ライフサイエンスコーパス: estimated GFR

1 ar disease or diabetes, and lower tertile of estimated GFR.

2 seline urine protein excretion, and baseline estimated GFR.

3 ted with tubulointerstitial fibrosis and low estimated GFR.

4 cause mortality reversed at higher levels of estimated GFR.

5 to be stronger among participants with lower estimated GFR.

6 the range of normal to moderately decreased estimated GFR.

7 n of an ARB did not alter the decline in the estimated GFR.

8 hat is not detected with serum creatinine or estimated GFR.

9 the patients were grouped according to their estimated GFR.

10 Similar results were found for decline in estimated GFR.

11 isease, or a 50% reduction from the baseline estimated GFR.

12 ictors of renal risk that are independent of estimated GFR.

13 ith significantly greater improvement in the estimated GFR.

14 renal function were related to the baseline estimated GFR.

15 at these common SNPs are not associated with estimated GFR.

16 iated with a significantly greater change in estimated GFR (-1.21 mL/min per 1.73 m2 [CI, -2.34 to -0

17 lar events also increased inversely with the estimated GFR: 1.4 (95 percent confidence interval, 1.4

18 cohorts of patients with CKD stages 3 to 5 (estimated GFR, 10-59 mL/min/1.73 m(2)) who were referred

19 bias (median difference between measured and estimated GFR, 2.5 vs. 5.5 mL/min per 1.73 m(2)), improv

20 We randomly assigned 148 patients with estimated GFR=20-45 ml/min per 1.73 m(2) to calcium acet

21 Even moderate renal insufficiency (estimated GFR 30-59cc/min/1.73m(2)) was associated with

22 Patients with ARVD (age 70.7 +/- 7.5 yr; estimated GFR 36 +/- 19 ml/min) had significantly more c

23 d early stage 3 chronic kidney disease (CKD; estimated GFR 45 to 60 ml/min) and followed them longitu

24 severe renal failure at presentation (median estimated GFR 9 ml/min per 1.73 m(2)).

25 was the first occurrence of a change in the estimated GFR (a decline of >/= 30 ml per minute per 1.7

26 otal kidney volume, no overall change in the estimated GFR, a greater decline in the left-ventricular

27 rine sample; and reduced GFR-Cockcroft-Gault estimated GFR (abnormal: <60 ml/min per 1.73 m(2)).

28 The most accurate model included age, sex, estimated GFR, albuminuria, serum calcium, serum phospha

29 e patients, which was not detected by SCr or estimated GFR alone.

30 multaneously, a 10-ml/minute/1.73 m(2) lower estimated GFR (among persons with estimated GFR <60 ml/m

31 Estimated GFR and 24-hr plasma creatinine clearance unde

32 e authors conclude that moderately decreased estimated GFR and albuminuria independently predict card

33 When estimated GFR and albuminuria were examined simultaneous

34 r associations, with the association between estimated GFR and all-cause mortality reversed at higher

35 nt and anti-inflammatory response, increases estimated GFR and decreases BUN, serum phosphorus, and u

36 d association was observed between a reduced estimated GFR and the risk of death, cardiovascular even

37 ed the multivariable association between the estimated GFR and the risks of death, cardiovascular eve

38 than a simpler model that included age, sex, estimated GFR, and albuminuria (integrated discriminatio

39 Cystatin C, estimated GFR, and albuminuria were not associated with

40 y factors (including diabetes, hypertension, estimated GFR, and albuminuria), participants with 25(OH

41 erly adults were categorized on the basis of estimated GFR, and cystatin C (available in 4734 partici

42 he isotope glomerular filtration rate (GFR), estimated GFR, and cystatin C.

43 However, cystatin clearance, estimated GFR, and hemoglobin levels increased significa

44 defined a rapid decline in cystatin C-based estimated GFR as >3 ml/min per 1.73 m(2)/yr, on the basi

45 ad significant increases in the mean (+/-SD) estimated GFR, as compared with placebo, at 24 weeks (wi

46 ubular atrophy independently associated with estimated GFR at 12 months.

47 We estimated GFR at each interval, analyzed changes within

48 between immunohistology scores and age, sex, estimated GFR at entry, or requirement for dialysis.

49 However, the mean estimated GFR at initiation of dialysis in the United St

50 Estimated GFR at LT was the only pretransplantation inde

51 In participants whose estimated GFR based on creatinine was 45 to 74 ml per mi

52 Lower estimated GFR based on cystatin C was strongly associate

53 FR, measuring serum creatinine and reporting estimated GFR based on serum creatinine (eGFRcr) using t

54 Estimated GFR based on serum creatinine is now widely re

55 n after adjustment for age, body mass index, estimated GFR, baseline BP, physical activity, smoking,

56 asured among 807 ARIC participants with CKD (estimated GFR between 15 and 59 ml/min per 1.73 m(2)).

57 with a laboratory finding of CKD (defined as estimated GFR between 15 and 90 ml/min per 1.73 m(2) in

58 age renal disease among participants with an estimated GFR between 30 and 44 mL/min/1.73 m(2) (HR, 1.

59 Estimated GFR, blood pressure, and the urinary albumin-t

60 er minute per 1.73 m2, each reduction of the estimated GFR by 10 units was associated with a hazard r

61 We estimated GFR by mean clearance of creatinine and urea f

62 Estimated GFR by the MDRD4 results declined throughout t

63 res of kidney function were creatinine-based estimated GFR by using the Modification of Diet in Renal

64 Similar findings were observed in other estimated GFR categories by the MDRD Study equation.

65 Net reclassification improvement based on estimated GFR categories was significantly positive for

66 orts were reclassified to a higher and lower estimated GFR category, respectively, by the CKD-EPI equ

67 GFR cystatin C in fully adjusted models with estimated GFR creatinine and ACR.

68 nal disease was 6.4% (P < .001) after adding estimated GFR cystatin C in fully adjusted models with e

69 s to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/

70 progression of CKD, respectively (defined as estimated GFR decline of 0 to 1, 1 to 4, and >4 ml/min p

71 In contrast, estimated GFR decreased by about 3 ml/min per 1.73 m(2)

72 Estimated GFR decreased early with irbesartan treatment

73 Furthermore, as preadmission estimated GFR decreased, a significant trend of increasi

74 ed by the difference of 125I-iothalamate GFR-estimated GFR (delta GFR), and precision was estimated f

75 Associations with estimated GFR demonstrated similar trends.

76 After adjustment for demographics and estimated GFR, each 1-mg/dl increment in serum phosphate

77 ch is safe and effective in patients with an estimated GFR (eGFR) < 45 ml/min per 1.73 m(2) is unknow

78 R >30 mL/min/1.73 m(2), 15 patients (7%) had estimated GFR (eGFR) </=40 mL/min/1.73 m(2) based on the

79 ted of 3834 patients aged 2 to 17 yr with an estimated GFR (eGFR) </=75 ml/min.1.73 m2 enrolled onto

80 en January 2003 and December 2008 who had an estimated GFR (eGFR) <60 ml/min per 1.73 m(2) 30 days af

81 est was CKD at age 60-64 years, suggested by estimated GFR (eGFR) <60 ml/min per 1.73 m(2) and/or uri

82 se mortality among 3093 participants with an estimated GFR (eGFR) <60 ml/min per 1.73 m(2) from the p

83 e defined CKD at follow-up (2005 to 2008) as estimated GFR (eGFR) <60 ml/min per 1.73 m(2); we define

84 Incident CKD was defined as an estimated GFR (eGFR) <60 ml/min per 1.73 m2 at study yea

85 Participants with CKD, defined as an estimated GFR (eGFR) <60 ml/min per 1.73 m2, were furthe

86 thy who had elevated albuminuria and reduced estimated GFR (eGFR) (20 to 75 ml/min per 1.73 m(2)).

87 Moderate CKD was defined as estimated GFR (eGFR) 30 to 59 ml/min per 1.73 m(2).

88 Estimated GFR (eGFR) and albuminuria were followed up to

89 ed to calculate the association of recipient estimated GFR (eGFR) at 1 yr after renal transplantation

90 Mean estimated GFR (eGFR) at the time of pre-emptive transpla

91 We calculated estimated GFR (eGFR) based on serum creatinine measureme

92 Patients were designated as having CKD when estimated GFR (eGFR) decreased to <60 ml/min per 1.73 m(

93 rch has investigated equations for obtaining estimated GFR (eGFR) from serum creatinine in cross-sect

94 (51)Cr-EDTA GFR was compared with the estimated GFR (eGFR) from seven published models and our

95 r, it is unclear whether different levels of estimated GFR (eGFR) have the same prognostic significan

96 on between proteinuria and rate of change in estimated GFR (eGFR) in a cohort of 638,150 adults from

97 rinary albumin-to-creatinine ratio (ACR) and estimated GFR (eGFR) measured at baseline.

98 d who had demonstrated a slope of decline in estimated GFR (eGFR) of > or =5 ml/min per 1.73 m(2)/yr

99 Participants with an estimated GFR (eGFR) of 15-59 ml/min per 1.73 m(2) at ba

100 e primary end point was percentage change in estimated GFR (eGFR) trajectory over the treatment perio

101 ney function was evaluated by cystatin C and estimated GFR (eGFR) using the Modification of Diet in R

102 ,741 people with CKD G3a or G3b defined by 2 estimated GFR (eGFR) values more than 90 days apart were

103 At enrollment, estimated GFR (eGFR) was 51 +/- 21 ml/min per 1.73 m(2)

104 ohort of 416 OLT patients from 1996 to 2009, estimated GFR (eGFR) was assessed during the 12 months b

105 Estimated GFR (eGFR) was calculated for 882 diabetic sib

106 Estimated GFR (eGFR) was calculated using the abbreviate

107 Estimated GFR (eGFR) was calculated using the Chronic Ki

108 Estimated GFR (eGFR) was calculated with the Cockcroft-G

109 the equation in a large, diverse population, estimated GFR (eGFR) was compared to measured GFR (mGFR)

110 Estimated GFR (eGFR) was determined with the Modificatio

111 ure, the associations of different stages of estimated GFR (eGFR) with changes in cardiac structure a

112 is known about the association of changes in estimated GFR (eGFR) with clinical outcomes.

113 seline urine albumin-to-creatinine ratio and estimated GFR (eGFR) with hospitalizations or death with

114 Automated reporting of estimated GFR (eGFR) with serum creatinine measurement i

115 ortality outcomes among patients with early [estimated GFR (eGFR)>/=10 ml/min per 1.73 m(2)] versus l

116 An estimated GFR (eGFR)<60 ml/min per 1.73 m2 was present i

117 e risk for ESRD associated with proteinuria, estimated GFR (eGFR), and hematocrit in men who did not

118 h at least one measurement of fasting LDL-C, estimated GFR (eGFR), and proteinuria between 2002 and 2

119 (CCl), Modification of Diet in Renal Disease estimated GFR (eGFR), and serum creatinine (sCr).

120 analyses were conducted of serum creatinine, estimated GFR (eGFR), and urine albumin-creatinine ratio

121 sed risk for adverse outcomes independent of estimated GFR (eGFR), but whether albuminuria also assoc

122 ney function was assessed by albuminuria and estimated GFR (eGFR), calculated by modification of diet

123 iGFR), modification of diet in renal disease estimated GFR (eGFR), Cockcroft-Gault estimated creatini

124 s iothalamate (iGFR) is superior to equation-estimated GFR (eGFR), each of these methods has distinct

125 patitis C seropositivity and albuminuria and estimated GFR (eGFR), respectively, was examined among 1

126 d total slopes defined by the mean change in estimated GFR (eGFR), where eGFR was estimated from a re

127 GF-23 and PTH were inversely associated with estimated GFR (eGFR), whereas calcitriol levels were lin

128 ociate with chronic kidney disease (CKD) and estimated GFR (eGFR).

129 ar mean age and distribution of preoperative estimated GFR (eGFR).

130 was categorized by cystatin C quartiles and estimated GFR (eGFR; < to >60 ml/min per 1.73 m(2)), and

131 ference scores (differences between mGFR and estimated GFR [eGFR] or between mGFR and CrCl, or betwee

132 /=3 ml/min per 1.73 m(2) per year decline in estimated GFR [eGFR]), CKD (eGFR < 60 ml/min per 1.73 m(

133 0 participants with CKD stages 2-4 (baseline estimated GFR [eGFR], 44+/-15 ml/min per 1.73 m(2)).

134 Renal function was categorized as estimated GFR (expressed in ml/min per 1.73 m(2)).

135 usted risk of hospitalization with a reduced estimated GFR followed a similar pattern.

136 inine), provides a good approximation to the estimated GFR formula.

137 The primary end point was the change in the estimated GFR from baseline to follow-up, with adjustmen

138 The authors estimated GFR from standardized serum creatinine levels.

139 recipients for early post-HT mortality using estimated GFR from the MDRD and the CKD-EPI equations.

140 At enrolment and 4 years' follow-up we estimated GFR from the plasma clearance of 51Cr-labelled

141 with mild renal insufficiency (defined as an estimated GFR > 55 mL/min per 1.73 m2 but <80 mL/min per

142 en with normal renal function (defined as an estimated GFR > or = 80 mL/min per 1.73 m2).

143 cipants did not have chronic kidney disease (estimated GFR > or =60 mL/min per 1.73 m2) and mean cyst

144 ion of renal replacement therapy (RRT) at an estimated GFR >/=10 ml/min per 1.73 m(2).

145 aged adults were categorized on the basis of estimated GFR >/=90, 60 to 89, and 15 to 59 ml/min per 1

146 n for age, race or ethnicity, and sex, lower estimated GFR (> or =90, 60 to 89, or <60 mL/min per 1.7

147 episodes of severe infection (HR, 2.15), and estimated GFR (HR, 0.89) after LT were identified as ind

148 Therefore, we estimated GFR in 18,015 individuals from the IMPROVE-IT

149 ey disease was assessed using cystatin C and estimated GFR in 4637 participants in 1992 to 1993.

150 within these genes for association with the estimated GFR in 74,354 European-ancestry participants f

151 lele was significantly associated with lower estimated GFR in adjusted analyses (P = 0.049), as were

152 of creatinine-based equations to obtain the estimated GFR in adolescents and young adults is poorly

153 ciates with increased fibrosis and decreased estimated GFR in diabetic nephropathy in vivo, perhaps b

154 ethyl was associated with improvement in the estimated GFR in patients with advanced CKD and type 2 d

155 uent elevations of creatinine and decline in estimated GFR in the Cardiovascular Health Study, a comm

156 Change in estimated GFR in this subgroup over the 11-year period w

157 not significantly associated with change in estimated GFR in women with normal renal function (defin

158 Furthermore, the mean estimated GFR increased from 111.3+/-25.7 to 121.8+/-29.

159 Estimated GFR is a powerful and independent predictor of

160 cal laboratories, and in most circumstances, estimated GFR is sufficient for clinical decision making

161 Over 12 years, 69 patients developed estimated GFR less than 60 mL/min per 1.73 m(2) (16 per

162 The cumulative incidence of estimated GFR less than 60 mL/min per 1.73 m(2) for pati

163 I was greatest among patients with a reduced estimated GFR (less than 45.0 ml per minute per 1.73 m2)

164 dition, the proportions of participants with estimated GFR < 60 ml/min per 1.73 m(2) was 1.5% for non

165 CKD was defined either by an estimated GFR < 60 ml/min per 1.73 m2 or by the presence

166 y albumin/creatinine ratio >/=30 mg/g and/or estimated GFR </=60 ml/min per 1.73 m(2), was present in

167 Patients with severe CKD (estimated GFR <30 ml/min per 1.73 kg/m2) required signif

168 en patients were stratified by CKD stage IV (estimated GFR <30 ml/min per 1.73 m(2)).

169 We excluded participants with an estimated GFR <45 ml/min per 1.73 m(2) to focus on phosp

170 with heart failure, notably in patients with estimated GFR <50 ml/min per 1.73 m(2).

171 eporting a hip fracture in participants with estimated GFR <60 ml/min (odds ratio [OR] 2.12; 95% conf

172 with and 976 without chronic kidney disease (estimated GFR <60 ml/min per 1.73 m(2)).

173 Only 0.2% of participants had estimated GFR <60 ml/min per 1.73 m(2).

174 CKD was defined as estimated GFR <60 ml/min per 1.73 m(2).

175 als with FH-ESRD were more likely to have an estimated GFR <60 ml/min per 1.73 m(2).

176 CKD was defined as an estimated GFR <60 ml/min per 1.73 m(2).

177 iagnostic codes compared with CKD defined by estimated GFR <60 ml/min per 1.73 m2 were 11 and 96%, re

178 y disease marked by overt proteinuria and/or estimated GFR <60 ml/min per 1.73 m2.

179 um creatinine; prevalence of CKD, defined as estimated GFR <60 ml/min per 1.73 m2; and sensitivity of

180 fness did not associate with CKD (defined by estimated GFR <60 ml/min/1.73 m(2)) in either age- and g

181 on, and the prevalence of CKD stages 3 to 5 (estimated GFR <60 mL/min/1.73 m(2)) was reduced from 8.7

182 atin C or creatinine, and CKD was defined by estimated GFR <60 ml/min/1.73 m(2).

183 m(2) lower estimated GFR (among persons with estimated GFR <60 ml/minute/1.73 m(2)) was associated wi

184 CKD was defined based on estimated GFR <60 mL/minute/1.73m(2) and albuminuria >/=

185 nly among those with chronic kidney disease (estimated GFR, <60 mL/minute/1.73 m(2)): relative differ

186 at lower suPAR levels associated with higher estimated GFR, male sex, and treatment with mycophenolat

187 acrolimus groups, respectively, (n.s.); mean estimated GFR (Nankivell) was 75.3+/-16.6 mL/min and 72.

188 person-years among ARIC participants with an estimated GFR of >/=90, 60 to 89, and 15 to 59 ml/min pe

189 Compared with subjects with estimated GFR of >or=90 ml/min, those with estimated GFR

190 eaths/1000 person-yr among participants with estimated GFR of >or=90, 70 to 89, and <70 ml/min, respe

191 123 individuals developed CKD, defined by an estimated GFR of <60 ml/min per 1.73 m(2).

192 h estimated GFR of >or=90 ml/min, those with estimated GFR of <70 ml/min exhibited higher relative ri

193 as significantly associated with a change in estimated GFR of -1.69 mL/min per 1.73 m2 (CI, -2.93 to

194 onfidence interval, 1.7 to 1.9), 3.2 with an estimated GFR of 15 to 29 ml per minute per 1.73 m2 (95

195 CKD was defined as an estimated GFR of 15 to 60 ml/min per 1.73 m(2).

196 urface area or 56 to 65 years of age with an estimated GFR of 25 to 44 ml per minute per 1.73 m(2) we

197 ho were either 18 to 55 years of age with an estimated GFR of 25 to 65 ml per minute per 1.73 m(2) of

198 ith a median difference between measured and estimated GFR of 3.9 ml per minute per 1.73 m(2) with th

199 onfidence interval, 1.1 to 1.2), 1.8 with an estimated GFR of 30 to 44 ml per minute per 1.73 m2 (95

200 orrectly reclassified 16.9% of those with an estimated GFR of 45 to 59 ml per minute per 1.73 m(2) as

201 usted hazard ratio for death was 1.2 with an estimated GFR of 45 to 59 ml per minute per 1.73 m2 (95

202 In estimated GFR of 45 to 59 mL/min/1.73 m(2) by the MDRD S

203 , 34.7% of participants were reclassified to estimated GFR of 60 to 89 mL/min/1.73 m(2) by the CKD-EP

204 n 872 outpatients with stable CVD and a mean estimated GFR of 71 ml/min per 1.73 m(2).

205 of 588 (12.7%) individuals had a decline in estimated GFR of at least 3 ml/min per yr per 1.73 m(2).

206 about 33% recovered renal function to above estimated GFR of greater than 60 mL per min.

207 dence interval, 3.1 to 3.4), and 5.9 with an estimated GFR of less than 15 ml per minute per 1.73 m2

208 Chronic kidney disease was defined as an estimated GFR of less than 60 mL/min per 1.73 m2 based o

209 was the first occurrence of a decline in the estimated GFR or ESRD.

210 alysis, 20,806 patients (75.0%) had a normal estimated GFR or stage 1 CKD, 5011 (18.07%) had stage 2

211 lted in a slower decline than placebo in the estimated GFR over a 1-year period in patients with late

212 buminuria was associated with higher risk of estimated GFR overall and within every category.

213 lele was significantly associated with lower estimated GFR (P = 0.01) and higher cystatin C (P = 0.00

214 dynamic range, and the best correlation with estimated GFR (R(2) = 0.38 to 0.50, P < 0.01 to 0.001).

215 dinal Study of Adult Men cohort (R=-0.52 for estimated GFR, R=0.22 for urinary albumin-to-creatinine

216 Estimated GFR remained unchanged after the procedure, ir

217 y, mechanical ventilation, and postdischarge estimated GFR (residual kidney function).

218 the assay, cystatin C should be measured and estimated GFR should be calculated and reported using cy

219 Even mild renal disease, as assessed by the estimated GFR, should be considered a major risk factor

220 Adding gait speed to a model that included estimated GFR significantly improved the prediction of 3

221 om 4.6% for those with stage 1 CKD or normal estimated GFR to 9.9% for those with stage 5 CKD (test f

222 The rates of decline in the estimated GFR, urinary albumin excretion, and other seco

223 We estimated GFR using both cystatin C (eGFRcys) and creati

224 We estimated GFR using cystatin C.

225 We estimated GFR using equations that included standardized

226 CHD risk factors and estimated GFR using serum creatinine were measured among

227 Estimated GFR using the CKD-EPI equation is comparable t

228 using the CKD-EPI equation is comparable to estimated GFR using the MDRD equation in risk stratifica

229 0 ml per minute per 1.73 m(2) if the initial estimated GFR was >/= 60 ml per minute per 1.73 m(2) or

230 m(2) or a decline of >/= 50% if the initial estimated GFR was <60 ml per minute per 1.73 m(2)), end-

231 The change from baseline in the estimated GFR was -2.34 ml per minute per 1.73 m(2) (95%

232 measurement-error adjustment, the change in estimated GFR was -7.72 mL/min per 1.73 m2 (CI, -15.52 t

233 In the intervention group, the decrease in estimated GFR was 0.45 ml/min per 1.73 m(2) per year les

234 -g increase in protein intake; the change in estimated GFR was 1.14 mL/min per 1.73 m2 (CI, -3.63 to

235 The mean estimated GFR was 34 ml/min per 1.73 m(2) (10%-90% range

236 Mean age was 61 years and the mean estimated GFR was 41 ml/min per 1.73 m(2).

237 reatinine clearance was 55 +/- 24 ml/min and estimated GFR was 57 +/- 21 ml/min per 1.73 m(2) at base

238 GFR were greater for all equations when the estimated GFR was 60 mL/min per 1.73 m2 or greater.

239 ge was 68 (+/-10) years, 89% were male, mean estimated GFR was 64 (+/-19) mL/min per 1.73 m(2), and 3

240 ine was 0.9 +/- 0.2 mg/dl, and mean baseline estimated GFR was 90.4 +/- 19.4 ml/min/1.73 m(2).

241 In NHANES, the median estimated GFR was 94.5 mL/min per 1.73 m(2) (IQR, 79.7 t

242 Estimated GFR was an independent predictor of mortality

243 Lower estimated GFR was associated with higher risks of cardio

244 Estimated GFR was calculated from the Modification of Di

245 Estimated GFR was classified into 6 categories (>/=90, 6

246 Mean estimated GFR was consistently higher in the tacrolimus/

247 The rate of change in estimated GFR was similar in the two medication groups,

248 The distribution of estimated GFR was wide and normally shaped, with a mean

249 rum cystatin C, by itself or as a part of an estimated GFR, was a significant predictor of mortality.

250 concentration, creatinine concentration, and estimated GFR were 1.0 mg/L, 79.6 micromol/L (0.9 mg/dL)

251 Serial annual serum creatinine and estimated GFR were also comparable amongst the three gro

252 erum creatinine concentration and changes in estimated GFR were determined.

253 Differences between measured and estimated GFR were greater for all equations when the es

254 Results for estimated GFR were similar.

255 outcome was the change from baseline in the estimated GFR with bardoxolone methyl, as compared with

256 was 116 (24) (64-160) mL/min per 1.73 m(2), estimated GFR with CKD-EPI was 108 (22) (64-153) mL/min

257 dels were used to explore the association of estimated GFR with incident CVD and all-cause mortality.

258 compare performance of existing equations of estimated GFR with measured GFR of the gold standard; es

259 3 m(2)), and greater accuracy (percentage of estimated GFR within 30% of measured GFR, 84.1% vs. 80.6

260 This formula yielded 87.7% of estimated GFR within 30% of the iGFR, and 45.6% within 1