ライフサイエンスコーパス: escalate

1 o occur in chick appearances when arms races escalate.

2 1.5 mg if >/=60 kg) and therapy is gradually escalated.

3 rapy, 12.5% of empirical antimicrobials were escalated, 21.5% were narrowed or discontinued, and 66.4

4 FVII-G96E dogs received escalating AAV doses (2E11 to 4.95E13 vector genomes [vg

5 ally on days 1, 3, 8, 10, 22, and 24 and was escalated according to a rolling-six design.

6 teases was conserved, alkaloid diversity has escalated across the studied species, oxidative activity

7 roversy over the authenticity of these silks escalated after the purchase of the silks by museums thr

8 PFC, interacted with prior alcohol intake to escalate aggression in ANAs.

9 described 14 techniques used in response to escalated aggression applied on a continuum between supp

10 Escalated aggression is a behavioral sign of numerous ps

11 The neurobiology underlying escalated aggression is unknown and is particularly unde

12 erstanding staff intervention in response to escalated aggression, a continuum between support and co

13 adaptive value by reducing the potential for escalated aggression, benefiting both senders and receiv

14 for preclinical studies of the treatment of escalated aggression, with the added benefit that emergi

15 ring the pre-escalation phase but not during escalated aggression.

16 Alcohol can escalate aggressive behavior in a significant subgroup o

17 nt aggression, and required to manage and de-escalate aggressive incidents; coercive measures such as

18 However, Nf1(+/-) mice failed to escalate alcohol drinking following chronic intermittent

19 itment of miR-206 in the mPFC contributes to escalated alcohol consumption following a history of dep

20 of microRNA (miR) 206 in mPFC contributes to escalated alcohol consumption.

21 ohol's effects on CeA activity and drive the escalated alcohol intake of alcohol-dependent rats.

22 ohol's effects on CeA activity and drive the escalated alcohol intake of alcohol-dependent rats.

23 Postdependent rats showed escalated alcohol intake, which was associated with incr

24 tent alcohol vapor exposure that resulted in escalated alcohol self-administration and elevated physi

25 arify the nature of the stimulus that drives escalated alcohol self-administration during acute withd

26 ecific KOR antagonism in the CeA ameliorated escalated alcohol self-administration during both acute

27 These results dissociate escalated alcohol self-administration from physiological

28 onfirmed a DYN/KOR system involvement in the escalated alcohol self-administration.

29 at drives dependence-like phenotypes such as escalated alcohol self-administration.

30 Alcohol tolerance is a key step toward escalating alcohol consumption and subsequent dependence

31 bly by PacC(27) and/or PacC(53), prevents an escalating alkaline pH response.

32 This exposed escalating amalgamation of function or abstraction with

33 ch 34 healthy adults (aged 35-55 y) consumed escalating amounts of CFs, ranging from 1000 to 2000 mg/

34 idence of endometrial carcinoma continues to escalate and, although surgical treatment has improved,

35 on of baseline antiarrhythmic medications or escalated antiarrhythmic drug therapy (escalated-therapy

36 nce of Escherichia coli K1 meningitis due to escalating antibiotic resistance warrants alternate trea

37 tural infections expose the immune system to escalating antigen and inflammation over days to weeks,

38 Responding to escalating antimicrobial resistance (AMR), the US Depart

39 important strategy in efforts to address the escalating antimicrobial resistance crisis.

40 ponsible use of antimicrobials in a world of escalating antimicrobial resistance.

41 7-beta-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A(-/-) mice.

42 onflict may lead to stalemate rather than an escalating arms race.

43 Liver dysfunction in SCD is likely to escalate as life span increases and patients incur incre

44 source intensive process whose scale quickly escalates as more drugs can be combined.

45 hospital mortality was 9.5% but cumulatively escalated at 1, 3, 6, and 12 months after discharge to 1

46 conducted, starting at 10(7) total cells and escalating at half-log increments to approximately 10(11

47 that increased bacterial genotypic richness escalates bacterial antagonism and decreases the ability

48 The dose was escalated based on tolerance or safety data from higher

49 lidomide was initiated at 2.5 mg/day and was escalated based on treatment tolerability to a maximum o

50 The escalated BEN was associated with more years of smoking

51 Among smokers CMH prevalence escalated between ages 36 and 43 from 7.6 +/- 2.0% to 13

52 ts (Deauville score 4 to 5) were switched to escalated bleomycin, etoposide, doxorubicin, cyclophosph

53 Liraglutide or placebo was escalated by 0.6 mg/day each week for 5 weeks and contin

54 id-mediated pancreatic damage can be further escalated by bradykinin-induced signals in stellate cell

55 500 mg/m(2) per day; the dose level was then escalated by doubling the previous dose if there were no

56 The ability to escalate care appropriately when managing deteriorating

57 Although failure to escalate care can lead to increased morbidity and mortal

58 vasopressors, 4) no hemodialysis, 5) do not escalate care, or 6) other limitations (e.g., "comfort c

59 l the Rapid Response Team can cause delay in escalating care.

60 l Therapy (PHACeT) trial was a phase 1, dose-escalating clinical study of the tolerability of culture

61 The ELEVATE-TIMI 56 (Escalating Clopidogrel by Involving a Genetic Strategy-T

62 d Rac1 activation and suggests that Rap1a de-escalates CNV development by interfering with ROS-depend

63 , obtained directly from scalp hair, implies escalating coca and alcohol ingestion in the lead-up to

64 Amphetamine treatment also reversed escalated cocaine intake and decreased motivation to obt

65 by decreased cocaine-induced locomotion and escalated cocaine intake despite extended abstinence fro

66 evented dopaminergic cross-sensitization and escalated cocaine self-administration during a 24 h "bin

67 the aVTA during each social defeat prevented escalated cocaine self-administration in a 24 h "binge."

68 ion, (2) dopaminergic sensitization, and (3) escalated cocaine self-administration in rats.

69 c cross-sensitization to cocaine, as well as escalated cocaine self-administration.

70 A both during and after stress to fuel later escalated cocaine taking and seeking behavior.

71 nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable

72 elease during stress may contribute to later escalated cocaine taking, and that persistently elevated

73 The trial was subsequently revised to escalating cohorts of 5 patients treated every 2 weeks x

74 in-Darby canine kidney cells with or without escalating concentrations of oseltamivir over serial pas

75 across the northeastern United States is an escalating concern threatening the ecological health of

76 ned with parental control over marriages may escalate conflict between same-sex siblings who compete

77 The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose confo

78 sis highlights the importance of considering escalating conservation costs from agricultural intensif

79 administration might factor in binge-related escalated consumption.

80 Mortality risk escalated continuously with increasing number of metasta

81 gression of non-target lesions, new lesions, escalating corticosteroids, progressive neurologic signs

82 merican College of Physicians to address the escalating costs of prescription drugs in the United Sta

83 Escalating costs secondary to rapidly evolving technolog

84 intravitreal anti-VEGF therapy, there was an escalating degree of proteinuria.

85 nsion in rice cultivation needed to meet the escalating demand for food in the coming decades.

86 insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia inte

87 rldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy fro

88 Depletion of TgEB1 results in escalated disintegration of kinetochore clustering.

89 ls for high-throughput chemistry offering an escalating diversity of warheads, opportunities for inno

90 and Methods Adult patients were treated with escalating dosages of BGJ398 5 to 150 mg once daily or 5

91 has the potential to selectively and safely escalate dose to high-risk tumors; however, research res

92 cute and late toxicities associated with the escalated dose and emphasise the importance of use of ap

93 This open-label, phase 2, escalating dose clinical study assessed the safety and t

94 009, with five participants assigned to each escalating dose group.

95 cell transcriptome, at consecutive stages of escalating dose immunotherapy, reveals progressive suppr

96 Three escalating dose levels (DL) were administered IM in 8 su

97 Groups of healthy consenting adults ingested escalating dose levels of S. Typhi and were closely moni

98 Twenty-seven patients were enrolled to 6 escalating dose levels, with expansion at the highest do

99 eive high-dose MTX with leucovorin rescue or escalating dose MTX with PEG asparaginase without leucov

100 effect was most profound with a continuous, escalating dose of factor VIIa.

101 ats before and after they were exposed to an escalating dose regimen of MA (or saline control).

102 saline by i.p. injections for 5 days with an escalating dose regimen.

103 The introduction of BEACOPP(escalated) (escalated-dose bleomycin, etoposide, doxorubicin, cyclop

104 orted after 5 years of follow-up showed that escalated-dose conformal radiotherapy improved biochemic

105 At a median follow-up of 10 years, escalated-dose conformal radiotherapy with neoadjuvant a

106 e at the time the trial was designed) or the escalated-dose group (74 Gy in 37 fractions).

107 in the control group and 55% (50-61) in the escalated-dose group (HR 0.69, 95% CI 0.56-0.84; p=0.000

108 3 subsequently randomly assigned: 422 to the escalated-dose group and 421 to the control group.

109 %] in the control group and 170 [43%] in the escalated-dose group).

110 d asparaginase, 18 doses of vincristine, and escalated-dose intravenous methotrexate without folinic

111 These efficacy data for escalated-dose treatment must be weighed against the inc

112 s infusion of placebo or OM in 3 sequential, escalating-dose cohorts.

113 on and high-dose methotrexate versus Capizzi escalating-dose methotrexate plus pegaspargase during in

114 le C57BL/6J mice were treated with a chronic escalating-dose morphine regimen (20-100 mg/kg/day, i.p.

115 rt B) with an interactive response system to escalating-dose subcutaneous IONIS-APO(a)Rx (100 mg, 200

116 to determine the safety and tolerability of escalated doses of an adeno-associated virus vector (AAV

117 re (18)F-FMISO-positive, 24 of whom received escalated doses of up to 86 Gy.

118 neous injections of rAvPAL-PEG were given in escalating doses (0.001, 0.003, 0.010, 0.030, and 0.100

119 Vehicle or CSCs at 5 escalating doses (0.3x10(6), 0.75x10(6), 1.5x10(6), 3.0x

120 We gave escalating doses (from 40-240 mg once daily to 160 mg tw

121 ve healthy adults were treated with 4 weekly escalating doses after which 10 peanut-allergic adults r

122 ed a novel dosing regime comprising multiple escalating doses and the resultant achievement of high p

123 rst 60 participants were given sertraline at escalating doses of 100 mg/day, 200 mg/day, 300 mg/day,

124 s with negative results were challenged with escalating doses of aztreonam and carbapenems.

125 study, we tested the safety and efficacy of escalating doses of bendamustine (70, 90, 110, and 130 m

126 Then, dosage was determined by infusing escalating doses of cardiospheres in the left anterior d

127 uman hookworms, and following challenge with escalating doses of dietary gluten.

128 In phase 1, we gave patients escalating doses of ixazomib (1.68-3.95 mg/m(2)) to esta

129 eak oxygen uptake and LV mass increased with escalating doses of lifelong exercise, with little chang

130 ale and female C57Bl/6J mice were exposed to escalating doses of METH or saline from adolescence thro

131 Mice were treated with saline or escalating doses of morphine (5, 8, 10, and 15 mg/kg) ev

132 nce was induced in rodents by treatment with escalating doses of morphine.

133 Concurrent cohorts 1, 2, 2a, and 3 received escalating doses of NIVO plus IPI once every 3 weeks for

134 oth lean and obese participants, infusion of escalating doses of obestatin resulted in a progressive

135 the opioid pharmacodynamic profile following escalating doses of SAM co-administered with BUP in opio

136 size of 14), to receive either one of three escalating doses of the measles-virus-based candidate va

137 Escalating doses were given to subsequent cohorts, and o

138 Escalating doses were given until a dose was reached tha

139 increase in their circulating platelets with escalating doses.

140 ine, and no such changes in effort following escalating doses.

141 baseline and after follow-up, identifying 18 escalating drinkers and 18 constant drinkers.

142 Escalating drinkers displayed greater impulsivity/compul

143 fundamental link between stress history and escalated drug self-administration.

144 ion is a neuropsychiatric disorder marked by escalating drug use.

145 ents to treat systemic fungal infections has escalated due to increasing resistance to the 2 main cla

146 s with ITX5061 (n = 8) or placebo (n = 2) to escalate duration (3 to 14 to 28 days) or deescalate dos

147 proportion of patients in whom treatment was escalated during follow-up over 14 mo, and case detectio

148 Doses were gradually escalated during phases 1 and 2, with individual maximum

149 oreover, we found that PKCepsilon expression escalates during megakarocyte differentiation and remain

150 mmation, which fuels a self-feeding cycle of escalating dysbiosis and inflammatory bone loss, potenti

151 Dose-escalated EBRT is associated with improved overall survi

152 Dose-escalated EBRT was associated with improved survival in

153 The developing world faces dual crises of escalating energy demand and lack of urban sanitation in

154 leading to its cytoplasmic translocation and escalated enzymatic activities.

155 The introduction of BEACOPP(escalated) (escalated-dose bleomycin, etoposide, doxorub

156 ersed SI-mediated hypodopaminergic state and escalated ethanol intake suggest that KOR antagonists ma

157 es (Pieridae), and uncovered evidence for an escalating evolutionary arms-race.

158 randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) with br

159 5 published randomized clinical trials, dose-escalated external-beam radiation therapy (EBRT) for pro

160 were designed to mimic tumor progression by escalating flow complexity and chaoticity.

161 profiles are collected from the same tap at escalating flow rates.

162 The escalating food demand by a growing and increasingly aff

163 This escalating frame requires agents to continuously balance

164 Intravenous LY2606368 was dose escalated from 10 to 50 mg/m(2) on schedule 1 (days 1 to

165 , administered after oral THU 10 mg/kg, were escalated from a very low starting level (0.01, 0.02, 0.

166 uptake in human PC-3 xenografts in SCID mice escalated from less than 4 %ID/g to greater than 21 %ID/

167 expected rise in prevalence in line with the escalating global burden of obesity.

168 lated with 20 Necator americanus larvae, and escalating gluten challenges consumed as pasta were subs

169 kworm infection on the predicted outcomes of escalating gluten challenges in CeD subjects.

170 dard-dose (from 68.4 Gy to <75.6 Gy) or dose-escalated (>/=75.6 Gy to 90 Gy) EBRT (1 Gy = 100 rad).

171 nts who received 4 or more cycles of BEACOPP(escalated) had an increased risk to develop t-AML/MDS wh

172 availability of community-based providers to escalate HCV therapy, bridging existing gaps in the cont

173 In the ever-escalating host-pathogen arms race, viruses have evolved

174 ories of evolutionary challenges result from escalating human impacts on the planet.

175 These forests are experiencing escalating human influence, altering their health and th

176 2007) received induction chemotherapy, dose-escalated hyperfractionated craniospinal radiotherapy, a

177 e therapeutic potential of varenicline would escalate if it also diminished conditioned responses eli

178 parasites to therapeutic drugs continues to escalate in developing countries, and in many instances,

179 In both groups, treatment was escalated in a stepwise manner, from no treatment, to ad

180 ed after pathogen clearance and irreversibly escalated in severity with repeated infections.

181 amide dosing started at 150 mg/kg and was de-escalated in steps of 50 mg/kg (to 100 mg/kg, 50 mg/kg,

182 2a starting dose was 0.25 mg/kg and was then escalated in successive dose cohorts of three patients (

183 aily schedule and 60 mg for other schedules, escalating in 30 mg increments.

184 y associated with prescription opioid use is escalating in the United States.

185 Importance: An escalating incidence of human papillomavirus (HPV)-relat

186 a-mediated signal transduction via JAK-STAT, escalating inducible NO synthase transcription levels an

187 Patients were treated at escalating injected activities (10, 15 and 20 MBq/kg) of

188 ficiency and staff anxiety had a key role in escalating intervention.

189 between stages showed how an index case can escalate into a widespread epidemic in the absence of in

190 what begins as small acts of dishonesty can escalate into larger transgressions.

191 The resulting positive feedback cycle escalates into bulimia for many, and anorexia in a few.

192 public health problem, and cancer treatment escalates its prevalence and complexity.

193 d an intravenous (IV) dose of saline and two escalating IV doses of nicotine.

194 Using an escalating L-DOPA dose protocol, LID severity was decrea

195 Intermittent social defeat stress escalates later cocaine self-administration.

196 day for 21 days per 28-day cycle, with a de-escalated level of 3 mg if not tolerable, and aspirin 81

197 ing environmental concerns of our age is the escalating level of atmospheric CO2 .

198 After abstinence, escalated levels of cocaine taking decreased toward pre-

199 s mortality has diminished, only to steadily escalate long after "recovery" from acute events.

200 In young adults, an escalating MaxDrinks trajectory was prospectively associ

201 tuates a loop of reciprocal stimulation with escalating negative effects on honey bee immunity and he

202 marketing, do-it-yourself enthusiasm, and an escalating number of clinical trials.

203 Lomitapide dose was escalated on the basis of safety and tolerability from 5

204 ed the impact of intra-CeA KOR antagonism on escalated operant alcohol self-administration and physio

205 Doses were escalated or reduced using an algorithm to reach a targe

206 y worsening abdominal pain in the context of escalating or continuous opioid therapy.

207 esis that a decision can reliably be made on escalating or deescalating therapy based on interim PET

208 s treated with less than 4 cycles of BEACOPP(escalated) or no BEACOPP chemotherapy (1.7% vs 0.7% vs 0

209 goods, risk and reward are often coupled and escalate over time, for instance, during foraging, tradi

210 Interest in these bioparticles has escalated over the years, leading to discoveries regardi

211 Use of escalated peptide mass and nephroprotective agents were

212 With the escalating persuasion of economic and nutritional import

213 Dose escalating PK studies in dog revealed significant issues

214 eomycin, vinblastine, and dacarbazine), four escalated plus two standard cycles of BEACOPP (bleomycin

215 ke hold and may be the primary driver of the escalating poleward migration of species.

216 mics are an important evolutionary driver of escalating predation mode and efficiency, and commensura

217 has raised concerns, in part because of the escalating prescription of atypical antipsychotics.

218 he response ratio (lever presses per reward) escalated, Q175 mice exerted less effort to earn fewer r

219 Adapting RT-escalated radiation dose to the FDG-avid tumor detected

220 dengue viruses and then an exploratory, dose-escalating, randomized placebo-controlled trial in adult

221 rescription opioid abuse and dependence have escalated rapidly in the United States over the past 20

222 ted AKT suppresses MRN complex expression to escalate RAS-induced DNA damage and thereby reinforce on

223 thin the drug discovery industry are causing escalating rates of failure of development pipelines.

224 GLP-1 receptor agonist liraglutide in a dose-escalating regimen to reverse hyperglucagonemia or its v

225 experience in female hamsters resulted in an escalated response to future aggressive encounters and a

226 , and STN in computing the trade-off between escalating reward and risk in sequential decision-making

227 An escalating risk of mortality was observed with each hour

228 We identified low but escalating risk of severe M. chimaera infection associat

229 ng a die to accumulate monetary reward under escalating risk, or the alternative option to stop to ba

230 ce immunity, microbiota might have played an escalating role in the evolution of sociality.

231 up performance status, 0 to 1) received dose-escalated RT to 70 to 90 Gy (median, 74 Gy) in six trial

232 nivolumab monotherapy or assessed in a dose-escalating safety phase for the nivolumab/ipilimumab com

233 icity were assessed during standard and dose-escalated sorafenib treatment.

234 However, escalating stressful conditions enable some symbionts to

235 Dopamine depletion escalated striatal net output but had contrasting effect

236 This was a phase 1, open-label, dose-escalating study done at four outpatient retina clinics

237 ized, double-blind, placebo-controlled, dose-escalating study of BMS-936559, including HIV-1-infected

238 In the second stage, a phase 2a dose-escalating study, 14 patients with early-stage ALS recei

239 en-label, single-center, intra-patient, dose-escalating study, adult patients with HPP received 3 asc

240 Recognizing and responding early to escalating symptoms is essential to preventing hospitali

241 of reversible pathology or a decision not to escalate the level of care.

242 Furthermore, G/G male mice escalated the amount of heroin self-administration acros

243 enomic data can be generated has drastically escalated the computational burden for even routine phyl

244 and immune system cross-modulate each other, escalating the destructive feedback cycle between them t

245 Escalating the dose may be an effective treatment strate

246 Its areas of focus have included escalating the level of priority afforded to polio eradi

247 larial therapies remains a pressing concern, escalating the need for compounds that demonstrate novel

248 more alcohol than controls and spontaneously escalate their consumption.

249 ancy rate, and the unemployment rate) people escalate their support for dominant leaders.

250 ostoperative patient in a simulated ward and escalated their care to a senior colleague.

251 ccess (ShA; 1 h/day) to vaporized sufentanil escalated their drug intake over time and exhibited both

252 ost patients, but the data suggest a need to escalate therapy to higher mycophenolate doses, and in o

253 ed-field radiation therapy or a switch to an escalated therapy protocol, particularly in advanced-sta

254 ively, and who therefore might warrant early escalated therapy.

255 the ablation group and 68.5% of those in the escalated-therapy group (hazard ratio in the ablation gr

256 ns or escalated antiarrhythmic drug therapy (escalated-therapy group).

257 In the escalated-therapy group, amiodarone was initiated if ano

258 ssigned to the ablation group and 127 to the escalated-therapy group.

259 ects and one from hepatic dysfunction in the escalated-therapy group.

260 of drug-resistant tuberculosis (TB) poses an escalating threat to national TB control programs.

261 conservation projects confront immediate and escalating threats with limited funding.

262 cribed hemocompatibility score, which uses 4 escalating tiers of hierarchal severity to derive a tota

263 ffuse and chronic diseases provoke gradually escalating tissue changes.

264 intrinsic ROS level in the tumors could not escalate to an adequate level that the developed materia

265 in the reacting octopus were more likely to escalate to grappling.

266 ne 20 mg, and panobinostat 10, 15, or 20 mg (escalated to 20 mg according to the escalation schedule)

267 ery 28-day cycle for 12 cycles; the dose was escalated to 25 mg daily after the first cycle if no dos

268 Doses were escalated to 3.7 mg/d (SLIT) or 2000 mg/d (OIT), and sub

269 Lapatinib dose was escalated to 7,000 mg per day in twice-daily dosing with

270 rting dose was 60 mg/day orally but could be escalated to 80 mg if the patient did not experience a r

271 for 12 weeks at an initial dose of 50 mg/d (escalated to a maximum dose of 200 mg/d based on tolerab

272 roxycarbamide at 20 mg/kg per day, which was escalated to each participant's maximum tolerated dose.

273 Cohort 1 patients failing any target escalated to imatinib 800 mg/day, and subsequently switc

274 Immunosuppression was escalated to mycophenolate 3 g daily, with addition of a

275 fixed risk of RILT (grade >2) and adaptively escalated to the residual tumor defined on midtreatment

276 tenance was started with 5 mg daily, and was escalated to the target dose of 15 mg.

277 rting dose was two capsules (10 mg) per day, escalated to three capsules (15 mg) per day after 3 mont

278 otrexate at an initial weekly dose of 10 mg, escalating to 25 mg/week (n = 63), or placebo (n = 63).

279 on cases of severe flulike illness annually, escalating to life-threatening hemorrhagic fever or shoc

280 elated with their response to host defences: escalating traits largely affected generalists and diver

281 ergent traits specialists; but the effect of escalating traits on extreme specialists was positive.

282 d of receiving (OR, 1.4; 95% CI, 1.2-1.8) or escalating treatment (OR, 1.2; 95% CI, 1.0-1.4) was incr

283 t was also associated with increased odds of escalating treatment (OR, 3.0; 95% CI, 2.4-3.7).

284 ents offers the possibility of commencing or escalating treatment at an earlier stage.

285 function of sampling, closely resembling an escalating urgency signal.

286 d (2) chronic changes in behavior, including escalated use, tolerance, compulsive seeking, and depend

287 ities of membership in a class that reported escalating use (P=0.001).

288 and (c) individuals at genetic risk for both escalating use of addictive substances and poor abilitie

289 ency management (three pound10 vouchers), or escalating value contingency management ( pound5, pound1

290 ), as did 32 (49%) of 65 participants in the escalating value contingency management group (14.0, 4.2

291 d NPCs, and loss of this function results in escalated Vegfa and Igf2 signaling, which exacerbates bo

292 ized comparative effectiveness study of dose-escalated vs standard-dose EBRT for prostate cancer diag

293 such as South East Australia are faced with escalating water scarcity and security challenges.

294 The impacts of escalating wildfire in many regions - the lives and home

295 of phenotypic variation, thus evolvability, escalates with the degree of overall growth suppression.

296 The need for stroke care is escalating with an ageing population, yet methods to est

297 would suffer; health-care expenditures would escalate, with patients bearing increasing costs; and a

298 the studied species, oxidative activity has escalated within one clade, and trichomes have diverged

299 e of atopy and allergic disease continues to escalate worldwide.

300 ated-5 homolog, up-regulates YAP expression, escalating YAP levels in the nucleus and promoting cance