ライフサイエンスコーパス: escape

1 Study of Cohorts for Air Pollution Effects (ESCAPE)).

2 while socially dominants favor swimming over escape.

3 n as part of an acquired mechanism of immune escape.

4 aughter cells was associated with senescence escape.

5 TME) is a major barrier to overcoming immune escape.

6 ly manipulated to have a reduced capacity to escape.

7 elements in a non-sequential fashion during escape.

8 durable benefits with relatively infrequent escape.

9 10 (6.1%) LPs in 9 patients represented CSF escape.

10 subvert the effector phase and enable tumor escape.

11 stinct cell types cooperate to promote their escape.

12 n effective strategy to blunt tumoral immune escape.

13 vely capture tumor cells with slim chance to escape.

14 ntibiotic resistance development and vaccine escape.

15 raise suspicion of possible CSF discordance/escape.

16 reduces the risk of antigen-negative disease escape.

17 equence cause immune failure and allow viral escape.

18 synthesis to overcome OC stability and drive escape.

19 ion plays an important role in cancer immune escape.

20 c strategy for the prevention of therapeutic escape.

21 hat initiation with them stimulates promoter escape.

22 high sequence variability leading to immune escape.

23 ents, reduce toxicities, and prevent antigen escape.

24 ad-groups to facilitate pseudopilin membrane escape.

25 tendency to freeze and subsequent efforts to escape.

26 ase their short RNA and make another without escaping.

27 sids highlight a back door route for nuclear escape, a process referred to nuclear envelope (NE) budd

28 y both their transduction efficiency and Nab escape activity.

29 raniofacial-to-PBL projection induced robust escape and avoidance behaviors and stress calls, whereas

30 lving endocytic uptake followed by endosomal escape and cytosolic access.

31 (NP) enabling excellent endosomal/lysosomal escape and efficient siRNA decomplexation inside the tar

32 be leveraged in HIV cure efforts if epitope escape and lack of sustained effector memory responses w

33 her alkalinizing compounds similarly inhibit escape and MNGC formation.

34 In turn, some animal viruses are able to escape and modulate autophagy for enhanced pathogenicity

35 ophagic degradation and to promote endosomal escape and nuclear trafficking.

36 olecule antiretrovirals, the issues of viral escape and resistance will have to be addressed.

37 iotropic effects, orchestrating tumor immune escape and supporting RS cell survival.

38 vior and neural circuit responses that drive escape and swim behaviors in fish.

39 onstructed a neurocomputational model of the escape and swim circuits.

40 changes in the relative excitability of the escape and swim networks.

41 abilities of the Mauthner command neuron for escape and the inhibitory interneurons that regulate swi

42 es have evolved to minimize the time between escaping and invading the next cell.

43 amine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which

44 ug, inhibits Burkholderia growth, phagosomal escape, and subsequent MNGC formation.

45 ovides new insights into HIV-1's capacity to escape aptamer-mediated inhibition, the potential utilit

46 e cancer (CRPC) cells are eventually able to escape available hormonal treatments due to reactivation

47 tions and possibly triggering an approach or escape behavior depending on their identity.

48 this, we have investigated the dependence of escape behavior on learned knowledge about the spatial e

49 New work on innate escape behavior shows that mice spontaneously form a spa

50 ulation can produce robust modality-specific escape behavior.

51 foot-shocks, excite LHb neurons and promote escape behaviors in mice.

52 A sudden aversive event produces escape behaviors, an innate response essential for survi

53 he LH-to-LHb pathway impairs aversion-driven escape behaviors.

54 have occurred in healthcare workers but have escaped being diagnosed.

55 spiral-like fashion and enables the cell to escape by a screw-like backward motion.

56 Larvae escape by backward locomotion when touched on the head,

57 Thus, reduced escape capability resulting from infection may also cont

58 s, thousands of enslaved Africans managed to escape captivity and establish lasting communities, such

59 le of p40 monomer in helping cancer cells to escape cell death via suppression of IL-12Rbeta1 interna

60 st; forcing selection of viral variants that escape cellular and antibody (Ab)-mediated immune pressu

61 -synuclein misfolding and why the aggregates escape cellular degradation under disease conditions.

62 sized to generate a safe replicative body to escape cellular immune responses in the insect gut.

63 m circuit, but an enhanced activation of the escape circuit.

64 formation to the Drosophila giant fiber (GF) escape circuit.

65 Despite escaping conscious perception, manipulable objects activ

66 by which mRNAs encoding cold shock proteins escape cooling-induced translational repression are unkn

67 k 18, placebo-treated patients meeting early escape criteria (<20% improvement in swollen and tender

68 as evidenced by the failure of the phagosome escape-deficient mutant SCHU S4 DeltafevR to induce cell

69 uling out Taz modification as a mechanism of escaping degradation.

70 ressive eosinophils expressing CD16 that may escape detection because CD16-based negative selection i

71 Influenza viruses steadily evolve to escape detection by antibodies, necessitating vaccine up

72 RNA modifications that once escaped detection are now thought to be pivotal for gove

73 copies HIV-1 RNA greater than plasma VL) or escape (detection of HIV VL >50 copies/mL in CSF in pati

74 ound states and their internal dynamics have escaped direct experimental observation.

75 DNA lesions that have escaped DNA repair can induce replication stress and gen

76 etween liquid and vapour, followed by vapour escape during accretionary growth of planetesimals, gene

77 biases motor selection to rapid, GF-mediated escapes during fast looms.

78 e a delayed immune response caused by immune escape established by HCMV strains.

79 HCV variants that included RAS identified in escape experiments, using recombinants with or without T

80 NOTCH2 carrying a truncated C terminus that escapes FBW7-mediated ubiquitination and degradation.

81 via multiple pathways and took longer, with escape first occurring through an increase in V1 loop le

82 growth environment of a population, with an escape frequency of less than 1 in 10(5) after 10 days o

83 single small-molecule-based kill switch, low escape frequency, and unaffected protein function.

84 t from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on addit

85 release the genome, and that the genome may escape from a 5-fold vertex to initiate infection.

86 trations <40 ppm, suggesting a rather narrow escape from a fully glaciated Snowball Earth state given

87 ressor p53 remain a vital mechanism of tumor escape from apoptosis and senescence.

88 rget (V3C3), showing slower and more complex escape from bNAbs.

89 hile amino acid substitutions that result in escape from CD8(+) T cell recognition were not observed,

90 tal, highly aggressive growth potential upon escape from cell-cycle blockade, and is enriched in rela

91 ome - namely, male specificity, haploidy and escape from crossing over - make it an unusual component

92 This mechanism of FoxP3 control may allow escape from dominant Treg control during infection or ca

93 sults highlight that a fraction of virus can escape from high concentrations of antibody through cell

94 ses have generated a strategy to efficiently escape from host defence mechanisms during reactivation

95 factor that kills leukocytes permitting it's escape from host immune surveillance.

96 variability in C-PfCSP may benefit parasite escape from humoral and cellular immunity.

97 changes that lead to therapy resistance and escape from immune control before establishing acquired

98 enchymal transition, tumor cell dormancy and escape from immune surveillance, with emerging functions

99 +) T lymphocytes plays a major role in tumor escape from immune system during cancer progression.

100 Escape from MAb neutralization may be a powerful epidemi

101 iL4 modification (TiL4 @BPs) can efficiently escape from macrophages uptake, and reduce cytotoxicity

102 s with CAF-derived mtDNA(hi) EVs promoted an escape from metabolic quiescence and HTR disease both in

103 w that it is more difficult for the flies to escape from Mono Lake water than from fresh water, due t

104 tive autoimmune T cell development and their escape from negative selection in the thymus.

105 in the last or penultimate exon, suggesting escape from nonsense-mediated mRNA decay.

106 is a therapeutically targetable mechanism of escape from NRAS oncogene addiction in AML.

107 and could be an important mechanism driving escape from Ras-induced senescence.

108 commands adaptation for survival rather than escape from stress.

109 the ability of renin-angiotensin activity to escape from suppression during long-term treatment.

110 argeting H3K9me3 or p53 to mimic spontaneous escape from the arrested condition, we found that cells

111 In contrast, escape from the bNAbs was mediated via multiple pathways

112 tructure that allow the endocytosed virus to escape from the endosome, pass through the cell cytoplas

113 for degradation while enabling WT proinsulin escape from the ER.

114 l division protein and factors important for escape from the host immune system.

115 o resist to lysozyme degradation and thus to escape from the host innate immune system but little is

116 to be inherently cytolytic, wherein CVB can escape from the infected host cell only by causing it to

117 n via interaction with CD36 and in bacterial escape from the phagolysosomes.

118 depends on the ability of this bacterium to escape from the phagosome of the host cells via the acti

119 apabilities to target cancerous cells and to escape from the recognition and elimination by the retic

120 rains suggests an 'arms race' in which phage escape from the type I-F system can be overcome through

121 The majority of exogenous mitochondria escape from these compartments and fuse with the endogen

122 cancers, enable HPV-positive cancer cells to escape from these regulatory principles: E6/E7 is effici

123 equalized and how imprinting control regions escape from this reprogramming is largely unknown.

124 In effect, functional lincRNAs must escape from this targeted nuclear surveillance process.

125 ed "bystander" antigens, might enable B-cell escape from tolerance.

126 rotection, controlled by novel mechanisms of escape from translational inhibition on cooling.

127 istant nature of cancer cells leads to their escape from treatment and to liver metastasis, which in

128 stance-associated substitutions (RAS) on HCV escape from treatment.

129 toward the hybrid state, suggesting possible escape from treatment.

130 We also find that escape from X-inactivation is tissue-specific, with leg

131 To identify putative 'escape from X-inactivation tumor-suppressor' (EXITS) gen

132 tiple lines of evidence and demonstrate that escape from XCI results in sex biases in gene expression

133 hagocytosis, wild-type (WT) L. monocytogenes escaped from a noncanonical autophagic process that targ

134 r phagocytosis, A. fumigatus conidia rapidly escaped from DCs, whereas A. terreus conidia remained pe

135 fessional cytosol-dwelling Shigella flexneri escapes from LUBAC-mediated restriction through the anta

136 is a facultative intracellular pathogen that escapes from phagosomes, grows in the host cytosol, and

137 o-editing process supporting cancer cells in escaping from the human immune system.

138 tively) in female cells, with the degree of 'escape' from inactivation varying between genes and indi

139 Additionally, if wildflower species escape gardens these indirect effects may be compounded

140 ous bubbles to a facilitated removal through escaping gases/vapors.

141 Escape genes showing CH hypermethylation were the only g

142 among proponents of the cellular regression, escaped genes, and primordial virus world hypotheses.

143 Thus, comprehensively mapping HIV antibody escape gives a quantitative, mutation-level view of Env

144 reatment-experienced patients dominating the escape group.

145 rom cell to cell as a potential mechanism to escape host antiviral responses.

146 ns - protein introns - and describe how they escape host proteins, their uses in biotechnology, where

147 ey may be key in antagonistic coevolution to escape host suppression.

148 stance, in particular how HIV-infected cells escape immune elimination by the TRAIL:TRAILshort recept

149 luenza viruses are able to rapidly evolve to escape immune pressure in a process known as "antigenic

150 Cancer cells need to escape immune surveillance for successful tumor growth.

151 , a better understanding of how these tumors escape immune surveillance is required to enhance antitu

152 an evolve SE to drive CD47 overexpression to escape immune surveillance.

153 ng feature suggests that malignant HRS cells escape immunosurveillance and interact with immune cells

154 yte-deprived environment but promoted immune escape in a lymphocyte-enriched environment.

155 ose TE suppression as a mechanism for immune escape in AML and MDS.

156 ansmembrane mucin MUC1 contributes to immune escape in an aggressive form of breast cancer, with pote

157 eport mechanistic evidence of tumoral immune escape in an exemplary clinical case: a patient with met

158 K inhibition to overcome sorafenib treatment escape in HCC.

159 lymers that undergo acid-activated endosomal escape in living cells.Hydrogen bonding plays a major ro

160 ry stimuli, we show that the primary goal of escape in mice is to reach a previously memorized shelte

161 xplored risk factors for CSF discordance and escape in patients presenting with diverse neurological

162 findings show how MUC1 contributes to immune escape in TNBC, and they offer a rationale to target MUC

163 in later-stage disease, the tumor cells can escape into the blood, the lymph nodes, and at times the

164 ated O atom within the solvent cage prior to escape into the bulk solution.

165 Escape into the cytosol and outer-layer shedding depend

166 lar bacteria characterized by the ability to escape into the cytosol of the host cell and to stimulat

167 mococci existed as intravacuolar bacteria or escaped into the cytoplasm.

168 niche for M. tuberculosis replication before escaping into the extracellular milieu.

169 ia that were initially enriched subsequently escaped isolation.

170 Whereas the fly's escape jump has been well studied [8, 9, 13-18], the neu

171 as a molecular mimic to engage Siglec-11 and escape killing.

172 rugation and longitudinal phonons whose fast escape leaves behind a 2D-projected mass density increas

173 e mutation, suggesting that preventing HIV-1 escape may require coordinated direction of the CTL clon

174 nase activity induction in macrophages is an escape mechanism developed by parasites to cope with the

175 While leader cells provide an escape mechanism for followers, follower cells in turn p

176 el events suggests that HLA LOH is an immune escape mechanism that is subject to strong microenvironm

177 nce the therapeutic efficacy, restrict major escape mechanisms and increase tumor-targeting selectivi

178 ion enables a human Ab to cope with pathogen escape mechanisms and will aid in optimization of immuni

179 tified during the 2012-2015 outbreaks, 5 MAb escape MERS-CoV mutants, and 2 live human MERS-CoV strai

180 d live MERS-CoV strains, as well as antibody escape MERS-CoV mutants.

181 re most likely to have a wild-type PZase and escape molecular detection.

182 Competitive growth of the escape mutant viruses with the wild-type virus revealed

183 However, ZIKV escape mutants emerged in vitro and in vivo in the prese

184 with the wild-type virus revealed that some escape mutants possessing an amino acid substitution oth

185 alize the TF virus but also can select virus escape mutants that in turn select affinity-matured neut

186 nd the replacement of wild-type virus by CTL escape mutants within the latent reservoir.

187 everal Ags may limit the generation of viral escape mutants.

188 ralization in their human hosts by acquiring escape mutations at epitopes of prevalent antibodies.

189 V entry blockers are in clinical trials, but escape mutations challenge their potential.

190 Escape mutations were identified at position 129, 165, o

191 Escape mutations were mapped upon a three-dimensional (3

192 hat the triploid AAV2/8/9 vector was able to escape Nab activity from mouse sera immunized with paren

193 Escaping narwhals displayed a paradoxical cardiovascular

194 to drive acquisition of mutations in GP that escape neutralization.

195 -H, we identified a D4 genotype variant that escapes neutralization by MAbs targeting the neutralizin

196 levels and intron-retaining transcripts that escape nonsense-mediated decay are not actively translat

197 gesting that Myt1l allows newborn neurons to escape Notch activation during normal development.

198 e severe inflammatory response and increased escape of bacteria from the colon into the lymphatic sys

199 tigation of new strategies for endolysosomal escape of biomacromolecules to facilitate the developmen

200 eletes insulin-specific T cells and prevents escape of high-affinity thymocytes.

201 Mutational escape of HIV-1 from HIV-1-specific CD8(+) T lymphocytes

202 These results indicate that the escape of HIV-1 from host humoral immunity may play a di

203 tibility complex-1 downregulation and immune escape of HIV-infected cells required for functional int

204 for TLR detection, while its absence enables escape of innate immune surveillance.

205 duction of chemokines collectively favor the escape of malignant cells.

206 s or Alu-RNA accumulation triggers cytosolic escape of mitochondrial DNA, which engages cGAS.

207 We find that escape of soil gas through wetland trees is the dominant

208 plicate sequences diverge-until an eventual "escape" of the sequences from its influence.

209 her, our data suggest that lung cancer cells escape oncogene-induced premature senescence through dow

210 , we expect it to be a common and widespread escape or motility mode in complex and structured enviro

211 ta targeting might decrease risks of antigen escape or resistance to immune checkpoint blockade.

212 sh a successful infection, mycobacteria must escape out of the initially infected resident macrophage

213 show that socially subordinate animals favor escape over swimming, while socially dominants favor swi

214 hanism by which ErbB2-positive breast cancer escapes p110alpha inhibition.

215 he N332 glycan may have constrained the bNAb escape pathway.

216 vidence suggests that, while numerous immune escape pathways are shared between hematological and sol

217 hibit a powerful technology that reveals the escape pathways of HIV-1 and may enable its capture.

218 TL clonal repertoire to simultaneously block escape pathways.

219 ts assigned to placebo [62%, including early escape patients switched to sirukumab at week 18] of 294

220 IDs do not reflect an increased tumor immune escape per se.

221 utant viruses with RBS deletions are able to escape polyclonal antiserum binding and are able to infe

222 r of rare and minute marine species may have escaped previous characterization.

223 which requires RNA polymerase II (pol II) to escape promoter proximal pausing on chromatin.

224 atient missense variant, L344P, that largely escapes proteasomal surveillance and shows subtle but cl

225 in conflict with the urge to perform fast to escape punishment.

226 We also estimate the escape rates analytically and demonstrate that they are

227 r wind of TRAPPIST-1 and the atmospheric ion escape rates for all of the seven planets.

228 uption strategies that may ultimately enable escape-resistant antiviral therapies.

229 nt are essential for initiation and promoter escape, respectively, and the holoenzyme releases contac

230 synaptic transmission between neurons in the escape response neural circuit of adult flies.

231 rosophila giant fiber system (GFS), a simple escape response neuronal circuit, by increasing targetin

232 The escape response to a visual threat is, however, flexible

233 uding scototaxis, activity, exploration, and escape response were assessed after 7 and 14 days.

234 ious touch and temperature, with stereotyped escape responses through activation of multimodal nocice

235 es evoke slower, more kinematically variable escape responses with relatively long latencies as well

236 decades on habituation of startle and other escape responses, the underlying neural mechanisms are s

237 e required for the speed and coordination of escape responses.

238 ey determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-specific immune de

239 antibiotic-resistant anaerobic archaea that escape routine detection in clinical microbiology.

240 sed in vivo and how MITF-low cells in tumors escape senescence are poorly understood.

241 ise in a low oxygen environment, possibly to escape soil patches with reduced oxygen availability.

242 However, some escape strategies are more costly than others, and so it

243 ional studies and reveal additional sites of escape, such as positively charged mutations in the anti

244 previously uncharacterized functions and/or escape surveillance.

245 hether early thymic progenitors (ETPs) could escape T cell fate constraints imposed normally by a Not

246 e the jump muscle motor neuron to trigger an escape take off.

247 Memory of the escape target can be formed in a single shelter visit la

248 the endosome, is significantly more prone to escape than its l-counterpart.

249 GJ 436b could have triggered the atmospheric escape that now sustains its giant exosphere.

250 Vancomycin-resistant enterococci (VRE) escape the bactericidal action of vancomycin by chemical

251 encapsulated in host membrane components to escape the cell in an exosome-like particle.

252 ding to scavenger receptors and subsequently escape the early endosome through a pH-triggered disasse

253 ion of high-velocity stars, which could even escape the galaxy.

254 ved specific water-protein interactions that escape the generic treatments of solvent entropy based s

255 how photoswitchable molecules can be used to escape the global thermodynamic minimum by populating me

256 animals, Cataglyphis ants do not attempt to escape the heat; rather, they apply their impressive hea

257 at one mechanism used by some IAV strains to escape the host innate immune responses and modulate vir

258 For tumor progression MCC has to escape the host's immuno-surveillance, e.g. by loss of H

259 y high sequence variability, HCV can readily escape the immune response; thus, an effective vaccine m

260 AID and APOBEC viral targets have adopted to escape the impacts of deamination activity, including ch

261 tor to S. aureus survival and the ability to escape the innate immune system in blood.

262 by discerning subtle details of images that escape the notice of untrained viewers.

263 cent FXa product of TF-FVIIa can transiently escape the slow kinetics of Kunitz-type inhibition by TF

264 switch is reversible and bacteria that have escaped the trap can return to their normal swimming mod

265 anoparticle, but that once cleaved, the drug escapes the acidic endo-lysosomal compartment into the c

266 flammatory syndrome and neurosymptomatic CSF escape, the high prevalence of CNS lesions in macaques s

267 Finally, in an in vivo model of tumor escape, there was complete ACAR-mediated tumor clearance

268 d reproduction, develop counterstrategies to escape this immune defense.

269 How mitochondria escape this irreversible defect accumulation is a fundam

270 To escape this restriction, Gag promotes secretase-dependen

271 it remains unclear how the unaffected brain escapes this susceptibility to seizures.

272 lends insight into biochemical mechanisms of escape throughout the epitope, highlighting roles for ch

273 These quantities are determined from escape time experiments for a DNA molecule attached to a

274 These short cargo escape times predict the need for strong diffusion barri

275 nal center reaction (TNFRSF14, IRF8), immune escape (TNFRSF14), and anti-apoptosis (MAP2K1) have been

276 cluding changing the defensive strategy from escape to freezing.

277 Constrained bNAb escape, together with evidence of contemporaneous autolo

278 re more likely than immunodominant clones to escape tolerance mechanisms and may contribute to protec

279 by examining sympatric rodent species whose escape trajectories differ in dimensionality.

280 cal for understanding how cancers evolve and escape treatment.

281 y followed up pediatric CKD cohorts, ie, the ESCAPE Trial (1999-2007) and the 4C Study (2010-2016), w

282 and eGFR was measured every 2 months in the ESCAPE Trial and every 6 months in the 4C Study.

283 ionotus adults excavate long burrows with an escape tunnel, whereas P. maniculatus dig short, single-

284 catenin interaction is lost and beta-catenin escapes ubiquitylation-dependent proteasomal degradation

285 hree were on-drug relapses, with the CD19(-) escape variant first detected after only 2 treatment cou

286 However, antigen-loss tumor escape variants and the absence of currently targeted an

287 Engineered escape variants had high levels of fitness.

288 The occurrence of viral escape variants in an N6-LS-monotreated animal, however,

289 Emerging escape variants were generally resistant to the related

290 enotype 1-7 prototype isolates and resistant escape variants, and investigated the effects of pre-exi

291 g cancer progression, acting to drive immune escape via a C3/C5-dependent pathway.Significance: This

292 M or seed sequences, and thus prevents viral escape via single-nucleotide substitutions.

293 Importantly, bNAb escape was incomplete, with contemporaneous neutralizati

294 se neurological problems, CSF discordance or escape was observed in 15%, with treatment-experienced p

295 tivariate analysis, both CSF discordance and escape were associated with diffuse white matter signal

296 ng variables associated with CSF discordance/escape were identified using multivariate logistic regre

297 d Y chromosome genes, whereas genes known to escape X inactivation were higher in XX females.

298 Male-biased mutations in genes that escape X-inactivation were observed in combined analysis

299 ity, including the bodies of most genes that escape XCI and at the X-inactivation center, validating

300 chromosomal genes, identify seven genes that escape XCI with support from multiple lines of evidence