ライフサイエンスコーパス: evolve to

1 arters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontan

2 catastrophic failures, the plastic flow can evolve to a critical dynamics, making the catastrophic f

3 implicit assumption that cancer cells never evolve to a fitness maximum because they can always acqu

4 to transmit in a mammalian host and quickly evolve to a more virulent strain is cause for concern.

5 od-carved landscapes in fractured rock might evolve to a threshold state for bedrock erosion, thus im

6 cal nodular hyperplasia (FNH), which finally evolved to a giant hepatocellular-cholangiocarcinoma (HC

7 The liver transplant allocation system has evolved to a ranking system of "sickest-first" system ba

8 atheter aortic valve implantation (TAVI) has evolved to a treatment of choice in high-risk patients a

9 or may manifest severe panencephalitis that evolves to a minimally conscious state and diffuse corti

10 The mixed complex that is formed evolves to a more stabilized species due to the intramol

11 ase with recurrent flare-ups of inflammation evolving to a chronic phase leading to restrictive heart

12 DNA polymerase, SFM4-3, which was previously evolved to accept nucleotides with 2'-modifications, we

13 cade, business models for these clinics have evolved to accept public and private health insurance, a

14 at the C-terminal Bag6-binding groove, which evolved to accommodate Bag6, a unique metazoan factor.

15 eage, suggesting these enzyme complexes have evolved to accomplish unique tasks within metazoan genom

16 Since viruses have evolved to achieve optimal levels of fitness in their en

17 strains, sophisticated strategies have been evolved to achieve the complete degradation of dietary p

18 Our results reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 pro

19 ined largely unknown why microorganisms have evolved to acquire such proteases and how the host respo

20 Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which ci

21 34+ cells, splenomegaly, and a propensity to evolve to acute myeloid leukemia.

22 the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability.

23 ised commodity classification systems should evolve to address these gaps.

24 LAR is a consistent entity that does not evolve to allergic rhinitis with systemic atopy over tim

25 x computation, the chunking structure should evolve to allow progressively more efficient movements (

26 en mRNAs and their encoded proteins may have evolved to allow efficient and accurate protein folding.

27 rs to promote HBoV1 replication and may have evolved to allow HBoV1 to establish persistent infection

28 Such conditioning may have evolved to allow immunity to infection while limiting su

29 rovides a unique example of how viruses have evolved to alter host behavior to increase fitness.

30 Overall, the Peg3 locus may have evolved to an imprinted domain to cope with both parenta

31 In evolving to an obligate intracellular niche, Chlamydia h

32 Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to

33 te cancer, imaging modalities are constantly evolving to assist in clinical decisions.

34 apeutics to address disease agents that have evolved to avoid human antibody responses.

35 ntagonistic and synergistic interactions has evolved to avoid kinetic trapping and polymorphism.

36 of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis.

37 terest in determining how these animals have evolved to avoid SIV disease progression.

38 hance our understanding of how AGMs may have evolved to avoid transmission through breastfeeding.

39 human genome and human adapted viruses have evolved to avoid.

40 temperature variability: tropical ectotherms evolve to be 'thermal specialists' because their environ

41 However, with a connection cost, networks evolve to be both modular and hierarchical, and these ne

42 at networks without a connection cost do not evolve to be hierarchical, even when the task has a hier

43 less frequently required, the lag-phase will evolve to be longer whereas, in frequently changing envi

44 ly changing environments, the lag-phase will evolve to be shorter.

45 ervals around transcription start sites have evolved to be considerably wider in primates and dog tha

46 from damage, but deterministic asymmetry has evolved to be equally important in extant bacteria.

47 Reproduction and aging evolved to be intimately associated.

48 ions of O2, whereas PP_3233 and PP_3287 have evolved to be less sensitive to O2.

49 Obesity and the metabolic syndrome have evolved to be major health issues throughout the world.

50 folding and unfolding; both modern RNases H evolved to be more kinetically stable than their most re

51 ads for ion channels, because they naturally evolved to be potent ion channel blockers.

52 ross the animal kingdom, visual systems have evolved to be uniquely suited to the environments and be

53 e (describing the products of nature as they evolved to be) rather than normative (construing process

54 In this way, microbial genomes can evolve to become ecologically diverse where different ge

55 thways by which social information use could evolve to become more efficient and effective.

56 cquire knowledge and skills should over time evolve to become more intelligent.

57 t set of metabolic strategies, the grain has evolved to become an almost perfect entity for carbon st

58 hogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of

59 inase 1/2 (JAK1/2) inhibitor ruxolitinib has evolved to become the centerpiece of therapy for myelofi

60 loss of singlet character as the excitation evolves to become only TT.

61 propose that these strategies have initially evolved to benefit humans but are now maladaptive and in

62 the glucocorticoid receptor and its paralogs evolved to bind activating response elements [(+)GREs] a

63 GalR family of transcription regulators have evolved to bind diverse DNA sequences and allosteric reg

64 A large cadre of proteins has evolved to bind or transport calcium.

65 lpha/beta-peptides can bind to proteins that evolved to bind to alpha-helical partners.

66 sed with relative ease in E. coli and can be evolved to bind virtually any target.

67 bipartite or two-signal mechanism has likely evolved to both sustain protective immunity and avoid au

68 This is a remarkable example of a toxin evolving to broaden its enzymatic activities and adapt t

69 idence for the existence of a natural enzyme evolved to catalyze a Diels-Alder reaction and shows how

70 sults highlight how a prevalent scaffold has evolved to catalyze quorum signal synthesis and provide

71 and receptors, some riboswitch classes have evolved to change their ligand specificity.

72 This later evolved to chorioretinal atrophy, most marked in the mid

73 In this context, HEV infection frequently evolves to chronic infection with a rapid progression of

74 nt; thus, unusual enzyme reactions have also evolved to cleave the C-P bond.

75 Our results revealed that linear peptides evolved to coadapt specificity and affinity to functiona

76 cobalt and cobalt phosphide, which partially evolved to cobalt oxide during OER.

77 odevelopmental sequelae in children with CHD evolve to cognitive decline or dementia during adulthood

78 vores are no exception and the majority have evolved to colonise a small number of closely related ho

79 aboratory-adapted H3 strains tested may have evolved to compensate for the faster HA deactivation at

80 Symbionts commonly evolve to compete within the host ecosystem, while hosts

81 The L. pneumophila population has evolved to comprise 3 clonal variants, each associated w

82 ecificity, paradigms of cardiac disease have evolved to conceptualize myocardial disease and patient

83 This response may have evolved to confer a replicative advantage, thus allowing

84 part of an adaptive mechanism that may have evolved to conserve energy until more food becomes avail

85 at temperature control of flowering time has evolved to constrain seed set environment and therefore

86 hly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans,

87 This may suggest that miR-1 and miR-21 have evolved to contain distinct sequence elements that are m

88 vel mechanisms of Fat4-Dchs1 signalling have evolved to control cell proliferation within the develop

89 mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distri

90 and some of the diverse mechanisms that have evolved to control this critical developmental decision,

91 Immune mechanisms have evolved to cope with local entry of microbes acting in a

92 a eukaryotic quality control mechanism that evolved to cope with translational arrests.

93 a consequence of mechanisms not necessarily evolved to cope with variance [3, 4].

94 ect cell-to-cell transmission, yet many have evolved to counteract an antiviral protein called tether

95 ravels the intricate ways in which HSV-1 has evolved to counteract the host immune response and revea

96 These hotspots can be systematically evolved to create high-affinity, high-specificity bindin

97 Future research should evolve to define novel methods optimized for the role of

98 Type III protein secretion machines have evolved to deliver bacterially encoded effector proteins

99 protein secretion systems have specifically evolved to deliver bacterially encoded proteins into tar

100 inside cells, and a network of proteins has evolved to deliver this essential, but potentially toxic

101 e results highlight the diversity of systems evolved to deliver toxins between bacteria.

102 cations for the problem of how taste systems evolve to detect new environmental dangers.

103 ew of plant innate immunity as a system that evolves to detect invasion.

104 Multiple mechanisms have evolved to drive this segregation, including stochastic

105 Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in n

106 tal insights into how molecules interact and evolve to enable the control of reaction chemistry and t

107 l pathway to the amygdala is thought to have evolved to enable rapid detection of threat.

108 We hypothesize that these sites evolved to enable SULT isoforms to respond to metabolite

109 er, currently circulating pH1N1 viruses have evolved to encode 6 amino acid changes (E55K, L90I, I123

110 from currently circulating pH1N1 viruses has evolved to encode 6 amino acid changes (E55K, L90I, I123

111 ined, and this way, the genome has gradually evolved to encode for genes with multiple isoforms, ther

112 Our study demonstrates how yeast has evolved to encode multiple layers of information-protein

113 e activity of neurons in OFC and MFC rapidly evolved to encode the amount of reward associated with e

114 h mRNA abundance and splicing appear to have evolved to enhance developmental transitions in major cl

115 that codon choices and protein structures co-evolve to ensure proper protein folding in eukaryotic or

116 pose that sequence features within IDRs have evolved to ensure an optimal balance of sequence-encoded

117 Influenza viruses steadily evolve to escape detection by antibodies, necessitating

118 wever, influenza viruses are able to rapidly evolve to escape immune pressure in a process known as "

119 t these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metallop

120 One of the mechanisms that HIV has evolved to escape the host's immune response is to mask

121 otably, certain avian influenza viruses have evolved to escape this restriction, possibly contributin

122 Such so-called Rab cascades have evolved to establish domains that contain unique Rab pro

123 However, the molecular mechanisms that have evolved to establish these unparalleled developmental pr

124 However, tumors evolve to evade immune attack, and the tumor microenviro

125 resistance to bacterial pathogens that have evolved to evade FLS2-mediated immunity.

126 in pathogenic microorganisms that are always evolving to evade host defenses.

127 ell understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous

128 rchers to identify how migration routes have evolved to exploit predictable atmospheric and oceanic c

129 work elucidates how secreted proteases have evolved to exploit the pH of the secretory pathway by al

130 h the saddleback shell morphology could have evolved to facilitate self-righting.

131 Hence, telomeric sequences may have evolved to facilitate their ability to loop back on them

132 ariety of mechanosensitive ion channels have evolved to facilitate these responses, but the molecular

133 Because human energy metabolism evolved to favor adiposity over leanness, the availabili

134 ucture and function of biomacromolecules has evolved to fill many essential roles in biological syste

135 t crosslinks generally have shapes that have evolved to fit precisely into binding pockets on their t

136 a bilayer, the environment in which GlpG has evolved to fold.

137 ion and in vitro measurements, this FADA was evolved to form a homodimer for the activation of MG dye

138 Neural circuitry has evolved to form distributed networks that act dynamicall

139 Determine how the polarized morphology evolves to foster migration of IL-5-stimulated eosinophi

140 system to explore how different signals have evolved to frighten, warn or even trick predators.

141 on mutants suggests that secondary replicons evolved to fulfil a specialized function, particularly h

142 ave been shaped by natural selection as they evolved to fulfill changing functional roles in their na

143 Cilia have evolved to function as essential sensory organelles in a

144 Despite having evolved to generate a 24 h circadian period, we show tha

145 This work sets the stage to explore how MDRs evolved to generate structural and biological diversity

146 Biological systems have evolved to harness non-equilibrium processes from the mo

147 n suggest that a limit on working memory may evolve to help learning.

148 attitude, but a reactive defensive mechanism evolved to help individuals avoid shame.

149 text] theory, by which small populations can evolve to higher densities in the absence of disturbance

150 ilayers and numerous accessory proteins, has evolved to house the genetic material of all eukaryotic

151 e whether this distinctive vocal feature has evolved to improve the perception of formants, key acous

152 Organic chemistry is continually evolving to improve the syntheses of value added and bio

153 The toxicity-testing paradigm has evolved to include high-throughput (HT) methods for addr

154 ife host, suggesting that the disease may be evolving to include a wider spectrum of cloven-hoofed an

155 r, measures and countermeasures continuously evolve to increase survival on both sides.

156 , a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially t

157 king posture of white butterflies has indeed evolved to increase the temperature of their flight musc

158 To facilitate viral replication, Vpx has evolved to induce SAMHD1 degradation and Vpr to mediate

159 Archaeal viruses have evolved to infect hosts often thriving in extreme condit

160 ophage-tropic (M-tropic) HIV-1 variants have evolved to infect macrophages, which have only low level

161 In response, these viruses have evolved to infiltrate and hijack translational control p

162 Vif may have evolved to inhibit A3F and A3G by stoichiometric binding

163 ese results also indicate that H. pylori has evolved to integrate expression of the major virulence g

164 t trigger disease resistance in the host can evolve to interfere with the resistance process and, thu

165 P. knowlesi invasion, but that parasites may evolve to invade human RBCs through the use of sialic ac

166 small deltaproteobacterial predator that has evolved to invade, reseal, kill, and digest other gram-n

167 understanding on why only some DCIS lesions evolve to invasive cancer whereas others appear not to d

168 fractionation of the epimer, the enzyme was evolved to invert stereoselectivity, producing the pharm

169 e present a simple model in which plants can evolve to invest in a range of defensive toxins, and her

170 mpete within the host ecosystem, while hosts evolve to keep the ecosystem on a leash.

171 ther, these results show that the shell also evolved to kill parasitic nematodes and this is the only

172 We conclude that synaptic proteins have evolved to limit possible contact site assemblies and mo

173 Chronic HP may evolve to lung fibrosis.

174 we suggest negative cooperativity might have evolved to maintain a residual conjugating activity of G

175 Stress-response pathways have evolved to maintain cellular homeostasis and to ensure t

176 (TCR) are among the DNA repair pathways that evolved to maintain genome integrity by removing DNA dam

177 static modifiers of the cue polymorphism can evolve to make optimal use of the information in the gen

178 The strategies and traits males evolve to mate with females are incredible in their dive

179 nship between industry and academia needs to evolve to maximize the opportunity.

180 ce arises when the nutrient storage pathways evolved to maximize efficient energy utilization are exp

181 ession through the endocytic pathway and has evolved to maximize extraction of antigens from cell cor

182 ks of pores, with pore size ratios that have evolved to maximize mass transport and rates of reaction

183 uscle-tendon morphology of the human leg has evolved to maximize the metabolic efficiency of walking

184 small subset of VS/UWS patients, two of whom evolved to MCS.

185 ions between prokaryotes and eukaryotes have evolved to mediate microbe-dependent host physiology and

186 Distinct microbial ecosystems have evolved to meet the challenges of indoor environments, s

187 The biomechanics of animal limbs has evolved to meet the functional demands for movement asso

188 inases, suggesting that the viral enzyme has evolved to mimic VRK activity.

189 The E. coli exit tunnel has evidently evolved to minimize interaction with the exit tunnel and

190 c resources, elaborate egress processes have evolved to minimize the time between escaping and invadi

191 drial mechanisms of bat physiology that have evolved to mitigate oxidative stress incurred during met

192 This encoding strategy may have evolved to mitigate the constraints of a compact sensory

193 result of obstruction to bulk flow of CSF is evolving to models that incorporate dysfunctional cerebr

194 cular structures appeared that this cytokine evolved to modulate TD responses within the GC.

195 d public media speculated that the virus had evolved to more effectively transmit between humans.

196 This mechanism evolved to more rapidly produce RPs on demand in differe

197 cent insights into the strategies cells have evolved to neutralize toxic aggregates by sequestering t

198 idered as an environmental pathogen that has evolved to occupy a diverse set of environmental niches

199 ous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long pro

200 apable of causing pneumonic plague before it evolved to optimally cause invasive infections in mammal

201 e results suggest that binding pathways have evolved to optimize rapid responses of AMPA-type iGluRs

202 neck and legs of the saddlebacks could have evolved to optimize self-righting.

203 e substrate-binding surface of LPMOs have co-evolved to optimize several of the interconnected proper

204 In animals, circadian clocks have evolved to orchestrate the timing of behavior and metabo

205 this spacer diversity, viruses can no longer evolve to overcome CRISPR-Cas by point mutation, which r

206 Cancer stem-like cells (CSC) evolve to overcome the pressures of reduced oxygen, nutr

207 detailed, and the mechanisms that they have evolved to overcome these therapies are described.

208 side of the clinic, gene therapy research is evolving to overcome the poor responses and toxicity ass

209 otection from pathogen invasion but has also evolved to participate in physiological processes to mai

210 Proteins have evolved to perform diverse cellular functions, from serv

211 propose that fungal NAT isoenzymes may have evolved to perform diverse functions, potentially releva

212 Consequently, specialized structures have evolved to permit rapid communication among cells, tissu

213 n stages and the molecular preparations they evolved to perpetuate their infectious cycle.

214 ome of the ways in which the PAR network has evolved to polarize cells in different contexts and in r

215 Subjects with RIS evolve to PPMS at the same frequency as expected from ge

216 Subjects who evolved to PPMS had more spinal cord lesions (100%) befo

217 RIS evolved to PPMS more commonly in men (p = 0.005) and at

218 te clinical event consistent with CIS/MS, 15 evolved to PPMS).

219 ults illustrate how two related species have evolved to precisely adjust their volatile content by mo

220 that membrane-interaction mechanisms of ABPs evolved to precisely fulfill their specific functions in

221 perhaps inevitable that some bacteria would evolve to preferentially grow in environments that harbo

222 ese data suggest that EBNA3A and EBNA3C have evolved to prevent differentiation to PCs after infectio

223 The immune system has evolved to prevent invasion of foreign organisms and to

224 h radiologically isolated syndrome (RIS) who evolve to primary progressive multiple sclerosis (PPMS).

225 to unpredictable pollen availability, plants evolve to produce more ovules than they expect to be fer

226 produces nonprosocial effects that may have evolved to promote offspring survival.

227 at the wrapping mechanism of gyrase may have evolved to promote rapid removal of positive supercoils,

228 ural features used for reverse transcription evolved to promote the splicing of both group II and spl

229 The immune system has evolved to protect multicellular organisms from the atta

230 mation as a physicochemical process that has evolved to protect the integrity of the human vasculatur

231 ANCE Restriction factors are genes that have evolved to provide intrinsic defense against viruses.

232 These responses evolved to provide short-term benefit to the host to war

233 he treatment of hepatitis C virus (HCV) have evolved to provide shorter treatment duration and higher

234 the collective motion of the group of agents evolves to reach the most probable state with relatively

235 Whether TCRs have evolved to react with MHC or, instead, processes in the

236 e solutions that the human immune system can evolve to recognize a conserved motif buried under a can

237 A multitude of nanobodies have been evolved to recognize a diverse array of targets, includi

238 ptation or recycling of visual circuits that evolved to recognize everyday objects and shapes in our

239 data provide compelling evidence that ZFP809 evolved to recognize foreign DNA and establish histone m

240 These antibodies have evolved to recognize the dense array of glycans that coa

241 We propose importin alpha3 evolved to recognize topologically complex NLSs that lie

242 e propose that these cone-like rods may have evolved to regain spectral sensitivity and chromatic dis

243 ecular parasites and posit that some inteins evolved to regulate host protein function.

244 in the developing vertebrate nervous system evolved to regulate neurogenesis.SIGNIFICANCE STATEMENT

245 lts demonstrate that the PXY-CLE pathway has evolved to regulate secondary growth and manipulating th

246 Bud32, Cgi121, Pcc1 and Gon7 appear to have evolved to regulate the central t(6)A biosynthesis funct

247 has been hypothesized that proteins may have evolved to remove these structures.

248 NAP1L1 through NS5A.IMPORTANCE Viruses have evolved to replicate and to overcome antiviral counterme

249 are an unusual group of organisms that have evolved to replicate exclusively within the cytoplasm or

250 sory receptor cells are generally thought to evolve to respond to sensory cues as fast as they can.

251 However, as these pathways likely evolved to respond specifically to transient perturbatio

252 is transcriptionally regulated and may have evolved to respond to distinct photoprotective needs und

253 e ENaC/degenerin family of ion channels that evolved to respond to extracellular factors.

254 This role in plants may have evolved to restore the growth of embryos after the accum

255 TSA complex, indicating that the enzyme has evolved to restrict the conformational freedom along its

256 DNA damage responses have evolved to sense and react to DNA damage; the induction

257 Type 2 immune responses have evolved to sense and respond to large, non-replicating i

258 of regulatory mechanisms that bacteria have evolved to sense cellular RSS and mitigate their deleter

259 gregation prone Halo-tag mutant (AgHalo) was evolved to sense proteome stress through its aggregation

260 it instability and cognitive decline rapidly evolving to severe dementia and death within 3 months.

261 ise are therefore interdependent and have co-evolved to share an optimal physiological abundance poin

262 safe and effective when nonshockable rhythms evolve to shockable rhythms (ventricular fibrillation/pu

263 es in which the length of e ach displacement evolves to show a well-defined characteristic scale that

264 hnology and techniques, cataract surgery has evolved to small-incisional surgery with rapid visual re

265 Mother Nature has evolved to smartly capture far red-to-NIR light via thei

266 ke into account the tasks that these systems evolved to solve risk missing important insights.

267 a reveals how different neural circuits have evolved to solve the same problem, even when using diffe

268 lts reveal how interdomain interactions have evolved to stimulate the inhibitory activity of an integ

269 The HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering vir

270 s byproducts of a regulatory mechanism which evolved to support multiple DNA replication forks.

271 The mechanism by which white matter evolves to support this coordination is not well underst

272 1 mis-targeting and the mechanisms that have evolved to suppress it are poorly understood.

273 es, as well as in the neural circuitry, have evolved to suppress the noise and enhance the visual sig

274 nsequence, several restriction pathways have evolved to suppress their activity at both transcription

275 Hosts are constantly evolving to suppress virulence and replication, while vi

276 rotating filaments that microorganisms have evolved to swim.

277 Of the 453 subjects with RIS, 128 evolved to symptomatic MS during the follow-up (113 deve

278 h produces cis-polyisoprene, E. ulmoides has evolved to synthesize long-chain trans-polyisoprene via

279 terns of age-specific selection and thus can evolve to take divergent forms.

280 ibility that, like papillomaviruses, EBV has evolved to take advantage of epithelial differentiation

281 at the protein machinery in this process has evolved to take advantage of some set of physical design

282 g of the strategies human gut symbionts have evolved to target other members of this community may pr

283 eutic outcome once resistance has started to evolve to the partner drugs.

284 nto how the double-ring bacterial system has evolved to the single-ring mtHsp60-mtHsp10.

285 that is distinct from the pathways that have evolved to the three other beta-lactam antibiotic famili

286 ectiveness and control comes from resistance evolving to the partner drugs.

287 Although EM techniques are evolving to the point of directly obtaining structural d

288 Consequently, RB1 inactivation evolved to tolerate the resulting cellular alterations.

289 esents convergent lncRNAs that independently evolved to tune PRC1 repression at individual loci.

290 ample of a pathogen resistance gene that has evolved to underlie two types of resistance, yet ensure

291 cuss how solar-cell device architectures can evolve to use coherence-exploiting materials, and we spe

292 derstanding of how retroviruses enter cells, evolve to use new receptors, and maintain efficient entr

293 Although cells have evolved to use ROS as signaling molecules, their chemica

294 viously CLDN1-dependent virus was capable of evolving to use CLDN6.

295 ng to speculate that gammaherpesviruses have evolved to usurp the type I interferon pathway to compen

296 Biological systems have evolved to utilize numerous proteins with capacity to bi

297 Our studies reveal that KSHV has evolved to utilize the innate immune sensor IFI16 to kee

298 Genome sizes have evolved to vary widely, from 250 bases in viroids to 670

299 We conclude that this binding mode evolved to warrant that a subset of target genes is only

300 tness is the extent to which an organism has evolved to withstand the effects of deleterious mutation