ライフサイエンスコーパス: euploid

1 other regenerative adult tissues are largely euploid.

2 full-blown clonal adenomas remain remarkably euploid.

3 The cells also remain euploid after at least 12 passages.

4 ngs suggest that the fitness ranking between euploid and aneuploid cells is dependent on context and

5 uman pre-implantation embryos are mosaics of euploid and aneuploid cells.

6 ly, an unblinded clinical evaluation of 1269 euploid and aneuploid samples utilizing this high-throug

7 The combined results of the euploid and aneuploid studies suggest that aneuploid eff

8 s produced by maize rad51 double mutants are euploid and exhibit near-normal rates of meiotic crossov

9 omy 7 or 13 (DLD1+7 and DLD1+13), as well as euploid and trisomy 13 amniocytes (AF and AF+13).

10 a similar extent, in cortical cultures from euploid and trisomy 16 mice.

11 tly reduced incidence compared with control (euploid) animals that did not have trisomy.

12 ibute to divergence between the trisomic and euploid brains.

13 The majority of meiotic progeny are euploid, but approximately one-third are diploid/aneuplo

14 In euploid, but not trisomic cortical cultures, kainic acid

15 rwent apoptosis at rates similar to those of euploid cells in vitro.

16 potential, provided they contain sufficient euploid cells, a finding of significance for the assessm

17 essential for proper proteasome function in euploid cells, and deletion of this deubiquitinase leads

18 n chimeric embryos, containing aneuploid and euploid cells, reveal that the fate of aneuploid cells d

19 adulthood in trisomic mice are equivalent to euploid cells, we used microarrays to assess the trisomi

20 xenografts, relative to genetically matched euploid cells.

21 forming mosaics of intermixed aneuploid and euploid cells.

22 s to test genotype-phenotype correlations in euploid cells.

23 s that cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer therap

24 used microarrays to assess the trisomic and euploid cerebella.

25 the probability of successful delivery of a euploid chromosome set to each daughter cell.

26 ulti-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal developme

27 alin-preserved fetuses (eight trisomy 21, 10 euploid control fetuses), and the pelvic bone anatomy wa

28 d progenitor cell compartments compared with euploid control littermates.

29 n, and contrast threshold, compared with the euploid control mice.

30 inal physiology in Ts65Dn mice compared with euploid control mice.

31 ploid strains grew significantly better than euploid control strains under conditions suboptimal for

32 ally aneuploid isolates compared to isogenic euploid controls and found that 10-30% of amplified gene

33 id progeny of aneuploid parent(s) but not in euploid controls from diploid lineages.

34 fetuses with trisomy 21, age and sex-matched euploid controls, and embryonic day 15.5 forebrains from

35 e model) overexpress APP protein relative to euploid controls.

36 in thymus samples from 19 DS subjects and 21 euploid controls.

37 and decreased NFAT activation compared with euploid controls.

38 erations that were largely absent from their euploid counterparts and that correlated with improved f

39 chromosome mis-segregation compared to their euploid counterparts.

40 variation and improved fitness over that of euploid counterparts.

41 ntent was higher in trisomy 16 compared with euploid cultures.

42 nce in the Morris water maze is identical to euploid, demonstrating that this region is necessary for

43 of DNA synthesis and mitosis that maintains euploid DNA content during proliferation.

44 ction of Stat3 gene copy number in targeted, euploid E14 clones resulted in dose-dependent losses of

45 f the first mitotic phase when compared with euploid embryos (n=28).

46 ll cycle parameter timing is observed in all euploid embryos to the four-cell stage, whereas only 30%

47 on most X-chromosome markers, compared with euploid female reference DNA.

48 ave a significantly greater iliac angle than euploid fetuses have.

49 ween second trimester Down syndrome (DS) and euploid fetuses, we used Affymetrix microarrays to compa

50 mplexes are regulated to ensure formation of euploid gametes.

51 g microtubule dynamics and for maintaining a euploid genome.

52 Here we report that euploid human cells do not die in the absence of survivi

53 ith DS and periodontal disease (group 1), 20 euploid individuals with periodontal disease (group 2; p

54 patients was significantly lower compared to euploid individuals with periodontal disease, whereas IL

55 disease (group 2; positive control), and 12 euploid individuals without periodontal disease (group 3

56 s small and hypocellular compared to that of euploid individuals.

57 lso applies to other chromosomes, generating euploid iPSCs from cells of a Down syndrome mouse model.

58 It can also create euploid iPSCs from human trisomic patient fibroblasts.

59 s) promoting efficient chromosome sorting in euploids is adjusted to promote crossover formation betw

60 ell lines derived from ST zygotes had normal euploid karyotypes and contained exclusively donor mtDNA

61 measured in 52 middle-trimester fetuses with euploid karyotypes and in 52 fetuses with Down syndrome.

62 separately from Ts16 mouse fetuses and their euploid littermates, were cultured in various combinatio

63 ertheless extended host survival relative to euploid littermates.

64 ewer granule cells in dentate gyrus than did euploid littermates.

65 cortex from fetal trisomy 16 mice and their euploid littermates.

66 c VHL functions with missense mutations in a euploid model offers a novel opportunity to elucidate th

67 ogenous truncated trkB expression in normal, euploid neurons reproduced the Ts16 BDNF signaling failu

68 APP fragments from highly compartmentalized, euploid neurons that express APP and processing enzymes

69 , as well as numerous subchromosomal CNVs in euploid neurons.

70 Similarly, compared to euploid, P6 trisomic mice showed an 18% reduction in mit

71 of meiosis in near isogenic allohaploid and euploid plants showed that the mechanism(s) promoting ef

72 m the estimated gestational age (EGA) in the euploid population with the quadratic equation FTD = -0.

73 esize that a threshold exists in both DS and euploid populations for the number of genetic perturbati

74 ation was found to be longer in Ts16 than in euploid progenitors, the Ts16 growth fraction was reduce

75 enitors exit the cell cycle than do control, euploid progenitors.

76 Consequently, the term 'euploid' refers to a chromosome complement that is an ex

77 nase C (AURKC) is essential for formation of euploid sperm in humans because mutations in AURKC are c

78 Moreover, the reliance on viable (euploid) spores has the potential to introduce selection

79 There are various natural euploid states with some organisms existing as haploids

80 hibited a general fitness defect relative to euploid strains when grown under replete conditions.

81 Trisomic and euploid transcriptomes were robustly distinguished.

82 Euploid types that have more than two sets of chromosome

83 tetraploids and function as bridges between euploid types.

84 at hepatocytes in the stage of promotion are euploid, whereas those in the stage of progression exhib

85 Resulting euploid XY iPSCs can be differentiated into the male ger