ライフサイエンスコーパス: establish

1 regulation of nucleolar biology is not well established.

2 enhanced meningitis surveillance network was established.

3 tivation of food-borne pathogens in foods is established.

4 ion to death after coronary heart disease is established.

5 or systems where biotrophic interactions are established.

6 tissue-specific gene regulatory networks are established.

7 rotection against breast cancer has not been established.

8 opinions and three no recommendations) were established.

9 ld affect the commensal flora have yet to be established.

10 direct AM-specific gene expression have been established.

11 of P. aeruginosa infections is not yet well established.

12 related mortality remains to be specifically established.

13 and consequences of TPMs have not been fully established.

14 y B cells (MBC), in which EBV persistence is established.

15 atomic steps and surface defects, is firmly established.

16 phthalmitis associated with DEX has not been established.

17 st reinfection, its pathogenesis is not well established.

18 of regulatory T cells (Tregs) are less well established.

19 l circuits, but this hypothesis has not been established.

20 the cirrus cloud lateral boundary (CCLB) was established.

21 w these two proteins interact have yet to be established.

22 f core areas of work for communications were established: (1) generating awareness and political comm

23 These findings establish 15D11 as a potential therapeutic agent for the

24 The resulting feature weights were used to establish 3 predictive models per binning configuration:

25 ld Data Centre for Microorganisms (WDCM) was established 50 years ago as the data center of the World

26 A phase 1 study established 60 mg/m(2) guadecitabine for 5 days as an ef

27 We aim to establish a classifier capable of simulating human 'gazi

28 transport, and cargo release functionalities establish a continuum under a mechanism of Kap-centric c

29 t of Cas13a with isothermal amplification to establish a CRISPR-based diagnostic (CRISPR-Dx), providi

30 ding to facility for this indication, and to establish a current average radiation dose for CT evalua

31 t-transcriptional regulator of cell fate and establish a direct, previously unappreciated link betwee

32 Collectively, these data establish a framework of genetic, anatomical, and molecu

33 -Cas nuclease(s) during crRNA maturation and establish a link between Type III-A CRISPR-Cas immunity

34 Such networks establish a new formal phenotype of cancer which capture

35 These data establish a new link between the pluripotency factor NAN

36 Further, using recombinant viruses that establish a nonreactivating, latent-like or a replicativ

37 Collectively, these findings establish a novel mechanism of humoral protection in the

38 Here we establish a novel system for mechanistic analysis of the

39 ts that K265 interacts with D590 and Q633 to establish a pivotal allosteric branching point.

40 These results establish a regulatory role for BCAT1 in macrophage func

41 ion approaches are more successful when they establish a reliable framework for converting creative i

42 To investigate such protein interactions, we establish a ribosome affinity purification method that u

43 Together, our findings establish a role for RFRP-3 in preserving reproductive i

44 Using this mouse line, we establish a specific requirement for the P1-RUNX1C isofo

45 on vaccine potency, or, conversely, it might establish a temporary state that limits the initial SAM-

46 and their relative value must be encoded to establish a value-biased state of preparation for an imp

47 t 2 years, the goal of our group has been to establish a way to identify originator attributes, speci

48 e low cost diagnostic solutions, we recently established a citrate-derived synthesis platform for the

49 referred to as biparametric MR imaging), and established a diagnosis according to the Prostate Imagin

50 We established a feline HFpEF model induced by slow-progres

51 ion seamlessly between environments, we next established a freely controllable virtual reality system

52 We established a hypothesis whereby the variability in the

53 d kinetic and thermodynamic measurements, we established a kinetic model of Ena/VASP-mediated actin f

54 We established a large-scale, prospective clinical sequenci

55 We established a mouse xenograft model of human acute myelo

56 We established a multi-step protocol involving protein immo

57 Two case-control studies established a point-source outbreak associated with 2 sp

58 Through medicinal chemistry exploration, we established a robust structure-activity relationship of

59 In this study, we established a role for lncRNAs in chondrocyte differenti

60 study, we describe Cycloclasticus that have established a symbiosis with Bathymodiolus heckerae muss

61 Mutant IDH1 establishes a CD24(+) population with a proliferative ad

62 This establishes a clear link between inner membrane architec

63 Our strategy establishes a distinct yet complementary set of imaging

64 miniaturized sample preparation microdevice establishes a key technology that intended to develop ne

65 tal approach accurately models human NBL and establishes a new system with potential to study early s

66 s study gives insights into apoE biology and establishes a robust screening system to monitor apoE co

67 The present study establishes a widely prevalent mechanism of resistance t

68 n vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and moni

69 us of this article is to assist hospitals in establishing a rapid response for identification, notifi

70 iltrating and resident myeloid cells in GBM, establishing a rationale to target infiltrating cells in

71 sin before continental-scale ice sheets were established about 34 million years ago.

72 ss that serves as a surrogate for other well-established alkyne syntheses.

73 bust and reliable kit-labeling procedure was established, allowing the preparation of (99m)Tc-MAS3-y-

74 introduction of SOD1(G93A) and TDP43(A315T), established ALS-related mutations, changed the subcellul

75 larly edge-to-edge leaflet repair, is a well-established alternative for patients with severe primary

76 Our findings establish an elevating mitochondrial cristae density as

77 that is shared between fish and mammals and establish an experimental platform for studying how evol

78 expands Tregs and suppresses CD8 T cells to establish an immunosuppressive microenvironment conduciv

79 dress this deficit, in the present study, we established an in vitro mouse brain slice preparation th

80 Significance: This large cohort study firmly establishes an association between an index of vitamin B

81 lex event mediated by inductive signals that establish and maintain the distinct developmental domain

82 wastes, products, residues, and emissions is established and quantified.

83 An electrical-circuit model is established and the graphene-sheet pattern is designed o

84 Level A IVIVCs were established and validated for predictability.

85 The limits of lowering Vt have not yet been established, and some patients may benefit from Vts that

86 In this study, we established another Arabidopsis mutant line harbouring a

87 Doxorubicin is a highly efficacious and well-established anthracycline chemotherapeutic agent commonl

88 ndings imply that, in addition to their well-established antimicrobial properties, neutrophils can co

89 rol strategies are vitally needed to address established arthropod-borne infectious diseases such as

90 However, NAD(P)H FLIM has not been established as a metabolic proxy in bacteria.

91 Dopaminergic signalling is established as playing an important role in novelty rela

92 and Cell Line Ontology (CLO) have long been established as reference ontologies in the OBO framework

93 While linear multichannel pipets enable many established assays, they do not support analytical tools

94 ION: A maximum tolerated dose of CPI-613 was established at 500 mg/m(2) when used in combination with

95 ke, or cardiovascular death in patients with established atherosclerotic cardiovascular disease.

96 ivity significantly increases CD20 levels in established B-cell tumor cell lines and primary malignan

97 CR assays perform at a similar level to well-established bacterial human-associated fecal-source-iden

98 The final diagnosis was established based on selective angiography, which was fo

99 These observations establish BiP and its J domain co-chaperones as key regu

100 CD4(+) and CD8(+) T cells against a panel of established blood cancers and primary, patient-derived B

101 regulation, and 1 independent variant at an established BP locus.

102 Our results establish brain capillaries as an active sensory web tha

103 antification of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the manag

104 d ejection fraction (HFrEF; EF <40%) is well established, but its pathogenic and prognostic significa

105 ydroxymethylfurfural) were within the limits established by EU legislation, and all parameters in pre

106 issues and their absence in normal liver was established by immunohistochemistry staining and mass sp

107 s of double aza-substituted alkyne, has been established by the copper(I)-catalyzed cross-coupling of

108 Absolute stereochemistry was unequivocally established by X-ray analysis of precursor trans-(+)-5a

109 od presented here and in comparison with the established C18 extraction approach.

110 n patients with type 2 diabetes mellitus and established cardiovascular disease in the EMPA-REG OUTCO

111 s in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney d

112 We show that the established Cdc48 cofactor Ufd1 is required for SREBP cl

113 HIV-1 establishes chronic infection and stimulates vigorous im

114 Together, these results establish circadian clock and cell cycle as interdepende

115 Future research should aim to establish clinical, serological, and imaging biomarkers

116 ed a predictive model based on genetic risk, established clinical risk factors, and diagnostic biomar

117 n brain regions and serves a central role in establishing complex and adaptive cognitive and behavior

118 hypothesis by comparing the output of a well-established computational saliency model with the activa

119 his work, we provide an overview of how well-established concepts in the fields of quantum chemistry

120 ibility of published proteomic results, well-established confidence criteria should be reported for t

121 Together, our results establish connections between chirality, protease resist

122 Our results establish CRISPR-Cas13a as a flexible platform for study

123 teristic curve, 0.87, which is comparable to established CSF biomarkers).

124 The ability to establish cytoplasmic continuity between the proximal an

125 data and RNA immunoprecipitation experiments established DGCR8 as a direct interactor of Tcf7l1 mRNA,

126 enabled chemotherapy-induced regressions of established disease followed by lethal regrowth of more

127 quality control (QC) study was performed to establish disk diffusion and MIC ranges for cefepime-taz

128 In a previously established Drosophila heart model for long-term hypoxia

129 complex connectivity is encoded and robustly established during nervous system development.

130 coated with a broad H3K27me3 domain that is established during oocyte growth and persists through pr

131 tion, whereas feedback control appears to be established dynamically by oscillations in the alpha (8-

132 KD is not a homogeneous disorder and further establish DZIP1L as a second gene involved in ARPKD path

133 of a PI3K/mTOR dual inhibitor, LY3023414, on established EAC in an in vivo model.

134 results are in excellent agreement with well established experimental values when such values exist,

135 Reference equations have been established for Mexican Americans but not for others wit

136 steric influence similar to that previously established for the 6,6'-dimesityl-2,2'-bipyridine ligan

137 We have established for the first time the total phenolic compou

138 When subpopulations with established foraging traditions for one technique were s

139 The Au279S84 geometry was established from a low-temperature 120 K sc-XRD study at

140 ilies, which do not always correspond to the established FXYD classification.

141 experimental observations and physical model establish general rules for raft partitioning of TMDs an

142 sequencing of underivatized oligosaccharides.Establishing generic carbohydrate sequencing methods is

143 55 had kidney biopsy results, and 212 had an established genetic diagnosis.

144 were also genotyped in all family members to establish genotype-phenotype cosegregation.

145 emistry interpretations and other methods to establish goliath catfish migratory routes, their season

146 prospectively for clinical assessment and to establish ground truth.

147 t low-frequency non-synonymous variant in an established heart rate locus (KIAA1755).

148 Established home monitoring technology is already facili

149 Furthermore, G40 can also establish hydrogen bonding interactions with the nonbrid

150 This work establishes hyperpolarized [(13)C]-Glyc as a novel agent

151 The aim of this study was to establish if systemic oxidative status in POAG patients

152 s clinically actionable genetic changes with established implications for cancer screening or prevent

153 Invaded species often can rapidly expand and establish in novel environments through adaptive evoluti

154 We resampled plots that were established in 1972 and repeated the full C inventory by

155 onary aspergillosis relies on criteria first established in 1977.

156 aversive consequences, parallel memories are established in a way that appetitive and aversive inform

157 n CRAF kinase in KRAS mutant tumors has been established in genetically engineered mouse models and h

158 show that a posterior glycolytic gradient is established in response to graded transcription of glyco

159 c quantification of ovary development can be established in species with either synchronous and async

160 y sample (<50 mg) is needed for the approach established in the current work.

161 account the low maximum permitted level (ML) established in the European Union (EU) for the sum of fo

162 atic contrasts and the Mediterranean climate established in the Mediterranean Basin.

163 We also show that a well-established in vivo mild chronic hypoxia (MCH) mouse mod

164 In this model, C. jejuni successfully established infection and piglets developed an increased

165 Three dermatopathologists established interobserver ground truth consensus (GTC) d

166 METHODS AND In mouse carotid arteries with established intimal lesions tailored to resemble the sub

167 Preclinical studies have established its role in maintaining allograft acceptance

168 um hydroxide (Al) is a promising option, and establishing its effectiveness in the target population

169 Using an established laboratory model aimed at evaluating behavio

170 After initial infection, the virus establishes latent reservoirs in sensory neurons and per

171 ck-grass, while no direct causative link was established linking viral infection to herbicide resista

172 hern and east Africa, and from patients with established liver disease.

173 een within later precancerous lesions and in established malignancy can also occur in PIPs within nor

174 Using an established mating paradigm, fetal microchimeric cells p

175 ) assessment at baseline in individuals with established metabolic syndrome (MetS) or diabetes identi

176 ling (rRibo-seq) data and outperform several established methods in both computational efficiency and

177 Study quality was assessed using established methods, per study design.

178 ntial binding to Hippo core kinases, thereby establishing MOB1 variants with selective loss-of-intera

179 o verify the accuracy and feasibility of the established model equation.

180 Thus, our studies, which have established mouse models for parathyroid tumours and ute

181 CancerLocator outperforms two established multi-class classification methods on simula

182 suggests the potential for restoration to re-establish native plant-pollinator interactions critical

183 nt and -independent ICL repair networks, and establish nematodes as a model for investigating the rep

184 en restricted due to incompatibility between established neuroimaging techniques and the surgically i

185 arget sequences in inaccessible chromatin to establish new transcriptional networks throughout develo

186 n the other hand, late ablation of AnkG from established nodal complexes leads to slow but progressiv

187 tions in RNA metabolism and DNA maintenance, establishing Nol12 as a multifunctional RBP essential fo

188 Eight established non-HLA risk loci showed pleiotropic associa

189 The most well established of these are the blood eosinophil count and

190 these, 117 711 (89.2%) had their HIV status established, of whom 11 964 (10.2%) were HIV positive.

191 ive blood pressure-lowering treatment can be established only via randomized clinical trials.

192 ion, but this maturation is not required for establishing or retaining cocaine-CPP.

193 ard conditioning and contingency reversal to establish outcome-specific conditioned inhibitors for tw

194 pharmacological inhibition of HDAC6 improved established PAH in two experimental models and can be sa

195 We propose that, contrary to the established paradigm, TRPV4 is activated by increased ce

196 Our findings deviate from established paradigms and warrant further assessment of

197 The unique ability to establish parallel or opposing gradients of gases and ch

198 Further, with the established PCA-tdTHz, we evaluated the severity of myel

199 By identifying the residues that establish plaque stability, these studies lay the ground

200 guidelines to inform patient care, and those establishing policies for guideline development.

201 hereby show that the very first individuals establishing populations in the Mediterranean Sea displa

202 Our results establish potent Sirt6 activation with small molecules a

203 erapeutic effects of cortistatin in two well-established preclinical models of atherosclerosis, and t

204 GLS provides incremental prognostic use over established predictors and could potentially aid in surg

205 Using the clinically established PRETEXT groups I, II, III, and IV as our ste

206 de should be acknowledged as a criterion for establishing prognosis in all stages of disease.

207 lly relevant backbone groups on the basis of established prognostic factors: PRETEXT I/II, PRETEXT II

208 differentiated arthritis (UA), early RA, and established RA cohorts in comparison with healthy donors

209 d in synovial tissues from UA, early RA, and established RA patients.

210 aromatic core that seemingly contradicts the established reactivity pattern of polyketide phenol nucl

211 lt of their inherent chemical properties and established reactivity patterns.

212 PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in pati

213 nance strategies to maximize pollination and establish resilience in the face of environmental change

214 tremely common across the lifespan and is an established risk factor for dementia.

215 c strategies in addition to the treatment of established risk factors (hypercholesterolemia, hyperten

216 trafficking at the Golgi in addition to its established role in autophagy.

217 Our data establish rRNA 2'-O-Me plasticity as a mechanism providi

218 red sensitive by the inverse K277R mutation, establishing RT as the genetic locus for aptamer-mediate

219 s required for proliferation in vitro and in established SCC tumors in vivo.

220 dy of cellular mechanisms in human cells, we established several human stem cell lines: human embryon

221 negative feedback regulation is essential to establish sex-specific differences in muscle metabolism

222 of travel distance with institutional volume established short travel/low-volume (ST/LV) and long tra

223 We establish small error rates in the identification of evo

224 76%) by applying Health Canada benchmarks.If established sodium standards are applied to commercially

225 dinated firing during sleep is essential for establishing sparse activation patterns that reflect the

226 the procurement of defined glycans is key to establishing structure-activity relationships and thereb

227 d by the transcription factor Nkx2-1, a well-established suppressor of metastatic progression.

228 pportunity" for changes in cell identity, we established synchronized cultures of mouse embryonic ste

229 2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant d

230 e human sodium-iodide symporter (hNIS) is an established target for molecular imaging and radionuclid

231 e also observe an overwhelming effect of the established TCF4 locus.

232 minimally invasive and cost effective using established technologies.

233 Here, we establish that although ICP34.5 binds TBK1 under certain

234 We further establish that BONCAT can be coupled to tandem liquid ch

235 Altogether, our data clearly establish that Ca(2+) entry exerts a feedback control on

236 Our data establish that cargoes containing Yxxphi motif, but not

237 brain tumor patients to healthy children, we establish that changes in the microstructure of the opti

238 These data definitively establish that complete structural integrity is necessar

239 Further biochemical studies establish that coordination of Ni(II) at the hexahistidi

240 We further establish that DNA demethylation induced by XPC expressi

241 Taken together, our findings establish that EVs secreted by AFSC could target a speci

242 These findings establish that PXR signaling contributes to ALD developm

243 Together, these observations establish that small molecules that bind to the interfac

244 These data establish that the RP-MDM2-p53 pathway, in contrast to t

245 We further establish that TNFalpha induces IR in cardiomyocytes.

246 Protein X-ray crystallography established that 3-unsubstituted 2,4-oxazolidinediones b

247 We have previously established that despite the apparent surface uniformity

248 We further established that FI-HSV-2 alone or in combination with a

249 It is well established that glutamate and GABA signal through both

250 However, we recently established that HIV-1 can infect kidney transplant epit

251 We have recently established that in Arabidopsis, the regulator of G-prot

252 Recent studies established that nascent autophagosomes in distal axons

253 em.SIGNIFICANCE STATEMENT Prior studies have established that substantia nigra pars compacta (SNc) do

254 Additional studies established that the increased toxicity upon mutating Ub

255 A competition experiment established that the reaction involves formation of free

256 It is well established that viral pathogens exploit PD to spread be

257 and kernel density bandwidths were tested to establish the consistency of findings.

258 linical, endoscopic, and histologic findings establish the diagnosis.

259 We sought to establish the effect of MABp1 with a new primary endpoin

260 regulate each other during embryogenesis to establish the embryonic SAM and to specify cotyledon bou

261 ular mechanisms of how cohesin and condensin establish the functional 3D genome structures.

262 vectors, a key area of future research is to establish the impact of this endosymbiont on vector comp

263 mega-transaminase (omega-TA) biocatalysts to establish the key stereocentres of these molecules.

264 Here, we establish the landscape of human cell-specific microRNA

265 We aimed to establish the maximum tolerated dose and establish the r

266 Steered simulations along the bilayer normal establish the metastable nature of the inserted pore, yi

267 may be stabilized by an external source and establish the minimum seeding power required.

268 progress that has been made using rodents to establish the motor cortex as an adaptive structure that

269 We could not establish the proportion of casualties caused by AXO fro

270 to establish the maximum tolerated dose and establish the recommended phase 2 dose of veliparib comb

271 cell-cell distance in individual tissues to establish the role of complex interdependence and intera

272 a molecular epidemiological investigation to establish the source of these patients' disease.

273 al circuits in the hypothalamus is needed to establish the utility of targeting oxytocin signalling i

274 More broadly, our results establish the utility of the new live-imaging tools for

275 Recent research has established the bronchodilatory effect of bitter taste r

276 Bismarck's Health Insurance Act of 1883 established the first social health insurance system in

277 In conclusion, in this study we established the involvement of the complement system in

278 In this study, we established the optical trapping technique for determini

279 The resulting electrochemistry establishes the basis for a remarkably simple procedure

280 This study establishes the occurrence of biological epistasis in hu

281 This work establishes the relevance of thymic function, measured b

282 une surveillance, with emerging functions in establishing the pre-metastatic niche and other aspects

283 efficacy against EAC in a preclinical model, establishing the rationale for clinical testing.

284 Establishing the relationship between rates of change in

285 es must also adapt to novel conditions while establishing themselves in a host species.

286 Her2 (ERBB2) is one of the most established therapeutic targets in breast and gastric ca

287 The outer blood-retina barrier is established through the coordinated terminal maturation

288 Here we establish, through fine mapping, genome sequencing, gene

289 A comprehensive kinetic model was established to elucidate the mechanisms of radical gener

290 of academic and industrial partners has been established to overcome this challenge.

291 These established transcriptomes provide a reference catalog f

292 e and adaptive immune effectors to eradicate established tumors.

293 We established two levels (high/low quality) of within-patc

294 Set1) to ensure that chromatin marks are not established until nutrient/energy contingencies are sati

295 ming of SOX2 expression did not parallel the established vestibular-then-auditory sequence.

296 The purpose of the study was to establish whether blue light filtering could modify proa

297 We did a study to establish whether educating religious leaders about male

298 Using this system, we have been able to establish which decorations underpin the formation of AV

299 rough correlation, it remains challenging to establish which marks actually have causative roles in g

300 e - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side on