ライフサイエンスコーパス: essential

1 we confirmed that glycolysis is not strictly essential.

2 ring of magnetic domain shapes and sizes are essential.

3 ocesses during activated sludge treatment is essential.

4 rus (PRV), have suggested that UL37 plays an essential albeit poorly defined role in intracellular ca

5 trongly reduced the lysosomal efflux of most essential amino acids, converting the lysosome into a ce

6 The eukaryotic RNA exosome is an essential and conserved protein complex that can degrade

7 N-Linked protein glycosylation is an essential and highly conserved post-translational modifi

8 An essential aspect of the MVM-induced DDR is establishment

9 This unique architecture dictates essential aspects of Ca signaling under both normal and

10 Here we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remode

11 ed high-affinity cytochrome bd oxidase as an essential bacterial gene product for mosquito growth.

12 etween labs, and outline why this process is essential before the cells are introduced into chemical

13 e find that a core set of 51 constraints are essential but that additional constraints are still nece

14 such as with proteins that serve as hubs for essential cellular functions.

15 SPA proteins are essential cofactors of COP1, but their exact role in the

16 gh the fractalkine receptor CX3CR1 is not an essential component in the mechanisms of visual cortical

17 apical proteins in T. gondii and identify an essential component named conoid protein hub 1 (CPH1), w

18 provide limited financial value, they are an essential component of ecosystem functioning by offering

19 vision of quality health care and thus is an essential component of nurse education.

20 uspicion combined with diagnostic testing is essential component of severe acute respiratory infectio

21 We view these developments as essential components of an emerging 'respectful modeling

22 Interferons (IFNs) are essential components of the host innate immune system an

23 An essential coordinator of all DNA metabolic processes is

24 Temporal simultaneity provides an essential cue for integrating multisensory signals into

25 Mitochondria are essential cytoplasmic organelles that generate energy (A

26 The identification of essential disulfide bonds that underlie this process lay

27 mic models for ten core proteins, nearly all essential domains of its RNA, and five stably associated

28 Fire is an essential Earth system process that alters ecosystem and

29 Concerning essential elements bioaccessibility in raw seafood, sele

30 to highlight key conserved residues driving essential elements of TCR recognition.

31 as a molecular scaffold for the assembly of essential enhancer-protein complexes with an impact on t

32 n arginine methyltransferase 1 (PRMT1) is an essential enzyme controlling about 85% of the total cell

33 n Mycobacterium tuberculosis (Mtb) and is an essential enzyme for bacterial survival and persistence

34 rbored by beta-1,3 galactosyltransferase, an essential enzyme in forming plant-specific Le(a) structu

35 titutive activation of the STAT3 pathway, an essential event for uncontrolled cellular proliferation

36 The measurement of research impact is an essential exercise to help direct the allocation of limi

37 We identify the MuvB protein Lin37 as an essential factor for DREAM function.

38 accompanying lipid cargo could be a general essential feature of the mechanism underlying the phenom

39 aeal MCMs are powerful tools for elucidating essential features of MCM function.

40 g of fear-extinction learning in children is essential for (1) detecting the source of developmental

41 dispensable for alpha cell development, but essential for alpha cell maturation during the transitio

42 that while the central DNA binding domain is essential for anchoring at parS, this interaction is not

43 ting RNAs (piRNAs) are small non-coding RNAs essential for animal germ cell development.

44 position 5 (E5) of mature (pseudo)pilins is essential for assembly.

45 d catalytic interface that was thought to be essential for ATP synthesis, and cannot convert gamma-su

46 Although CML38 was essential for AtRALF1-mediated root inhibition, it appea

47 nthomonas citri subsp. malvacearum (Xcm) are essential for bacterial blight of cotton (BBC).

48 her, our results demonstrate that the PVT is essential for balancing conflicting behavioral tendencie

49 f the clinical benefits relative to costs is essential for both appropriate clinical use and rational

50 ering aspects of cognitive reserve is likely essential for both interpreting cognitive outcomes assoc

51 g intergenic RNA)-Nkx2.1 gene duplex that is essential for buffering Nkx2.1 expression, lung epitheli

52 roximal to the dimer-dimer interface that is essential for catalysis (i.e. the "activation loop").

53 hin this putative DNA-binding cleft that are essential for catalytic activity.

54 ctively, these results support that Usp36 is essential for cell and organism viability because of its

55 and depolymerize stochastically, a behavior essential for cell division, motility, and differentiati

56 Further, we show that RECQL5 is essential for cell survival in the absence of WRN.

57 Microglia are essential for CNS homeostasis and innate neuroimmune fun

58 However, the pathways essential for conferring the tolerizing DC phenotype and

59 oth conformational rigidity and dynamics are essential for controlling protein activity.

60 erebral neural precursors, a cell population essential for cortical development, but the cause of thi

61 revious work demonstrates that HIF-2alpha is essential for CRC growth and progression.

62 intrinsically disordered proteins (TDPs) are essential for desiccation tolerance.

63 BCL2/BCL6 in high-grade B-cell lymphomas are essential for diagnosis.

64 It is essential for differentiation and early embryonic develo

65 were localized near or at conserved residues essential for diiron ion coordination.

66 cellularly in macrophages, a process that is essential for disease progression.

67 decades that optimal levels of dopamine are essential for dlPFC working memory function, with many b

68 The Star-PAP-mediated APA of PTEN is essential for DNA damage-induced increase of PTEN protei

69 Cks2, share an overlapping function that is essential for early development.

70 the T3SS needle pore protein EspD, which is essential for effector protein translocation into host c

71 a cellular quality-control pathway, which is essential for elimination of unhealthy mitochondria.

72 Cu(+) transporter for Cu acquisition and is essential for embryonic development, a homologous protei

73 gest that coordinated firing during sleep is essential for establishing sparse activation patterns th

74 aracterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety.

75 Essential for fetal testis descent, INSL3 has been impli

76 A total of 331 homologous gene clusters were essential for fitness during in vitro growth in three C.

77 ng the memory about the perturbation that is essential for forelimb motor adaptation.

78 ion of GABAergic inhibitory interneurons are essential for functional neural circuits in the brain.

79 studied, recent findings indicate that it is essential for functions apart from mitochondrial bioener

80 curs by pretriggering conformational changes essential for fusion.

81 r analysis identified 16 genes conditionally essential for GBS survival in blood, of which 75% were m

82 rafollicular area, whereas downregulation is essential for GC formation.

83 establishing Nol12 as a multifunctional RBP essential for genome integrity.

84 that the presence of BamD, but not BamE, is essential for gonococcal viability.

85 hree sets of chromosomal non-essential genes essential for growth during exposure to colistin (n = 35

86 While DNA binding is not essential for H3-H4 tetrasome deposition in vitro, it is

87 rthermore, the enzymatic activity of LSD1 is essential for H3K9me2 demethylation at cell cycle gene l

88 a make contact with the beta clamp, which is essential for Hda function in RIDA.

89 f the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the

90 onal atomic layered p-n heterostructures are essential for high-performance integrated optoelectronic

91 To find an appropriate NIR-absorbing BHJ is essential for highly efficient, organic, photovoltaics (

92 a large-scale Mediator rearrangement that is essential for holoenzyme formation.

93 The latter is essential for human health.

94 iological variable in research is absolutely essential for improving our understanding of disease mec

95 pal PAT for Glut4 and that this mechanism is essential for insulin-regulated glucose homeostasis.

96 Yeast Nop15 is an RRM protein that is essential for large ribosomal subunit biogenesis.

97 brain that influence innate behavior and are essential for learned responses to taste compounds.

98 ity to suppress host macrophage apoptosis is essential for M. tuberculosis (Mtb) to replicate intrace

99 IsaR1 is essential for maintaining physiological levels of Fe/S c

100 rate and C1a domains, however, are minimally essential for maintaining the inactivated state.

101 of motor cortex that, before lesions, is not essential for manual skills, but becomes so as a result

102 esidues His154 and His216 were identified as essential for metal-chelation of sirohydrochlorin.

103 d us to investigate whether IGF signaling is essential for mitochondrial maintenance in cancer cells

104 lination in the peripheral nervous system is essential for motor function, and uncontrolled SC prolif

105 ial designs and interpretation of results is essential for moving forward.

106 thase (PKS) gene PfmaE and showed that it is essential for multicellular conidial pigmentation and de

107 GABAergic interneurons are essential for neural circuit function, and their loss or

108 cies, we found that unlike Nna1, CCP5 is not essential for neuronal survival in mouse.

109 increases oxidative phosphorylation, and is essential for neutrophil maturation.

110 Despite MLL proteins being postulated as essential for normal development, little is known about

111 hese data support that SMN:HuD complexes are essential for normal motoneuron development and indicate

112 arge variations in maternal supplies, and is essential for normal progression of embryogenesis.

113 cav3, and cavin1b, we show that caveolae are essential for notochord integrity.

114 wo distinct sets of loop conformations, each essential for one function.

115 Thus, AlyA1 appears to be essential for optimal attack of alginate in intact cell

116 nistration and meticulous intensive care are essential for optimal outcome.

117 relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted appro

118 Although ARG was found to be essential for ornithine and polyamine synthesis, ornithi

119 region encompassing KOW4 and KOW5 of Spt5 is essential for pausing, and mutations in KOW5 specificall

120 Importantly, although catalytic activity was essential for Pck1 function, Pck2 remained partially fun

121 l pigment epithelium (RPE), a cell monolayer essential for photoreceptor survival, and is the leading

122 line biosynthesis, that were not known to be essential for phototrophic growth.

123 e GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitoc

124 , whose cleavage via the prepilin peptidase, essential for pilin membrane extraction and assembly, is

125 ays critical roles during development and is essential for plant-specific responses to abiotic and bi

126 physiological levels of mTORC1 signaling is essential for postnatal tendon development and maturatio

127 moieties in the flavone A-ring backbone are essential for potent inhibition of LasR/RhlR.

128 TMEM16A is shown to be essential for proper activation and membrane expression

129 Our results show that CM Tln2 is essential for proper beta1D-integrin expression and that

130 Sleep is essential for proper brain function in mammals and insec

131 We also show that the presence of barr2 is essential for proper CAMKII function in beta-cells.

132 RNA-protein interactions are essential for proper gene expression regulation, particu

133 ein MTSs and their receptor site on SecA are essential for protein secretion.

134 is experimentally observed and appears to be essential for receptor activation.

135 issect the coupling of synthesis and folding essential for riboswitch function, revealing the importa

136 We conclude that seed coat suberin is essential for seed dormancy imposition by low temperatur

137 Here, we show that copper is essential for spore germination in Schizosaccharomyces p

138 ract (GIT) and its associated microbiota are essential for survival and milk production, as this comm

139 ctively, our results show that PI3K delta is essential for survival during sepsis.

140 ms evolution more intricate, but were surely essential for sustaining far-from-equilibrium chemical d

141 However, subtelomere integrity is essential for T. brucei viability.

142 The transmembrane segments of RHD3 are essential for targeting and retention of RHD3 in the ER

143 it has been assumed that the pilin domain is essential for the allosteric propagation within the lect

144 n-conserved regions showed that they are not essential for the catalytic activity of Pah1 and its phy

145 The nuclease ARTEMIS is essential for the development of B and T lymphocytes.

146 Such a shift appears essential for the development of complex animal life.

147 e periphery can influence brain processes is essential for the development of therapies to prevent or

148 -signal-induced transcription factor Irf4 is essential for the differentiation of Bcl6-expressing Tfh

149 l freedom of the FMN domain is thought to be essential for the electron transfer (ET) reactions in NO

150 tal disorders Joubert and MORM syndromes, is essential for the function of the primary cilium and mai

151 erminus of Swc5, called Bucentaur (BCNT), is essential for the histone exchange activity of SWR, wher

152 diffusion and phonon drag contributions are essential for the hole surface carriers.

153 This strongly suggests that glycylation is essential for the homeostasis of primary cilia, which ha

154 CL13 recruits both Tfh and B cells, which is essential for the homing of Tfh cells and the developmen

155 In this issue, Yin et al. identify GOP-1 as essential for the maturation of phagosomes containing ap

156 present in dopaminergic nigral afferents is essential for the normal cycling and maintenance of neur

157 n model, we demonstrate that macrophages are essential for the regeneration process.

158 DAAM) is a diaphanous-related formin protein essential for the regulation of actin cytoskeleton dynam

159 the functional polymerase complex, which is essential for the replication and transcription of influ

160 18 times independently over 550 MYA and are essential for the success of the Gastropoda.

161 Although essential for the support and survival of these infants,

162 PERK is essential for the survival and differentiation of activa

163 We identified 50 genes essential for the survival of A. baumannii in NHS, inclu

164 modified graphene vs. oxidized graphenes) is essential for the translation of this material into clin

165 anotransduction channel in hair cells and is essential for the transport of some of these components

166 and endow many species with traits that are essential for their survival.

167 that the precise geometry of these rings is essential for this synergistic activity.

168 s a hierarchically organized complex network essential for tissue fluid homeostasis, immune trafficki

169 hanism comprising NF-kappaB and MMP7 that is essential for TNBC cell invasiveness, thereby providing

170 We demonstrate that PRMT5-MEP50 is essential for transcriptional regulation promoting cance

171 erence of the biofilm to the flea foregut is essential for transmission.

172 presence of right ventricular dysfunction is essential for triage; however, comprehensive transthorac

173 g neural circuits across defined synapses is essential for understanding brain function.

174 h-resolution membrane protein structures are essential for understanding the molecular basis of diver

175 Cyclic-nucleotide-gated channels are essential for vision and olfaction.

176 These findings reveal essential functions for chromatin-remodelling in the act

177 ch, we defined three sets of chromosomal non-essential genes essential for growth during exposure to

178 It is enriched in cell-essential genes identified in a CRISPR screen, as well a

179 ing the 'knockout-first' allele and identify essential genes in ES cells, including the histone methy

180 identify drug targets, (3) detects not only essential genes, but also essential protein domains, (4)

181 Rc identified 98% of previously defined cell essential genes.

182 ause they first bound to the Bam complex, an essential heteroligomer that catalyzes the membrane inse

183 tidylinositol 4-kinase IIIbeta (PI4KB) is an essential host factor for many positive-sense single-str

184 tween the human and mouse orthologues of two essential host factors, the tetraspanin CD81 and the tig

185 g information (i.e., inhibitory control) are essential human cognitive abilities.

186 carotid bodies are hyperactive at rest, e.g. essential hypertension, obstructive sleep apnoea and hea

187 r age-related macular degeneration (nAMD) is essential in discussing prognosis and treatment options

188 ydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been as

189 Clathrin- and actin-mediated endocytosis is essential in eukaryotic cells.

190 Talin, a cytoskeletal protein essential in mediating integrin activation, has been pre

191 here that, as in the patients, Zc3h14 is not essential in mice.

192 l recruitment to colon tumors and that it is essential in shaping the protumorigenic inflammatory mic

193 gest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms

194 cognition and its consequences would provide essential insight into allograft rejection and lead to b

195 This structure provides essential insight into multiple mechanisms by which path

196 exclusively in the Vbeta8.1 segment mediated essential interactions with the GAP5040-48 peptide.

197 res of a viral genome maturation complex, an essential intermediate in the development of complex dsD

198 N(6)-methyladenosine (m(6)A) is an essential internal RNA modification that is critical for

199 RNA helicase Aquarius/EMB-4 as a direct and essential link between small RNA pathways and the transc

200 alpha-dependent neutrophil recruitment as an essential mechanism to increase colon carcinogenesis.

201 Type I interferons (IFNs) are essential mediators of antiviral responses.

202 or staff safety or threatens interruption of essential medical therapies.

203 Tim17 is an essential, membrane-embedded subunit of the translocase;

204 onized by trillions of bacteria that perform essential metabolic functions for their hosts.

205 by Enterobacteriaceae for acquiring iron, an essential metal nutrient.

206 e influenza A virus nucleoprotein (NP) is an essential multifunctional protein that encapsidates the

207 Our work shows that Tuba1a plays an essential, noncompensated role in neuronal saltatory mig

208 nd how chromatin domains in general regulate essential nuclear functions.

209 Although phosphorus is an essential nutrient required for multiple physiological f

210 view of the potential contributions of these essential nutrients in biology.

211 central nervous system and thus presents an essential obstacle to brain transport of therapeutics.

212 Rosemary essential oil (REO) contains bioactives having antioxida

213 ngal spoilage of strawberry jams, minimising essential oil's sensory impact, was evaluated in this wo

214 Lavenders produce essential oils consisting mainly of monoterpenes, includ

215 GTPase activity was essential only for turnover of FtsZ2 and FtsZA filaments

216 marise the key findings and present a costed essential package of interventions to reduce risk of and

217 llapsed onto master curves governed by three essential parameters: (1) an expansion length beyond whi

218 The selection of an appropriate Vt is an essential part of a lung-protective MV strategy.

219 nt of antimicrobials that target this novel, essential pathway.

220 Transporters are essential players in bacterial growth and survival, sinc

221 RNA editing is an essential post-transcriptional process that creates func

222 G3P is an essential precursor for glycerolipid synthesis and the a

223 nitoring of possible key intermediates as an essential prerequisite for proposing catalytic mechanism

224 ate to ensure the correct functioning of the essential presequence processing machinery.

225 ) detects not only essential genes, but also essential protein domains, (4) generates both null and o

226 This essential protein has also been implicated in mediating

227 Essential proteins are indispensable to the survival and

228 ropionate 4, but with a lysine residue as an essential proton shuttle.

229 HQ-induced TRPA1 activation was dependent on essential redox-sensitive cysteine and lysine residues w

230 omal passenger complex (CPC) is a conserved, essential regulator of cell division.

231 CXCR2 is an essential regulator of neutrophil recruitment to inflame

232 activator protein-1 (AP-1) factor JunB is an essential regulator of Th17 cell identity.

233 he protein DELAY OF GERMINATION 1 (DOG1) are essential regulators of dormancy.

234 PAI-1 is an essential repressor of cardiac fibrosis in mammals.

235 Our findings identify NDPK-C as an essential requirement for both the interaction between N

236 ion of tooth-inducing cell populations is an essential requirement for further development of this ap

237 ntaining a robust blood product supply is an essential requirement to guarantee optimal patient care

238 Some missense mutations changed essential residues conserved among Schizosaccharomyces s

239 This screen uncovered essential residues within Synaptotagmin that suggest a s

240 By ruling out an essential role for fractalkine signaling, our study narr

241 These data reveal an essential role for n1-src in amphibian neural developmen

242 Collectively, our findings uncover an essential role for PRDM15 as a chromatin factor that mod

243 The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J r

244 , protein complexes, or chromatin and has an essential role in autophagy and the ubiquitin proteasome

245 of the RNA molecule-and its absence-plays an essential role in determining capsid structure during th

246 n tomography ([(18)F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; howeve

247 wed that A-kinase anchoring proteins play an essential role in ICAM-4 activation.

248 we show that AP-2 has a clathrin-independent essential role in polarity maintenance and growth.

249 demonstrate that the glycosylation plays an essential role in the flagellar assembly and motility of

250 These membrane proteins play an essential role in the insertion of the new SPB into the

251 ries across space and time and revealing the essential role it played in maintaining stability and fu

252 healthy children, providing evidence for an essential role of a DNA sensor in human immunity.

253 ned chiral binaphthyl-based ligand plays the essential role of a general base catalyst and selectivel

254 In vivo studies demonstrate the essential role of RbpA, show the effects of RbpA truncat

255 The RNA sequencing also pointed to an essential role of the Sox18 transcription factor.

256 paired expression and splicing of genes with essential roles in cochlea development and auditory func

257 tously expressed, mitochondrial protein with essential roles in cytochrome c oxidase (COX) assembly a

258 Redox-active tyrosines (Ys) play essential roles in enzymes involved in primary metabolis

259 d tail structures of DNA bacteriophages play essential roles in life cycles.

260 ant component of eukaryotic genomes that has essential roles in nuclear architecture, DNA repair and

261 elegans uncoordinated gene 13) proteins play essential roles in regulated exocytosis.

262 ortant class of epigenetic enzymes that play essential roles in regulation of gene expression in huma

263 Ionic calcium (Ca(2+)) is an essential signal for axon guidance that mediates opposin

264 ance of these pathways for the generation of essential sphingolipids in differentiated cells is not w

265 sufficient to evoke painful thermal TCE, an essential step in transforming transient afferent nocice

266 Hemoglobin degradation/hemozoin formation, essential steps in the Plasmodium life cycle, are target

267 A simple stochastic model accounting for the essential steps of conversion showed excellent agreement

268 nctional validation of oncogenic drivers are essential steps toward advancing cancer precision medici

269 ondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation syst

270 Thiol-Michael "click" reactions are essential synthetic tools in the preparation of various

271 lied to massive population level data, it is essential that the graphs be represented efficiently.

272 It is essential that we understand better the immunologic fact

273 thromboembolism (VTE) in pregnant women with essential thrombocythemia.

274 We report novel C. jejuni factors essential throughout its life cycle.

275 These loci prove essential to accurately modeling yeast growth in respons

276 dressing socioenvironmental determinants are essential to achieve thriving populations.

277 the sternum and their imaging appearance is essential to arrive at an early diagnosis and also to ob

278 ional mRNAs coding for a variety of proteins essential to cell growth and survival.

279 pid identification of bacterial infection is essential to ensure early appropriate administration of

280 ue selective negative feedback regulation is essential to establish sex-specific differences in muscl

281 Reversibility in bond formation is essential to generate ordered networks, as it allows the

282 gs indicate that ventral hippocampal trkB is essential to goal-directed action selection, countering

283 identify practical and achievable priorities essential to health progress, and to present policy init

284 mous potential in device applications, it is essential to optimize epitaxial growth for the precise c

285 ue burden and seasonality of disease that is essential to plan the optimal target groups, timing, and

286 n, whereas proper limitation of signaling is essential to prevent immunopathology and autoimmune dise

287 Cell proliferation is essential to rapid tissue growth and repair, but can res

288 hensive, and real-time surveillance data are essential to reduce the burden of antimicrobial resistan

289 Moreover, MYCN was essential to retinoblastoma cell growth and tumor format

290 These microbial commensals are essential to skin health and can potentially lead to dis

291 l millet (Setaria italica) is an orphan crop essential to the food security of many small farmers in

292 nucleus (RTN), but the specific ion channels essential to these activities remain to be identified.

293 Quantifying stochastic processes is essential to understand many natural phenomena, particul

294 internal limiting membrane of the retina is essential to understanding the cause of rhegmatogenous r

295 rformance for Parkinson's disease tremor and essential tremor, in both test and validation datasets.

296 that the combined treatment of curcumin and essential turmeric oils provides superior protection fro

297 nked chains are synthesized and processed by essential ubiquitin ligases and effectors that are mutat

298 dequate ethical approval and availability of essential variables.

299 As tRNA nuclear export is essential, we previously interrogated the budding yeast

300 A gene can be defined as essential when loss of its function compromises viabilit