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1 f the heme methyl and to trap it to give the ester bond.
2 ised for nucleophilic attack of the scissile ester bond.
3 ween Val(1) and Gly(2) in gramicidin A by an ester bond.
4 ked to endogenous DmSUMO-1 through an oxygen ester bond.
5 d that the Lp(a) was covalently linked by an ester bond.
6 the incoming ubiquitin acceptor to the thiol ester bond.
7 distance between the aromatic group and the ester bond.
8 give RNA labelled through a native phosphate ester bond.
9 ally mediated by an unusual heme-polypeptide ester bond.
10 that have an amide replacement of the labile ester bond.
11 y replacement of individual amide bonds with ester bonds.
12 n is attached to hD4R through isopeptide and ester bonds.
13 ydration is sufficient to drive synthesis of ester bonds.
14 they undergo biodegradation by hydrolysis of ester bonds.
15 spontaneous hydrolysis expected of arsenate ester bonds.
16 eins with peptide bonds being substituted by ester bonds.
17 -derived unit that are linked by peptide and ester bonds.
18 e bond 26a, a hybrid azatetrapeptide with an ester bond 26b, and a hybrid azatripeptide with an ester
20 terminal splice junction rather than a (thio)ester bond, alleviating the need to form the initial (th
22 pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on go
24 bortezomib prodrugs with reversible boronic ester bonds and then incorporating the resulting prodrug
25 e nonbridging oxygen atoms and in the P-O(R) ester bond, and solvent deuterium isotope effects, have
26 e distance between the aromatic ring and the ester bond, and the substitutions on the aromatic ring.
27 its ester bond in the region of the lipids' ester bonds, and associated dipole field and the aromati
30 emical warfare agents containing phosphonate ester bonds are among the most toxic chemicals known to
31 e heterodimeric channels, with only a single ester bond, are more easily characterized; the lone este
32 demonstrate that cleavage of the acylenzyme ester bond, as opposed to either the initial attack on t
35 tion at pH < 3 to afford an Xaa-thiazolidine ester bond between a peptide containing a carboxyl termi
36 nally-modified heme with one single covalent ester bond between the 1-methyl heme substituent and Glu
37 The energy required for the formation of the ester bond between the amino acid carboxylate group and
38 utational data, suggests a model for how the ester bond between the peptidyl tRNA and the nascent pep
39 e is covalently bound to the protein via two ester bonds between carboxylic side chains and heme meth
40 und form of the TGase 1 enzyme can also form ester bonds between specific glutaminyl residues of huma
41 actoperoxidase is attached to the protein by ester bonds between the heme 1- and 5-methyl groups and
42 ated several cyclic peptide motifs linked by ester bonds between the P2 and P1' or the P1 and P2' sid
44 not depend on the intrinsic lability of the ester bond, but depends on both the distance between the
48 l characterization of two backbone-modified, ester bond-containing analogues of the homohexameric enz
49 hat inhibition of the proteasome activity by ester bond-containing polyphenols may contribute to the
51 tabilization could result in a weakened P-OR ester bond, contributing to the observed faster rate of
52 cificity for a 3'-O location of the scissile ester bond could be forced to the 2'-position by introdu
53 stic GDSL1 silencing leads to a reduction in ester bond cross-links and to the appearance of nanopore
54 c analysis suggests that similar domains and ester bond cross-links are widespread in Gram-positive b
55 the first step, alpha(2)M* reforms its thiol ester bond, entering a reactive state that mimics the pr
56 iquitination of hydroxylated amino acids via ester bonds even when lysine residues are present on wil
57 acid (histone deacetylase inhibitor) via an ester bond, exhibits antiangiogenic activity, being able
58 id by a coenzyme A (CoA) synthetase and (ii) ester bond formation between an isoprenoid alcohol and i
59 , an NRPS condensation enzyme that catalyzes ester bond formation between the SgcC2-tethered (S)-3-ch
62 posomal nanoparticles via reversible boronic ester bond formation to enhance the therapeutic index fo
64 , and D302 (in hydroxyl group activation for ester bond formation) in the polymerization process.
66 The esterase cannot hydrolyse the second ester bond from the 8-5-benzofuran monoester and therefo
67 ll wall degradation by cleaving at least one ester bond from the diferulate cross-links that exist be
70 ndicating that they were not (only) based on ester bonds; however, most were cleaved by 6 m NaOH, whi
71 nserved base-pair plays an important role in ester bond hydrolysis during translation termination.
72 combination of ester-amide bond exchange and ester bond hydrolysis, depsipeptides are enriched with a
74 ence properties as well as hydrolysis of the ester bond in both single- and double-stranded conformat
76 triazole formation and/or hydrolysis of the ester bond in the iminophosphorane intermediate to give
78 ine near the phosphate of the headgroup, its ester bond in the region of the lipids' ester bonds, and
79 t solvent-induced weakening of the phosphate ester bonds in any of the solvents tested, and this is u
80 r the formation of the three amide and three ester bonds in enterobactin using ATP, L-serine, and acy
81 drophilic PGMA chains to form phenylboronate ester bonds in mildly alkaline aqueous solution (pH appr
82 roup pKa (betalg = -1.23) arises from weaker ester bonds in the reactants as the pKa of the leaving g
83 hy suggest that the carbon of the polyphenol ester bond is essential for targeting, thereby inhibitin
84 strategically different approach whereby the ester bond is formed intermolecularly at an early stage
85 containing both a disulfide and a sulfonate ester bond is grafted onto the surface of ordered mesopo
90 epared on hydroxy-bearing ITO surface via an ester bond linkage of polymer P3 to immobilize anti-TNF
91 rporated in the coumarin derivative near the ester bond linking both moieties in combination with the
92 but has been attempted with the inclusion of ester bonds (mivacurium) and binding agents that are in
93 4OT analogue containing a backbone amide to ester bond mutation between Ile-7 and Leu-8 [(OL8)4OT] w
95 bly, the five paired analogues with amide-to-ester bond mutations at structurally equivalent position
99 causes preferential cleavage of the phospho-ester bond of peptides, particularly under conditions of
101 holipase A2 (cPLA2) hydrolyzes the sn-2-acyl ester bond of phospholipids and shows a preference for a
103 pimelate moiety of biotin is cleavage of the ester bond of pimeloyl-acyl carrier protein (ACP) methyl
104 ine lactonase, an enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserin
105 T2282 gene product preferentially hydrolyzes ester bonds of substrates with intermediate carbon chain
106 on by ALP, but CES-catalyzed cleavage of the ester bond on the molecules results in disassembly of th
111 OT and (OI7)4OT analogues each contained one ester bond per monomer that effectively deleted 12 backb
113 tion, it appears that substituting ether for ester bonds presents an additional barrier to proton flu
114 e (Abeta16-20) by replacing amide bonds with ester bonds prevents the aggregation of the peptide.
115 By mutagenesis, we show that loss of the ester bond reduces the thermal stability drastically and
117 osed to facilitate enzymatic cleavage of the ester bond, releasing free omega-hydroxyceramide for cov
118 ehavior results from weakening of the P-O(R) ester bond resulting from protonation, an effect which c
119 t the carboxy terminus of the peptide via an ester bond, resulting in a cyclic depsipeptide in contra
120 ed with tri(ethylene glycol) attached at the ester bond(s) for a 1:1 conjugate at the 17(3)-position,
121 robable catalytic base (Tyr150) and the acyl ester bond so as to block the approach of a potentially
122 ied analogue of ProtL containing an amide-to-ester bond substitution between residues 105 and 106 was
123 essor analogues, each containing an amide-to-ester bond substitution in the backbone of their polypep
127 affinities and trigger the hydrolysis of the ester bond that links the polypeptide with the P-site tR
128 e controlling mechanism is hydrolysis of the ester bond that links timolol to the PGT matrix, but oth
129 tilized to catalytically hydrolyze phosphate ester bonds, the utility of a zirconium(IV)-cluster-cont
131 g inhibitor mechanism depends on cleavage of ester bonds, this class of inhibitors may have advantage
132 uld be relieved by opening the s-cis lactone ester bond to an s-trans ester bond in the polymer.
133 chains (HCs) that are covalently bound by an ester bond to chondroitin sulfate (CS), which itself is
134 ylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX conjugate.
135 ons were made mainly on the aryl side of the ester bond to permit possible rapid labeling of the carb
137 that (a) covalent heme binding occurs via an ester bond to the heme 5-methyl group, (b) covalent bind
138 omega-hydroxyceramides covalently linked by ester bonds to cornified envelope proteins, most abundan
139 and eukaryotes use fatty acids attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.
141 ng was ascribed to elevated accessibility of ester bonds to the catalytic site of RoL due to increasi
143 e glutamic acid is linked, presumably via an ester bond, to a hydroxyl group on the heme 5-methyl gro
145 operoxy derivatives of oxidized PS, the sn-2 ester bond was positioned very close (<3 A) to the Ser27
146 modimer Q2, which was tethered by reversible ester bonds, was particularly potent (IC(50) approximate
148 Leu44, or Ala49 and Ile50 are replaced with ester bonds were generated by incorporating alpha-hydrox
151 alently attached to Ogamma of Thr 302 via an ester bond, which is consistent with the increased mass
153 10 of this motif auto-catalytically forms an ester bond with the heme 5-methyl, and the immobilized G
154 -dicyclopentadiene derivatives linked by the ester bonds with tethers are highly regio- and stereosel
155 s are embedded within the polyamide and form ester bonds with trimesoyl chloride, one of the monomers
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