ライフサイエンスコーパス: evolutionary conservation

1 itional genomic or other attributes (such as evolutionary conservation).

2 y of diverse ParB homologs, suggesting broad evolutionary conservation.

3 ome organization, fast mutation rate and low evolutionary conservation.

4 determine the same stoichiometry, indicating evolutionary conservation.

5 vivo occupancy, binding site prediction, and evolutionary conservation.

6 and a rationale for the minor spliceosome's evolutionary conservation.

7 tolerance to loss-of-function mutations and evolutionary conservation.

8 middle, in parallel with a higher degree of evolutionary conservation.

9 or all these functions, despite their strict evolutionary conservation.

10 be influenced by mechanisms that show strong evolutionary conservation.

11 d mouse, we demonstrate their functional and evolutionary conservation.

12 omic information such as gene annotation and evolutionary conservation.

13 tures, post-translational modifications, and evolutionary conservation.

14 regions, with greater than 95% showing clear evolutionary conservation.

15 Many lncRNAs show poor evolutionary conservation.

16 ding spatial clustering of residue types and evolutionary conservation.

17 coding sORF for evidence of transcription or evolutionary conservation.

18 ucleotide polymorphisms, gene expression and evolutionary conservation.

19 as independently correlated with measures of evolutionary conservation.

20 sstalk is evident from the analysis of their evolutionary conservation.

21 place their yeast counterparts demonstrating evolutionary conservation.

22 erved in Caenorhabditis briggsae, indicating evolutionary conservation.

23 ineage-specific lncRNAs indicated their weak evolutionary conservation.

24 ween signal intensity, genomic coverage, and evolutionary conservation.

25 Our findings demonstrate the evolutionary conservation across all gnathostomes of at

26 ion methods have been proposed that quantify evolutionary conservation among homologous proteins from

27 ic marks at their transcription start sites, evolutionary conservation among other schistosome specie

28 However, due to the lack of evolutionary conservation amongst diverse viruses, it is

29 Structural and evolutionary conservation analysis identified a highly v

30 Gene ontology and evolutionary conservation analysis suggest that these T-

31 Here we use evolutionary conservation analysis to build a model stru

32 rimordial activity that explains their great evolutionary conservation and abundant expression in mos

33 Based on prior studies indicating evolutionary conservation and adaptation of morphinergic

34 he cis-eQTL genes exhibit lower-than-average evolutionary conservation and are depleted for developme

35 y across diverse species due to processes of evolutionary conservation and convergence.

36 retain wild-type fitness was correlated with evolutionary conservation and distance to active site, a

37 To evaluate the evolutionary conservation and divergence of APA patterns

38 of choriogenesis that takes into account the evolutionary conservation and divergence of the underlyi

39 Its importance is confirmed by the evolutionary conservation and diversification of alterna

40 sible 8-base-pair sequences, we examined the evolutionary conservation and enrichment within putative

41 c complexity enhances the potential for both evolutionary conservation and evolutionary innovation.

42 Here we reveal the evolutionary conservation and function of m(6)A by mappi

43 xamples, most (>95%) show little evidence of evolutionary conservation and have been suggested to rep

44 RBDs display a high degree of evolutionary conservation and incidence of Mendelian mut

45 CNS function is implied by evolutionary conservation and independently supported be

46 The high evolutionary conservation and low redundancy of Drosophi

47 dering by periodic structure (CYCLOPS), uses evolutionary conservation and machine learning to identi

48 elated cell-type dynamics exhibited striking evolutionary conservation and modulated behavior similar

49 lie in the intergenic region, which exhibits evolutionary conservation and open chromatin conformatio

50 motif scores, TF footprints, CpG/GC content, evolutionary conservation and other factors in an ensemb

51 We conclude that the patterns of long-term evolutionary conservation and permissible sequence diver

52 , "core" and "rim", which differ in terms of evolutionary conservation and physicochemical properties

53 To study the evolutionary conservation and physiological functions of

54 At GGAA repeat elements, which lack evolutionary conservation and regulatory potential in ot

55 in vivo relevance of these targets, and the evolutionary conservation and relevance of these targets

56 ated start codon, and additional analysis of evolutionary conservation and ribosome footprinting sugg

57 Our analysis of evolutionary conservation and structural properties reve

58 of individual mutations were correlated with evolutionary conservation and structural stability.

59 otide "microexons" display the most striking evolutionary conservation and switch-like regulation.

60 I cleavage patterns mirror nucleotide-level evolutionary conservation and track the crystallographic

61 (SNPs) to areas of chromatin accessibility, evolutionary conservation and transcription factor bindi

62 approach consisting of searching lncRNAs by evolutionary conservation and validating their expressio

63 le in vitro assays, chromatin accessibility, evolutionary conservation, and pCRE combinatorial relati

64 Shared variants were filtered for rarity, evolutionary conservation, and predicted functional sign

65 tal signaling mechanisms and their potential evolutionary conservation are incompletely understood.

66 e genomic analyses based on the principle of evolutionary conservation are needed to enable a complet

67 the large nonkinase domain of Hsl1p by using evolutionary conservation as a guide, identifying region

68 ations with respect to the widespread use of evolutionary conservation as a surrogate for functionall

69 specific sequences recognized by the TFs and evolutionary conservation, as well as cell type-specific

70 been identified, little is known about their evolutionary conservation at the level of species and su

71 data, RNA secondary-structure stability, and evolutionary conservation at the protein and nucleic-aci

72 RF set: (1) coding-potential prediction, (2) evolutionary conservation between P. deltoides and other

73 rithms are used for verification in terms of evolutionary conservation, biological importance of bind

74 itional subset of transcripts that have high evolutionary conservation but may include short ORFs and

75 erforms not only previous tools that utilize evolutionary conservation, but also several highly used

76 er purifying selection should show increased evolutionary conservation compared to typical protein-co

77 sis of all AGXT missense variants, including evolutionary conservation data in a multisequence alignm

78 Translational evidence for 10 genes, evolutionary conservation data supporting 35 predictions

79 sidues in a dataset of 524 distinct enzymes: evolutionary conservation decreases approximately linear

80 lly important plant AS events based on their evolutionary conservation, determine the influence of ge

81 ddressing functions, phenotypes, expression, evolutionary conservation, disease association, protein

82 , axosomatic synaptic endings whose size and evolutionary conservation emphasize their importance.

83 well defined and describe a unique story of evolutionary conservation extending from sequence identi

84 Cistematic uses two different evolutionary conservation-filtering algorithms in conjun

85 redictors are based on protein structure and evolutionary conservation, following the assumption that

86 r to the Toll-like receptors (TLRs) in their evolutionary conservation from flies to mammals.

87 tional protein design that uses knowledge of evolutionary conservation from protein structural famili

88 Evolutionary conservation, functional genomics, chromati

89 paternal allele-specific expression, and the evolutionary conservation further suggests potential rol

90 ted that this biophysically motivated use of evolutionary conservation gives rise to dramatic improve

91 ere, we confirm this unusual pattern and its evolutionary conservation in additional samples from var

92 r function of Hint and the rationale for its evolutionary conservation in bacteria have remained a my

93 tional properties are correlated with higher evolutionary conservation in both DNA and RNA motifs and

94 Because of the evolutionary conservation in dopaminergic neurotransmiss

95 nteractions (SeedNet) that shows evidence of evolutionary conservation in flowering plants.

96 ion in A. thaliana, suggesting that there is evolutionary conservation in gene imprinting.

97 Given its evolutionary conservation in jawed vertebrates, we used

98 n the present study we took advantage of the evolutionary conservation in the biogenesis of beta-barr

99 Deep evolutionary conservation in the genetic programs of put

100 ands in gene transcription strongly suggests evolutionary conservation in the mammalian genome.

101 bines structural similarity and accounts for evolutionary conservation in the template interfaces.

102 these putative stem cells, along with their evolutionary conservation in vertebrates and the signall

103 and position specificity, in addition to the evolutionary conservation, in discovering cis-regulatory

104 and the high degree of microRNA-binding site evolutionary conservation indicates that all members of

105 if confidence, which enables us to translate evolutionary conservation into a confidence measure for

106 Furthermore, evolutionary conservation is an important discriminating

107 To cope with the high false positives, evolutionary conservation is routinely used.

108 ization on gene expression and its degree of evolutionary conservation is still poorly understood.

109 betaIII as well as with the observation that evolutionary conservation is total for Ala(428) and freq

110 long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and cance

111 Thus ISE2's evolutionary conservation may be explained by its numero

112 esponses that targeted epitopes with greater evolutionary conservation (mean entropy [+/-SD], 0.32 +/

113 Consistent with evolutionary conservation, mir-34b/mir-34c were also dow

114 ving changes maintain enhancer activity; (2) evolutionary conservation, nucleosome exclusion, binding

115 uracy during translation, and the widespread evolutionary conservation of aaRS proofreading pathways,

116 The evolutionary conservation of abundant miRNAs in normal p

117 This finding has implications for the evolutionary conservation of Ago proteins in the mammali

118 functional results are reflected in the high evolutionary conservation of all four glycosylation site

119 Here, we assess directly the evolutionary conservation of alphabeta TCR specificity f

120 edicted to contain SHF progenitors, based on evolutionary conservation of ALPM patterning.

121 The evolutionary conservation of amino acid residue serine 1

122 ground genotype of the strain used, and that evolutionary conservation of amino acids in eRF1 is only

123 The degree of evolutionary conservation of an amino acid in a protein

124 The evolutionary conservation of an arginine guanidinium as

125 n, the existence of the [URE3] prion and the evolutionary conservation of an N-terminal extension hav

126 Given the evolutionary conservation of APC in Wnt signal transduct

127 genetic approach that takes advantage of the evolutionary conservation of AR signaling, we have condu

128 ct of ARK1 binding on transcript levels, and evolutionary conservation of ARK1 binding loci.

129 etermined human ASC-PYD filament, suggesting evolutionary conservation of ASC-dependent inflammasome

130 The number, diversity, and apparent evolutionary conservation of autoantibody profiles sugge

131 TUNA showed striking evolutionary conservation of both sequence- and CNS-rest

132 The method requires not only evolutionary conservation of candidate TFBSs and sets of

133 the geometry, physicochemical properties and evolutionary conservation of catalytic residue activity.

134 Evolutionary conservation of cellular pathways that resp

135 Results suggest evolutionary conservation of chimeric signals and bimoda

136 To test whether evolutionary conservation of cis-regulatory modules (CRM

137 uptake induced by dAMN knockdown, suggesting evolutionary conservation of Cubilin/AMN co-receptors fu

138 Given the general evolutionary conservation of developmental signaling mec

139 analysis of the functional implications and evolutionary conservation of different compositionally b

140 Evolutionary conservation of DNA sequences provides a to

141 mapped to the target genome using TransMap, evolutionary conservation of DNA, mRNA and ESTs of the t

142 epresents the first experimental test of the evolutionary conservation of dynamic behavior and demons

143 imary objective of this work was to test the evolutionary conservation of dynamic behavior for a part

144 In addition, the evolutionary conservation of each A. thaliana sORF was e

145 es comparative genomic analysis to study the evolutionary conservation of each cluster.

146 Evolutionary conservation of efficient T[CPD]T bypass by

147 nserved heart enhancers and suggest that the evolutionary conservation of embryonic enhancers can var

148 Comparative genomic analysis revealed that evolutionary conservation of enhancers decreases followi

149 es have suggested a relatively low degree of evolutionary conservation of experimentally defined TF b

150 Moreover, the evolutionary conservation of fasting regulation of SREBP

151 The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta

152 N) protein rescues asun flies, demonstrating evolutionary conservation of function.

153 ian cells and in Xenopus embryos, indicating evolutionary conservation of function.

154 s for zebrafish snrk-1 knockdown, suggesting evolutionary conservation of function.

155 se three GATA1 motifs, we demonstrate strong evolutionary conservation of GATA1 motifs in regulatory

156 of methylation profiles among species reveal evolutionary conservation of gene body methylation patte

157 We also provide genomewide evidence that the evolutionary conservation of genes and gene sequences po

158 isms have revealed a surprising depth to the evolutionary conservation of genetic modules.

159 The evolutionary conservation of H3 and H4 cytoplasmic acety

160 These results demonstrate the evolutionary conservation of haem sensing among multiple

161 The evolutionary conservation of hepatovirus structure and p

162 The extensive evolutionary conservation of insomniac and Cul3 suggests

163 The biological relevance and evolutionary conservation of iT cells have recently been

164 ed on the secondary structure prediction and evolutionary conservation of its sequence.

165 We assessed the prevalence and evolutionary conservation of J-protein complexation and

166 both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional

167 Overall the results shed light on evolutionary conservation of Ku, X4, and L4 activities,

168 As one indication of the evolutionary conservation of Kv1 channel functions, muta

169 troyed there, providing a hypothesis for the evolutionary conservation of large CD1 families containi

170 of this interaction may be reflected in the evolutionary conservation of length and anionic charge i

171 Given the evolutionary conservation of let-7-C microRNA sequences

172 Our studies demonstrate unanticipated evolutionary conservation of mature tRNA processing to t

173 ype 2a, type 2b, and type 3), suggesting the evolutionary conservation of milestones of neuronal deve

174 elegans and that this provides evidence for evolutionary conservation of molecular components of a p

175 ted in carcinogenesis, because of the strong evolutionary conservation of molecular mechanisms betwee

176 r Ciona intestinalis were found, pinpointing evolutionary conservation of most regulatory cascades un

177 The extraordinary level of evolutionary conservation of MR1 and the limited known d

178 y, which transitions to apoptosis, revealing evolutionary conservation of myocardin function in SMCs

179 aracterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties

180 Ia antigen-processing and -presenting genes, evolutionary conservation of NKT-class Ib recognition, a

181 delays WD in human DRG neurons demonstrating evolutionary conservation of NMNAT function.

182 The positions and evolutionary conservation of O-Man glycans in cadherins

183 Despite the evolutionary conservation of omega and its role in assem

184 immunological memory and may account for the evolutionary conservation of parasite macrophage migrati

185 ched bins were analyzed for the presence and evolutionary conservation of Pitx2 consensus binding seq

186 re further analyzed for the presence and the evolutionary conservation of Pitx2 consensus binding seq

187 The marked evolutionary conservation of Pitx2 function in eye and c

188 trating the specificity of the knockdown and evolutionary conservation of pitx2a function.

189 Our results describe a link between the evolutionary conservation of plant MIRNAs and the mechan

190 The evolutionary conservation of Pol III affirms its potenti

191 bation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances

192 ifies a gene's intolerance to mutation using evolutionary conservation of protein sequences and can i

193 upstream regions of genes; (iii) examine the evolutionary conservation of putative TFBSs by phylogene

194 ntact and cell-free preparations demonstrate evolutionary conservation of regulation.

195 We explored evolutionary conservation of regulatory elements and nat

196 o share co-expression is further evidence of evolutionary conservation of regulatory mechanisms.

197 Considering the evolutionary conservation of rOmpB and its crucial contr

198 In this study, we systematically studied the evolutionary conservation of SLiMs recognized by SH2, SH

199 Here, we review the structure and evolutionary conservation of SUN and KASH domain-contain

200 Furthermore, we quantify the evolutionary conservation of surface patches by an index

201 To test the evolutionary conservation of SV sRNAs we examined isolat

202 The evolutionary conservation of T lymphocyte subsets bearin

203 Thus, despite evolutionary conservation of talin's integrin/cytoskelet

204 ls from human and mouse, we demonstrate that evolutionary conservation of TFBEs within orthologous pr

205 ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old ox

206 his structure/function analysis demonstrates evolutionary conservation of the ancient Nudt16 protein

207 Given the evolutionary conservation of the asDOG1 promoter, we pro

208 Owing to evolutionary conservation of the ATP-binding site, most

209 The extreme evolutionary conservation of the BSL suggests that it re

210 We observed a remarkable evolutionary conservation of the DNA binding preferences

211 We investigated the evolutionary conservation of the dopaminergic repressor

212 Taking advantage of the evolutionary conservation of the E2F pathway, we have co

213 Evolutionary conservation of the EDC and the transcripti

214 ction of its human counterpart suggested the evolutionary conservation of the elucidated architecture

215 Thus, despite evolutionary conservation of the entire MeCP2 protein se

216 This is reflected by the evolutionary conservation of the functional short altern

217 parathyroid glands, begging questions on the evolutionary conservation of the Gcm cascade in higher o

218 spread significance given the high degree of evolutionary conservation of the genes analyzed.

219 Given the evolutionary conservation of the genes involved in energ

220 te occupancy by Brn3a can be correlated with evolutionary conservation of the genomic regions contain

221 0% of the genes tested, indicating extensive evolutionary conservation of the hypoxic regulatory acti

222 The high degree of evolutionary conservation of the identified mutation sit

223 one or an automatically generated profile of evolutionary conservation of the input sequence in the f

224 respective Atg8 proteins, demonstrating the evolutionary conservation of the interaction.

225 Despite strong evolutionary conservation of the invariant TCR-alpha cha

226 The evolutionary conservation of the L1 signature at the PWS

227 These results reveal the evolutionary conservation of the lymphatic-like phenotyp

228 These results suggest evolutionary conservation of the mechanisms for both D/V

229 in yeast cells, indicating a high degree of evolutionary conservation of the mechanisms that control

230 able controversy exists about the nature and evolutionary conservation of the molecular mechanisms th

231 Our findings highlight the evolutionary conservation of the myomaker-myomixer partn

232 , but not cardiac muscle, despite the strong evolutionary conservation of the P838 residue.

233 imal aging, together with the high degree of evolutionary conservation of the pathway, suggests that

234 onal predictions need to be sensitive to the evolutionary conservation of the positions harboring the

235 Our findings reveal evolutionary conservation of the positive Ret/Wnt signal

236 Despite the apparently high evolutionary conservation of the pre-rRNA processing pat

237 site regulation by HD-ZIPIII and KANADI, and evolutionary conservation of the regulator-target relati

238 We propose that evolutionary conservation of the single additional argin

239 The evolutionary conservation of the TAAR family suggests a

240 ling that modular organization underpins the evolutionary conservation of the transcriptome structure

241 We demonstrate the evolutionary conservation of the translocon component Ti

242 Evolutionary conservation of the two routes to skeletal

243 This implies ~200 million years of evolutionary conservation of the underlying immune mecha

244 The evolutionary conservation of the vestibulo-ocular circui

245 Co-localized noisy gene pairs exhibit lower evolutionary conservation of their adjacent genome locat

246 We defined five RBP motifs based on the evolutionary conservation of their recognition sites in

247 Despite a strong evolutionary conservation of their sequences, the concom

248 r opisthokonts, provides a framework for the evolutionary conservation of these accessory subunits an

249 avian and non-human primate spleen, showing evolutionary conservation of these cells.

250 ing transposases Hermes and Tn5 suggests the evolutionary conservation of these DNA rearrangements.

251 The evolutionary conservation of these domains indicates the

252 Evolutionary conservation of this core recognition featu

253 The high degree of evolutionary conservation of this domain implies that st

254 an sulphotransferases, which illustrates the evolutionary conservation of this multifunctional enzyme

255 Despite the importance and evolutionary conservation of this pathway between insect

256 in dTORC2-deficient flies, highlighting the evolutionary conservation of this pathway.

257 The evolutionary conservation of this transcription factor a

258 D8 memory differentiation, suggesting marked evolutionary conservation of this transcriptional progra

259 Together, these data are consistent with evolutionary conservation of TSP-mediated H2S as a media

260 Taken together, these data demonstrate evolutionary conservation of VDUP1 regulation and functi

261 lied to Vg-unsequenced species thanks to the evolutionary conservation of Vg-proteotypic peptide moti

262 To address the evolutionary conservation of WT1 targets, we performed f

263 Some of the mechanisms involved show evolutionary conservation, opening the way to using simp

264 As the result of evolutionary conservation or convergence, lateralization

265 relatively distant species suggesting either evolutionary conservation or convergent evolution within

266 nclude diverse supporting data types such as evolutionary conservation or nucleosome placement.

267 ingle type of data, such as sequence motifs, evolutionary conservation, or the binding of enhancer-as

268 Considering its extensive evolutionary conservation, our results suggest that glyc

269 type has so far been detected despite strong evolutionary conservation over at least 400 Myr.

270 related species, a probability model for the evolutionary conservation pattern of codons across diffe

271 We also find that footprints reveal a unique evolutionary conservation pattern that differentiates fu

272 e (FIS) for amino acid residue changes using evolutionary conservation patterns.

273 Because of its evolutionary conservation, peroxiredoxin signaling might

274 e complex-disease risk shows little signs of evolutionary conservation, possibly because this categor

275 The key idea is to utilize the evolutionary conservation principle relative to the codi

276 ed method demonstrates an application of the evolutionary conservation principle to coding exons.

277 if overrepresentation property and the motif evolutionary conservation property.

278 entified using various approaches, including evolutionary conservation, regulatory protein binding, c

279 epigenome through this transition and their evolutionary conservation remain elusive.

280 ctivity and mitochondrial metabolism and its evolutionary conservation remain to be fully established

281 The evolutionary conservation suggests a common role of Obst

282 al., describe a novel p63 target gene whose evolutionary conservation suggests a critical role for t

283 Finally, as a striking example of evolutionary conservation, the Drosophila homolog of the

284 t predicts site efficacy without recourse to evolutionary conservation, the model also identifies eff

285 luding ORFs simply because they fail to show evolutionary conservation: the alternative hypothesis is

286 actions with different classes of RNA, their evolutionary conservation, their abundance and their tis

287 partners are subject to increased levels of evolutionary conservation, their more numerous partners

288 Despite its evolutionary conservation, this pattern of modification

289 on pheromone pathway components, and we used evolutionary conservation to assign priority to a list o

290 yed an approach that uses a relative lack of evolutionary conservation to inform epitope tag site sel

291 bution to multiple important factors such as evolutionary conservation, tumorigenesis, the length of

292 Evolutionary conservation was established using mouse er

293 Genome evolutionary conservation was used to predict important

294 -I hypersensitivity chromatin signatures and evolutionary conservation we identified seven candidate

295 Using evolutionary conservation, we identified a core set of f

296 ses in nematode and mammalian sperm suggests evolutionary conservation, we show PP1s have independent

297 or components of the genetic networks having evolutionary conservation with human biology.

298 impact of these variants rely primarily upon evolutionary conservation with little to no consideratio

299 ranscripts, because they show no evidence of evolutionary conservation with mouse or dog.

300 s less well understood, and whether there is evolutionary conservation with the proteins studied in f