ライフサイエンスコーパス: eugenol

1 o fresh aroma (linalool, nerol, geraniol and eugenol).

2 ted phenylpropanoids in these glands such as eugenol.

3 it was much more efficient in O-methylating eugenol.

4 clove essential oil and its main component, eugenol.

5 ntained the DPPH-scavenging activity of free eugenol.

6 natural products in four steps or less from eugenol.

7 panoid compounds that include isoeugenol and eugenol.

8 ate, the flowers synthesize higher levels of eugenol.

9 t-anol over chavicol and for isoeugenol over eugenol.

10 , eugenol synthase 1 (ObEGS1), that produces eugenol.

11 emit mostly isoeugenol with small amounts of eugenol.

12 tity) and that converts coniferyl acetate to eugenol.

13 ated and sensitized by carvacrol, thymol and eugenol.

14 can use coniferyl acetate and NADPH to form eugenol.

15 methylation of the para-4'-hydroxyl of both eugenol and (iso)eugenol to methyleugenol and isomethyle

16 nol, while FaEGS2 catalyzes the formation of eugenol and also of isoeugenol with a lower catalytic ef

17 Both eugenol and beta-asarone inhibited Ca(2+) intake by PC-1

18 Both purified eugenol and beta-asarone protected PC-12 cells from the

19 Further, eugenol and beta-asarone were isolated and identified as

20 r could promote a higher impact of furfural, eugenol and both whisky lactones on the composition of h

21 cid, quercetin, sinapic acid, cinnamic acid, eugenol and cinnamaldehyde) in multilevel ratios.

22 l, were used to prepare liposomes at various eugenol and clove essential oil concentrations.

23 ne treatments, comprising the application of eugenol and guaiacol (individually or as a mixture) or w

24 synergistic effect was observed between the eugenol and guaiacol on the glycosidically bound aroma p

25 l peltate glands that are actively producing eugenol and is not active in glands of noneugenol-produc

26 The anethole analogues eugenol and isoeugenol also blocked TNF signaling.

27 The protein encoded by this cDNA can use eugenol and isoeugenol as substrates, but not caffeic ac

28 thesize the volatile phenylpropene compounds eugenol and isoeugenol to serve in defense against herbi

29 Clarkia breweri flowers emit a mixture of eugenol and isoeugenol, while Petunia hybrida flowers em

30 rate here that the volatile oil constituents eugenol and methylchavicol accumulate, respectively, in

31 Ca(2+) channel, Cch1p, was hypersensitive to eugenol and that this correlated with reduced Ca(2+) ele

32 Carvacrol, eugenol and thymol are major components of plants such a

33 hylguaiacol, 4-ethylguaiacol, 4-ethylphenol, eugenol and vanillin, using microwave-assisted deuterium

34 ials based on a readily available precursor (eugenol) and efficient chemistries [tris(pentafluorophen

35 il lines SW (which produces essentially only eugenol) and EMX-1 (which produces essentially only meth

36 Phenylpropenes such as chavicol, t-anol, eugenol, and isoeugenol are produced by plants as defens

37 ial oils - 100muM JA increased the linalool, eugenol, and limonene levels, while 1muM JA caused the h

38 trongest ligands, such as homovanillic acid, eugenol, and methyl vanillate all contain a hydroxy grou

39 C. bombi growth was inhibited by anabasine, eugenol, and thymol.

40 ances (guaiacol, 4-methylguaiacol, syringol, eugenol, and trans-isoeugenol) were investigated in smou

41 used this in vivo assay to re-identify known eugenol- and muscone-responsive mouse ORs.

42 uctural similarity (eucalyptol-benzaldehyde, eugenol-benzaldehyde, octanol-octanal, and [+/-]-limonen

43 rida, which contributes to the regulation of eugenol biosynthesis in petals.

44 s subsp. parodii emit neither isoeugenol nor eugenol but contain high levels of dihydroconiferyl acet

45 Some basil lines do not synthesize eugenol but instead synthesize chavicol, a phenylpropano

46 Eugenol but not its isomer, isoeugenol (2-methoxy-4-prop

47 We investigated the eugenol Ca(2+) signature in further detail and show that

48 l molecular weight phenylpropanoids, such as eugenol, caffeic acid, and rosmarinic acid, that result

49 discrimination, the antioxidant capacity of eugenol, carvacrol, thymol, alpha-pinene, limonene and l

50 cDNA array analysis showed that eugenol caused deregulation of the E2F family of transcr

51 mineral trioxide aggregate (MTA), zinc-oxide eugenol cement (ZOEC), hybrid ionomer composite resin (H

52 otoxic than the positive control (zinc oxide-eugenol cement).

53 efense compounds of the phenylpropene class (eugenol, chavicol, and their derivatives) have been reco

54 ely different structures, including carvone, eugenol, cinnamaldehyde, and acetophenone.

55 Except for eugenol, concentrations of extracted aromas appeared to

56 xpression pattern of FaEOBII correlated with eugenol content in both fruit receptacle and petals.

57 A subsequent decrease in eugenol content in ripe receptacles was also observed, c

58 These expression patterns correlate with the eugenol content, which is highest in the achene at the g

59 JA caused the highest increase in the methyl eugenol content.

60 f melanoma cells, these results suggest that eugenol could be developed as an E2F-targeted agent for

61 In this work, we synthesized new eugenol derivatives (ED) and then treated them with an N

62 ) of tyrosinase with ED and plasma activated eugenol derivatives (PAED) in a cell-free environment.

63 e (EC(50) = 400 microM) or the TRPV3 agonist eugenol (EC(50) = 2.3 mM).

64 by a pair of structurally related odorants, eugenol (EG) and methyl isoeugenol (MIEG).

65 l, possess an enzyme homologous to the basil eugenol-forming enzyme that also uses coniferyl acetate

66 ied, CbEGS2, also catalyzes the formation of eugenol from coniferyl acetate and is only 46% identical

67 and spherical shaped vesicles and protected eugenol from degradation induced by UV exposure; they al

68 guaiacol, nerolidol, pantolactone+furaneol, eugenol, gamma-dodecalactone and phenylacetic acid.

69 tive between 1 and 100 microM, and 10 microM eugenol gave approximately a 50% response.

70 of six aroma compounds (vanillin, furfural, eugenol, guaiacol and cis- and trans-whisky lactones) in

71 Eugenol has antifungal activity and is recognised as hav

72 erance should lead to better exploitation of eugenol in antifungal therapies.

73 which should lead to better exploitation of eugenol in antifungal therapies.

74 In parallel, the amount of eugenol in FaMYB10-silenced receptacles was also diminis

75 We recently showed that both isoeugenol and eugenol in P. hybrida are biosynthesized from coniferyl

76 mechanism of the antiproliferative action of eugenol in the human malignant melanoma cell line, WM120

77 and volatile phenylpropenes (isoeugenol and eugenol) in petunia (Petunia hybrida) flowers have the p

78 with biochemical analyses demonstrated that eugenol induced apoptosis.

79 and extracellular sources contribute to the eugenol-induced Ca(2+) elevation.

80 expressing apoaequorin was used to show that eugenol induces cytosolic Ca(2+) elevations.

81 ainly inhibited basal Ca(2+) intake, whereas eugenol inhibited Abeta-induced Ca(2+) intake preferenti

82 rophoretic mobility shift assays showed that eugenol inhibits the transcriptional activity of E2F1.

83 Eugenol is a volatile phenylpropanoid that contributes t

84 Eugenol is a volatile that serves as an attractant for p

85 rry (Fragaria x ananassa) fruit receptacles, eugenol is biosynthesized by eugenol synthase (FaEGS2).

86 nd deacetyl glycosides were synthesized from eugenol, isoeugenol and dihydroeugenol.

87 breweri plants emit all 4 phenylpropanoids (eugenol, isoeugenol, methyleugenol, and isomethyleugenol

88 These results suggest that eugenol may act by blocking Abeta-induced-Ca(2+) intake

89 deregulation of E2F1 may be a key factor in eugenol-mediated melanoma growth inhibition both in vitr

90 alcohols and phenols, four natural products (eugenol, menthol, cholesterol, and estrone) were labeled

91 ed, confirming the involvement of FaEOBII in eugenol metabolism.

92 anced with 1 of 2 periodontal dressings (non-eugenol [NE] or 2-octyl cyanoacrylate [2-octyl]).

93 nted to three different chemotypes: linalool/eugenol, neral/geranial, and estragol, for Genovese, Gre

94 MT from Clarkia breweri, indicating that the eugenol O-methylating enzymes in basil and C. breweri ev

95 Chavicol O-methyltransferase (CVOMT) and eugenol O-methyltransferase (EOMT) cDNAs were isolated f

96 he activity of S-adenosyl-L-methionine: (iso)eugenol O-methyltransferase (IEMT), a novel enzyme that

97 1-ol, (Z)-3-hexen-1-ol, and benzaldehyde and eugenol, obtained greater area response using EG-Silicon

98 and EOMT1 are related only distantly to (iso)eugenol OMT from Clarkia breweri, indicating that the eu

99 We identified additional ORs responsive to eugenol or muscone.

100 methyl vanillate, damascenone, 3-oxo-ionol, eugenol, p-cymen-8-ol, 2,3 pinanediol, coumaran and rasp

101 We used agents (eugenol, phenyl ethyl alcohol, or phenyl ethyl alcohol a

102 ing of PhCCoAOMT1 resulted in a reduction of eugenol production but not of isoeugenol.

103 d pathway gene expression that gives rise to eugenol production in ripe strawberry receptacles.

104 and FaEGS2, two structural genes involved in eugenol production, was down-regulated.

105 ate additional biochemical steps toward (iso)eugenol production, we cloned and characterized a caffeo

106 In addition to coumarin, estragole, methyl-eugenol, (R)-(+)-pulegone and thujone were EU-regulated

107 and catalyze the formation of isoeugenol and eugenol, respectively.

108 eterologous expression assays confirmed nine eugenol-responsive ORs (Olfr73, Olfr178, Olfr432, Olfr61

109 opyl-2-methoxyphenol, gamma-nonalactone, and eugenol showed the highest values and should be consider

110 The production of isoeugenol and eugenol starts when flowers open and peaks after anthesi

111 it receptacles, eugenol is biosynthesized by eugenol synthase (FaEGS2).

112 atalyzed by isoeugenol synthase (PhIGS1) and eugenol synthase (PhEGS1), respectively, via a quinone m

113 nol, and an Ocimum basilicum (basil) enzyme, eugenol synthase 1 (ObEGS1), that produces eugenol.

114 ) that encode proteins with high identity to eugenol synthases from several plant species.

115 volatile analyses confirm FaEGSs as genuine eugenol synthases in planta.

116 xt, the antimicrobial activity of carvacrol, eugenol, thymol and vanillin grafted onto the surface of

117 e to convert the phenylpropenes chavicol and eugenol to methylchavicol and methyleugenol, respectivel

118 he para-4'-hydroxyl of both eugenol and (iso)eugenol to methyleugenol and isomethyleugenol, respectiv

119 ungal activity and a better understanding of eugenol tolerance should lead to better exploitation of

120 the mechanisms employed by fungi to tolerate eugenol toxicity which should lead to better exploitatio

121 intracellular signal which protects against eugenol toxicity.

122 In a B16 xenograft study, eugenol treatment produced a significant tumor growth de

123 picy and vanilla descriptors were related to eugenol, vanillin and other odorous chemicals.

124 ne, trans-whisky lactone, gamma-nonalactone, eugenol, vanillin, and acetovanillone in a single run.

125 udomonas strains, the metabolic pathway from eugenol via ferulic acid to vanillin has been characteri

126 Eugenol was active between 1 and 100 microM, and 10 micr

127 Eugenol was well tolerated as determined by measurement

128 4-Allyl-2-methoxyphenol (eugenol) was tested for its ability to inhibit prolifera

129 d FaEGS1b catalyze the in vitro formation of eugenol, while FaEGS2 catalyzes the formation of eugenol

130 in epithelial cells respond to carvacrol and eugenol with an increase in intracellular Ca2+ levels.

131 able translucent nanoemulsions of thymol and eugenol with spherical droplets smaller than 100nm, cont