ライフサイエンスコーパス: estrone

1 -1) for the conversion of androstenedione to estrone).

2 ddle cerebral artery occlusion (MCAO) as was estrone.

3 ated in part by alterations in serum PTH and estrone.

4 e activity and can synthesize estradiol from estrone.

5 d a 6.8% (95% CI: -12.7%, -0.6%) decrease in estrone.

6 catalyzes the inactivation of estradiol into estrone.

7 larity analytes including both estradiol and estrone.

8 19-aldehyde androstenedione intermediates to estrone.

9 with lower risk (top vs. bottom quartile RR: estrone = 0.52; 95% CI, 0.30-0.88; estradiol = 0.51; 95%

10 ion limits of the method were 0.045 ng/L for estrone, 0.086 ng/L for 17beta-estradiol, 0.030 ng/L for

11 ng to a total synthesis of the steroid (+/-)-estrone 1 and to a synthesis of 14-epiestrone 40 are des

12 ich, on deprotection using BBr(3) gave (+/-)-estrone 1.

13 he A2/A2 genotype to have elevated levels of estrone (+14.3%, P = 0.01), estradiol (+13.8%, P = 0.08)

14 product ion spectra of the PS derivatives of estrone, 17alpha-ethinylestradiol, equilin, and equileni

15 In WTP influents, estrogens (estrone, 17beta-estradiol, and estriol), androgens (andr

16 The estrogens included for study were estrone, 17beta-estradiol, estriol, 17alpha-ethinylestra

17 ase activity, a number of novel analogues of estrone 3-O-sulfate possessing sulfate surrogates were s

18 r endogenous estrogen sulfates in the human, estrone 3-sulfate (E1-3S), estriol 3-sulfate (E3-3S), an

19 g the cellular uptake of OATP1A2 substrates, estrone 3-sulfate and two delta-opioid receptor agonists

20 Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important a

21 rom human, mouse, or skate) generated robust estrone 3-sulfate transport activity.

22 dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-bet

23 skate proteins by measuring transport of [3H]estrone 3-sulfate.

24 cholesterol epoxides (12.3 mumol/rat) and of estrone-3,4-quinone (30 mumol/rat)were 10- and 25- fold

25 xide), and 1,5(10)estradiene-3,14,17-trione (estrone-3,4-quinone).

26 -alpha-epoxide, cholesterol-beta-epoxide, or estrone-3,4-quinone.

27 , inversely associated with weekly levels of estrone-3-glucuronide and human chorionic gonadotropin.

28 ome fertility monitors that measured urinary estrone-3-glucuronide and luteinizing hormone (LH).

29 an chorionic gonadotropin and inversely with estrone-3-glucuronide and pregnanediol-3-glucuronide.

30 cted to assess human chorionic gonadotropin, estrone-3-glucuronide, and pregnanediol-3-glucuronide.

31 ase (STS) in comparison to a lead inhibitor, estrone-3-O-methylthiophosphonate (E1-3-MTP).

32 k from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potent

33 t estrone sulfatase inhibitors, most notably estrone-3-O-sulfamate.

34 Docking studies using the substrate and estrone-3-sulfate mimics that are active inhibitors indi

35 Para-aminohippurate (PAH) and estrone-3-sulfate transport across the bovine ciliary bo

36 detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17beta-estradi

37 ver microsomal glucuronidation of estradiol, estrone, 4-aminophenol, and 4-nitrophenol by 103, 187, 1

38 bited the uterotropic effect of estradiol or estrone (45 or 75 ng/mouse, i.p. once daily for 3 days)

39 um was analyzed for testosterone, estradiol, estrone, 5alpha-androstane-3alpha, 17beta-diol-glucuroni

40 improved estrone retention while decreasing estrone adsorption to membranes.

41 (Z)- and (E)-diethylstilbestrol, hexestrol, estrone, alpha-estradiol, and 17-ethynylestradiol) is sh

42 High concentrations of equilin or estrone also attenuated the submaximal neuronal injury i

43 mulating hormone and to 17beta-estradiol and estrone, although the latter estrogen has a much lower a

44 > or = 30) had 35% higher concentrations of estrone and 130% higher concentrations of estradiol comp

45 found to contain florfenicol, pyrimethamine, estrone and 17beta-estradiol at levels from 0.095 to 2.7

46 For comparison, estrone and 17beta-estradiol were modeled and are likely

47 Six additional putative dimers between estrone and 17beta-estradiol with structures similar to

48 milar efficacy to 17 beta-estradiol, whereas estrone and 2-methoxyestriol were less effective.

49 ently contaminated by the classical estrogen estrone and a variety of EDCs produced by plants (phytoe

50 hod was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o'-

51 All isoflavone doses resulted in lower serum estrone and E(2) concentrations in the high-estrogen env

52 Estrone and equol persisted along the waste disposal rou

53 Higher urinary estrone and estradiol levels were strongly significantly

54 5% on average and removed significantly more estrone and estradiol than nonaugmented filters.

55 tho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylat

56 A preferential hydroxylation of estrone and increased oxidation of testosterone in patie

57 15 estrogens and estrogen metabolites (EM): estrone and its 2-, 4-, and 16alpha-hydroxy and 2- and 4

58 yet is capable of simultaneously quantifying estrone and its 2-, 4-methoxy and 2-, 4-, and 16alpha-hy

59 This method is capable of quantifying estrone and its 2-, and 4- and 16alpha-hydroxy and its 2

60 rine, yet is able to simultaneously quantify estrone and its 2-methoxy and 2-, 4-, and 16alpha-hydrox

61 The positive association of caffeine with estrone and its inverse association with bioavailable te

62 of estrone, whereas charge repulsion between estrone and negative functional groups of the membrane d

63 erum levels of DHEA, DHEAS, testosterone and estrone and substantially alters the patterns of correla

64 ly, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were 12-28% lowe

65 the holo form and as ternary complexes with estrone and with the first potent, nonsteroidal inhibito

66 ens from 19-norsteroids, the 2-hydrogen from estrone, and (in this case) the 1-, 5beta-, and 9beta-hy

67 Prediagnostic concentrations of estradiol, estrone, and 13 metabolites were measured in 1,298 postm

68 lestrone (ZYC-26), with its parent estrogen, estrone, and an expected non-neuroprotective 3-O-methyl

69 d serum levels of DHEA, DHEAS, testosterone, estrone, and cortisol were measured in the DHEA and plac

70 Linearity for dansylated estriol, estrone, and estradiol was excellent over the estrogen r

71 s that are distinct from diethylstilbestrol, estrone, and estradiol.

72 mplete within 10 min for dansylated estriol, estrone, and estradiol.

73 chemicals, particularly 17beta-estradiol and estrone, and fish exposed to the postupgrade effluent in

74 rum levels of DHEA, DHEAS, testosterone, and estrone, and regression analyses demonstrated that level

75 Estradiol, estrone, and sex hormone-binding globulin levels increas

76 . injection of 100 or 300 ng of estradiol or estrone, and these levels were decreased by 30-60% in an

77 en 6 and 10 and chemical formulas similar to estrone- and estradiol-like compounds.

78 However, analytes including estrone, androstenedione, progesterone, and equol remain

79 Endogenous estradiol and estrone are linked causally to increased risks of breast

80 We determined whether increases in serum estrone as a function of treatment predict increases in

81 intake was positively associated with plasma estrone before and after adjustment for confounders (r =

82 bundant than androgens or progesterone, with estrone being the predominant estrogen species.

83 e last hormone therapy use, higher levels of estrone (beta = 0.0013, p = 0.014), estradiol (beta = 0.

84 HA concentration determined the amount of estrone bound to HA and hence affected estrone retention

85 cted with MNU, and treated with estradiol or estrone by a continuous-release, subcutaneous Silastic i

86 d conversion of estradiol to the less-active estrone by HSD IV induction may explain how phthalate ex

87 NADPH-dependent metabolism of estradiol and estrone by liver microsomes of BHA-treated animals as de

88 may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.

89 linear regression to determine whether serum estrone changes predicted mammographic percent density c

90 Outcomes were estrone concentration (primary) and estradiol, free estr

91 The serum estrone concentration was significantly higher (P<.05) a

92 st positive relation between PAI-1 and serum estrone concentrations (rs = 0.29).

93 urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E(1)C) levels.

94 centrations of estrone (E1), estradiol (E2), estrone conjugates, androstenedione, and testosterone we

95 Increases in the concentration of estrone could be observed downstream from potential sour

96 The electron density in the estrone crystal has been described with the multipole mo

97 Compared with controls, estrone decreased 9.6% (P = .001) with diet, 5.5% (P = .

98 atherosclerosis and increasing quartiles of estrone, dehydroepiandrosterone sulfate, or androstenedi

99 monstrated previously that the sulfamoylated estrone derivative 2-methoxyestrone-3-O-sulfamate (2-MeO

100 st cancer cells in vitro, whereas the parent estrone derivative, 2-methoxyestrone, did not.

101 The estrone derivatives also underwent 6beta-hydroxylation,

102 sulfamoylation on the anticancer activity of estrone derivatives and to elucidate their mechanism of

103 X-ray structures of the cholesterol and estrone derivatives are discussed.

104 er antimicrotubule agents, the sulfamoylated estrone derivatives induced BCL-2 and BCL-XL phosphoryla

105 In each assay, the sulfamoylated estrone derivatives were >10-fold more potent than their

106 The sulfamoylated estrone derivatives were also significantly more potent

107 ), 6b (or 6a), and Dane's diene (15, to give estrone derivatives) or N-benzyl-N-(cyclohexylethynyl)-4

108 enic compounds such as ethinyl estradiol and estrone did not have any effect on TNFalpha-induced VCAM

109 d for by baseline TAS, serum ferritin, serum estrone, dietary zinc, and dietary meat, fish, and poult

110 versely associated with plasma estradiol and estrone during the luteal phase of the menstrual cycle.

111 two groups of women was greater than that in estrone (E(1)), estradiol (E(2)) and estriol (E(3)).

112 Physiological estrogens, including estrone (E(1)), estradiol (E(2)), and estriol (E(3)), fl

113 Mean levels of circulating estrone (E(1)), estradiol (E(2)), and estrone sulfate de

114 the NADPH-dependent 16alpha-hydroxylation of estrone (E(1); at 10 nM to 200 microM substrate concentr

115 Environmental endocrine disruptors such as estrone (E1) and beta-estradiol (E2) are excreted in hum

116 nogenic 4-hydroxy catechol estrogens (CE) of estrone (E1) and estradiol (E2) to catechol estrogen-3,4

117 Estrone (E1) and trendione (TD) were detected as primary

118 ogen-sensitive breast cancer by transforming estrone (E1) into estradiol (E2).

119 Higher estrone (E1) levels and carrying the APOE epsilon4 allel

120 tive metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OH

121 ), which catalyzes the reduction of inactive estrone (E1) to the active 17beta-estradiol in breast ti

122 entrations and loading on the degradation of estrone (E1) were examined under various conditions in b

123 rements of laccase for the transformation of estrone (E1), 17beta-estradiol (E2), and 17alpha-ethinyl

124 imultaneous determination of four estrogens [estrone (E1), 17beta-estradiol (E2), estriol (E3), and 1

125 A third steroid, estrone (E1), also can occur at high concentrations in s

126 f the steroid estrogens beta-estradiol (E2), estrone (E1), and alpha-ethynylestradiol (E2) in wastewa

127 E2 and its primary degradation intermediate, estrone (E1), are largely unknown.

128 alpha-E2), 17beta-estradiol (17beta-E2), and estrone (E1), are routinely detected in surface water ne

129 aptamers bind E2 and a structural analogue, estrone (E1), equally well and are up to 74-fold selecti

130 during anastrozole plasma concentrations of estrone (E1), estradiol (E2), estrone conjugates, andros

131 activity, we expanded our testing to include estrone (E1), estriol (E3), progesterone, and dexamethas

132 he free estrogens, 17beta-estradiol (E2) and estrone (E1), respectively.

133 estrogens [17beta-estradiol (17beta-E2) and estrone (E1)] and two synthetic estrogen mimics [zeranol

134 d NADPH-dependent oxidation of estradiol and estrone, enhanced the in vivo metabolism of these estrog

135 compounds, E2, diethylstilbestrol (DES), and estrone (EST), activated expression of the reporter gene

136 ermine whether removal of natural estrogens (estrone, estradiol, and estriol) and overall SSF perform

137 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and

138 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively.

139 determined the levels of aromatase activity, estrone, estradiol, and tumor size in patients pre-AI an

140 erone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth facto

141 spectrometry was used for the separation of estrone, estradiol, estriol, 16-epiestriol, 17-epiestrio

142 selected for study including four estrogens (estrone, estradiol, estriol, and ethinylestradiol), eigh

143 rbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method u

144 riminatory ability as indicators of estriol, estrone, estradiol, or progesterone levels.

145 circumference ratio, with concentrations of estrone, estradiol, testosterone, SHBG, dehydroepiandros

146 Four steroidal estrogens (17beta-estradiol, estrone, estriol, and 17alpha-estradiol) were tested in

147 Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone,

148 uated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandros

149 olysis of E2-3G and its oxidized metabolite, estrone glucuronide (E1-3G), both of which were transfor

150 ons in estrogen levels, by measuring urinary estrone glucuronide (E1G) in the periovulatory and lutea

151 onal effects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an assoc

152 ectrostatic potential (ESP) distributions of estrone have been determined using X-ray diffraction ana

153 Solute-solute interactions between HA and estrone improved estrone retention while decreasing estr

154 Both 17 beta-estradiol and estrone improved retention on an equimolar basis in a do

155 port of 4-nonylphenol, 17beta-estradiol, and estrone in a 10-km reach of the Redwood River in southwe

156 es (17alpha-estradiol, 17beta-estradiol, and estrone) in aqueous solutions blended with dairy lagoon

157 wo prototypical aglycones, p-nitrophenol and estrone, in intact and digitonin-treated microsomes.

158 ta-HSD1, the enzyme catalyzing conversion of estrone into estradiol.

159 Estrone (k(stream) = 0.6 +/- 0.8 day(-1)) and 4-nonylphe

160 hat metabolites derived from cholesterol and estrone lack tumorigenic activity in the rat mammary gla

161 ase of 2.95% per 100 pg/mL increase in serum estrone level (P =.0003).

162 Greater increase in serum estrone level as a function of treatment is a significan

163 density increased with increasing change in estrone level in the EPT groups, but not in the CEE grou

164 in was also positively correlated with serum estrone levels (r(s) = 0.38) among HRT nonusers.

165 However, estrone levels decreased after alcohol and placebo in wo

166 epiandrosterone sulfate (DHEA-S) and reduced estrone levels in KC patients compared to healthy contro

167 sured mammographic percent density and serum estrone levels in participants in the Postmenopausal Est

168 of alcohol ingestion on plasma estradiol and estrone levels.

169 tion had low concentrations of two hormones (estrone <0.8 to 2.23 ng L(-1) and androstenedione <0.8 t

170 of 4- and 16alpha-hydroxylated estradiol and estrone metabolites.

171 hree-step synthesis of the tricyclic core of estrone methyl ether.

172 The use of a boronate group on an estrone molecule allows for activation of gene expressio

173 We observed that in contrast to estrone, neither ZYC-26 nor ZYC-23 bound to either estro

174 nto the hippocampus of 17 beta-estradiol and estrone on retention of T-maze footshock avoidance in fe

175 various human cytochrome P450 isoforms with estrone or 17beta-estradiol alone or two estrogens in co

176 Treatment of HOSE or OCa cells with estrone or 17beta-estradiol at 10(-8) M for a period of

177 evaluation of novel inhibitors based on the estrone or estradiol template.

178 siologic concentrations of 17beta-estradiol, estrone, or equilin attenuated neuronal loss due to prol

179 directly associated with a decrease in serum estrone (P < 0.01, R(2) = 0.50).

180 ds, including L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-naphthol.

181 nancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breast cance

182 They provided serum for free estradiol, estrone, progesterone, free testosterone, and sex hormon

183 Estrone quinol was also equipotent with its parent estro

184 also underwent 6beta-hydroxylation, but only estrone quinol yielded a second product consistent with

185 gation of the chemical reactivity of Gen and estrone quinones to determine the chemical differences o

186 st-to-thigh circumference ratio ((r = 0.24), estrone ((r = 0.18), and estradiol ((r = 0.28) (albumin-

187 Concentrations of estrone ranged from between the detection and quantifica

188 The ability of UGT1A10 to glucuronidate estrone represents only the second example of a human es

189 of 17alpha-estradiol, 17beta-estradiol, and estrone, respectively.

190 functional groups of the membrane dominated estrone retention above the pK(a).

191 nt of estrone bound to HA and hence affected estrone retention based on the mechanism of size exclusi

192 interactions between HA and estrone improved estrone retention while decreasing estrone adsorption to

193 administration also inhibited estradiol- or estrone-stimulated [3H]thymidine incorporation into uter

194 Estrone sulfatase (ES; 562 amino acids), one of the key

195 e synthesized and evaluated as inhibitors of estrone sulfatase (STS) in comparison to a lead inhibito

196 The inhibition of MDA-MB-231 cell estrone sulfatase activity by this compound was found to

197 famoyl)-N-alkanoyl tyramines to inhibit: (a) estrone sulfatase activity in intact cultures of human b

198 the test compounds (1 microM) inhibited the estrone sulfatase activity of intact MDA-MB-231 cells; h

199 n some of the requirements for inhibition of estrone sulfatase activity, a number of novel analogues

200 fluence the ability of a compound to inhibit estrone sulfatase activity.

201 nes for the inhibition of breast cancer cell estrone sulfatase activity.

202 yl tyramine for the inhibition of MDA-MB-231 estrone sulfatase activity.

203 Thus, inhibitors of estrone sulfatase have potential for the treatment of es

204 r data support the concept that nonsteroidal estrone sulfatase inhibitors may be useful as therapeuti

205 l agents have been developed that are potent estrone sulfatase inhibitors, most notably estrone-3-O-s

206 famoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors.

207 of estrone sulfate to estrone by the enzyme estrone sulfatase.

208 est compounds (10 microM) in the presence of estrone sulfate (1 microM) as the only source of estroge

209 zeta, increased both OAT3-mediated uptake of estrone sulfate (ES) and PKCzeta activity.

210 Treatment with the STS substrate estrone sulfate also improved metabolic functions in bot

211 edly reduced uptake of the OATP-C substrates estrone sulfate and estradiol 17beta-d-glucuronide.

212 the short OATP2B1 variant toward substrates estrone sulfate and rosuvastatin are similar to the well

213 ic anions such as p-aminohippurate (PAH) and estrone sulfate as well as the basic compound, cimetidin

214 lating estrone (E(1)), estradiol (E(2)), and estrone sulfate decreased to 11%, 22%, and 13% of baseli

215 he suppressed levels of plasma estradiol and estrone sulfate in postmenopausal women with early ER-po

216 For example, estrone sulfate levels in quintiles 1-5 of metabolic equ

217 breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfata

218 Estrone sulfate uptake in oocytes expressing any one of

219 Estrone sulfate was statistically significantly associat

220 Baseline values of estradiol and estrone sulfate were significantly correlated with BMI (

221 strates MK571, probenecid, taurocholic acid, estrone sulfate, and bromosulfophthalein and inhibited b

222 The uptakes of p-aminohippurate (PAH), estrone sulfate, and ochratoxin A were approximately 10-

223 or probenecid was observed for taurocholate, estrone sulfate, and para-aminohippurate in renal slices

224 Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone, dehydroe

225 parately, were able to take up taurocholate, estrone sulfate, digoxin, and prostaglandin E(2), but no

226 13, and r = 0.30; P = .035 for estradiol and estrone sulfate, respectively), it was not with anastroz

227 ort function for the non-bile acid substrate estrone sulfate, suggesting this position may be part of

228 Estrone sulfate, testosterone, and prolactin were select

229 ther inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone su

230 eceptor-positive disease (selected hormones: estrone sulfate, testosterone, prolactin, and SHBG; chan

231 COS-7 cells by measuring the uptake of [(3)H]estrone sulfate.

232 n to the large hydrophobic organic substrate estrone sulfate.

233 k (odds ratio doubling, 0.82 [SHBG] to 1.37 [estrone sulfate]).

234 ns including extracellular glutamate (OAT4), estrone-sulphate and bromosulphothalein (both OAT4 and O

235 hours with 10 nM of either 17beta-estradiol, estrone, testosterone, 5alpha-dihydrotestosterone, 5alph

236 Estradiol, estrone, testosterone, luteinizing hormone (LH), follicl

237 The rate of 2-hydroxylation of estradiol and estrone (the major metabolic pathway) was increased by 2

238 yme (17beta-HSD1) catalyzes the reduction of estrone to estradiol and is expressed in malignant breas

239 The reduction of estrone to estradiol, the most potent estrogen in human,

240 Estradiol or estrone treatment reduced the incidence of cataractous e

241 epresents only the second example of a human estrone UGT.

242 Conversion of androstenedione to estrone (under single turnover conditions) generated a p

243 A2/A2 genotype and steroid hormone fractions estrone (versus A1/A1 genotype: +10.9%; P = 0.05) and es

244 Estrone was detected in all of the samples and 17beta-es

245 No significant increase in circulating estrone was detected in either group.

246 17 alpha-Estradiol was less effective, and estrone was devoid of vasorelaxing activity.

247 Estrone was found to be the greatest contributor to estr

248 n 17alpha-estradiol and 17beta-estradiol via estrone was observed in aqueous solutions in the presenc

249 UGT enzyme activity toward estrone was unchanged 1 day posthepatectomy compared wit

250 ne (EaM), estromustine (EoM), estradiol, and estrone were assessed after weeks 1 and 4 of treatment.

251 D, sex hormone binding globulin, leptin, and estrone were measured at baseline and at week 25.

252 Measurable levels of estradiol and estrone were observed in the serum and uterus of ovariec

253 ven targeted steroids, 17alpha-estradiol and estrone were the most commonly detected, identified in o

254 ved from the A-rings of 17beta-estradiol and estrone were utilized to further compare these reactions

255 products (eugenol, menthol, cholesterol, and estrone) were labeled in a simple fashion.

256 tions were most important below the pK(a) of estrone, whereas charge repulsion between estrone and ne