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1 ric oxygen on the Earth (the Great Oxidation Event).
2 ind the reasons for this unusual replacement event.
3 cated chromosome ends as a single elongation event.
4 ting the downstream sequelae of this primary event.
5 the folding occurs after the initial binding event.
6 ents had a serious treatment-related adverse event.
7 ssion in mouse NK cells is a late activation event.
8 h associated adverse cardiovascular and limb events.
9 ic retinopathy, with no unanticipated safety events.
10 iation and termination are inherently random events.
11 viding evidence of interspecies transmission events.
12 te time cutoff for reporting of reintubation events.
13 ervention was high and there were no adverse events.
14 be recovered by prevention of cardiovascular events.
15 e how rainfall in the region responds to D-O events.
16 risk of complicated appendicitis and adverse events.
17 tcomes included major adverse cardiovascular events.
18 effects on loge(CAC+1) and incident coronary events.
19 le shapes, through stereotyped morphogenetic events.
20 is not a simple continuation of gastrulation events.
21 ant to understand underlying early molecular events.
22          The main safety measure was adverse events.
23  the Common Terminology Criteria for Adverse Events.
24  practices can prevent ventilator-associated events.
25  flow, antibiotic use, or nonserious adverse events.
26 ath, sudden death, and other cardiac adverse events.
27 se events or discontinuations due to adverse events.
28 e even a feature of Phanerozoic ocean anoxic events.
29  the risk for mortality, stroke, and cardiac events.
30 ase the prevalence of cardiovascular disease events.
31  84.8% of sediment loss across all high wind events.
32 atelet therapy, and long-term cardiovascular events.
33 vity that influences several mRNA processing events.
34 ugh discrete, single-electron transfer (SET) events.
35 ore conducive for intrafacility transmission events.
36 n complex that mediates downstream signaling events.
37 respectively, in a chain of self-reinforcing events.
38 aneous and inhibits Ca(2+)-triggered release events.
39  among participants who experienced an ASCVD event (0.390; 95% CI, 0.312-0.467 vs 0.08; 95% CI -0.001
40 orted low rates of death and serious adverse events (0% to 1.25%) in nontransported patients after su
41 %), anastomotic leakage (15.9%), and cardiac events (13.5%).
42  outcomes were treatment failure and adverse events 14 days after diagnosis.
43 vors were hospitalized for a cerebrovascular event-40% higher than expected (SHR=1.4, 95% confidence
44                  Ninety percent survived the event, 68% with return of spontaneous circulation and 22
45 f 3096 acute cerebral or peripheral vascular events, 748 (24.2%) were AF-related.
46  In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft function
47 r-voxilaprevir therapy because of an adverse event (AE).
48             Safety measures included adverse events (AEs), clinical laboratory tests, vital signs, el
49 or vitreous detachment being a common ocular event affecting most individuals in an aging population,
50 c experienced an extremely anomalous warming event after an extraordinary increase in air temperature
51 reatment failure was a relatively infrequent event after I-125 brachytherapy in our series.
52 factors in primary cells or during the early events after SIV infection and suggest that the level of
53  accurate reclassification of risk for ASCVD events among these individuals.
54 primary outcome was the incidence of adverse events among vaccine and placebo recipients throughout t
55   Receptor signaling relays on intracellular events amplified by secondary and tertiary messenger mol
56                     The Kaplan-Meier time-to-event analyses showed that OCT detected progression earl
57                                    A time-to-event analysis was performed to examine the occurrence o
58 ,7-cyclooctatetraenyl via a single-collision event and opens up a versatile, unconventional path to a
59 erstanding and prediction of El Nino/La Nina events and also may be applied in the investigation of o
60 in early childhood exposure to unpredictable events and environments.
61 pulation dynamics after multiple disturbance events and for management of river flows and fire regime
62 deficiency syndrome (AIDS)-related (NLR-NAR) events and mortality in a cohort of human immunodeficien
63 c imaging, is associated with cardiovascular events and predisposes to the development of clinically
64  region scanned, type, dose, related adverse events and route of administration of sedatives as well
65 gic asthma that acts upstream of proallergic events and suggest that targeting this molecule could be
66      The homogeneity of these severe weather events and their association with the ocean temperatures
67            Aging is a biologically universal event, and yet the key events that drive aging are still
68 s or TIAs, 42 myocardial infarctions, 156 HF events, and 38 cardiovascular deaths occurred.
69 s unclear why such independent amplification events, and associated receptor overexpression, would be
70 ve of others, when imagining future and past events, and during mind wandering.
71 rature of seawater with more extreme thermal events, and frequent rainfalls in some coastal regions.
72 tereotypical sequential pattern during ictal events, and that these stereotypical patterns were repro
73                    Treatment-related adverse events (any grade) prompted treatment discontinuation in
74                             Two of the three events are contemporaneous with large-magnitude paleoear
75                                 Colonization events are crucibles for rapid evolution, but it is not
76 xact timing of and relationships among these events are debated because of poor age constraints and c
77          Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impa
78 Prevention strategies for medication-related events are reviewed by medication use process node (pres
79    Time-lapse imaging reveals that branching events are synchronized across distant locations within
80                                      Even if events are under recorded, this measure could provide an
81 ATATE uptake in patients with recent carotid events, assessed inter- and intraobserver variability of
82 ents died from non-treatment-related adverse events associated with death, and one patient died from
83 ines of the binding pocket of HCAII, binding events associated with enthalpically favorable rearrange
84 h FLNC reads, including a large number of AS events associated with rhizome systems.
85                         However, the adverse events associated with smoking limit its clinical signif
86 ferences in risk of systemic serious adverse events between these two anti-VEGF drugs; i.e., relative
87 uce the risk of major adverse cardiovascular events, but did reduce the incidence of diabetes.
88 do not necessarily represent inter-dependent events, but MafB is broadly involved in both the process
89  26 (39%) of 44 patients had grade 3 adverse events, but no grade 4 events were reported.
90 of patients with at least 1 skeletal-related event by disease type, pain as assessed by the Brief Pai
91 % (P=0.033) and major adverse cardiovascular events by 25% (P=0.037) during the initial trial phase a
92 TRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implement
93 scores the potential predictability of these events by two-to-three weeks, which offers hope in mitig
94         Our findings indicate that congruent events can trigger an accelerated onset of neural encodi
95 ry objectives included evaluation of adverse events, changes in sexual quality of life using the Canc
96 e larger fluctuations in archaeal cell cycle events contribute to cell size variability and control.
97  a product of both alpha- and gamma-cleavage events, could also induce TrkB phosphorylation.
98 een shown to be predictive of cardiovascular events (CVEs) in patients who are at high cardiovascular
99 nts experienced intrahospital cardiovascular events (CVEs) including 281 (23.8%) with heart failure,
100  disease were followed until their first CHF event, death, last follow-up date, or December 31, 2011.
101          The overall rate of serious adverse events did not differ between treatment groups, although
102 ed to TASC, the proportion of cardiovascular events did not markedly decrease over the last two decad
103 tified 26 ancient and more recent polyploidy events distributed throughout Caryophyllales.
104 ied into point stresses, where a temperature event during a sensitive stage drives a reduction in yie
105 is used to detect ligand binding as blocking events during DNA unzipping, allowing determination of l
106  a 50-min movie, then verbally described the events during functional MRI, producing unguided detaile
107                                      Adverse events (eg, lethargy, diarrhoea, rash, and nausea) impro
108                        There were no adverse events either immediately or at 2-week follow-up.
109 rarchal severity to derive a total score for events encountered during the entire follow-up experienc
110 multaneously, enabling the reconstruction of events exhibiting remarkable complexity.
111              Nine patients died from adverse events; five of these deaths were judged to be related t
112                                         This event followed the suspected introduction of ZIKV in Bra
113           Finally, to dissect early and late events following interspecific hybridization, we examine
114 face in contact with a cavity, a fundamental event for all subsequent development.
115 ctivation of the STAT3 pathway, an essential event for uncontrolled cellular proliferation and transf
116 osis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina u
117  viruses must antagonize antiviral signaling events for survival.
118 (89% +/- 3% vs 90% +/- 4%; Plog-rank = .64), event-free survival (EFS; 87% +/- 3% vs 89% +/- 4%; Plog
119 emission with incomplete recovery), inferior event-free survival as well as overall survival in both
120 BG led to lower rates of 5-year survival and event-free survival than on-pump CABG.
121  report a record of 54 detected annihilation events from a single release of the trapped anti-atoms a
122  followed-up for medically certified cardiac events from January 1994 to December 2014.
123 disease and subsequent injury after ischemic events, fundamental knowledge in these areas lag behind
124 4sU-RNA-seq to identify aberrant DNA-binding events genome wide and ectopic transcriptional consequen
125 p in atmospheric oxygen, the Great Oxidation Event (GOE), began in the early Paleoproterozoic in asso
126 es, 55-76 yr; apnea-hypopnea index, 0.2-96.6 events/h) were evaluated by magnetic resonance imaging.
127         12 patients reported serious adverse events; haemolysis and pyrexia were the most common (eac
128  Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders.
129 known and it is likely that N-Src signalling events have been misattributed to C-Src because they can
130              Our results suggest that chance events have played important and possibly opposing roles
131 sk of death, hospitalization, thromboembolic events, heart failure (HF), and AF progression.
132 96 to 8.78) for major adverse cardiovascular events, hospitalizations, and vascular access thrombosis
133 ations) a lower risk of major cardiovascular events; however, they also had lower ischemic risk.
134  mainly relies on the declaration of adverse events, identification of their predictors, self-assessm
135 y breast tumors, confirming many of the exon events identified in the TCGA cohort.
136 cells within the vascular wall is a critical event in chronic inflammatory processes, such as atheros
137 chanical ventilation is viewed as an adverse event in ICUs.
138 4 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 +/-
139           The first cellular differentiation event in mouse development leads to the formation of the
140              The most common serious adverse event in the active surveillance group was myocardial in
141 rmation to aggressive lymphoma is a critical event in the clinical course of follicular lymphoma (FL)
142 s taken during two rainfall and one snowmelt event in two watersheds with contrasting levels of urban
143                                   Stochastic events in a single ion channel system can be measured us
144 g-term aspirin use, the changes of molecular events in AM but not IM may be an important factor in th
145 ntly at centromeres during G1, mediate early events in centromere establishment at an ectopic chromos
146 independently associated with cardiovascular events in coronary artery disease (CAD) patients and red
147  complexes and transcription-repair coupling events in genes throughout the genome.
148                                     Dramatic events in human prehistory, such as the spread of agricu
149 t BRAF-inactivating mutations are initiating events in lung oncogenesis.
150 s is more efficacious than targeting private events in reducing the tumor burden.
151                          We recorded adverse events in ten (34%) of 29 patients given twice-weekly re
152  the formation and storage of memories about events in the environment that predict the availability
153  macrophages, predicts future cardiovascular events in the general population.
154 ng, for the increased risk of neurocognitive events in the ongoing outcome studies and post-marketing
155 nding the mechanisms by which immune-related events in the periphery can influence brain processes is
156 d multiple sub-populations and recombination events in these diverse mixtures.
157                                    Acute CHD events included myocardial infarctions (MIs; nonfatal an
158 s (range, 3.2-10.1 years), 1203 incident CVD events, including 916 coronary heart disease cases, were
159 in an increased number of abortive infection events, including bursting of ITs and a reduction in the
160 nising, responding to and disclosing adverse events, including errors and near misses.
161 integration of semantic information with the event input.
162 otein levels, and the risk of cardiovascular events involving 102837 participants from 14 cohort or c
163                              Local endocytic events involving receptors for axon guidance cues play a
164 tion, two further interspecies recombination events involving the S gene were identified, suggesting
165                                         This event is then followed by the dynamic formation of filam
166               We show that targeting truncal events is more efficacious than targeting private events
167 sk of all-cause mortality and cardiovascular events is no higher than in healthy nondonors.
168 eclining monsoon, the number of extreme rain events is on the rise over central India.
169           Whether it prevents cardiovascular events is uncertain.
170 ifficult because the initiation of endocytic events is unpredictable.
171 onnections between the apoptotic cascade and events leading to extrusion are not fully understood.
172                                        These events likely underpin the improvement in oocyte quality
173 verexpressed in the absence of known genetic events linked to cetuximab resistance.
174 ed the occurrence of a major adverse cardiac event (MACE) assessed as the composite of cardiac death,
175 1 and T2MI, and major adverse cardiovascular events (MACE, a composite of all-cause death, nonfatal m
176 NHE inhibitors on the risk of cardiovascular events may be enhanced when heart failure and glucose in
177                                    How these events may influence one another is only partly known.
178                         Frequency of adverse events, mostly mild self-limited joint and back pain, di
179  patient died from treatment-related adverse events (myositis in addition to grade 3 thyroiditis, gra
180 Two (1%) of 166 patients had serious adverse events; neither were considered related to study drug tr
181 key intermediaries between peripheral immune events, neuronal processing, and potentially cognition.
182                          A primary end-point event occurred in 68 of 1012 patients (6.7%) in the iFR
183 ixaban, 12886 patients), 4770 major bleeding events occurred during 447037 person-quarters with NOAC
184 In this study, extreme rainfall and snowfall events occurred during a 3-year field experiment, allowi
185                        Major adverse cardiac events occurred in 1.1% and 4.2% of everolimus-treated a
186 -hospital major adverse cardiac and cerebral events occurred in 2.0% in fTRA and 2.9% in TFA (P=0.40)
187                                Minor adverse events occurred in 22% of patients in the control group
188                 Drug-related serious adverse events occurred in 28 (38%) of 74 patients.
189 nly grade 1 (mild) local or systemic adverse events occurred in both groups.
190 tment groups, although some specific adverse events occurred more often in the intensive group.
191          We report a "polyclonal" autoimmune event occurring in the airways of prednisone-dependent a
192                              Serious adverse events occurring in more than two patients included alan
193 pared with rat claustrum are consistent with events occurring in population subsets rather than the f
194 or tracing the source of contamination in an event of a B. canis outbreak.
195 3), and this is hypothesized to be a driving event of DIPG oncogenesis.
196 enrollment and at 6 months (or prior, in the event of early treatment failure).
197 iral RNA-Gag interactions are the nucleation event of infectious virion assembly, ensuring that one R
198 h a conformational change in BTN3A1 is a key event of pAg sensing that ultimately leads to T cell act
199                      The most common adverse events of grade 3 or higher during treatment were neutro
200                                      Adverse events of grade 3 or higher were reported in 87% of the
201                      The most common adverse events of grade 3 or worse severity were anaemia (38 [19
202 quitin-proteasome systems regulate the major events of meiotic prophase in mouse.
203            In the presence of tRNA, blocking events of single-channel currents through the pore forme
204 ate the influence of a major biomass burning event on the light absorption properties of atmospheric
205                                        For 1 event, opposite polarity leaders were observed to accele
206     VF progression was reached if either the event or trend analysis reached significance.
207 mary outcome was a composite of long-term CV events or death, which was assessed via national health
208                There were no serious adverse events or discontinuations due to adverse events.
209 ant differences in local or systemic adverse events or laboratory abnormalities between the PfSPZ Vac
210 ce or new breast cancer, intolerable adverse events, or consent withdrawal occurred.
211 hreefold increase in widespread extreme rain events over central India during 1950-2015.
212 mportant for reducing the risk of future CHF events, particularly among HIV and hepatitis C infected
213 natomy is associated with increased ischemic events, particularly within the first year after PCI.
214 ngly, we showed that the number of infection events per cell during cell-free HIV-1 infection follows
215 mean (SD) SMR was 0.46 (1.06) vs 0.50 (1.50) events per year in the every 4 weeks vs every 12 weeks g
216 bidity rate (mean number of skeletal-related events per year), and, in a subset of 553 patients, supp
217 show that the occurrence of extreme rainfall events, primarily in the break phase of an LF-ISO cycle,
218 n recruited APC and TC may occur as an early event promoting allergic airway inflammation.
219 moted tolerance of chromosome missegregation events, propagation of aneuploidy, and genetic heterogen
220                              Rate of adverse events, quality of life, and patient satisfaction were n
221     Major adverse cardiac and cardiovascular event rate at 30 days was low (4%) and occurred in 1 pat
222 5% confidence interval for the difference in event rates fell within the prespecified noninferiority
223 s excellent prognostic information, with low event rates in patients with normal myocardial perfusion
224  1007 (6.1%) in the FFR group (difference in event rates, 0.7 percentage points; 95% confidence inter
225 tients in the stent group (2-year cumulative event rates, 3.5% vs. 0.9%; hazard ratio, 3.87; 95% CI,
226                            Recurrent MI, CHD events (recurrent MI or a coronary revascularization pro
227 y subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design.
228 ion of T2MI on its incidence, treatment, and event-related mortality, thereby addressing an important
229                        In the present study, event-related potential (ERP) and behavioral measures we
230  (sympathetic adrenal medullary system), EEG event-related potentials (nociceptive cortical activity)
231            Mechanisms that orchestrate these events remain poorly understood.
232     The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary sourc
233 clathrin waves, but not individual endocytic events, requires feedback from downstream factors, inclu
234  or placebo (32 of 255 [12.5%]); all adverse events resolved without sequelae.
235 s (VSMCs) phenotypic switch, one of the main events responsible for bare metal in-stent restenosis af
236  have emerged from a recent gene duplication event resulting from the ongoing diversification of sHsp
237     Ancestral reconstruction of transmission events reveals that intraspecific PLVA transmission has
238 reate a hub around which nighttime signaling events revolve, including inactivation of KaiA and recip
239                      We performed a discrete event simulation to forecast patient characteristics and
240                                  The smaller event sizes in bat claustrum compared with rat claustrum
241 tion using a new database of individual rain events spanning the contiguous United States.
242 <0.0001), and risk of cardiovascular disease events (standardised hazard ratio 1.59, 95% CI 1.27-1.98
243 ual outcome of the first versus second NAION events (standardized mean differences of visual acuity 0
244 tably (suppressed agonist Emax) in signaling events such as guanosine 5'-3-O-(thio)triphosphate bindi
245                                   Apoplastic events such as monolignol oxidation and lignin polymeriz
246  MRS2365 (5'-diphosphates) in some signaling events, such as extracellular signal-regulated kinase 1/
247               Frost is an important episodic event that damages plant tissues through the formation o
248 sure in connection with an abnormal cortical event that underlies a neurological disorder.
249 een the abundance of insight gained into the events that constitute the metastatic cascade and the pa
250 iologically universal event, and yet the key events that drive aging are still poorly understood.
251 ity-related complications, but the molecular events that initiate and propagate such inflammation rem
252                      Finally, the initiating events that lead to gene body methylation are discussed
253 re initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functiona
254              The most common serious adverse events that occurred through week 24 were anaemia (10 [5
255 hat principal cell discharges dominate ictal events, the ictal sequences were predominantly composed
256             To properly resolve transmission events, these processes need to be taken into account.
257  studies in which rates of immediate adverse events to GBCAs were reported.
258        However, explicitly linking predation events to individual behaviour under natural conditions
259  trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients).
260 ded clinical outcomes (major adverse cardiac events), use of healthcare resources, and impact on heal
261  greatest risk to experience an extreme cold event varied among years.
262 ase 3 trials), the most common local adverse events versus placebo within the first 14 days were arm
263 e annualized mortality rate after a bleeding event was 21.5 (95% CI, 15.4-29.1) per 100 person-years.
264                            A severe critical event was defined as the occurrence of respiratory, card
265  increase in disability near the time of the event was greater for stroke (0.88 points on the disabil
266       The mean follow-up period for incident events was 12.5 years, from the year 15 computed tomogra
267 ho discontinued treatment because of adverse events was low (range, 0%-1%).
268 cations of interest and second breast cancer events was observed when surveillance was removed from o
269                         Incidence of adverse events was similar for alirocumab versus control, except
270                         Incidence of adverse events was similar in all groups (43 [88%] of 49 in the
271                        The number of adverse events was similar regardless of immunisation status.
272 -frequency hearing loss, an expected adverse event, was documented in all participants.
273 d supplementation on clinical cardiovascular events, we update prior recommendations for patients wit
274              The most common serious adverse events were anaemia (eight [4%]), upper gastrointestinal
275                              Serious adverse events were experienced by 35 (18%) patients in the olap
276                    Treatment-related adverse events were generally grade 1 or 2 in severity.
277                                      Adverse events were generally mild (</= grade 2), with diarrhea
278                      The most common adverse events were infective pulmonary exacerbations, cough, in
279   The most common isatuximab-related adverse events were infusion-associated reactions (IARs) (56%),
280                              Data on adverse events were limited, but suggested an increased risk of
281                                        These events were linked to a decrease in the macrophage capac
282                                      Adverse events were more frequent with clindamycin (58 of 265 [2
283 thout airflow obstruction, acute respiratory events were not associated with additional FEV1 decline.
284               In this small study, no safety events were noted, but no safety conclusions can be draw
285 ewer grade 3 and 4 treatment-related adverse events were observed in patients on nivolumab (14% v 34%
286                                      Adverse events were rarely reported.
287                            No severe adverse events were recorded.
288                              Serious adverse events were reported in 56 (58%) eltrombopag-treated pat
289 s had grade 3 adverse events, but no grade 4 events were reported.
290                                  The binding events were studied by monitoring cyclic voltammetry sig
291 st frequently observed grade 3 and 4 adverse events were transaminase increases (40% alanine aminotra
292       Such a disruption induces a cascade of events which impacts glycan biosynthesis through Hexosam
293                   Extreme summer temperature events - which are expected to occur with increasing fre
294  Safety was assessed on the basis of adverse events, which were graded according to the Common Termin
295 the synthesis of a protein to ensure that an event will occur at a precise time, while minimizing dev
296              Interventions that target these events will interrupt tuberculosis transmission and acce
297 analysis to detect individual vesicle fusion events with approximately 27 nm localization precision a
298  There was no increase in vascular occlusive events with tranexamic acid, with no heterogeneity by si
299 1.16] in the 10-14 d period following an SSO event, with positive ORs for all age groups and for thre
300  college and above], previous cardiovascular events [yes or no], current smoker [yes or no], and diab

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