ライフサイエンスコーパス: ethacrynic acid

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1 ress and by agents that deplete glutathione (ethacrynic acid).

2 at the indole of Trp38 is less than 4 A from ethacrynic acid.

3 ualitatively, for a second GSH conjugate, GS-ethacrynic acid.

4 Ethacrynic acid (0.03-15 microM) inhibited cytosolic bus

5 tivity for the conjugation of glutathione to ethacrynic acid, a compound that is not recognized by ei

6 ne was inhibited in the presence of 1 microM ethacrynic acid (an inhibitor of glutathione S-transfera

7 nce was abolished when cells were exposed to ethacrynic acid (an inhibitor of GST-Pi), buthionine sul

8 lecules (up-regulation) are all inhibited by ethacrynic acid and certain aminomethyl phenols.

9 a caspase inhibitor, both were sensitive to ethacrynic acid and CP-424,174, two pharmacological agen

10 Ethacrynic acid and DIDS (4,4'-diisothiocyanato-stilbene

11 1/B2 exhibited GSH-conjugating activity with ethacrynic acid and GSH peroxidase activity with cumene

12 In the presence of bumetanide, ethacrynic acid and N-ethyl maleimide caused a dose-depe

13 ta unsaturated carbonyl containing compounds ethacrynic acid and parthenolide activated Nrf2 in norma

14 is provided by dinitrophenol, nitrobenzene, ethacrynic acid, and S-hexylglutathione, analogues of xe

15 isothiocyanatostilbene-2,2'-disulfonic acid, ethacrynic acid, and Zn(2+) revealed a pharmacological p

16 However, ethacrynic acid, at the same concentration that inhibits

17 inhibitors of anion transport, glyburide and ethacrynic acid, blocked maturation of both caspase-1 an

18 Furthermore, ethacrynic acid bound directly to the Nrf2-negative regu

19 Cellular contraction was observed with ethacrynic acid, colchicine, and vinblastine in the 10(-

20 d on an inverted microscope and treated with ethacrynic acid, colchicine, vinblastine, cytochalasin B

21 The crystal structure of the human GST pi-ethacrynic acid complex (2GSS) shows that the indole of

22 Ethacrynic acid (EA) is known to interact with aminoglyc

23 inal truncated (Delta209-222) rGST A1-1 with ethacrynic acid (EA) were measured in the presence of va

24 Treatment of astrocytes in culture with ethacrynic acid (EA), a mitochondrion-penetrating thiol

25 n with the substrate EA-SG, to yield GSH and ethacrynic acid (EA), nor the conjugation reaction betwe

26 either GSH or the conjugate between GSH and ethacrynic acid (EASG) causes this segment to become a s

27 ts, including cytochalasin D, latrunculin A, ethacrynic acid (ECA), a Rho kinase inhibitor (Y-27632),

28 The phenoxyacetic acid, ethacrynic acid (ECA), has potential use in glaucoma the

29 is provided by the electrophilic substrate (ethacrynic acid), electrophilic substrate analogue (dini

30 nst inactivation provided by S-(hydroxyethyl)ethacrynic acid indicates that MOI reacts in the active

31 Ethacrynic acid-induced GSH depletion and intracellular

32 Ethacrynic acid inhibits MAP2K6 in part through alkylati

33 Ethacrynic acid inhibits release of both forms of IL-1 w

34 :protein interactions and also revealed that ethacrynic acid is a novel ligand and inhibitor of MAP2K

35 inomethyl benzoic acid, AMAB) to connect two ethacrynic acid moieties was prepared and decoded via it

36 enyl, dexamethasone, buthionine sulfoximine, ethacrynic acid, or N-acetylcysteine pretreatments, was

37 binding and dissociation of the glutathione-ethacrynic acid product conjugate (GS-EA) to wild-type,

38 Dissociation rates of the glutathione-ethacrynic acid product conjugate (GS-EA), determined by

39 the nucleophilic addition reaction of GSH to ethacrynic acid, the H107S substitution has no effect on

40 he loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride

41 HT+ formation was decreased 97% by 15 microM ethacrynic acid with no effect on the spontaneous reacti

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