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1 n that pulmonary injury during influenza was exacerbated.
2 ajor adverse kidney events outcomes would be exacerbated.
3 challenges there is a risk that some will be exacerbated.
4 ently locate its substrates before damage is exacerbated.
5 s a result, KATP channel inhibition probably exacerbates a mismatch between energy demand and energy
6 amyloid-based transgenic mouse models of AD exacerbate Abeta pathology, neuroinflammation, and cogni
8 induced LQT3 model, acute interstitial edema exacerbated action potential duration prolongation and p
9 ated endogenous glutamate tone results in an exacerbated activation of eNMDARs, which in turn contrib
10 , but not sensory, neurons.IMPORTANCE Stress exacerbates acute disease symptoms resulting from HSV-1
11 als expressing both human proteins exhibited exacerbated AD-like pathology compared with AD transgeni
12 ne-induced decrease in G9a activity actually exacerbates addiction and sensitivity to relapse under s
16 ells to irradiated wild-type (WT) recipients exacerbates airway hyperresponsiveness and inflammation,
18 s albuminuria, and in vivo injection of BTP2 exacerbates albuminuria in streptozotocin-induced and Ak
19 These results suggest that urban PM2.5 may exacerbate allergic inflammation in the murine lung via
21 Strikingly, mutants blocking acetylation exacerbate alpha-synuclein toxicity in vivo, in the subs
22 f apoptosis and sensory deprivation leads to exacerbated amounts of apoptotic neurons in the correspo
23 R-V7, at their conserved SET/NAP domain, and exacerbate and repress the transactivation of the AR/AR-
25 bolism, predates changes in brain perfusion, exacerbates and works synergistically with amyloidosis t
26 modeling and function, cardiac MSCs from LVD exacerbated anterior wall thinning 28 days after myocard
31 measures to reduce the risk of developing or exacerbating asthma are well recognised, there is still
33 lar network and vascular complexity that are exacerbated at the lesion site and provide structural ev
34 onstitution of Ldlr-/- Arhgef1-/- with WT BM exacerbated atherosclerotic lesion formation, supporting
39 inant tissue plasminogen activator (tPA) may exacerbate blood-brain barrier breakdown after ischaemic
44 ransplantation-mediated helminth infections, exacerbated by coincident immunosuppression, must be con
46 cally observed in unlesioned P301S mice were exacerbated by DSP-4, and mortality was also accelerated
48 resulted in increased body weight, which was exacerbated by high fat diet and driven by increased foo
50 he kynurenine pathway, an effect that may be exacerbated by inflammatory responses in immunocompetent
53 pact adult survival but also this impact was exacerbated by lower food availability in years followin
54 est that mitochondrial dysfunction, possibly exacerbated by prion protein overexpression, occurs at l
55 d with global warming on long timescales and exacerbated by shifts in ocean dynamics on shorter times
57 shows a high mutagenic bypass rate, which is exacerbated by TEFM (transcription elongation factor mit
58 in less-developed regions of the world, and exacerbated by the HIV/AIDS pandemic and emergence of mu
61 rising and this global challenge is further exacerbated by tumour resistance to available medicines.
62 overfishing in this ecosystem will likely be exacerbated by warming, but this loss may be counteracte
63 t that enhanced morbidity is associated with exacerbated C. albicans pathogenesis and elevated inflam
64 FRD) animals exhibit arrhythmias produced by exacerbated Ca(2+) /calmodulin-protein kinase (CaMKII) a
67 n an aromatase-independent fashion, but also exacerbated cell death in induced pluripotent stem cell-
74 We found that the lack of Nrf2 significantly exacerbates cognitive deficits in APP/PS1, without alter
76 Available therapies for myelofibrosis can exacerbate cytopenias and are not indicated for patients
79 of the central chemoreflex pathway in HFpEF exacerbates diastolic dysfunction, worsens sympatho-vaga
83 During infection, RAGE functions to either exacerbate disease severity or enhance pathogen clearanc
84 of MPO431-439-specific CD8(+) T cell clones exacerbated disease mediated by MPO-specific CD4(+) cell
86 IL-22BP deficiency (Il22ra2(-/-)) displayed exacerbated disease that associated with enhanced expres
87 iciency does not reverse neuropathology, but exacerbates disease both in the brain and globally despi
90 -associated, context-specific dysregulation, exacerbates disruption of dopaminergic neurons in vivo,
91 levels in a BRCA2-deficient cancer cell line exacerbated DNA damage in response to chemotherapeutics.
97 est whether oscillatory shear stress further exacerbates endothelial dysfunction in patients with mod
98 upstream complement anaphylatoxin production exacerbates endothelial exocytosis and leukocyte recruit
99 ures (SATs) that surpassed national records, exacerbated energy consumption, disrupted agriculture an
101 Nutrient deprivation is therefore likely to exacerbate environmental warming's effects on communitie
103 l overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice an
105 precipitation are especially likely to also exacerbate eutrophication in India, China, and Southeast
106 poxaemia (EIAH) can decrease O2 delivery and exacerbate exercise-induced quadriceps fatigue in health
107 here they prime antigen-specific T cells and exacerbate experimental autoimmune encephalomyelitis (EA
108 suggest that altered chitin clearance could exacerbate fibrogenic pathways in the setting of lung di
112 cortex as Abeta amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the
114 ese compounds are parts of mixtures that can exacerbate harmful effects of the individual mixture com
117 Our results show that alcohol intoxication exacerbated hemorrhagic shock and resuscitation-induced
118 roinflammatory immune responses and markedly exacerbated high-fat diet (HFD)-induced NAFLD pathogenes
120 Herpes simplex virus type 2 (HSV-2; herpes) exacerbates human immunodeficiency virus type 1 (HIV) by
121 lance, increases in chronic inflammation, or exacerbated hypothalamic-pituitary-adrenal axis activity
130 -kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX(-/-) mice
133 as been hypothesised that the effect will be exacerbated in polygamous species with higher levels of
135 mbly of the spore protective layers that are exacerbated in the presence of a functional GerA recepto
137 ingly, hypercapnic stimulation in HFpEF rats exacerbated increases in sympathetic outflow to the hear
139 have examined how environmental degradation exacerbates infectious disease, the effects of human hea
140 g on nephrogenesis or kidney homeostasis but exacerbated inflammation and fibrosis after ureteral obs
141 hy B cell depletion can either ameliorate or exacerbate inflammatory diseases; however, these cells r
142 disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pat
143 unengulfed dead cells after MI, resulting in exacerbated inflammatory responses and a substantial dec
145 r, is a potent proinflammatory mediator that exacerbates inflammatory responses and cardiovascular va
149 balance by changing larval body composition, exacerbating instability and eliciting more frequent swi
151 ncy ameliorates amyloid pathology early, but exacerbates it late in disease progression in the APPPS1
152 Importantly, sympatho-excitation in CHF exacerbates its progression and is strongly related to p
153 d L-ala,SP prodrug metabolite formation, yet exacerbated L-ala,SP + amiodarone effects, implicating t
154 astrocyte-specific Cldn4 deletion displayed exacerbated leukocyte and humoral infiltration, neuropat
155 LPS, Lcn2(-/-) mice challenged with LPS had exacerbated levels of pro-inflammatory cytokines and exh
157 is were tested against the Recompensation of Exacerbated Liver Insufficiency with Hyperbilirubinemia
158 bsequent reanalysis of the Recompensation of Exacerbated Liver Insufficiency with Hyperbilirubinemia
159 the prospective randomized Recompensation of Exacerbated Liver Insufficiency with Hyperbilirubinemia
160 Only those methodological settings that exacerbated long-branch attraction artifacts yielded Cte
161 ch as water abstraction is likely to further exacerbate loss of taxa and ecosystem alteration, especi
167 nfection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non-classical
170 cells protects and depletion of macrophages exacerbates MERS-CoV-induced pathology and clinical symp
171 cations including sleep disorders, which can exacerbate metabolic disturbances and disrupt cognitive
172 PTX), a frontline chemotherapeutic agent, to exacerbate metastasis in mouse models of breast cancer.
173 model with intact neuron-microglial networks exacerbated mHTTx1-induced degeneration of striatal medi
174 tered eNMDAR-IA coupling also contributes to exacerbated MNC activity and neurohumoral activation dur
176 nges in SK function/expression contribute to exacerbated MNC activity during diseases such as heart f
182 virus, which also expresses a neuraminidase, exacerbates nasal colonization and disease by S. pneumon
186 xample, the absence of STAT1, STAT2, or IRF9 exacerbates neurological disease in transgenic mice with
187 Taken together, our results support (1) an exacerbated NMDAR-DeltaCa(2+) response in somatodendriti
189 els to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and p
190 tivation in oligodendrocytes and resulted in exacerbated oligodendrocyte death and hypomyelination in
193 ms that loss of Kruppel-like factor 4 (KLF4) exacerbates oncogenic TGF-beta signaling in human HCC.
194 ron communication could allow these cells to exacerbate or synchronize neuronal firing on shorter tim
195 adenovirus-mediated overexpression of DsbA-L exacerbates or alleviates, respectively, high-fat diet-i
198 ins and acquisition of antibiotic resistance exacerbates pathogenesis; however, the survival strategy
201 iency in miR-146a leads to earlier onset and exacerbated pathology of skin inflammation, with increas
204 evating PEX5 levels via a 35S:PEX5 transgene exacerbated pex26 defects and ameliorated the defects of
205 lining diversity could thus contribute to or exacerbate phenological changes attributed to rising glo
209 esides, palmitate conditions macrophages for exacerbated proinflammatory responses (lower IL-10 and C
213 Acute sleep deprivation (SD) can trigger or exacerbate psychosis- and mania-related symptoms; the ne
214 licit inflammatory responses in lungs and to exacerbate pulmonary allergic reactions in animal models
216 F1 mice with agonist anti-Ox40 mAbs potently exacerbated renal disease, which was accompanied by acti
217 cological inhibition of PTEN with bpV(HOpic) exacerbated renal dysfunction and promoted tubular damag
219 ne-bound complement regulators CD55 and CD59 exacerbates renal ischemia-reperfusion injury (IRI) in m
222 several diseases, including asthma, aspirin-exacerbated respiratory disease (AERD), inflammatory bow
224 the nasal polyps of 3 patients with aspirin-exacerbated respiratory disease by using fluorescence-ac
226 p 2 innate lymphoid cells (ILC2s) in aspirin-exacerbated respiratory disease-like Ptges(-/-) mice.
230 ssion, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection.
233 se (SFK) activation in LSC and that LIC with exacerbated SFK activation was uniquely found within the
234 n Sphk2-overexpressing mice, UUO resulted in exacerbated signs of fibrosis with increased collagen ac
235 ound that extensive SCIN ablation results in exacerbated social interactions, in which normal social
237 to altered social interactions together with exacerbated spontaneously emitted repetitive behaviors.
238 itory synaptic protein gephyrin subsequently exacerbated SSC-mediated excitotoxicity and promoted los
239 mage caused by low levels of PGC1A in liver, exacerbating steatohepatitis associated with diets high
241 mbining SYNJ1(+/-) and LRRK2 G2019S does not exacerbate SV endocytosis but impairs sustained exocytos
242 ides, monosaccharides, and polyols (FODMAPs) exacerbate symptoms of irritable bowel syndrome (IBS); h
243 ur data show that LTB4 and its receptor BLT1 exacerbate synovial inflammation in vivo and bone resorp
246 athway in which HCV infection in hepatocytes exacerbates Tfr cell responses to subvert antiviral immu
247 stantially impact clonal deletion nor did it exacerbate the defect in clonal deletion in the absence
248 The potential for chemical exposures to exacerbate the development and/or prevalence of metaboli
249 icity of the action of psychostimulants that exacerbate the disorder, and antipsychotics that amelior
250 ecies suggest that biological invasions will exacerbate the impacts of climate change on soil systems
251 n and compromised endosomal function further exacerbate the inhibitory effects of apoE4 on insulin si
252 blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter c
253 t, and associated activity increases, likely exacerbate the physiological stress experienced by polar
255 ed by heightened sexual selection, which may exacerbate the problem of local extinction at this retre
256 in autophagy or mitophagy have been shown to exacerbate the propensity of laboratory animals to spont
257 dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promot
258 E markedly prolonged the apneic response and exacerbated the bradycardic response to intralaryngeal p
259 he intravenous infusion of apolipoprotein E4 exacerbated the brain accumulation of aggregated amylin
261 osylation event enhanced viral productivity, exacerbated the host response, and thereby contributed t
263 uli, such as high-NaCl concentration or LPS, exacerbated the mitochondrial damage and dysfunction.
266 ies conflict as to whether CBD attenuates or exacerbates the behavioral and cognitive effects of THC.
267 hway in CNS endothelium before disease onset exacerbates the clinical presentation of EAE, CD4(+) T-c
270 e identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insuf
272 n, where the abundance of repeated sequences exacerbates the risk of ectopic recombination and chromo
275 previously unappreciated role for Nlrp12 in exacerbating the pathogenesis of IAV infection through t
278 , and whether continued lifelong Mn exposure exacerbates these effects, using a rat model of environm
282 el, while ectopic expression of FGF2 in vivo exacerbated tissue inflammation and disease symptom in t
283 nistration of a miR-31-3p chemical inhibitor exacerbated TNBS- and DSS-induced colitis and increased
285 indings collectively suggest that stress may exacerbate TS symptoms by promoting allopregnanolone syn
286 egnanolone (5-15 mg/kg, IP) dose-dependently exacerbated TS-like manifestations in D1CT-7, but not wi
291 of pulmonary F. tularensis LVS infection was exacerbated under conditions of alveolar macrophage depl
292 lls showed mitochondrial swelling, which was exacerbated upon treatment with hydrogen peroxide (H2O2)
293 In human artery-SCID chimeras, PD-1 blockade exacerbated vascular inflammation, enriched for PD-1(+)
294 n various tissues, as well as in tumors, and exacerbated vascular permeability in response to VEGF, a
299 These data suggest that MIOX overexpression exacerbates, whereas MIOX gene disruption protects again
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