ライフサイエンスコーパス: ethylnitrosourea

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1 poptosis induced by the DNA-alkylating agent ethylnitrosourea.

2 ecessive mutations by treatment of mice with ethylnitrosourea and have identified 43 mutations that a

3 e demonstrate that chemical mutagenesis with ethylnitrosourea can be combined with the resources of m

4 The Sagg/+ mouse is an ethylnitrosourea-derived mutant with a dermal phenotype

5 ed with a single dose of the neurocarcinogen ethylnitrosourea (ENU) in utero.

6 in the GlyR alpha1 subunit gene found in the ethylnitrosourea (ENU) murine mutant, Nmf11, which cause

7 driven approaches using the chemical mutagen ethylnitrosourea (ENU) represent a potentially efficient

8 e adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of m

9 The mutation Oed-Sml, induced by ethylnitrosourea (ENU), has been mapped to the distal ch

10 We show that hearing loss in the ethylnitrosourea (ENU)-induced samba mouse line is cause

11 to causation of rapidly growing tumors by N-ethylnitrosourea (ENU).

12 rea (MNU), ethylmethane sulfonate (EMS), and ethylnitrosourea (ENU).

13 ere probed with dimethylsulfate (DMS) and N -ethylnitrosourea (EtNU) to identify guanines and phospha

14 liver increased insignificantly 5 days after ethylnitrosourea exposure, but increased 3.5-, 5.7- and

15 we show that progressive hearing loss in the ethylnitrosourea-generated mambo mouse line is caused by

16 or embryonic patterning mutations induced by ethylnitrosourea, here we identify two mouse mutants, wi

17 We isolated two ethylnitrosourea-induced alleles in the gene encoding th

18 The ethylnitrosourea-induced fl02k mutant showed heart failu

19 h, we identified DNA sequence changes in two ethylnitrosourea-induced mutants.

20 studies demonstrated that mice harboring an ethylnitrosourea-induced mutation in the gene encoding m

21 During a screen for ethylnitrosourea-induced mutations in mice affecting blo

22 Ethylnitrosourea-induced rat mammary tumor cell lines we

23 lopment of the digestive organs caused by an ethylnitrosourea-induced recessive lethal point mutation

24 partial hepatectomy and administered 100 mg ethylnitrosourea/kg 24 h later.

25 CBFbeta-SMMHC-transduced cells to a mutagen, ethylnitrosourea, markedly accelerated leukemogenesis co

26 eport that asteroid, a gene identified in an ethylnitrosourea mutagenesis screen of zebrafish larvae

27 To address this issue, we used ethylnitrosourea mutagenesis to identify a previously un

28 Ethylnitrosourea mutagenized mice were ultrasound-interr

29 eening for amino acidurias in the progeny of ethylnitrosourea-mutagenized mice.

30 Treatment with ethylnitrosourea resulted in concentration-dependent, ti

31 dopted the ECT test to screen the progeny of ethylnitrosourea treated male C57BL/6J mice.

32 proximately 9.6 Mb of DNA from G1 progeny of ethylnitrosourea-treated mice in a large, broad-spectrum

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