ライフサイエンスコーパス: evolutionary change

1 rations in regulatory networks contribute to evolutionary change.

2 ions, a property that seems contradictory to evolutionary change.

3 process, is dominated by events of concerted evolutionary change.

4 heritable disease and the ultimate source of evolutionary change.

5 vel environment to directing the patterns of evolutionary change.

6 r a window into the genetic underpinnings of evolutionary change.

7 reate a time void which could aid additional evolutionary change.

8 ems can evolve to both promote and constrain evolutionary change.

9 nt understanding of the mechanistic basis of evolutionary change.

10 al factors can instruct our understanding of evolutionary change.

11 n may be a general mechanism contributing to evolutionary change.

12 regulation are also the most susceptible to evolutionary change.

13 ng diversity into a population and promoting evolutionary change.

14 ate but not be absolutely required for rapid evolutionary change.

15 ions, particularly under conditions of rapid evolutionary change.

16 mense potential to address the mechanisms of evolutionary change.

17 ge and environmental deterioration caused by evolutionary change.

18 lar phylogenies suggest smoother patterns of evolutionary change.

19 oth condition-dependent and subject to rapid evolutionary change.

20 s therefore expected to provide insight into evolutionary change.

21 and demonstrates how development helps shape evolutionary change.

22 l selection is acting to cause slow, gradual evolutionary change.

23 of museum specimens as "silent witnesses" of evolutionary change.

24 hat patterning of growth must be amenable to evolutionary change.

25 a functional consequence of this structural evolutionary change.

26 ading results about the genes involved in an evolutionary change.

27 purely phenotypic estimates of selection and evolutionary change.

28 e the genome, they could be a rich source of evolutionary change.

29 nce of confounding effects of post-insertion evolutionary change.

30 insight into the ways behavior may influence evolutionary change.

31 studies help us understand the processes of evolutionary change.

32 quently, such sequences are subject to rapid evolutionary change.

33 es might reflect a general mechanism driving evolutionary change.

34 ith reduced plant fitness possibly hindering evolutionary change.

35 ory evolution, one of the basic processes of evolutionary change.

36 indicate types of network linkage subject to evolutionary change.

37 permits them to shift location as a part of evolutionary change.

38 hly conserved, it is uniquely susceptible to evolutionary change.

39 rsification can be overcome by ecological or evolutionary change.

40 species to understand the genetic basis for evolutionary change.

41 nderscore the need to link macroecology with evolutionary change.

42 istatic interactions can frustrate and shape evolutionary change.

43 h changes in numbers or size structure cause evolutionary change.

44 ies and creating a cascade of ecological and evolutionary change.

45 al view, point centromeres can undergo rapid evolutionary changes.

46 the face of unpredictable environmental and evolutionary changes.

47 subgroup of a species may lead to important evolutionary changes.

48 asts of higher plants has undergone dramatic evolutionary changes.

49 edictability underlying the genetic basis of evolutionary changes.

50 size the molecular mechanisms underlying the evolutionary changes.

51 ressures can then influence subsequent rapid evolutionary changes.

52 trict version of stasis that entails no real evolutionary changes.

53 As (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known e

54 uses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes

55 y, we evaluated the extent of both long term evolutionary changes, across the mammalian phylogeny of

56 owever, if a stock is managed optimally, the evolutionary changes actually increase economic yield be

57 species, gain insight into the direction of evolutionary change and assess whether breakpoint region

58 genetic conflict, are an important motor for evolutionary change and innovation.

59 Mutations stimulate evolutionary change and lead to birth defects and cancer

60 Although rates of evolutionary change and selection pressures varied among

61 3-year period, we show that both the rate of evolutionary change and the pattern of natural selection

62 address this issue, we estimated the rate of evolutionary change and time of origin of each segment o

63 g on the phylogeny was conducted to identify evolutionary changes and to assess the correlation betwe

64 the source of genetic variation required for evolutionary change, and are therefore important for man

65 Heritable variation is the raw material for evolutionary change, and understanding its genetic basis

66 This combination of evolutionary changes appears to have resolved an adaptiv

67 y common situation in changing environments: evolutionary changes are not strong enough to fully comp

68 rapid evolution, but it is not known whether evolutionary changes arise mainly after successful colon

69 testing whether these genes experience rapid evolutionary change as a result of conflict over spore-s

70 gists and biochemists, who used experimental evolutionary change as a tool to understand structure-fu

71 complexities of the Bologna process and its evolutionary changes as it relates to nursing education

72 provide an original example of rapid ongoing evolutionary change associated with relaxed selection (l

73 teractions between bacterial cells can drive evolutionary change at the population level, but signifi

74 that directly links regulatory mutations to evolutionary change at the species level.

75 pport the general prediction that functional evolutionary changes at pleiotropic loci will most often

76 hermobifida fusca, we were able to show that evolutionary changes balance ATP energetic consideration

77 yptic evolution has been defined as adaptive evolutionary change being masked by concurrent environme

78 branch lengths record the amount of time or evolutionary change between successive events of speciat

79 an-altered habitats and is a known driver of evolutionary change, but evidence and understanding of t

80 This evolutionary change can be startlingly rapid, making wee

81 late with the strength of selection, whereas evolutionary change can leave an ecological signature.

82 biologists have increasingly recognized that evolutionary change can occur rapidly when natural selec

83 Theory suggests evolutionary change can significantly influence and act

84 operative behaviors, thus demonstrating that evolutionary changes can have profound implications for

85 was a time of fundamental environmental and evolutionary change, culminating in the first appearance

86 and body size have been used as a proxy for evolutionary change, despite the validity of this approa

87 daptation and, consequently, the dynamics of evolutionary change differed qualitatively among scenari

88 of the ratio of nonsynonymous to synonymous evolutionary changes (dN/dS ratio) located a region of o

89 red as ratios of nonsynonymous to synonymous evolutionary changes [dN/dS ratios]) acting on individua

90 enetic divergence and test for signatures of evolutionary change driven by long-term simulated climat

91 a vertebrate population provides evidence of evolutionary change due to selective pressure at a singl

92 Evolutionary change during infection is often interprete

93 ese patterns exemplify the complex nature of evolutionary changes during dog domestication: the crani

94 logs in sister species shows that subsequent evolutionary changes following the birth of JGW altered

95 Surprisingly, the major locus of evolutionary change for KChIP2 gene expression in heart

96 in understanding the consequences of ongoing evolutionary change for populations, communities and eco

97 ating on contemporary humans, predict future evolutionary change for specific traits with medical sig

98 linking urban development patterns to rapid evolutionary changes for species that play important fun

99 r fitness may yield erroneous projections of evolutionary change, for example if there is little or n

100 Heckmann et al. simulate likely sequences of evolutionary changes from C3 to C4 photosynthesis bioche

101 e been put forward attempting to explain the evolutionary changes from monkeys to humans that potenti

102 The evolutionary changes had significant repercussions for t

103 demonstrate that both subtle and significant evolutionary change has occurred within antibody epitope

104 s resulting from scenarios where substantial evolutionary change has taken place in a small number of

105 While the mechanisms underlying these evolutionary changes have not been elucidated, altered a

106 Unexpectedly, substantial evolutionary changes have occurred in giraffe and okapi

107 lopment are highly conserved and that recent evolutionary changes have occurred primarily in the char

108 buffer global change effects through marked evolutionary changes, highlighting the importance of fac

109 These evolutionary changes impact nearly all members of the hn

110 The revealed evolutionary changes imply unrealized risks present in g

111 function, we then demonstrate that adaptive evolutionary change in a duplicated gene of the anthocya

112 Phenotypic plasticity can influence evolutionary change in a lineage, ranging from facilitat

113 Here, we show that evolutionary change in a region of the brain devoted to

114 Evolutionary change in animal morphology results from al

115 te change and for the opportunity to observe evolutionary change in contemporary time.

116 the regulatory genome, causal explanation of evolutionary change in developmental process must be con

117 Evolutionary change in gene expression is generally cons

118 Evolutionary change in gene regulation can result from c

119 A major mechanism of evolutionary change in GRN structure is alteration of ci

120 he beta(A)-globin gene has contributed to an evolutionary change in hemoglobin (Hb) function in high-

121 that the tectum's reduced size is due to an evolutionary change in how much tissue was allocated to

122 Evolutionary change in individual species has been hypot

123 tifying predictable, directional patterns of evolutionary change in island birds, however, has proved

124 However, Fisher emphasized that evolutionary change in itself is likely to be an importa

125 lysis of tooth microwear, we show that rapid evolutionary change in Miocene stickleback was associate

126 in shaping complex adaptations that require evolutionary change in multiple genes.

127 e assessment of the anthropogenic impacts on evolutionary change in natural populations, we need long

128 This evolutionary change in pathogen characteristics is predi

129 crobes are rarely investigated as drivers of evolutionary change in plants.

130 preexisting folds and, in particular, to an evolutionary change in secondary structure and oligomeri

131 The anatomical and physiological basis of evolutionary change in sensory processing at cellular an

132 increase in studies attempting to understand evolutionary change in such populations.

133 for the pattern and timing of ecological and evolutionary change in the fossil record.

134 However, the role of evolutionary change in the pathogen during the progressi

135 he detrimental effects of warming is through evolutionary change in thermal physiology.

136 ittle phenotypic plasticity or potential for evolutionary change in tolerance to high temperature.

137 poral scales of the disease; and analysis of evolutionary change in virus control to identify risks o

138 s to consider social dynamics shown to drive evolutionary change in vitro.

139 ry expression analysis reveal intra-regional evolutionary changes in a multi-regional neural circuit

140 We propose a model of evolutionary changes in Act1-mediated signalling, which

141 Evolutionary changes in ancestral regulatory circuits ca

142 tomy, development, and genomics suggest that evolutionary changes in AP patterning establish ecologic

143 ransgenic overexpression of GDF6 phenocopies evolutionary changes in armor-plate size.

144 Evolutionary changes in both host and pathogen lead to a

145 ween two closely related species result from evolutionary changes in brain development.

146 Collectively these findings indicate that evolutionary changes in brain region proportions are cau

147 from butchering processes could have fueled evolutionary changes in brain size.

148 olecules-and thereby modules-associated with evolutionary changes in cell-biological phenotypes.

149 Our results show how evolutionary changes in cis as well as trans acting sign

150 comparison among Onygenales genomes revealed evolutionary changes in Coccidioides that may underlie i

151 To identify evolutionary changes in connectivity patterns, we quanti

152 Evolutionary changes in CorTFL1 and CorAP1 expression co

153 appreciation for the relative importance of evolutionary changes in different regulatory genetic and

154 Several lines of evidence suggest that evolutionary changes in dopaminergic afferents of the st

155 ological niches are rare compared to gradual evolutionary changes in existing traits.

156 ploration of intraspecific plasticity versus evolutionary changes in gastropod nervous systems.

157 for identifying, quantifying, and polarizing evolutionary changes in gene expression profiles across

158 Evolutionary changes in gene expression underlie many as

159 heory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent

160 We also discuss how evolutionary changes in genomic elements influence socia

161 en the applicability of this model and probe evolutionary changes in gradient distributions, we adjus

162 fic traits and novel structures results from evolutionary changes in GRNs.

163 t retropositions are associated with greater evolutionary changes in H3K27me3 and gene expression tha

164 s enigma in some detail, identifying several evolutionary changes in hippocampal cytoarchitecture and

165 derstanding trade-offs in host use caused by evolutionary changes in host immune responses and parasi

166 on of somas of putative HSN, consistent with evolutionary changes in HSN migration.

167 lectroreception and demonstrate how discrete evolutionary changes in ion channel structure facilitate

168 al models to investigate the consequences of evolutionary changes in language area connectivity and d

169 uggestions that parent-offspring conflict or evolutionary changes in life history might drive placent

170 election, setting the stage for contemporary evolutionary changes in local populations.

171 in transcriptional networks and suggest that evolutionary changes in LYRATE expression may contribute

172 ing approach to compare the genetic basis of evolutionary changes in male-limited pigmentation in sev

173 ing cochlear development and to interpreting evolutionary changes in mammalian hearing.

174 of natural morphological variation caused by evolutionary changes in miRNA expression.

175 ant Physcomitrella patens in order to assess evolutionary changes in mitochondrial and plastid proteo

176 ailed the remarkable plasticity and speed of evolutionary changes in multidrug-resistant K. pneumonia

177 Evolutionary changes in organismal traits may occur eith

178 putational methods for investigating coupled evolutionary changes in pairs of positions along the ami

179 ver, to what extent elevated CO2 will induce evolutionary changes in photosynthetic organisms is stil

180 Evolutionary changes in placental morphology remain poor

181 lant productivity and impacts ecological and evolutionary changes in plant populations.

182 y a few dominant drivers explain most of the evolutionary changes in population growth rates.

183 oth timing and dependence on Hfq, suggesting evolutionary changes in posttranscriptional regulation b

184 developmental cost hypothesis, we show that evolutionary changes in pre- and postnatal brain growth

185 rsatile and scalable approach to investigate evolutionary changes in protein function and thus can pr

186 By studying the reversibility of evolutionary changes in protein structure and function,

187 f conservation, we detected many non-neutral evolutionary changes in protein-coding genes and noncodi

188 genetic toolkits of deeply conserved genes, evolutionary changes in protein-coding genes, cis regula

189 MA silk evolved ~376 MYA and identifying how evolutionary changes in proteins influenced silk mechani

190 olved from C3 ancestors, this work links the evolutionary changes in sequence, PPCK expression, and p

191 Evolutionary changes in staging embryogenesis and in mut

192 s, and bioinformatics provides means to link evolutionary changes in structure-dynamics function to t

193 of knowledge concerning the variability and evolutionary changes in termite breeding structure.

194 results highlight a significant tolerance to evolutionary changes in TF binding intensity in mammalia

195 Key to cell type identity are evolutionary changes in the 'core regulatory complex' (C

196 We analyzed the molecular evolutionary changes in the attachment (G) glycoprotein

197 s within Florideophyceae were accompanied by evolutionary changes in the carposporophyte stage, leadi

198 , we propose a method that aims at detecting evolutionary changes in the configuration of a complex s

199 rstanding of complex internal morphology and evolutionary changes in the cranium.

200 Specifically, evolutionary changes in the expression boundary of Ubx h

201 Our data suggest that evolutionary changes in the expression profile of indivi

202 ynamics and tissue specification result from evolutionary changes in the gene regulatory network that

203 It also explores the evidence for evolutionary changes in the genetic structure of anatomi

204 In theory, a few naturally occurring evolutionary changes in the genome of a model organism m

205 mans can be traced back to developmental and evolutionary changes in the lateral frontoparietal netwo

206 This observation indicates recent evolutionary changes in the osmoprotection strategy of t

207 cular recognition mechanisms associated with evolutionary changes in the pIgR protein.

208 Heterochrony, that is, evolutionary changes in the relative timing of developme

209 anding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs

210 species that are uncovering new evidence for evolutionary changes in the size and the number of neuro

211 in substrate discrimination as reflected in evolutionary changes in the specificity constant (k(cat)

212 ated great apes leaves unresolved when these evolutionary changes in the timing of cortical developme

213 ing genes and demonstrates the high rates of evolutionary changes in the un-translated regions.

214 m the same or different generations revealed evolutionary changes in their interaction, including an

215 o the Recent; this allowed us to investigate evolutionary changes in these species in response to cli

216 Evolutionary changes in this gene are hypothesized to ha

217 How do evolutionary changes in this organization affect large-s

218 The work also raises questions about the evolutionary changes in this protein family following th

219 Evolutionary changes in traits involved in both ecologic

220 Evolutionary changes in transcription networks are an im

221 channel Nav1.4, were facilitated by ancient evolutionary changes in two other members of the same ge

222 regulates the number of maxillipeds and that evolutionary changes in Ubx expression have generated va

223 the location of RA synthesis correlate with evolutionary changes in vertebrate dentitions.

224 ve polyploidy and aneuploidy are the initial evolutionary changes in yeast selected in vitro to overc

225 ested a role in brain evolution; however the evolutionary changes involved have not been investigated

226 Although evolutionary changes involving heteroblasty might contri

227 It is currently not known whether evolutionary change is likely to be able to keep pace wi

228 This evolutionary change is likely to destabilize the host-pa

229 in an experimental design in which host cell evolutionary change is prevented.

230 olve and which molecular components underlie evolutionary changes is poorly understood.

231 on created by mutation, the raw material for evolutionary change, is translated into phenotypes by fl

232 e this methodology emphasizes the process of evolutionary change, it is easier to test and interpret

233 thus elucidating the mechanisms of adaptive evolutionary change leading to evolutionary novelty.

234 field to better understand the molecular and evolutionary changes leading to pandemic strains.

235 Accounting for evolutionary change may be critical when predicting the

236 Feedbacks between ecological and evolutionary change may play important roles in communit

237 ment, consistent with suggestions that their evolutionary changes may have altered social and/or cogn

238 lity is as high as it has been historically, evolutionary changes may result in economic losses, but

239 Although these evolutionary changes most likely contributed to the orig

240 Importantly, neither the negative evolutionary change, nor the selective pressures that dr

241 terized by profound global environmental and evolutionary changes, not least of which included a majo

242 um DSX binding sites was used to examine the evolutionary changes occurring in DSX and its targets in

243 This theory assumes that significant evolutionary change occurs over ecologically relevant ti

244 y Synthesis is needed to reconceptualize how evolutionary change occurs.

245 In addition, we found that the evolutionary change of copy number of OR genes approxima

246 Antagonistic coevolution--the reciprocal evolutionary change of interacting species--might reconc

247 f genetic processes and increase the rate of evolutionary change of the bacterial host, which could u

248 specific families of flies, reveals frequent evolutionary changes of body axis determinants and a rem

249 ecialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and th

250 We speculate that evolutionary changes of intramolecular regulation have l

251 To understand the evolutionary changes of OR genes, we identified all OR g

252 In contrast, evolutionary changes of the epigenome and the transcript

253 h factors might have contributed to the fast evolutionary changes of this gradient.

254 cis-regulatory elements but can also require evolutionary changes of transcription factor proteins th

255 sitional vertebrae survive to allow eventual evolutionary changes of trunk vertebral numbers.

256 acts on nontarget species, including driving evolutionary change, often with unknown consequences for

257 Although the genomes showed very little evolutionary change on a nucleotide level, we found evid

258 ns between closely related species can drive evolutionary change on observable time scales.

259 By tracing the evolutionary changes on a molecular phylogeny, we found

260 has been a prime example of recapitulation - evolutionary change (phylogeny) mirrored in development

261 Collectively, these evolutionary changes probably occurred to minimize delet

262 The nature of evolutionary changes recorded by the fossil record has l

263 The subject of CAAs is undergoing profound evolutionary changes related to the definition, morphoge

264 Moreover, how they might affect evolutionary change remains enigmatic.

265 Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4].

266 but quantifying the selective forces shaping evolutionary changes remains challenging.

267 d linguistic barriers and can promote faster evolutionary changes shaped by gene-culture interactions

268 ed that TFC number regulation is a target of evolutionary change that affects ovariole number.

269 These traits could all result from an evolutionary change that enhanced radial migration of NS

270 in an ultrasocial manner without the radical evolutionary changes that are experienced by other speci

271 ffer unique opportunities to reconstruct the evolutionary changes that decouple male and female trait

272 dentity might therefore uncover the steps of evolutionary changes that eventually resulted in modific

273 systems for interrogating the types of deep evolutionary changes that have restructured developmenta

274 ting in the community, but we found multiple evolutionary changes that in combination over time incre

275 a major challenge is to detect genomic-level evolutionary changes that increase microbial virulence.

276 The evolutionary changes that led to the muscular anatomy of

277 The evolutionary changes that occur over a small number of g

278 In SLO3 channels this region may permit evolutionary changes that tune the gating properties in

279 ronmental change is expected to generate eco-evolutionary change, that changes in the average environ

280 s once provided the main data for studies of evolutionary change, the mechanisms shaping phenotypic d

281 The most widely accepted model of evolutionary change, the Modern Evolutionary Synthesis,

282 These results suggest that evolutionary changes to neocortical development promotin

283 Here, we examine evolutionary changes to the sequence and structure of sp

284 We find that evolutionary changes toward faster growth and earlier ma

285 equence provides important insights into the evolutionary changes underlying host specialization.

286 entury constitutes an exceptional case of an evolutionary change, varying in both time and space, and

287 ity and circuitry of nervous systems undergo evolutionary change, we lack understanding of the genera

288 the indirect effects of predators influence evolutionary change, we reared second-generation-born fi

289 understand the physical constraints on these evolutionary changes, we reconstructed in silico ancestr

290 Estimates of rates of evolutionary change were similar to those observed in ot

291 Constraint is particularly likely to govern evolutionary change when a trait is at perceived upper o

292 also for the understanding of human-induced evolutionary change, which is an increasingly important

293 paradox" highlights our inability to predict evolutionary change, which is especially concerning with

294 predicts that directional selection leads to evolutionary change while depleting standing genetic var

295 netic heterogeneity is the result of ongoing evolutionary change within each cancer.

296 ution, and is likely to be a major driver of evolutionary change within species.

297 By extracting correlated evolutionary changes within 700+ sequences, we built a m

298 While several traits have been resolved to evolutionary changes within a single gene, the evolution

299 e results led us to propose a model in which evolutionary changes within and between the antigenicall

300 This EE strategy may reflect evolutionary changes within the holometabolous insects a