ライフサイエンスコーパス: eventual

1 oteinase" 10 (ADAM10) cleaves APP within the eventual Abeta sequence and precludes Abeta generation.

2 ch signaling pathway activity determines the eventual abundance of target proteins is complex and poo

3 G is well tolerated in most tissues, but the eventual accumulation in neurons and their axons causes

4 ed to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechan

5 e relate the transition to the formation-and eventual activation-of an inversion layer that acts as t

6 netic parameters of clathrin assembly to the eventual adaptor distribution indicate that adaptor clus

7 sceptibility to opioid medication misuse and eventual addiction in the context of chronic pain.

8 namic process of publication, and thereby on eventual aggregation of knowledge, we provide a new pers

9 H that likely promotes further oxidation and eventual aggregation.

10 down, condensation of chromosomes, and their eventual alignment on metaphase plates.

11 e and self-governance from the French and by eventual alignment with eastern bloc Communist countries

12 ating traumatic mechanical events leading to eventual alterations of cell, tissue, and organ structur

13 moval drives elevated brain Abeta levels and eventual amyloid plaque deposition.

14 sized proteins are segregated in the TGN for eventual apical delivery.

15 tion, DNA damage, misoriented divisions, and eventual apoptosis.

16 radiofluorination under mild conditions for eventual application in molecular imaging with positron

17 ort copper into the mitochondrial matrix for eventual assembly of cytochrome c oxidase.

18 mal inclusions preceded cystine crystals and eventual atrophy without crystals.

19 or disassembly at elevated temperatures with eventual backbone hydrolysis have not been reported to d

20 te water uptake to enhance tissue damage and eventual bacterial egression from the apoplast to the le

21 of early visual processing centers precedes eventual behavioral choices made by these insects.

22 Complex motor skills of eventual benefit can be learned after considerable trial

23 ssification will lead to better insights and eventual better prognosis of the disease.

24 s long exposure of the cell to the laser and eventual bleaching of the sample.

25 f the intraocular pressure and assessment of eventual bleb morphology variations in the follow-up per

26 ogressive loss of photoreceptor neurons with eventual blindness.

27 rity, CC normalization could not control for eventual BV differences, but using BV as a covariate in

28 accounting for the less-than-certain risk of eventual cancer disease even when cancer cells are prese

29 scription factors (TFs) are correlative with eventual cardiomyogenic outcome.

30 diate, thereby alkylating DNA and leading to eventual cell death.

31 p53 or Rb, leading to cell cycle arrest and eventual cell death.

32 lting in intracellular calcium elevation and eventual cell death.

33 membranes, resulting in membrane rupture and eventual cell death.

34 thological stimuli differentially affect the eventual cell fates of c-kit(+) cells.

35 he default option value, irrespective of the eventual choice.

36 site colonization, infection initiation, and eventual clearance.

37 , subsequent activation of caspases, and the eventual cleavage of microtubules, leading to local dege

38 w anergic phenotype, incompatible with their eventual clinical application.

39 cromolar concentrations, showing promise for eventual clinical applications.

40 translation of this microneedle platform to eventual clinical deployment.

41 g the gap between laboratory discoveries and eventual clinical implementation.

42 revealed that IFN signatures could influence eventual clinical outcomes and lung FDG avidity, even be

43 Since eventual clinical reassessment, including muscle imaging

44 ical, quantitative imaging framework for the eventual clinical translation of molecular imaging contr

45 ion about the potential of (18)F-FTC-146 for eventual clinical translation.

46 ied to predict human traits, with the aim of eventual clinical utility.

47 ortality with specific symptoms, followed by eventual colony loss weeks later.

48 de increase will likely be needed to support eventual commercial supply requirements for many of the

49 The eventual commercialisation of this biosensor system coul

50 approach can play a significant role in the eventual commercialization of this class of materials.

51 nthesis results in chromosome shortening and eventual compromise of genome stability.

52 randed DNA leads to inter-DNA attraction and eventual condensation.

53 nsporting organic semiconductors and for the eventual construction of larger carbonaceous systems.

54 r support and maintenance of enamel rods and eventual contribution to unique enamel mechanical proper

55 bundles was linked with early twitching and eventual coordinated movement.

56 iate meiotic recombination greatly outnumber eventual COs, this process requires exquisite regulation

57 es hope for a complete understanding of, and eventual cure for, these childhood epilepsy syndromes.

58 energy, materials) to integrated measures of eventual damage (for example, extinction of species).

59 onsible for tumour dormancy, relapse and the eventual death of most cancer patients.

60 ell migration and adhesion to the heart, and eventual death of the embryo.

61 t CAG-independent processes and then lead to eventual death.

62 long-term L-DOPA treatment is complicated by eventual debilitating abnormal involuntary movements ter

63 e-delayed future release of carbon, from the eventual decay either of forest products or of slash lef

64 ilable through energy transfer following the eventual decay of LSPRs.

65 red to a compact 3D network structure before eventual decomposition into periclase and ice.

66 gene ISG signature (P < 0.001) predicted the eventual decreased DeltaHCVART .

67 Eventual decreases in photosynthesis among C4 plants wer

68 non-adapting barrel cortex neurons, and that eventual deficits in inhibition may have differential ef

69 so noted that the round spermatids underwent eventual degeneration with the formation of multinucleat

70 ized CD4 to multivesicular bodies (MVBs) for eventual degradation in lysosomes.

71 hat the coupling of EXO1 activation with its eventual degradation is a timing mechanism that limits t

72 ich results in rapid enzyme inactivation and eventual degradation.

73 alyze iterative oxidation of 5mC, leading to eventual demethylation.

74 h occurring at the electrode surface and the eventual dendrite growth between the electrodes.

75 g cell division and apoptosis, leading to an eventual depletion of LSCs.

76 nocytes, which results in the impairment and eventual destruction of insulin-producing beta-cells.

77 uveitis from initial retinal inflammation to eventual destruction of the neuroretina with loss of pho

78 ontribute little genetic variation, so their eventual detection is less relevant for resolving the mi

79 remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function

80 tion and T cell exhaustion contribute to the eventual deterioration of the immune system.

81 before treatment initiation predict SVR and eventual development of a higher frequency of functional

82 expansion of intestinal progenitor cells and eventual development of adenomas.

83 her magnesium solid ionic conductors and the eventual development of an all-solid-state magnesium bat

84 chaperone-bound forms is a key step for the eventual development of antibacterials that block transl

85 ies contributed important groundwork for the eventual development of antiviral drugs to treat AIDS.

86 to explore whether this correlates with the eventual development of delayed cerebral ischemia.

87 individualization of care will result in the eventual development of effective therapeutic strategies

88 ng to involve the lungs and kidneys with the eventual development of lymphoma.

89 nescence, which is hypothesized to drive the eventual development of multiple comorbidities.

90 r explaining observed reactivity and for the eventual development of new applications.

91 e discuss our approach in the context of the eventual development of organ-specific molecular signatu

92 associate clinically available factors with eventual development of PCS in children.

93 he most common heritable human diseases with eventual development of renal failure; however, effectiv

94 nd afatinib, but outcomes are limited by the eventual development of resistance to these agents.

95 nt may underlie reduced beta cell growth and eventual development of T2DM later in life.

96 n of the evolution of conduction channel and eventual device failure.

97 inical diagnosis and correctly predicted the eventual diagnosis as the clinical presentation evolved.

98 Eventual diagnosis of aggressive fibromatosis is based o

99 anges that precede the onset of symptoms and eventual diagnosis of Alzheimer's disease (AD) are a tar

100 In the cases where we made an eventual diagnosis, the delay was 3-35 years (mean 18.1

101 These data are essential to rationalize eventual, different nutritional, antimicrobial, cell sti

102 fferent anions and cations are discussed and eventual disagreements between different sources are cri

103 enhanced polymerization, rapid turnover, and eventual disassembly.

104 okine storm in AHI may be beneficial to slow eventual disease progression.

105 based nanomaterials, to device operation and eventual disintegration into naturally degradable yet po

106 w this complex promotes a rearrangement, and eventual dissociation of, the integrin alpha and beta tr

107 d have undergone transport, cultivation, and eventual domestication over such a long period of time.

108 uple lesion detection to ATPase activity and eventual downstream repair.

109 We hypothesized that prior probability of eventual drug approval was significantly different acros

110 cessful memory formation, independent of the eventual durability.

111 ost cell invasion, parasite replication, and eventual egress that constitute the lytic cycle, as well

112 immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies.

113 llowed by stepwise catalyzed degradation and eventual elimination along the mercapturic acid pathway.

114 inued reduction in size of the devices, plus eventual elimination of the external drive line will mak

115 ion of 'omic' approaches for the control and eventual elimination of VL.

116 er, whether tolerance delays or promotes the eventual emergence of resistance is unclear.

117 ced heart failure, little is known about the eventual end-of-life care that patients with DT-LVAD rec

118 s at donor nephrectomy increases the risk of eventual end-stage renal disease (ESRD).

119 ially be used as a partner of experiment for eventual engineering of P450 BM3 with site-selective C-H

120 o prepare for higher land temperatures in an eventual equilibrium climatic state.

121 essential for surveillance, prevention, and eventual eradication of HIV.

122 down as duplicate sequences diverge-until an eventual "escape" of the sequences from its influence.

123 o induce bacterial clearance and prevent the eventual establishment of cellular reservoirs of this pa

124 of Au(I)-thiolate complex precursors to the eventual evolution of and focusing to the atomically pre

125 with transitional vertebrae survive to allow eventual evolutionary changes of trunk vertebral numbers

126 ry signaling that leads to the expansion and eventual exhaustion of hematopoietic cells, and this occ

127 es, it provides background data prior to the eventual exploitation of shale gas through hydraulic fra

128 Rigid matrices are further required for eventual expression of osteogenic markers, and RARG-anta

129 and dynamics of development, resolution, and eventual extinction are not well understood because huma

130 hic stochasticity is expected to lead to the eventual extinction of all but one of them.

131 cular explanation for the cardiotoxicity and eventual failure of GSK932121 in phase-1 clinical trial

132 tion has dramatically improved survival, yet eventual failure of the systemic right ventricle necessi

133 ty from these waves indicate a weakening and eventual failure of their source.

134 nascent daughter cells that influence their eventual fate towards the effector or memory lineages.

135 Gene-expression signatures predictive of eventual fates could be discerned as early as the first

136 n which, when coupled with the emergence and eventual fixation of compensatory mutations, enables the

137 y to both hydrolyze lignocellulose and repel eventual food competitors and/or cheaters.

138 cs of the medium become dominant, enable the eventual formation of a filament downstream.

139 ed tumorigenesis, but failed to suppress the eventual formation of colonic tumors.

140 e and its re-association with amino acid and eventual formation of the chlorinating agent in the form

141 freedom from seizures and Engel score of 1 (eventual freedom from seizures allowing for some initial

142 n the fermentation time, beans used and the (eventual) frying process.

143 (tOPV) to bivalent OPV (bOPV) can inform the eventual full global withdrawal of OPV.

144 n of CCR2, thus limiting their migration and eventual function in the pancreas.

145 igens expressed by the graft would avoid its eventual functional loss and the severe side effects of

146 age of a tissue, providing a foundation for eventual genetic manipulation or tracking of specific br

147 fy the synonym sets most responsible for the eventual genre distinguishability.

148 missions up to the year 2100 would commit an eventual global sea-level rise of 4.3-9.9 m.

149 to future global health efforts, such as the eventual global withdrawal of bOPV.

150 itical for preventing podocyte apoptosis and eventual glomerulosclerosis in the kidney; however, the

151 Moving towards the eventual goal of clinical application it is necessary to

152 With the eventual goal of enhancing rice phytonutrient concentrat

153 in enhancing mechanical properties, and the eventual goal of nanolattice design may be to replicate

154 Treg frequency increase of 20%-50%, with the eventual goal of preventing T1D.

155 The eventual goal of this research is to develop a method to

156 ially, followed by further linear growth and eventual gradual saturation.

157 (CN)y synthon that serves as a precursor for eventual H-cluster assembly.

158 epwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans.

159 ate in adverse cardiac remodeling leading to eventual heart failure.

160 netrating, thus denying the detection of any eventual hidden material.

161 of DD risk beyond a middle value (PD50), and eventual higher DD risk asymptotes at higher DU frequenc

162 The eventual identification and characterization of 908 extr

163 Advancing the SAR of this series led to the eventual identification of (R)-1-(7-chloro-2,2-bis(fluor

164 This study lays the groundwork for the eventual identification of common TS susceptibility vari

165 d to so-called "stress shielding effect" and eventual implant failure.

166 rtantly identify multiple new candidates for eventual in vivo evaluation.

167 ion and biocompatibility, paving the path to eventual in vivo studies.

168 n is preferable for identifying aptamers for eventual in vivo use.

169 olecules undergo dissociative adsorption and eventual incorporation into magnetite.

170 rate of fatty acid beta-oxidation, with the eventual increase in fat accumulation.

171 small initial disparities can lead to larger eventual inequalities, (2) feedback loops can embed earl

172 plications relies on urgent chemotherapy and eventual instrumental or surgical procedures, combined w

173 ycaemia to prediabetes, type 2 diabetes, and eventual insulin use.

174 and analysis of rule-based models and their eventual integration into comprehensive whole-cell model

175 bjected to existing regulatory gauntlets for eventual introduction into clinical practice.

176 fic antibodies partially responsible for the eventual islet xenograft rejection.

177 tforms for biosensing as well as to overcome eventual leakage current-related problems in capacitive

178 pheric asymmetry in connectivity between the eventual lesion and the caudate (for responders vs nonre

179 t anterior cingulate cortex, anterior to the eventual lesion, for which signal strength correlated wi

180 ction fraction relative to control mice, and eventual lethality in the absence of cardiac fibrosis.

181 stantial knowledge gap and impediment to the eventual licensing of new antiviral drugs and vaccines f

182 subpopulations at high- versus low-risk for eventual liver-related morbidity and mortality.

183 k end labeling (TUNEL)-positive soma and the eventual loss of 5HT neurons in the DRif and its project

184 letion of undifferentiated spermatogonia and eventual loss of all germ cells after undifferentiated s

185 characterized by insulin resistance and the eventual loss of beta cell function.

186 underwent progressive neurodegeneration with eventual loss of both rods and cones by twelve weeks.

187 the contributions of three mechanisms to the eventual loss of gene silencing activity.

188 ation of macropinosome-derived vacuoles with eventual loss of membrane integrity.

189 on/reduction processes within the ice and an eventual loss of mercury via brine drainage or gas evasi

190 their axons, neuroinflammatory reaction, and eventual loss of selective motor neuron populations.

191 However, with eventual loss of the additional copies of rstC, the nont

192 retinal cells, causing the deterioration and eventual loss of vision.

193 ion of the old pole of M. tuberculosis, with eventual lysis.

194 We suggest that their eventual manipulation could promote revascularization af

195 lation in immune activation characterized by eventual massive target tissue apoptosis has allowed the

196 t component of overall fruit development and eventual maturation and ripening.

197 m an irregular plexus of tubules to form the eventual mature, branched ductal arbor.

198 droplets collected by microdialysis for the eventual measurement of neuropeptides at high spatial an

199 creases of 0.28 log10 IU/mL were followed by eventual median decreases from baseline of 0.21 log10 IU

200 he substrate, followed by lattice growth and eventual merging of CA patches into a continuous monolay

201 Successful outgrowth of tumours and eventual metastasis is not determined solely by genetic

202 acilitate tumor-induced immunomodulation and eventual metastasis.

203 esis, which supports tumor cell survival and eventual metastasis.

204 sion in the early stages of DN formation and eventual mitochondrial degeneration at later stages.

205 allergens for several months, building up to eventual monthly injections for typically 3 to 5 years.

206 ded tadpole survival and did not prevent the eventual mortality of these animals.

207 ce interval, 34.9-40.9 minutes), 99% with an eventual mRS score of 0 to 3 at discharge achieved ROSC.

208 rly corticostriatal synaptic dysfunction and eventual neurodegeneration of medium spine neurons (MSNs

209 iatal neuron dysfunction, synaptic loss, and eventual neurodegeneration.

210 s impair exocytosis, which may contribute to eventual neurodegeneration.

211 rment of exocytosis, which may contribute to eventual neurodegeneration.

212 otein-folding capacity of the ER, leading to eventual neuron death.

213 he nucleus, re-entry into the cell-cycle and eventual neuronal death.

214 synaptic dysfunction, tau accumulation, and eventual neuronal death.

215 Following completion of phase III studies, eventual new drug application approval rates varied from

216 of the causative tumour is necessay to allow eventual normalisation of the hypothalamic-pituitary-adr

217 tion of LIF-JAK1-STAT3 signaling that delays eventual nuclear translocation of p16(INK4a).

218 s correct cellular patterning of tissues and eventual organ function.

219 smussen's encephalitis, without changing the eventual outcome.

220 nfection, and the factors that determine its eventual outcome.

221 tinent literature on causes, procedures, and eventual outcomes of Hispanic migration waves throughout

222 otes rapid tumor regression, followed by the eventual outgrowth of resistant cells.

223 ants still accounts for roughly one-third of eventual participation.

224 Further, the eventual patterning of the striosomal compartment reflec

225 d preserving or building bony ridges for the eventual placement of implants.

226 ers using SiNW sensors render them ideal for eventual POC diagnostics.

227 genicity of the routine schedule, we predict eventual population-level repercussions that may lead to

228 g or synthesizing metabolite standard(s) for eventual positive metabolite identification.

229 d during the infusion and did not affect the eventual positive treatment outcome.

230 domains result in rapid fiber formation and eventual precipitation or gelation while short nucleatio

231 Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Ara

232 ays on the miniaturized system to detect the eventual presence of anti-TAAs autoantibodies.

233 cally useful biomarker in the prediction and eventual prevention of these disorders.

234 e whether these genetic changes impacted the eventual processing of glycans on the HIV Env and the su

235 n) brings about an unambiguous answer to the eventual production of methanol and formate, much more s

236 ated atrophic spots, which progressed to the eventual profound chorioretinal atrophy.

237 hology was shown to be dampened by IL-10 and eventual programmed death 1-mediated T cell exhaustion.

238 ing prediabetes, as are data for the risk of eventual progression from prediabetes to diabetes and fo

239 moylated during activation, facilitating its eventual promoter eviction and transcriptional shut off.

240 factor 1 alpha (HIF1alpha), targeting it for eventual proteasomal degradation.

241 of RNA structural motifs and will aid in the eventual quantitative description of RNA folding from it

242 porting information, people, or goods) under eventual random failures is of utmost importance to desi

243 experiments, and provide new schemes towards eventual realization of topological superconductors.

244 eological studies, which are consistent with eventual reconstitution of the worm phase on cooling to

245 irst days following injury could predict the eventual recovery of cortical sound processing weeks lat

246 than an encoded protein, is critical for the eventual recovery of transcription.

247 or regression and decrease the likelihood of eventual recurrence.

248 eristic orange color that contributes to the eventual red color of the ripe fruit.

249 pping revealed extensive early deficits, but eventual reestablishment of motor cortical output maps t

250 SMARCE1 expression is a strong predictor of eventual relapse and metastasis.

251 e adverse side-effects, drug resistance, and eventual relapse.

252 NA interface suggest factors responsible for eventual release of tRNA.

253 f, model 1 identified 44.9% of patients with eventual renal scarring.

254 inical investigation was conducted, with the eventual replacement of radiotracers with stable isotopi

255 amics of Neanderthals and modern humans, the eventual replacement of the Neanderthals was determined

256 rious for its aggressive clinical course and eventual resistance to existing therapies.

257 ective therapies and play a critical role in eventual resistance.

258 rly homolog alignment is correlated with the eventual resolution of DSBs as COs.

259 ectivity variations that could differentiate eventual responders from nonresponders.

260 xpansion of the surviving stem cells and the eventual restoration of tissue homeostasis and regenerat

261 ng cilia cause rhodopsin mislocalisation and eventual retinal degeneration in XLRP.Mutations in the R

262 ng donor myeloid chimerism (DMC) levels with eventual return of disease.

263 of oxygen throughout the Proterozoic and its eventual rise remain uncertain.

264 iod, the annual frequency of persons with an eventual RNA test did not change significantly; however,

265 te cytoskeleton, before permeabilization and eventual rupture of the erythrocyte membrane to release

266 against coalescence but not preventing their eventual sedimentation due to the mass of adsorbed parti

267 These responses, aimed to adapt to eventual shading from plant competitors, include a reduc

268 llasite parent body, capturing the decay and eventual shutdown of the magnetic field as core solidifi

269 ces induced by nanocrystal sedimentation and eventual solvent evaporation.

270 species, leading to restricted gene flow and eventual speciation.

271 s of the same tumour-suppressor pathways and eventual sporadic development of malignant mesothelioma.

272 gions, which compete and may resolve into an eventual stable categorization with the assistance of co

273 to the final product, the regiochemical and eventual stereochemical outcome of the kinetic cyclizati

274 f a mechanism-based strategy that led to the eventual successful outcome and the attendant support st

275 s that affect tropical precipitation and the eventual surface hydrological response to better assess

276 on resulting in a high rate of apoptosis and eventual symptoms related to bone marrow failure.

277 related compound 29, will be employed for an eventual synthesis of demethylmersicarpine.

278 With a view to the eventual synthesis of glycosyl donors for the stereocont

279 Perivascular-like cells as an eventual target in NSCLC warrants further investigation.

280 We demonstrate this potential for high eventual temperatures over land, even for contemporary G

281 NA in the peripheral blood and the patients' eventual therapeutic response to doxycycline are consist

282 of growth factors, potentially providing an eventual therapy to prevent OA.

283 (beta-elimination; c3LHyp dehydratase), with eventual total dehydration.

284 This work lays a foundation for an eventual total synthesis of Taxol capable of delivering

285 se gas levels may already commit Earth to an eventual total warming of 5 degrees Celsius (range 3 to

286 lattening and fusion of major processes, and eventual transformation into a podocyte sheet as the dis

287 proto-oncogene beta-catenin (CTNNB1) and its eventual translocation to the nucleus.

288 there may be a trade-off between preventing eventual treatment failure due to resistance in this way

289 tients, and that this may be associated with eventual treatment failure.

290 nce (AS) has been questioned on the basis of eventual treatment necessity and concerns of safety; how

291 to advancing diagnosis, interpretation, and eventual treatment of pediatric dysbiosis.

292 evelopment of late-life depression (LLD) and eventual treatment outcomes.

293 rs are only partially suppressed, leading to eventual tumor regrowth and/or the development of drug-r

294 onse that promotes beta-cell destruction and eventual type 1 diabetes.

295 napses in the nucleus accumbens (NAc), whose eventual unsilencing/maturation by recruitment of calciu

296 itutes a strong and significant predictor of eventual village-level participation.

297 f peak disease severity but had no effect on eventual viral clearance, disease symptoms, or survival.

298 ndition that causes retinal degeneration and eventual vision loss.

299 amework and 0-D triazolate clusters) and the eventual welding between the acs framework and triazolat

300 n spectroscopy (XPCS), while also monitoring eventual X-ray induced damage.