glucose and anion transporters and the erythropoietin receptor.

9 toward early differentiation with increased erythropoietin receptor.

10 lical dimerization motif found in the murine erythropoietin receptor.

11 gh its ability to transduce signals from the erythropoietin receptor.

12 his is similar to the K(d) of SOCS-3 for the erythropoietin receptor.

13 d virus envelope glycoprotein, gp55, and the erythropoietin receptor.

14 ytokine receptors such as growth hormone and erythropoietin receptors.

15 The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5

16 Lack of erythropoietin receptor affects brain development as ear

17 high doses (50 mug/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation-induc

18 ed whether a novel, synthetic, peptide-based erythropoietin-receptor agonist (Hematide, Affymax) can

19 treated them with a synthetic peptide-based erythropoietin-receptor agonist.

20 ther investigated in mice expressing minimal erythropoietin receptor alleles.

21 containing the intracellular portion of the erythropoietin receptor allowed cells normally dependent

22 FFV envelope glycoprotein interacts with the erythropoietin receptor and a short form of the receptor

23 as been proposed for the activation of human erythropoietin receptor and human growth hormone recepto

24 and negatively regulates signalling from the erythropoietin receptor and is likely to regulate other

25 , the thrombopoietin receptor (MPL), and the erythropoietin receptor and mutations of other genes inv

26 tracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain

27 ecies barrier exists between mouse and human erythropoietin receptor and that the human erythropoieti

28 hromosome 19p13.2/3, near genes encoding the erythropoietin receptor and the cytokine receptor-associ

29 trast to the acquired MPDs, mutations of the erythropoietin receptor and thrombopoietin receptor have

30 ociate with the IL-3 receptor beta chain and erythropoietin receptor and to inhibit signaling mediate

31 teraction of the viral protein gp55 with the erythropoietin receptor, and other host factors, drives

32 n receptor subunits, sucrase-isomaltase, the erythropoietin receptor, and two of the subunits of the

33 nic lethality in the erythropoietin(-/-) and erythropoietin receptor(-/-) animals.

34 mice, while it has no effect in hearts from erythropoietin receptor(-/-) animals.

35 of human erythroblasts with mouse antihuman erythropoietin receptor antibody but not mouse immunopur

36 Although high levels of erythropoietin receptor are produced in embryonic brain,

37 425 and 367 in the cytoplasmic domain of the erythropoietin receptor are required for the phosphoryla

38 -CSFR fused to the cytoplasmic domain of the erythropoietin receptor, are able to support the product

39 Specifically, an erythropoietin receptor-based dimerization assay was use

40 This novel agonist of the erythropoietin receptor can correct anemia in patients w

41 -9R alpha-chain, IL-2 receptor ss-chain, and erythropoietin receptor, can be polyubiquitinated and de

42 be immunoprecipitated by an antiserum to the erythropoietin receptor carboxyl-terminal domain.

43 2R beta with either gamma c or the truncated erythropoietin receptor chain led to an array of specifi

44 sion systems: 1) 32D cells expressing leptin/erythropoietin receptor chimeras, 2) COS-7 cells express

45 R) signaling complex by a severely truncated erythropoietin receptor cytoplasmic domain lacking tyros

46 We report that the erythropoietin receptor cytosolic juxtamembrane region i

47 extracellular ligand-binding domains of the erythropoietin receptor, determined at 1.9 A from two cr

48 al regulator of erythropoiesis, cell surface erythropoietin receptors dimerize and activate specific

49 n the extracellular dimerization site of the erythropoietin receptor, distant from the hormone bindin

50 In studies to identify the erythropoietin receptor domains required for activation

51 Erythropoietin(-/-) and erythropoietin receptor(-/-) embryos also suffered from

52 Both erythropoietin(-/-) and erythropoietin receptor(-/-) embryos suffered from ventr

53 Other modes of erythropoietin receptor (EPO-R) activation, such as inte

54 ning progressively truncated isoforms of the erythropoietin receptor (EPO-R) and determined the rate

55 d tyrosine phosphorylation of both c-kit and erythropoietin receptor (EPO-R) and significantly greate

56 Kit receptor tyrosine kinase and erythropoietin receptor (Epo-R) cooperate in regulating

57 Signaling through the erythropoietin receptor (EPO-R) is crucial for prolifera

58 Stimulation of the erythropoietin receptor (EPO-R) or the interleukin-2 rec

59 We previously found increased erythropoietin receptor (EPO-R) protein levels in vigoro

60 expression of erythroid genes including the erythropoietin receptor (EPO-R) that results in increase

61 e cytokine erythropoietin (EPO), its cognate erythropoietin receptor (EPO-R), and associated Janus ty

62 n vivo requires collaboration between c-Kit, erythropoietin receptor (Epo-R), and GATA-1.

63 93T cells heterologously expressing TRPC and erythropoietin receptor (Epo-R), Epo stimulated an incre

64 In the erythropoietin receptor (Epo-R), two such motifs (box1 a

65 Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)-/- fetal livers, infecte

66 at bind to the extra-cellular portion of the erythropoietin receptor (EPO-R).

67 uracil-treated mice expressing a compromised erythropoietin receptor EPOR-HM allele.

68 rosine residue (pY) peptide derived from the erythropoietin receptor (EpoR pY429) binds to the N-SH2

69 To understand the role of erythropoietin receptor (EpoR) activation in erythroid d

70 protein, SFFV gp55, forms a complex with the erythropoietin receptor (EpoR) and a short form of the r

71 Endothelial cells express erythropoietin receptor (EpoR) and are responsive to ery

72 failing signal transduction at the homomeric erythropoietin receptor (EpoR) and at the heteromeric in

73 displays 100-fold increased affinity for the erythropoietin receptor (EPOR) and correspondingly eleva

74 Here, to clarify the functional role of the erythropoietin receptor (EpoR) and its downstream transc

75 Ba/F3 and B6SUtA cells transfected with the erythropoietin receptor (EpoR) and selected with erythro

76 ceptors with the extracellular domain of the erythropoietin receptor (EpoR) and the cytoplasmic domai

77 whether or not tyrosine residues within the erythropoietin receptor (EPOR) are essential for biologi

78 Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary

79 a model involves mitogenic activation of the erythropoietin receptor (EpoR) by the virus env gene (F-

80 Inherited mutations in the erythropoietin receptor (EPOR) causing premature termina

81 2/p30) that are hyperphosphorylated in a DA3/erythropoietin receptor (EpoR) cell line that expresses

82 rythropoiesis, we investigated its action on erythropoietin receptor (EpoR) cellular dynamics.

83 lls, we employed a prolactin receptor (PrlR)/erythropoietin receptor (EpoR) chimera system, in which

84 The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-dista

85 ane targeted chimeric protein containing the erythropoietin receptor (EpoR) cytoplasmic domain fused

86 Erythropoietin receptor (EpoR) dimerization is an import

87 e cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated

88 unoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopo

89 Western blotting was used to detect AT1R and erythropoietin receptor (EpoR) expression.

90 om the anemic strain (gp55-A), activates the erythropoietin receptor (EpoR) for proliferation of hema

91 tor receptor (fgfr-1), and downregulation of erythropoietin receptor (EpoR) gene expression.

92 any cancer cells show some expression of the erythropoietin receptor (EPOR) gene, although the "funct

93 utation affecting codon 399 in exon 8 of the erythropoietin receptor (EPOR) gene, encoding an EpoR pe

94 f red cell production through agonism of the erythropoietin receptor (EpoR) has historically been acc

95 able to bind to one of the 2 subunits of the erythropoietin receptor (EpoR) homodimer and is thus a c

96 Erythropoietin receptor (EpoR) homodimerization is an in

97 ated with mutations in the gene encoding the erythropoietin receptor (EpoR) in a small number of fami

98 O) is used to treat anemia by activating the erythropoietin receptor (EPOR) in erythroid progenitor c

99 To elucidate the role of Epo and erythropoietin receptor (EpoR) in melanoma, we examined

100 L traptamers) that specifically activate the erythropoietin receptor (EPOR) in mouse cells to confer

101 Ectopic expression of the erythropoietin receptor (EpoR) in the interleukin-3 (IL-

102 The erythropoietin receptor (EPOR) is a member of a family o

103 The erythropoietin receptor (EPOr) is activated by ligand-in

104 Signal transduction by the erythropoietin receptor (EPOR) is activated by ligand-me

105 Notably, we found that the erythropoietin receptor (EPOR) is consistently highly ex

106 The erythropoietin receptor (EpoR) is essential for producti

107 Here, we show that erythropoietin receptor (EPOR) is hydroxylated on prolin

108 The erythropoietin receptor (EpoR) is required for the proli

109 Erythropoietin receptor (EPOR) is thought to be activate

110 We generated an erythropoietin receptor (EpoR) isoform (ER343/401-S3) th

111 Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular resp

112 Using myleoid cells expressing a series of erythropoietin receptor (EpoR) mutants, we have demonstr

113 The putative presence of the erythropoietin receptor (EpoR) on human cancer cells has

114 generate cells expressing high levels of the erythropoietin receptor (EpoR) or a dominant negative Sm

115 Mutagenesis of the erythropoietin receptor (EPOR) permits analysis of the c

116 In contrast, the erythropoietin receptor (EpoR) requires only one recepto

117 tions of the cytoplasmic domain of the human erythropoietin receptor (EPOR) result in a dominantly in

118 tial for normal red cell development and for erythropoietin receptor (EpoR) signaling.

119 und and unbound forms, the activation of the erythropoietin receptor (EPOR) was initially proposed to

120 We found that the 78-kDa erythropoietin receptor (EPOR), a highly modified form o

121 oprotein, gp55, constitutively activates the erythropoietin receptor (EPOR), causing uncontrolled ery

122 Ab12.6, an agonistic human Ab targeting the erythropoietin receptor (EPOR), exhibits several potenti

123 ate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively.

124 a homodimeric Type I cytokine receptor, the erythropoietin receptor (EpoR), the thrombopoietin recep

125 sly characterized a truncation mutant of the erythropoietin receptor (EpoR), which is associated with

126 erythroid-specific gene expression including erythropoietin receptor (EpoR), which suggests a novel m

127 Spry1 was discovered to be regulated via the erythropoietin receptor (EPOR), with marked EPO-induced

128 served in the content of beta-globin mRNA in erythropoietin receptor (EpoR)-transfected Ba/F3 cells b

129 ony-stimulating factor receptor (G-CSFR) and erythropoietin receptor (EPOR).

130 d with a growth factor receptor, such as the erythropoietin receptor (EpoR).

131 t studies indicate that cancer cells express erythropoietin receptor (EpoR).

132 n (Epo) can generate commitment cues via the erythropoietin receptor (EpoR); specifically, EpoR signa

133 agents (ESAs) have been reported to activate erythropoietin receptors (EpoR) on cell types, including

134 n apparent Mr of 55,000 (gp55) that binds to erythropoietin receptors (EpoR) to stimulate erythroblas

135 ein with apparent Mr of 55,000 that binds to erythropoietin receptors (EpoR) to stimulate erythroblas

136 n specifically binds to and activates murine erythropoietin receptors (EpoRs) coexpressed in the same

137 by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intrac

138 Mice lacking the erythropoietin receptor exhibit severe anaemia and defec

139 Mice lacking the erythropoietin receptor exhibit severe anemia and die at

140 Erythropoietin receptors expressed in Sf9 cells were ins

141 When we induced Jak2V617F expression in erythropoietin receptor expressing precursor cells, the

142 Erythropoietin receptor expression in nonhematopoietic t

143 In summary, enhanced erythropoietin receptor expression promotes transplanted

144 Here, we report that enhanced erythropoietin receptor expression, as well as exogenous

145 poietin expression and a tenfold increase in erythropoietin receptor expression, increased cell survi

146 but these cells required coexpression of the erythropoietin receptor for optimal signaling.

147 escribe four different rearrangements of the erythropoietin receptor gene EPOR in Philadelphia chromo

148 Thus, the truncated erythropoietin receptor gene shows promise as a means fo

149 vates the 3 main myeloid cytokine receptors (erythropoietin receptor, granulocyte colony-stimulating

150 Mutation of the erythropoietin receptor has been demonstrated to cause f

151 ermal growth factor receptor (ErbB1) and the erythropoietin receptor have indicated that interactions

152 lls, retroviral vectors containing the human erythropoietin receptor (hEpoR) gene were used to transd

153 d property of all EMAs, to bind on the human erythropoietin receptor (hEPOR), is therefore exploited.

154 For a hypomorphic erythropoietin receptor-HM allele, major defects in eryt

155 onstrated a novel role of erythropoietin and erythropoietin receptor in cardiac development in vivo.

156 ty, and when overexpressed together with the erythropoietin receptor in cells, it caused hyperactivat

157 regulation in the liver and associates with erythropoietin receptor in erythroid cells.

158 Expression of a truncated erythropoietin receptor in hematopoietic stem cells has

159 compounds that can cause dimerization of the erythropoietin receptor in solution.

160 Analysis of the distribution of erythropoietin receptors in Sf9 plasma membrane and cyto

161 basic science studies on erythropoietin and erythropoietin receptors in solid cancers, raise concern

162 Solubilized erythropoietin receptors in whole-cell lysates and isola

163 totic pathways, potentially activated by the erythropoietin receptor, interact to produce the remarka

164 The spectrum of progenitors targeted by the erythropoietin receptor is broader during stress than du

165 Activation of the erythropoietin receptor is essential for the survival, p

166 We found that erythropoietin receptor is expressed in the developing m

167 f Tyr(985) does not alter STAT3 signaling by erythropoietin receptor-LRb (ELR) chimeras in transfecte

168 te is regulated at least in part through the erythropoietin receptor-mediated survival of splenic ear

169 in of SHP-1 with the tyrosine phosphorylated erythropoietin receptor modestly potentiated but was not

170 Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around em

171 and beta common (beta c), whereas the normal erythropoietin receptor (nEpoR) comprises only one known

172 oetal liver, endocardium and myocardium, the erythropoietin receptor null mouse shows extensive apopt

173 esis and other organ defects observed in the erythropoietin receptor null mouse.

174 osis in fetal liver, heart, and brain in the erythropoietin receptor null phenotype was markedly redu

175 iously demonstrated expression of endogenous erythropoietin receptor on murine myoblasts, and erythro

176 Erythropoietin induces dimerization of the erythropoietin receptor on the surface of erythroid prog

177 ve agent that does not bind to the classical erythropoietin receptor or affect hematocrit.

178 cal and suggests that studying modulation of erythropoietin receptor pathway may lead to strategies i

179 een focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen,

180 Erythropoietin receptors produced in Sf9 cells could be

181 Possible erythropoietin/erythropoietin receptor proerythroblast stage specific e

182 Erythropoietin receptor protein production was maximal 4

183 Mice with erythropoietin receptor restricted to hematopoietic tiss

184 of C2C12 myoblasts overexpressing truncated erythropoietin receptor showed more transplanted cell in

185 system restores active hematopoiesis via the erythropoietin receptor/signal transducer and activator

186 During stress, erythropoietin receptor signaling downregulates erythrob

187 However, erythropoietin receptor signaling has been mostly studie

188 kemia cell lines and enhances ligand-induced erythropoietin receptor signaling in erythroid progenito

189 Further, the requirement for erythropoietin receptor signaling is more stringent duri

190 This work reveals that erythropoietin receptor/Stat5 pathway contributes to BMM

191 Animals expressing only the human erythropoietin receptor survived through adulthood with

192 port the design and validation of two mutant erythropoietin receptors that probe the role of individu

193 se coding for alpha-globin, beta-globin, the erythropoietin receptor, the erythroid krupple-like fact

194 e kinases activated during engagement of the erythropoietin receptor, the Janus family kinase Jak-2 a

195 trates of these kinases are tyrosines in the erythropoietin receptors themselves and the signal trans

196 cades are activated during engagement of the erythropoietin receptor to mediate the biological effect

197 ered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine sig

198 revious study, it was found that a truncated erythropoietin receptor transgene (tEpoR tg) enables mul

199 n erythropoietin receptor and that the human erythropoietin receptor transgene is able to provide spe

200 This phenotype can be rescued by the human erythropoietin receptor transgene.

201 c defect associated with embryos lacking the erythropoietin receptor was corrected and the increased

202 The full-length murine erythropoietin receptor was expressed in Spodoptera frug

203 these same samples, erythroid-specific mRNA (erythropoietin receptor) was also detected.

204 dentification of compounds that can dimerize erythropoietin receptor, we have developed a novel, high

205 corresponding to the extracellular domain of erythropoietin receptor were expressed in Escherichia co

206 teracting residues in the growth hormone and erythropoietin receptors, whereas Cys-161, Cys-210, and

207 Transplantation of a region from the erythropoietin receptor, which contains a docking site f

208 of 100 mutants within the WSXWS motif of the erythropoietin receptor, which represents all single ami