ライフサイエンスコーパス: estren

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1 st ICI-182780 failed to block the effects of estren.

2 of kinase-mediated actions of the ER with 4-estren-3alpha,17beta-diol (estren) or an estradiol-dendr

3 ver, administration of 17beta-estradiol or 4-estren-3alpha,17beta-diol to ovariectomized mice induces

4 A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotr

5 It has been found that 4-estren-3alpha,17beta-diol, a synthetic ligand for the es

6 We conclude that the estrens act mostly through the AR and, in mice, do not f

7 e effects of a SERM (PSK3471) and 2 estrens (estren-alpha and estren-beta) on bone and reproductive o

8 Estren also increased the expression of prostate-specifi

9 stosterone, but differently from raloxifene, estren alters the activity of Elk-1, CCAAT enhancer bind

10 Estrens and PSK3471 prevented gonadectomy-induced bone l

11 CI, Windahl et al. provide data showing that estrens are not as suitable a replacement for estrogen a

12 and reproductive organs to determine whether estrens are safe and act via the estrogen receptors and/

13 RM (PSK3471) and 2 estrens (estren-alpha and estren-beta) on bone and reproductive organs to determin

14 Estren binds recombinant AR with 10-fold higher affinity

15 Estren-bound AR can translocate AR to the nucleus and st

16 munoprecipitation analysis, we show that the estren-bound AR coimmunoprecipitates with a region of th

17 Consistent with the in vitro findings, estren, but not E(2), stimulated Wnt/beta-catenin-mediat

18 Our results show that estren can bind, translocate, transactivate, and regulat

19 Estrens directly activated transcription in several cell

20 mpared the effects of a SERM (PSK3471) and 2 estrens (estren-alpha and estren-beta) on bone and repro

21 Estrens have been suggested to not only prevent bone los

22 Unlike SERMs, the estrens induced reproductive organ hypertrophy in both m

23 an AR antagonist, bicalutamide, blocked the estren-induced increase in PSA expression.

24 e hitherto unidentified genotropic action of estren mediated by AR in androgen-responsive cells and t

25 of the ER with 4-estren-3alpha,17beta-diol (estren) or an estradiol-dendrimer conjugate, each a synt

26 In vivo analysis of estren's action on male-orchidectomized ICR mice reveale

27 on on male-orchidectomized ICR mice revealed estren's AR agonist actions on the levator ani and semin

28 Does this mean estrens should not be pursued as a therapy for osteoporo

29 Though not catabolic, estrens triggered only minor, nonsignificant increases i

30 In 2002, the synthetic ligand estren was described to reproduce the bone anabolic, non

31 The nongenotropic ligand estren was evaluated for its transcriptional activity me

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