ライフサイエンスコーパス: eventually lead to

1 These results may eventually lead to a basis for the development of dietar

2 of a susceptibility locus in this region may eventually lead to a better understanding of gene-enviro

3 disruptions of the basement membrane, which eventually lead to a breakdown of epithelial organizatio

4 imer disease and other progressive dementias eventually lead to a complete loss of financial capacity

5 embrane for accumulating lipid particles may eventually lead to a confluent lipid wall capable of iso

6 ng specific aspects of the immune system may eventually lead to a cure for HIV-infected patients.

7 importance of reservoirs of infection might eventually lead to a cure.

8 mpression decreases protein mobility and can eventually lead to a dramatic stalling of several unrela

9 in the development of the thymocytes, which eventually lead to a high incidence of thymic lymphomas.

10 hemselves and to implement institutions that eventually lead to a higher welfare for all.

11 er increases in the surfactant concentration eventually lead to a highly elongated protein that nonet

12 sent large lithospheric deformation that may eventually lead to a localized boundary between the Indi

13 It may eventually lead to a low-cost personal medical device fo

14 This model may eventually lead to a more unified conceptual understandi

15 infect and colonize the human host and could eventually lead to a novel drug target.

16 active interaction, no matter how weak, will eventually lead to a pairing instability.

17 l fluctuations, we show that such design can eventually lead to a superior energy-delay product.

18 n increasing number of genome sequences will eventually lead to a sustained development of marine bio

19 hance the sensitivity of GMR biosensors, and eventually lead to a versatile and portable device for m

20 t's immune reaction to the microbial plaque, eventually leading to a decrease in the ratio of RANKL/O

21 ex cascade of epigenetic and genetic events, eventually leading to a left-right asymmetric body plan.

22 ene loss, the pace of which slows over time, eventually leading to a paucity of genes, and stasis.

23 ion provided new insight into the mechanism, eventually leading to a refined catalytic cycle that als

24 data further show that excessive tooth wear eventually leads to a breakdown of the normal remodeling

25 aman data show that beta-lactam ring opening eventually leads to a complex mixture of reaction produc

26 ctivation of an sp(3) C-H bond, and reaction eventually leads to a doubly cyclometalated complex wher

27 hat cumulative, time-dependent tissue injury eventually leads to a fibrotic response.

28 ntangled through time dilation effect, which eventually leads to a loss of coherence of a single cloc

29 ted exposure to a novel physical environment eventually leads to a mature adaptive response whereby f

30 ect reciprocity can evolve if and only if it eventually leads to a net benefit in the long term.

31 stem to respond to new antigenic stimuli and eventually leads to a peripheral T-cell bias to the memo

32 e distal cyclopropane bonds in a manner that eventually leads to a retro-Diels-Alder reaction.

33 G2 phase, mitotic inducers accumulate, which eventually leads to a switch-like rise in mitotic kinase

34 Further exposure of cysteine eventually leads to a zwitterionic multilayer film invol

35 ciated growth defects, but continuous growth eventually leads to aerobic respiration defects, reduced

36 rnover may induce Ag species interconversion eventually leading to Ag release on longer time scales.

37 secondary to other pathogenic processes that eventually lead to age-related neurodegeneration.

38 cell culture, collective migration of cells eventually leads to aggregation in large clusters.

39 onged activation of the immune system by HIV eventually leads to AIDS, and several lines of evidence

40 ct on the stem domain of the gamma HC, which eventually leads to alterations in mechanochemical inter

41 gns of severe chronic allograft vasculopathy eventually led to amputation of the graft.

42 iviral innate immunity within the lungs that eventually lead to an exacerbated inflammatory cascades

43 t in myoblast fate from epaxial to hypaxial, eventually leading to an excess of hypaxial body wall mu

44 egradation through the autophagy pathway and eventually leading to an open chromatin structure that f

45 olvent-exposed [4Fe-4S] enzyme clusters that eventually leads to an increase in hydroxyl radical prod

46 ecoming generalized over a 5-10 year period, eventually leading to aphonia, dysphagia and severe moto

47 ExoS ADPRT to modulate host cell signaling, eventually leading to apoptosis, but also establishes Ex

48 ve oxygen species and nuclear fragmentation, eventually leading to apoptosis.

49 and caspase enzymes, inducing DNA damage and eventually leading to apoptosis.

50 to mitochondria and nucleus, a response that eventually leads to apoptosis, but how the two events ar

51 in activates caspase 1 in macrophages, which eventually leads to apoptosis.

52 ival, and depletion of any of these proteins eventually leads to apoptosis.

53 se early results affording nanoribbons could eventually lead to applications in fields of electronics

54 eatment of diabetic nephropathy, which could eventually lead to applications in renal transplantation

55 st cell immune and signaling pathways, which eventually lead to bacterial survival and replication in

56 of mammalian cardiomyocyte proliferation may eventually lead to better approaches for heart regenerat

57 y challenges remain, these interventions may eventually lead to better approaches to treat or prevent

58 the brain, fail to regenerate after damage, eventually leading to blindness.

59 revented complete neutralization escape, and eventually led to broadening of the response.

60 epigenetic programs and DNA repair) and may eventually lead to cancer development.

61 ane potential, and cytochrome c release that eventually led to cancer cell death.

62 ocesses include fibrotic reorganization that eventually leads to cardiac failure.

63 lium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via mul

64 ithin the tumor, eradicating this population eventually leads to castration-resistance, owing to the

65 ical function of key cellular structures and eventually lead to cell death.

66 ased RP photoreceptors begin to deteriorate, eventually leading to cell death and, consequently, loss

67 ight-dark regime triggered stress responses, eventually leading to cell death, in leaves of Arabidops

68 dative responses to S Typhimurium infection, eventually leading to cell death.

69 fibrils increase cell membrane permeability, eventually leading to cell death.

70 s been found to block centriole duplication, eventually leading to cell death.

71 ion of PstP is detrimental to cell survival, eventually leading to cell death.

72 ompetitors by a Type VI secretion apparatus, eventually leading to cell lysis and death.

73 This overexpression eventually leads to cell cycle arrest at the G1/S bounda

74 ll permeable to large organic cations, which eventually leads to cell death.

75 This eventually leads to cholestasis, and this causes bile sa

76 proliferation of growth plate chondrocytes, eventually leading to chondrodysplasia and reduced long

77 with loss of tolerance against liver tissue eventually leading to cirrhosis if left untreated.

78 O-O sigma bond makes reactions of O2, which eventually lead to cleavage of this bond, very favorable

79 er time to determine whether these anomalies eventually lead to clinical symptoms of schizophrenia.

80 vo experimental transplantation studies that eventually led to clinical PBSCT.

81 part of a cascade of pathologic events that eventually lead to cognitive decline and dementia.

82 tiform activity, some of the mechanisms that eventually lead to cognitive deficits in Alzheimer's dis

83 se (AD) begins as a malfunction of synapses, eventually leading to cognitive impairment and dementia.

84 the oscillations destabilize the population, eventually leading to collapse.

85 apacity for self-repair and focal damage can eventually lead to complete degradation of the tissue.

86 Further optimization eventually led to compound 37 that showed good TYK2 enzy

87 vatives to provide new inhibitors that could eventually lead to compounds with clinical usefulness ag

88 rucially important link in a chain that will eventually lead to consilience in reptile systematics, p

89 Eocene epoch, especially at high latitudes, eventually led to continental ice sheet development in A

90 caused oxidative stress in mitochondria that eventually led to cytochrome c release, proteolytic acti

91 orters, causing several cellular damages and eventually leading to death.

92 ng, most notably cardiovascular disease that eventually leads to death from myocardial infarction and

93 ucture and decreased cardiac function, which eventually led to death before 23 weeks of age.

94 oculture of the Candida and macrophage cells eventually led to death of the macrophages, but for the

95 riety of aging-associated abnormalities that eventually lead to decreased life expectancy.

96 2+) stores and alters mitochondrial fitness, eventually leading to decreased insulin release.

97 urn, triggers a gene regulation program that eventually leads to decreased myosin light-chain phospho

98 ane-bound and secreted fractions of Wnt3 and eventually led to defective brain development.

99 these changes in gene expression, which may eventually lead to degradation at the tissue level and c

100 ssociated with impaired learning and memory, eventually leading to dementia.

101 beta (Abeta) initiate the neurotoxicity that eventually leads to dementia in Alzheimer's disease.

102 s-prone mice, but that persistent high doses eventually led to depletion and ameliorated lupus.

103 olocalizes with microtubules when in excess, eventually leading to depolymerization, which is sequest

104 (Q) facilitates formation of htt aggregates, eventually leading to deposition of cytoplasmic and intr

105 terns of reproduction and connectivity which eventually lead to descendants returning to the patch fr

106 udies are needed to confirm our data and can eventually lead to development of more targeted treatmen

107 ions and the effect of graphene, which could eventually lead to development of novel methods to contr

108 ults in decreased responsiveness to insulin, eventually leading to diabetes and cardiovascular diseas

109 Xerostomia can eventually lead to difficulty in swallowing, severe and

110 s the destruction of articular cartilage and eventually leads to disability.

111 n the underlying evolutionary processes that eventually lead to disease emergence.

112 d structural changes of the protein molecule eventually lead to disorder in protein crystals.

113 ending and/or descending thoracic aorta that eventually leads to dissection or rupture.

114 lates tyrosinase expression and function and eventually leads to dramatic increases in melanin produc

115 etal remodeling, and retarding CSC motility, eventually led to drug resistance associated with a mark

116 ing the accumulation of cellular damage that eventually leads to dysfunction and, ultimately, the dem

117 s disease at the molecular level, which will eventually lead to early detection, prevention and treat

118 ations, suggesting that these reagents could eventually lead to effective therapies.

119 ic instability and neuronal apoptosis, which eventually lead to embryonic lethality.

120 per encoding of tone-shock associations that eventually lead to enhanced cue-specific fear.

121 the first steps in a cascade of events that eventually lead to epileptogenesis triggered by TBI.

122 timates of the genotypic effect and thus may eventually lead to errant results and incorrect inferenc

123 hich can interfere with implant function and eventually lead to failure.

124 on may retard the progression of injury that eventually leads to fibrosis.

125 undergo actin-based motility in the cytosol, eventually leading to formation of actin-rich protrusion

126 n betatron oscillation in the channel, which eventually leads to formation of the ultradense electron

127 ysis, electron transport, and ATP formation, eventually leading to functional impairment or death of

128 Such a strategy could eventually lead to future efficacious treatments of meta

129 nhibition of beta-catenin and proliferation, eventually leading to GC suppression.

130 d to Adjudin to induce AJ restructuring that eventually led to germ cell loss from the epithelium, th

131 use an increase in intraocular pressure that eventually leads to glaucoma.

132 ity and intraglomerular pressure, the latter eventually leading to glomerular capillary dropout (rare

133 re diagnosed with organ-specific SSIs, which eventually led to graft loss; six (31.5%) developed deep

134 This may eventually lead to hair cell death and irreversible deaf

135 ediate that subsequently becomes protonated, eventually leading to HDMF.

136 hypertrophy is initially beneficial, it can eventually lead to heart failure.

137 leads to stiffening of the heart, which can eventually lead to heart failure.

138 c in several cardiac proteinopathies and can eventually lead to heart failure.

139 An MI induces irreversible tissue damage, eventually leading to heart failure.

140 is one of the complications of diabetes that eventually leads to heart failure and death.

141 preserved contractility, sustained overload eventually leads to heart failure through poorly underst

142 eless, this self-destructive conversion will eventually lead to hot-spot extinction.

143 is the first crucial step in a process that eventually leads to human arsenicosis.

144 l help to elucidate the pathogenesis and may eventually lead to identification of molecular markers f

145 ncapacity to suppress effector responses and eventually leads to immunopathogenesis.

146 ccumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastroph

147 and allergic airways inflammation that could eventually lead to improved asthma control.

148 Further investigation may eventually lead to improved diagnosis, prognosis, and ma

149 esis of stroke in sickle cell disease should eventually lead to improved management of all central ne

150 This observation can eventually lead to improved red fluorescent proteins for

151 elopment of targeted nanoRx formulations and eventually lead to improved therapeutic efficacy.

152 stases in this breast cancer model and could eventually lead to improved therapeutics for metastatic

153 acid secretion in health and disease should eventually lead to improved therapies to prevent and tre

154 nslation back to the bedside, is expected to eventually lead to improvements at the patient interface

155 These interactions eventually led to inactivation of the small GTPase, RhoA

156 re uncertain, we hypothesize that they could eventually lead to increasing regional-scale biotic homo

157 horts will have their own internal dynamics, eventually leading to independent demographic and evolut

158 e identification of biosignatures that could eventually lead to individual recommendations for the du

159 e use of Tat-fusion peptide transduction may eventually lead to innovative therapeutic modalities to

160 truction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most p

161 of the stem and progenitor cell populations, eventually leading to intestinal polyposis resembling hu

162 nerating forces ( approximately 190 pN) that eventually lead to irreversible viral deformation.

163 oth drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retin

164 o both E- and Z-alkenyl iodides, which would eventually lead to isodomoic acid G and isodomoic acid H

165 arts from the center of the nanoparticle and eventually leads to its complete fragmentation.

166 3beta-inactivated prostate cancer cells that eventually leads to its enhanced proliferation and survi

167 Its domestication eventually led to its adoption as a model organism, aide

168 tigation on this activation principle, which eventually led to its elucidation.

169 nsversions or AT-->GC transitions, which can eventually lead to lethal mutations.

170 Long-term ectopic expression of Sox17 eventually led to leukemogenesis.

171 cirrhosis, an irreversible disease that may eventually lead to liver cancer development.

172 disease of the intrahepatic bile ducts that eventually leads to liver cirrhosis and organ failure, i

173 layer and growth-factor-independent variants eventually lead to loss of GJIC, which correlated with l

174 s pigmentosa, rod photoreceptor degeneration eventually leads to loss of cone photoreceptors.

175 inherited juvenile macular degeneration that eventually leads to loss of vision.

176 eversible lung inflammatory disease that may eventually lead to lung cancer.

177 o potently induces centrosome amplification, eventually leading to mammary hyperplasia and malignant

178 rtex and neocortices independently of Abeta, eventually leading to memory loss.

179 plate chondrocytes caused a series of events eventually leading to mineralization of these cultures:

180 t cell cycle arrest and cytokinesis defects, eventually leading to mitotic catastrophe/apoptosis.

181 n of covalent bonds in the protein backbone, eventually leading to molecular fracture.

182 nd biological modeling, which together could eventually lead to more accurate diagnoses and treatment

183 food choices in the supermarket, which will eventually lead to more balanced diets and to more benef

184 the inferobasal wall and papillary muscles, eventually leading to myocardial hypertrophy and scarrin

185 activated autophagy, blocked apoptosis, and eventually led to necrosis.

186 age, and reactive oxygen species production, eventually leading to necrotic death of U251 glioma cell

187 ndings have theoretical implications and may eventually lead to neural measures that allow early pred

188 aggregation, disrupt cellular function, and eventually lead to neuronal death.

189 omote their entry into the cell cycle, which eventually leads to neuronal cell death.

190 chondrial fusion and fission proteins, which eventually leads to neuronal stress.

191 t of new antiangiogenic compounds that could eventually lead to new drugs suitable for the treatment

192 s reason to hope that these discoveries will eventually lead to new preventive and therapeutic agents

193 Such results might eventually lead to new strategies that delay or prevent

194 parasites, and it is likely that these will eventually lead to new therapeutic approaches.

195 een surgical and nonsurgical treatments will eventually lead to new therapeutic options.

196 out underlying cellular pathways that should eventually lead to new therapies.

197 led insight into the pathogenesis of EBA may eventually lead to new treatment strategies for EBA and

198 tic applications in mouse models-which might eventually lead to new treatments for patients-as well a

199 racellular kinases, including Zap70 and Syk, eventually leading to NK cell activation.

200 s support a progressive JCV infection, which eventually leads to nonapoptotic cell death.

201 n relation to different disease patterns and eventually lead to optimized therapy.

202 If highly progressive, the fibrotic process eventually leads to organ malfunction and death.

203 n and proteasomal degradation of Mule, which eventually leads to p53 accumulation.

204 ing groups and manipulation of the oxazoline eventually led to pactamycin, pactamycate, and their des

205 espite the presence of DNA-damaging insults, eventually leading to PAH.

206 role of Slug in ADM, an early event that can eventually lead to pancreatic cancer development.

207 edium and large stroke, brain reorganization eventually leads to (partial) normalization of neuronal

208 ent of pharmacological chaperones, which may eventually lead to PD therapeutics.

209 iscuss the most recent developments that may eventually lead to perioperative renal protection.

210 signal a cascade of inflammatory events that eventually lead to permeability-reducing fibrotic encaps

211 ation of salicylic acid, reduced growth, and eventually lead to plant death, consistent with the curr

212 Further temperature increase eventually leads to poly-naphthalenes via reductive elim

213 regulator of breast cancer transitions that eventually lead to poor prognosis.

214 arge number of embryos in the mouse oviduct, eventually leading to pregnancy failure.

215 tropy gain for the rate-limiting step, which eventually leads to propene.

216 Abl-mediated tyrosine phosphorylations that eventually lead to protein kinase Cdelta (PKCdelta)-medi

217 ulfated Tyr335) into the FSH nascent pocket, eventually leading to receptor activation.

218 ures containing clathrin and other proteins--eventually leading to receptor internalization.

219 complexes, increasing the energy of N(beta) eventually leads to reduction from formally [W(VI) ident

220 es being practically relevant, challenge and eventually lead to refinement of theories concerning fun

221 le is compromised, delaying regeneration and eventually leading to regeneration failure.

222 regaining of normal developmental patterns, eventually leading to regeneration of a normal colony.

223 expansion during hematologic remission, and eventually lead to relapsed disease.

224 PARP-1 automodification eventually leads to release from DNA damage thus turning

225 kidneys and deterioration of their function, eventually leading to renal insufficiency.

226 urs with division of normal human cells, and eventually leads to replicative senescence.

227 ssive rise in pulmonary vascular resistance, eventually leading to right-heart failure and death.

228 ogic changes in the pulmonary arterial tree, eventually leads to right heart failure.

229 oth the precursors of the synthetic pathways eventually leading to RNA and to the key components of t

230 with significant atrophy of cell bodies and eventually leads to robust loss (approximately 50%) of s

231 t facilitates changes in adsorption site and eventually leads to S-S bonding.

232 zed Ca(2+) release events started to appear, eventually leading to sarcoplasmic reticulum (SR) Ca(2+)

233 However, prolonged collection of ions eventually leads to saturation of the amalgam accompanie

234 ulting in generation of epileptiform bursts, eventually leading to seizure activity.

235 uctance with increasing on/off current ratio eventually leading to semiconducting behavior, adding co

236 This gradual shortening of telomeres eventually leads to senescence.

237 ts in hair follicle development and cycling, eventually leading to severe hair loss.

238 gate markers and preventive treatments might eventually lead to so-called brain-check scans for deter

239 results in a progressive epileptic state and eventually leads to spontaneous seizures.

240 ome, thus blocking endocytic progression and eventually leading to stable residence.

241 t--chemically hydrogenated plant oils--could eventually lead to substantial reductions in cardiovascu

242 energy balance within the protein structure, eventually leading to such conformational changes.

243 impairments in the hippocampal formation and eventually led to synaptic dysfunction.

244 Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to

245 a kinetic proofreading chain of events that eventually leads to TCR triggering and negative selectio

246 receptor interacting protein kinase-3, which eventually lead to the activation of mixed lineage kinas

247 ion, possibly transducing a signal that will eventually lead to the activation of peptidoglycan remod

248 issegregation and multipolar spindles, which eventually lead to the activation of the DNA damage resp

249 overall view of the initial connections that eventually lead to the complex connectivity of the bulk

250 or zinc finger and polyamide binding and may eventually lead to the development of even more powerful

251 cs of ejaculatory and orgasmic function will eventually lead to the development of new, effective met

252 understanding of the pathogenesis of HL will eventually lead to the development of novel biologically

253 genome-wide association studies, which will eventually lead to the discovery of causal mutations tha

254 genomics for biomedical researchers and may eventually lead to the discovery of the causative genes

255 aps (or local folding defects), and this may eventually lead to the formation of disordered structure

256 petition-rate lasers (sub- to few MHz's) may eventually lead to the generation of high-flux, low-dive

257 MFG-E8 is mediated via the LPS-CD14 pathway, eventually leading to the accruement of apoptotic cells.

258 1 and receptor interacting protein kinase-3, eventually leading to the activation of mixed lineage ki

259 pcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease.

260 ivity increased and nocturnal activity fell, eventually leading to the complete disintegration of cir

261 pread emission into the aquatic environment, eventually leading to the contamination of drinking wate

262 d intrafollicular inflammation was observed, eventually leading to the destruction of virtually all H

263 fixation and maintenance of gene duplicates, eventually leading to the evolution of sexually dimorphi

264 tes; it also has been shown to self-assemble eventually leading to the formation of homo-multimers.

265 pid synthesis enzymes and undergo expansion, eventually leading to the giant LDs characteristic of se

266 modulating PI3K/Akt/GSK-3beta signaling and eventually leading to the high expression and nuclear ac

267 This feedback mechanism eventually leads to the collapse of the foam layer and t

268 The tauopathy in Ch4 eventually leads to the degeneration of the cholinergic

269 the high mutation rate of influenza viruses eventually leads to the development of antiviral resista

270 et1 and concomitantly its catalytic activity eventually leads to the displacement of Mbd1 from methyl

271 This unrelenting replenishment process eventually leads to the exhaustion of the naive CD4+T-ce

272 clusters directly onto the electrode surface eventually leads to the formation of a dense forest of m

273 rs spontaneously before pollen mitosis I and eventually leads to the formation of diploid and polyplo

274 ic pouch only, which launch the pathway that eventually leads to the formation of the adult that emer

275 random niche stem cell loss with replacement eventually leads to the loss of all stem cell lineages e

276 ed, causing wear and increasing shear, which eventually leads to the osteochondral degeneration.

277 This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and s

278 This contraction eventually leads to the restoration of the rest tension

279 ess, so posaconazole treatment was begun and eventually led to the cure of his infection.

280 with a decreased response to novel odors and eventually led to the demise of adult-born GCs.

281 elective Syk inhibitors and the efforts that eventually led to the desired improvements in physicoche

282 table agricultural extensification, and also eventually led to the development of a mounted warrior e

283 ls further eroded the beta-cell identity and eventually led to the development of undifferentiated pa

284 duction of a m-fluorine in the benzyl moiety eventually led to the discovery of compound 21b, a poten

285 sure the dimensions of oil monolayers, which eventually led to the formulation of the contemporary li

286 plants, including their medicinal uses, and eventually led to the plants' domestication.

287 ibuted to the mutant cell S-phase arrest and eventually led to the retarded cell growth.

288 tion of a partially folded intermediate that eventually leads to their increased oligomerization prop

289 effector binding function of Rho-GTPases and eventually leads to their proteasome-mediated degradatio

290 rther mutations in Brca1-delta11 thymocytes, eventually leading to thymic lymphoma formation.

291 favoring infection and inflammation that may eventually lead to tissue remodeling and respiratory dis

292 .g., Yersinia) Abs cross-reactive with TSHR, eventually leading to TSAbs.

293 emotaxis of microvascular endothelial cells, eventually leading to tumor neovascularization.

294 are known to form interacting circuits that eventually lead to various signaling events, detection o

295 s I alleles and that loss of these responses eventually leads to viremia.

296 in a dense vascularized corneal pannus, and eventually leading to visual impairment.

297 rofoundly affects their spatial distribution eventually leading to vortex cluster formation.

298 urn, triggers a cascade of oxidative events, eventually leading to water splitting and oxygen evoluti

299 overloads proliferating to downstream nodes eventually leading to widespread power outages, or syste

300 These false assignments will eventually lead to wrong conclusions on the structural i