ライフサイエンスコーパス: eukaryotic genome

1 , mutation rates are not uniform across each eukaryotic genome.

2 limited to cover the complexity of the whole eukaryotic genome.

3 rucial role of RNA in the functioning of the eukaryotic genome.

4 nscription factors and RNA polymerase to the eukaryotic genome.

5 ue insight into the cis-regulatory code of a eukaryotic genome.

6 mes are the fundamental packing units of the eukaryotic genome.

7 noncanonical nucleotides introduced into the eukaryotic genome.

8 interface between the form and function of a eukaryotic genome.

9 ve never been accurately mapped throughout a eukaryotic genome.

10 tage for completion of a designer, synthetic eukaryotic genome.

11 Copia superfamily, which is present in every eukaryotic genome.

12 riation in initial UV damage levels across a eukaryotic genome.

13 ansposable elements (MITEs) are prevalent in eukaryotic genomes.

14 ibute to long-term gene content evolution in eukaryotic genomes.

15 el for the three-dimensional organization of eukaryotic genomes.

16 s (TEs), which make up between 20 and 80% of eukaryotic genomes.

17 Divergent gene pairs (DGPs) are abundant in eukaryotic genomes.

18 y elements and inferring their activities in eukaryotic genomes.

19 sms at the heart of epigenetic regulation of eukaryotic genomes.

20 tion, expression, repair, and segregation of eukaryotic genomes.

21 l III type 2-like promoters are conserved in eukaryotic genomes.

22 romatin occupy a substantial portion of many eukaryotic genomes.

23 gene innovations during the evolution of the eukaryotic genomes.

24 ion is essential for accurate duplication of eukaryotic genomes.

25 easingly powerful with the growing wealth of eukaryotic genomes.

26 ncy plays a key role in regulating access to eukaryotic genomes.

27 ant roles in the regulation and stability of eukaryotic genomes.

28 eshifts predicted in mRNA sequences from 100 eukaryotic genomes.

29 o the prevalence of these genes within other eukaryotic genomes.

30 the architecture and function of many higher eukaryotic genomes.

31 t are present in millions of copies in large eukaryotic genomes.

32 t affects nearly all DNA-templated events in eukaryotic genomes.

33 at the center of the faithful duplication of eukaryotic genomes.

34 anding on: nuclear receptors, stem cells and eukaryotic genomes.

35 significant fraction of proteins encoded in eukaryotic genomes.

36 een regulatory elements and their targets in eukaryotic genomes.

37 form of DNA modification in prokaryotic and eukaryotic genomes.

38 allmark of functional regulatory elements in eukaryotic genomes.

39 epeats (LTRs) form a substantial fraction of eukaryotic genomes.

40 regulators in the expression and function of eukaryotic genomes.

41 d repetitive DNA arrays are abundant in most eukaryotic genomes.

42 , like retroviruses, to copy and move inside eukaryotic genomes.

43 of genes seen in modern-day prokaryotic and eukaryotic genomes.

44 to uncover the transcriptional complexity of eukaryotic genomes.

45 telomeres, exhibit characteristics unique to eukaryotic genomes.

46 ed as an important force in the evolution of eukaryotic genomes.

47 multidomain DNA polymerase encoded in higher eukaryotic genomes.

48 e body methylation is an ancient property of eukaryotic genomes.

49 ons occur in extremely large numbers in many eukaryotic genomes.

50 regulators in the expression and function of eukaryotic genomes.

51 A sequences that make up a large fraction of eukaryotic genomes.

52 of HP1 proteins in organizing and protecting eukaryotic genomes.

53 chromatin defines the regulatory program of eukaryotic genomes.

54 f pseudogenic protein coding regions of most eukaryotic genomes.

55 cated in a number of regulatory functions in eukaryotic genomes.

56 binding affinities for both prokaryotic and eukaryotic genomes.

57 thod for targeted, efficient modification of eukaryotic genomes.

58 Gene families compose a large proportion of eukaryotic genomes.

59 ur ability to engineer targeted mutations in eukaryotic genomes.

60 llite DNA (satDNA) repeats are found in most eukaryotic genomes.

61 ute a large percentage of the DNA content of eukaryotic genomes.

62 rved property of the spatial organization of eukaryotic genomes.

63 elements (TEs) make up a large proportion of eukaryotic genomes.

64 i.e. DNA encoded, nucleosome organization of eukaryotic genomes.

65 at it is an important driver of diversity in eukaryotic genomes.

66 subtelomeric regions, are unstable sites of eukaryotic genomes.

67 eoprotein complex that protects and compacts eukaryotic genomes.

68 parum but should be applicable to many other eukaryotic genomes.

69 ed to identify regions of DNA methylation in eukaryotic genomes.

70 a tool for editing, imaging, and regulating eukaryotic genomes.

71 e need to control noncoding transcription in eukaryotic genomes.

72 high-resolution structural understanding of eukaryotic genomes.

73 among the most evolutionary dynamic loci of eukaryotic genomes.

74 to visualize and analyze AT-AS events in 46 eukaryotic genomes; (2) compare and identify the differe

75 Eukaryotic genomes accommodate numerous types of informa

76 Transcriptome studies are revealing that the eukaryotic genome actively transcribes a diverse reperto

77 Although P5 ATPases are present in every eukaryotic genome analyzed so far, they have remained or

78 ey exist in large numbers in every sequenced eukaryotic genome and may be responsible for many differ

79 genomic location on our understanding of the eukaryotic genome and parasite biology.

80 ransposable elements are major components of eukaryotic genomes and are grouped into superfamilies (e

81 lomeric sequences (ITSs) are present in many eukaryotic genomes and are linked to genome instabilitie

82 Transposons are massively abundant in all eukaryotic genomes and are suppressed by epigenetic sile

83 discuss how LINEs and SINEs have expanded in eukaryotic genomes and contribute to genome evolution.

84 ve transcription events occurring throughout eukaryotic genomes and coupling their RNA products to ef

85 ononucleotide repeats (MNRs) are abundant in eukaryotic genomes and exhibit a high degree of length v

86 We quantified DNA methylation in 17 eukaryotic genomes and found that gene body methylation

87 Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human

88 hromatin represents a significant portion of eukaryotic genomes and has essential structural and regu

89 common modification in prokaryotic and lower eukaryotic genomes and has many biological functions, th

90 elements (TEs) can be found in virtually all eukaryotic genomes and have the potential to produce evo

91 DNA methylation is a common feature of eukaryotic genomes and is especially common in noncoding

92 Cytosine methylation is widespread in most eukaryotic genomes and is known to play a substantial ro

93 Transposons are prominent features of most eukaryotic genomes and mobilization of these elements tr

94 from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genom

95 ile elements, make up large portions of most eukaryotic genomes and provide enormous, albeit commonly

96 ed primarily for detecting gene exons within eukaryotic genomes and were therefore optimized for spee

97 osome is the fundamental packing unit of the eukaryotic genome, and CpG methylation is an epigenetic

98 roach provides detailed structural maps of a eukaryotic genome, and our findings provide insights int

99 gramming implementation that scales to large eukaryotic genomes, and a faster indexed based implement

100 ats (STRs) are found in many prokaryotic and eukaryotic genomes, and are commonly used as genetic mar

101 eported to integrate into human or any other eukaryotic genomes, and could thus serve for exploration

102 RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogen

103 nhances the diversity of proteins encoded by eukaryotic genomes, and is also important in gene expres

104 Repeated regions are widespread in eukaryotic genomes, and key functional elements such as

105 for assembling high-quality plant and other eukaryotic genomes, and serves as a valuable resource fo

106 ent the single largest component of numerous eukaryotic genomes, and their activity and dispersal con

107 repetitive DNA make up a sizable fraction of Eukaryotic genomes, and their annotation is crucial to t

108 Recent changes to NCBI's eukaryotic genome annotation pipeline provide higher thr

109 ve feature annotation and current policy for eukaryotic genome annotation via the NCBI annotation pip

110 Kinannote has had a significant impact on eukaryotic genome annotation, providing protein kinase a

111 cha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic va

112 Despite this, few complete eukaryotic genomes are available, and genome annotation

113 As an increasing number of eukaryotic genomes are being sequenced, comparative stud

114 Higher eukaryotic genomes are bound by a large number of coding

115 Eukaryotic genomes are broadly divided between gene-rich

116 Eukaryotic genomes are dynamically regulated through a h

117 Eukaryotic genomes are extensively transcribed, forming

118 Eukaryotic genomes are folded into three-dimensional str

119 r, source code, and pre-computed ages for 32 eukaryotic genomes are freely available under the GNU pu

120 Pairs of genes within eukaryotic genomes are often located on opposite DNA str

121 Eukaryotic genomes are organized into chromatin domains

122 Eukaryotic genomes are organized into domains of differi

123 Eukaryotic genomes are organized into higher order chrom

124 based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units c

125 Eukaryotic genomes are packaged in two basic forms, euch

126 Eukaryotic genomes are packaged into a nucleoprotein com

127 Eukaryotic genomes are packaged into an extensively fold

128 All eukaryotic genomes are packaged into basic units of DNA

129 Centric regions of eukaryotic genomes are packaged into heterochromatin, wh

130 Eukaryotic genomes are pervasively transcribed and only

131 Eukaryotic genomes are pervasively transcribed but until

132 Given that eukaryotic genomes are pervasively transcribed, transcri

133 Eukaryotic genomes are regulated by the diverse biochemi

134 Eukaryotic genomes are repetitively wrapped into nucleos

135 Eukaryotic genomes are replicated from many origin sites

136 Eukaryotic genomes are replicated from multiple DNA repl

137 Eukaryotic genomes are replicated in a reproducible temp

138 Eukaryotic genomes are rich in transcription units encod

139 Eukaryotic genomes are spatially organized within the nu

140 Eukaryotic genomes are transcribed into numerous regulat

141 The majority of eukaryotic genomes are unfinished due to the algorithmic

142 target H1 regulation to specific regions of eukaryotic genomes are unknown.

143 n in biological systems and the evolution of eukaryotic genomes as this was the day that Nature publi

144 le research tool, but obtaining high quality eukaryotic genome assemblies remains a challenge, mostly

145 Although annotating a eukaryotic genome assembly is now within the reach of no

146 Hundreds of different factors adorn the eukaryotic genome, binding to it in large number.

147 shes S. cerevisiae as the basis for designer eukaryotic genome biology.

148 (lncRNAs) are pervasively transcribed across eukaryotic genomes, but functions of only a very small s

149 thylation is ancient and highly conserved in eukaryotic genomes, but its role has not been clearly de

150 These domains are overrepresented in eukaryotic genomes, but predictive methods have not yet

151 replication initiates at distinct origins in eukaryotic genomes, but the genomic features that define

152 Transposons are highly abundant in eukaryotic genomes, but their mobilization must be finel

153 dynamically alter the chromatin packaging of eukaryotic genomes by assembling, sliding, and displacin

154 te genome-wide detection of MITEs in various eukaryotic genomes can improve our understanding of thei

155 The eukaryotic genome consists of DNA molecules far longer t

156 Eukaryotic genomes contain either one or two genes encod

157 Consequently, highly reduced eukaryotic genomes contain more genes of archaebacterial

158 Eukaryotic genomes contain multiple tubulin isotypes, an

159 Eukaryotic genomes contain numerous non-functional high-

160 Most eukaryotic genomes contain substantial amounts of repeti

161 suggests that transposases function in large eukaryotic genomes containing thousands of active transp

162 epetitive elements in human and other higher eukaryotic genomes contribute in large part to ambiguous

163 providing new insight into this key stage of eukaryotic genome copying.

164 iew major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding a

165 Analysis of prokaryotic and eukaryotic genome databases established that multiple in

166 The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for trans

167 rrect expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring-shaped protei

168 udio, an open-source framework developed for eukaryotic genome design, which coordinates design modif

169 For eukaryotic genomes, DNA synthesis initiates at multiple

170 se unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends o

171 Initiation of eukaryotic genome duplication begins when a six-subunit

172 Eukaryotic genome duplication relies on origins of repli

173 delta, and Pol epsilon), are responsible for eukaryotic genome duplication.

174 e bacterium (LbCpf1) have been harnessed for eukaryotic genome editing.

175 Many eukaryotic genomes encode cis-natural antisense transcri

176 S or SelD), conserved in all prokaryotic and eukaryotic genomes encoding selenoproteins.

177 icate that a third of translated proteins in eukaryotic genomes enter the secretory pathway.

178 biotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via or

179 They are ubiquitous constituents of most eukaryotic genomes, especially those of higher plants.

180 Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues

181 on (WGD) and diploidization are hallmarks of eukaryotic genome evolution and speciation.

182 erive a number of inferences with respect to eukaryotic genome evolution.

183 eus is a recurrent and consistent feature of eukaryotic genome evolution.

184 y thought, with interesting implications for eukaryotic genome evolution.

185 of genetic variation in populations and how eukaryotic genomes evolve.

186 Eukaryotic genomes exist as an elaborate three-dimension

187 In contrast, several eukaryotic genomes express moderately methylated genes.

188 Eukaryotic genomes generate a heterogeneous ensemble of

189 Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-codi

190 Pervasive transcription of eukaryotic genomes generates a plethora of noncoding RNA

191 Transcription in eukaryotic genomes generates an extensive array of non-p

192 In the eukaryotic genome, genes with similar functions tend to

193 Eukaryotic genomes harbor transposable elements and othe

194 expression, but their identification in the eukaryotic genome has been challenging.

195 The eukaryotic genome has vast intergenic regions containing

196 nd that the largest single component of many eukaryotic genomes has been generated by reverse transcr

197 The order of genes in eukaryotic genomes has generally been assumed to be neut

198 Our results suggest that eukaryotic genomes have developed tools to prevent R-loo

199 nces in the targeted modification of complex eukaryotic genomes have unlocked a new era of genome eng

200 weaknesses of short reads in the assembly of eukaryotic genomes; however, at present additional scaff

201 Consequently, the complexity of higher eukaryotic genomes imposes severe limitations on transcr

202 Plant genomes, and eukaryotic genomes in general, are typically repetitive,

203 on (WGD) is central to the evolution of many eukaryotic genomes, in particular rendering angiosperm (

204 ing DNA sequences are present throughout the eukaryotic genome, including in telomeric DNA.

205 We present methods for the analysis of small eukaryotic genomes, including a streamlined system (call

206 ansposable elements (MITEs) are prevalent in eukaryotic genomes, including plants and animals.

207 Complete sequences of myriad eukaryotic genomes, including several human genomes, are

208 y activated transcription is associated with eukaryotic genome instability, resulting in increased ra

209 ng GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity.

210 The packaging of the eukaryotic genome into chromatin represses gene expressi

211 l DNA sequence are believed to demarcate the eukaryotic genome into distinct structural and functiona

212 The organization of the eukaryotic genome into nucleosomes dramatically affects

213 Packaging of eukaryotic genomes into chromatin affects every process

214 in controlling transcription and organizing eukaryotic genomes into functional domains.

215 The packaging of eukaryotic genomes into nuclesomes plays critical roles

216 The duplication of eukaryotic genomes involves the replication of DNA from

217 The eukaryotic genome is a complex three-dimensional entity

218 The eukaryotic genome is highly compacted into a protein-DNA

219 The eukaryotic genome is highly organized in the nucleus, an

220 The eukaryotic genome is organized in the three-dimensional

221 The eukaryotic genome is organized into nucleosomes, the fun

222 The eukaryotic genome is organized within cells as chromatin

223 The eukaryotic genome is packaged into a highly ordered chro

224 The eukaryotic genome is primarily replicated by two DNA pol

225 The majority of the eukaryotic genome is transcribed, generating a significa

226 Most of the eukaryotic genome is transcribed, yielding a complex net

227 Transcription of the eukaryotic genomes is carried out by three distinct RNA

228 Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation

229 routine sequencing of large numbers of whole eukaryotic genomes is feasible, and so it is often neces

230 Replication of eukaryotic genomes is limited to once per cell cycle, by

231 The spatial organization of eukaryotic genomes is linked to their functions.

232 During evolution, gene repatterning across eukaryotic genomes is not uniform.

233 Gene finding in eukaryotic genomes is notoriously difficult to automate.

234 Assembling complete bacterial and small eukaryotic genomes is now possible, but the final step o

235 hich nucleosome repositioning is used within eukaryotic genomes is poorly understood.

236 and resolution of toxic SCI entanglements on eukaryotic genomes is proposed.

237 The spatial organization of eukaryotic genomes is thought to play an important role

238 A large proportion of eukaryotic genomes is transcribed from both positive and

239 tructural and positional organization across eukaryotic genomes is unknown.

240 tern has been observed in nucleosomes across eukaryotic genomes, its use for prediction of nucleosome

241 g it one of the smallest and most gene dense eukaryotic genomes known.

242 or influence on shaping both prokaryotic and eukaryotic genomes, largely through stochastic events fo

243 oles in nearly every aspect of bacterial and eukaryotic genome maintenance.

244 -protein coding RNAs are produced throughout eukaryotic genomes, many of which are transcribed antise

245 However, Ths is not encoded in any eukaryotic genomes, nor is it homologous to eukaryotic s

246 Every DNA segment in a eukaryotic genome normally replicates once and only once

247 In eukaryotic genomes, nucleosomes function to compact DNA

248 Epigenetic modifications in eukaryotic genomes occur primarily in the form of 5-meth

249 Eukaryotic genomes often contain large quantities of pot

250 s capable of analyzing annotations for large eukaryotic genomes on typical desktop or laptop hardware

251 ence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been ex

252 Eukaryotic genomes, particularly animal genomes, have a

253 Several recent eukaryotic genome projects have reported multiple gene s

254 Recent genome-wide experiments in different eukaryotic genomes provide an unprecedented view of tran

255 st long non-coding RNAs (lncRNAs) encoded by eukaryotic genomes remain uncharacterized.

256 of conserved replication timing patterns in eukaryotic genomes remains a mystery.

257 With eukaryotic genome replication, incomplete telomere synth

258 )-10(8) incorporations) and support faithful eukaryotic genome replication.

259 The expression, replication and repair of eukaryotic genomes require the fundamental organizing un

260 The integrity of eukaryotic genomes requires rapid and regulated chromati

261 ymes encoded in a variety of prokaryotic and eukaryotic genomes reveals convergence and divergence at

262 We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyce

263 We compared 86 divergent eukaryotic genome sequences to discern sets of proteins

264 Eukaryotic genome sequences, however, increasingly impli

265 sons discovered by bioinformatic analysis of eukaryotic genome sequences.

266 tifying LTRs and non-LTR retrotransposons in eukaryotic genome sequences.

267 ovo assembler capable of assembling multiple eukaryotic genomes simultaneously.

268 a class of MGEs that have been found in most eukaryotic genomes, sometimes in extremely high numbers.

269 esumed to be among the major determinants of eukaryotic genome structure.

270 imilar genes may colocalize (cluster) in the eukaryotic genome, suggesting the role of chromatin-leve

271 signals in approximately 10% of genes in all eukaryotic genomes surveyed suggests that -1 RF is a bro

272 dynamic and highly regulated feature of the eukaryotic genome that allows for the essential spatiote

273 l identity are particularly dynamic parts of eukaryotic genomes that are prone to molecular degenerat

274 heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear a

275 RISPR-Cas9 system is a powerful tool to edit eukaryotic genomes that has recently been adapted for fu

276 We assembled a collection of 172 complete eukaryotic genomes that is not only the largest, but als

277 urrently the only gene finding algorithm for eukaryotic genomes that performs automatic training in u

278 In the eukaryotic genome, the thousands of genes that encode me

279 cations comprise a significant proportion of eukaryotic genomes, these findings provide important new

280 Identified throughout eukaryotic genomes, they are thought to serve as regulat

281 In eukaryotic genomes this ubiquitous and highly conserved

282 es, using the largest set of prokaryotic and eukaryotic genomes to date.

283 We have applied it to both prokaryotic and eukaryotic genomes to illustrate its usability.

284 action might be among natural forces driving eukaryotic genomes to maintain the Zn(2+)-tolerant repet

285 lth of sequence data from recently sequenced eukaryotic genomes to uncover robust G-protein signaling

286 In many eukaryotic genomes, transposable elements (TEs) are wide

287 The promoter regions of active genes in the eukaryotic genome typically contain nucleosomes post-tra

288 l is most accessible for bacterial and small eukaryotic genomes (up to 300 Mb), such as pathogenic ba

289 sequence availability of about 100 complete eukaryotic genomes, up to now NumtS distribution has bee

290 a resulting from recently sequenced complete eukaryotic genomes, we conducted database searching by h

291 By applying these tools to diverse eukaryotic genomes, we provide a ranked list of newly pr

292 vel method for high-throughput sequencing of eukaryotic genomes, we sequenced and assembled 580 Mbp o

293 ansposable elements comprise the majority of eukaryotic genomes where they are major contributors to

294 cterial repertoire has a similar size in all eukaryotic genomes whereas the number of eubacterium-der

295 titive sequences are ubiquitously present in eukaryotic genomes which are in general epigenetically s

296 es, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-s

297 We further observe a similar relationship in eukaryotic genomes with a slower increase in TFs.

298 s, exist pervasively in both prokaryotic and eukaryotic genomes, with more than 10,000 copies identif

299 tegrated annotation on chordate and selected eukaryotic genomes within a consistent and accessible in

300 As part of the effort to build a designer eukaryotic genome, yeast synthetic chromosome X (synX),