ライフサイエンスコーパス: exceedingly

1 We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally deposited protein, is a

2 on of vacancies, and a proper control of the exceedingly active and anisotropic movement of the vacan

3 -Crry(flox/flox) mouse bone marrows revealed exceedingly active thrombopoiesis.

4 task to derive realistic network models from exceedingly advanced high throughput experimental data.

5 Therefore, Notch is an exceedingly attractive therapeutic target in cancer, but

6 hil granule major basic protein (MBP1) is an exceedingly basic (isoelectric point >11) 14-kDa protein

7 tructural features renders the lomaiviticins exceedingly challenging targets for chemical synthesis.

8 the development of the selective inhibitors exceedingly challenging.

9 om formation-flying telescopes--both require exceedingly clean wavefront control in the optics.

10 fore poorly understood gene implicated in an exceedingly common and complex sleep disorder and the de

11 sis uncovered that RAS pathway activation is exceedingly common in human RMS.

12 of electric heart diseases have proved to be exceedingly complex and in many respects contradictory.

13 ic patterns and stress history of Europa are exceedingly complex and many large-scale features remain

14 ent as well as those that promote repair are exceedingly complex and often superimposed.

15 need paradigm shifts as the unraveling of an exceedingly complex computational machine.

16 l one realizes that the cilia are themselves exceedingly complex machines that perform multiple funct

17 ere demonstrates that organic molecules with exceedingly complex structures can be covalently attache

18 he pathophysiology of severe sepsis/shock is exceedingly complex, but there is little doubt that infe

19 urons in the ventral tegmental area (VTA) is exceedingly complex.

20 rts thus far reflect the initial stage of an exceedingly complicated program, one that will likely ta

21 The synthesis of the exceedingly congested amine tris(1,3-dihydroxy-2-propyl)

22 A short synthesis of exceedingly congested amines, with insertion of a rhodiu

23 ow given by the ICRP 30 model (MIRDOSE2) are exceedingly conservative for both TBV and TBS sources, e

24 le limiting unfavorable outcomes that can be exceedingly costly for application of gene editing in pr

25 Academic surgery is exceedingly deficient of minority residents, junior facu

26 persionless broadband, high permittivity, is exceedingly demanding.

27 ulatory information on a given RNA target is exceedingly dependent on the cell type.

28 OsO4/NMO in MeOH conditions, resulted in an exceedingly diastereo- and enantioselective synthesis of

29 ause reproducible droplet generation becomes exceedingly difficult as the reagent droplet volume is d

30 the recovery of deletions of certain regions exceedingly difficult by traditional methods, resulting

31 al emitters at moderate temperatures, but is exceedingly difficult for hot emitters (>1,000 K).

32 o eat and increase caloric intake, making it exceedingly difficult for individuals to resist, especia

33 n function and pharmacology has proven to be exceedingly difficult in such large and complex proteins

34 mical properties, oncogenic Ras proteins are exceedingly difficult targets for rational drug discover

35 nrichment across large expanses, making them exceedingly difficult to define.

36 Many protein reactions are exceedingly difficult to dissect under standard conditio

37 e interactions among these three tissues are exceedingly difficult to distinguish and elucidate.

38 It is exceedingly difficult to distinguish the two via convent

39 However, protein-protein interactions are exceedingly difficult to inhibit.

40 free energy than nonnative structures but is exceedingly difficult to locate.

41 or malignant transformation, and it has been exceedingly difficult to measure in human cells.

42 As a result, it is exceedingly difficult to record the activation of MMP-2

43 c ripples in freestanding graphene have been exceedingly difficult to study.

44 ignificant roles in our evolution, but it is exceedingly difficult to understand the social behaviors

45 es, but their structural characterization is exceedingly difficult with standard technologies.

46 Measuring tuberculosis transmission is exceedingly difficult, given the remarkable variability

47 d temporal resolution that is impossible, or exceedingly difficult, using classical genetic methods.

48 tter highly mobile animals to this source is exceedingly difficult.

49 ation and quantitation of individual glycans exceedingly difficult.

50 pathomechanisms of these acquired disorders exceedingly difficult.

51 rational and clinically beneficial manner is exceedingly difficult.

52 hus making the design of specific inhibitors exceedingly difficult.

53 tients by using antiretroviral drugs will be exceedingly difficult.

54 an intuitive understanding of the situation exceedingly difficult.

55 ul proinflammatory mediator that displays an exceedingly diverse spectrum of biological effects.

56 myelin peptide monomers or oligomers, proved exceedingly effective at treating preestablished EAE, re

57 to such minimally expressed epitopes may be exceedingly effective due to the selective expansion of

58 es for their extraction and purification are exceedingly energy and chemical intensive.

59 Given that biological therapies are exceedingly expensive and pose an increased risk for inf

60 Exceedingly facile (23 degrees C) and chemoselective H-C

61 These exceedingly faint (apparent red magnitude m(R) = 24.2-25

62 apped, because intron sequences often evolve exceedingly fast and intron phylogenetic distributions a

63 , we demonstrate that the mechanism leads to exceedingly fast diffusion that is 2-3 orders of magnitu

64 The exceedingly fast exchange in novel [(Ph(3)P)(3)Rh(CF(3))

65 ably, while ZBTB7A-deficient tumors progress exceedingly fast, they exhibit an unusually heightened s

66 m (herpes zoster) have been published, while exceedingly few investigations have been carried out in

67 al skyrmions, however, are anticipated to be exceedingly fragile, suppressed by very small Zeeman ene

68 on velocity (CV), and wavelength (WL) at the exceedingly high activation frequencies that are relevan

69 sition state, which may be the origin of the exceedingly high affinity these inhibitors have for HPPD

70 The significance of this work is despite exceedingly high circulating levels of BNP-32 in the New

71 located far north of the industry, including exceedingly high concentrations in AR groundwater (A5w-G

72 tic cat (Felis catus) populations can attain exceedingly high densities and are not limited by natura

73 The rhodium complexes of these ligands show exceedingly high enantioselectivities (generally >95% ee

74 These recombination rates are exceedingly high even among retroviruses.

75 ventional stroke is still associated with an exceedingly high in-hospital mortality rate.

76 patients post-liver transplantation have an exceedingly high incidence of adrenal failure, which may

77 This trimeric rod displays an exceedingly high intrinsic thermostability (T(m) approxi

78 nd dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxi

79 tible solutes that accumulate in the cell at exceedingly high level under the conditions of high sali

80 ty in a nonlinear, biphasic way, so that for exceedingly high levels of pacing stochasticity, the ant

81 utation, revealing that P2P networks display exceedingly high levels of reciprocity.

82 ation occurs only when mTORC1 and S6K1 reach exceedingly high levels.

83 ated, these results may provide clues to the exceedingly high lung cancer incidence experienced by Af

84 small endotherms like hummingbirds that have exceedingly high mass-specific metabolic rates.

85 Collectively, the findings show that exceedingly high NO2(-) concentrations in nitritation sy

86 Small volume solutions of exceedingly high osmolarity, such as 23.4% saline, have

87 st and availability; however, because of the exceedingly high oxidation potential of trifluoroacetate

88 rom BTM generators very likely contribute to exceedingly high ozone concentrations in the Northeast C

89 rage capacity and do not require cryogens or exceedingly high pressures for operation.

90 ents, those with early HCV recurrence had an exceedingly high rate of LBAS (16%).

91 eficiency virus type 1 (HIV-1) recombines at exceedingly high rates, approximately 1 order of magnitu

92 The exceedingly high relative rate ratio (k(fast)/k(slow) up

93 ollowing K(+) stimulation, to be measured at exceedingly high resolution.

94 rs of versatile 2-vinyltetrahydrofurans with exceedingly high selectivity.

95 therapy for AL amyloidosis, but there is an exceedingly high treatment-related mortality in patients

96 perience unprecedented warming, yet there is exceedingly high uncertainty about their potential respo

97 Exceedingly high viral loads and rapid loss of CD4(+) T

98 protecting the kidney from deterioration are exceedingly important.

99 d as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond formi

100 To date, this approach has proved exceedingly inefficient.

101 ents indicate that in its few-layer form, an exceedingly large electric field in the order of several

102 pG-A, but not CpG-B, can multimerize to form exceedingly large lattices.

103 Despite an exceedingly large number of possible folding intermediat

104 on of the naphthopyran molecules leads to an exceedingly large order parameter in the open form, whic

105 ith bradycardia, showed large QRS amplitude, exceedingly large P-wave amplitude, and long P-wave dura

106 e, and structural data are now available for exceedingly large sample sizes.

107 is needed to characterize the role of these exceedingly large, non-locus-specific deletions in epile

108 algorithm, provided that the network is not exceedingly large.

109 sive research, systemic treatment for HCC is exceedingly limited, with only a handful of drugs provid

110 pment; as a result the antifungal arsenal is exceedingly limited.

111 ta(15)N of various NO(x) emission sources is exceedingly limited.

112 ion and the reversal of established IDDM are exceedingly limited.

113 premolars, combined with a very long muzzle, exceedingly long canines and evidence of highly speciali

114 The exceedingly long half-life of tiotropium (of more than 2

115 ond length of the single-electron bond is an exceedingly long metal-metal bond.

116 e part, the sAHP's importance stems from its exceedingly long-lasting time-course, which integrates a

117 ervation that Esigma(70) RP(o) complexes are exceedingly long-lived at moderate to high Glu(-) concen

118 he triplet state of cyclo[8]pyrrole, also an exceedingly long-lived species.

119 iated with moderate to vigorous exertion was exceedingly low at 1 per 36.5 million hours of exertion.

120 Although TLE procedural mortality is exceedingly low at high-volume centers, postprocedural a

121 s incorporated opposite ribavirin, but at an exceedingly low catalytic efficiency (200-3000-fold lowe

122 I-expressing gliomas in vitro (P < 0.001) at exceedingly low concentrations (10 ng/mL) and effector-t

123 cy leads to decay of HIV-1-infected cells to exceedingly low concentrations desired for HIV-1 remissi

124 Rs) alpha7, alpha9, and alpha10; exposure to exceedingly low concentrations of nicotine (nanomolar),

125 dherin bonds between cancer cells feature an exceedingly low energy barrier against tensile forces an

126 le because the extent of sumoylation appears exceedingly low for most substrates.

127 in-gel fluorescence detection, we quantified exceedingly low glycosylation rates that remained undete

128 Necl-5 is present at exceedingly low levels in adult epithelial tissues but i

129 on (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related ac

130 sphonate) lacks potential utility due to its exceedingly low membrane permeability at physiological p

131 Within 48 h of exposure to an exceedingly low multiplicity of infection (5 x 10(-4)),

132 Coupled with the exceedingly low prevalence of hip OA in China, these res

133 , with a very low rate of adverse events, an exceedingly low rate of serious adverse events, and an u

134 in solution as a monomer, which displays an exceedingly low structural stability (Tm 34 degrees C).

135 owever, these techniques are associated with exceedingly low success rates.

136 he loss of secretions under conditions of an exceedingly low virus inoculum.

137 Long-range and nonsyntenic LD are exceedingly low, however, when evaluated by the standard

138 frequency of spontaneous random mutations is exceedingly low, less than 1 x 10(-8) per base pair.

139 pathological aggregates in neural tissue is exceedingly low, precluding examination by conventional

140 act resistance of the resulting interface is exceedingly low.

141 th from breast cancer after surgery alone is exceedingly low.

142 isolated yields of metal-free products were exceedingly low.

143 ght internal jugular vein catheterization is exceedingly low.

144 ght internal jugular vein catheterization is exceedingly low.

145 component absorbing at long wavelengths was exceedingly low.

146 e number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL c

147 rbenes enabled high catalytic efficacy under exceedingly mild reaction conditions.

148 ver, neither NLSDM patients nor AKO mice are exceedingly obese.

149 variants, whereas the Bonferroni and FDR are exceedingly over-conservative for rare variants associat

150 of host cells may be directly linked to the exceedingly passive obligate life style of M. leprae wit

151 Because of its exceedingly poor association constant and, in contrast w

152 ransplantation for cholangiocarcinoma has an exceedingly poor outcome, although transplantation with

153 report a second-generation synthesis of the exceedingly potent antimitotic agent N(14)-desacetoxytub

154 vergent synthesis of cryptophycin 52 (2), an exceedingly potent cytotoxic agent, is described.

155 Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral poten

156 QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bar

157 ographic studies validate (D)PMI-delta as an exceedingly potent inhibitor of the p53-MDM2 interaction

158 Inhibitor 5 has exhibited exceedingly potent inhibitory activity (K(i) = 17 pM) an

159 2-Ketobenzothiazole 13 exhibited exceedingly potent thrombin inhibition (K(i) = 0.000 65

160 mally stable, insensitive compounds that are exceedingly powerful but safe to handle and prepare.

161 Pain problems are exceedingly prevalent among psychiatric patients.

162 karyotic cells, into the contributions of an exceedingly promiscuous exportin and it provides a new b

163 first in a sequence of three reactions is an exceedingly rapid amine-induced assembly of an amino-BOR

164 the solvent-controlled stages of folding are exceedingly rapid or else absent.

165 FPI has high resolution and is exceedingly rapid with instant image capture.

166 The calculation is thus exceedingly rapid.

167 slices, but in P0-P5 slices these cells were exceedingly rare (0.6%).

168 st phase, with leukemic transformation being exceedingly rare (3% risk at 10 years) in patients who r

169 Although this enzymatic activity is exceedingly rare among bacteria more broadly, analysis o

170 This arrangement is exceedingly rare among bacterial SSBs, which typically f

171 Food body rewards are exceedingly rare among eudicot flowering plants and are

172 elling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3

173 Fossil pentastomids are exceedingly rare and are known only from isolated juveni

174 The CNVs presented here are exceedingly rare and are not found in the Database of Ge

175 s to create wide solid-solutions fields with exceedingly rare and complex (3 + 3)-dimensional incomme

176 in vivo such unexpected transformations are exceedingly rare and in some cases can be accounted for

177 hat selection of sofosbuvir-resistant HCV is exceedingly rare and is associated with a significant re

178 ldest of which date to the Late Miocene, are exceedingly rare and likewise limited to the Southern He

179 udy of HSCs remains challenging, as they are exceedingly rare and methods to purify them are cumberso

180 cca syndrome, whereas cardiac involvement is exceedingly rare and neuropathy has not been reported.

181 Postoperative HORV is an exceedingly rare and potentially devastating condition t

182 nfortunately, the discovery of such drugs is exceedingly rare and there is no evidence that novel end

183 ing germline targeting to prime specific and exceedingly rare bnAb-precursor B cells within a humanli

184 demonstrated the existence and importance of exceedingly rare but unusually richly connected cells in

185 ions caused by type emm59 GAS, heretofore an exceedingly rare cause of disease, spread west to east a

186 Measuring the distribution of the exceedingly rare CO(2) isotopologue (16)O(13)C(18)O, in

187 -exome sequencing approach, we identified 19 exceedingly rare de novo CAMK2A or CAMK2B variants in 24

188 rors of immunity to HHV-8 might underlie the exceedingly rare development of classic KS in childhood.

189 ions associated with regional anesthesia are exceedingly rare events.

190 e enhancement of Raman vibrational bands are exceedingly rare for tetravalent actinide complexes and

191 Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basi

192 Cushing disease is exceedingly rare in children, especially in those under

193 Pseudo-tetraploid cells are exceedingly rare in early meiotic prophase, but they are

194 mice, a similar degree of PU.1 impairment is exceedingly rare in human AML; yet, moderate PU.1 inhibi

195 Metallic Pb is exceedingly rare in nature and previously has not been r

196 usands of insertions because such bursts are exceedingly rare in nature and therefore difficult to ob

197 ionality that is unprecedented in plants and exceedingly rare in nature; furthermore, the aryl cyanoh

198 ypes, but retinal ganglion cells (RGCs) were exceedingly rare in the Ascl1 lineage.

199 Preservation of soft-bodied organisms is exceedingly rare in the fossil record.

200 Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequ

201 7) CD4+ T cells, a requirement for detecting exceedingly rare latently infected cells.

202 Congenital cystic eye is an exceedingly rare ocular malformative disease, originated

203 carcinoma with normal overlying mucosa is an exceedingly rare presentation of primary ESCC with only

204 everal additional single case studies of the exceedingly rare rotational vertebral artery syndrome ha

205 fe span driven by environmental cues - is an exceedingly rare sexual system among angiosperms.

206 repair proteins is their ability to identify exceedingly rare sites of damage embedded in a large exc

207 It is exceedingly rare to have trans-splicing between protein-

208 Such outbreaks are exceedingly rare, and F. tularensis is seldom recovered

209 Ferroelectric ferromagnets are exceedingly rare, fundamentally interesting multiferroic

210 Such materials are exceedingly rare, however, owing to competing requiremen

211 genetic exchange between plants and fungi is exceedingly rare, particularly among the angiosperms, bu

212 As appendiceal signet ring cell carcinoma is exceedingly rare, the occurrence of this neoplasm in thi

213 ng Arg 54 in protein-ubiquitin complexes are exceedingly rare, these results provide additional insig

214 tion of team sizes in which larger teams are exceedingly rare.

215 DS-related deaths and new HIV infections are exceedingly rare.

216 eochemical course is completely reversed are exceedingly rare.

217 d the recently identified genetic causes are exceedingly rare.

218 presentation, cold panniculitis in adults is exceedingly rare.

219 genes involved in chromosome segregation are exceedingly rare.

220 Isolated CNS histoplasmosis is exceedingly rare.

221 linically significant intracranial injury is exceedingly rare.

222 s of non-marine origin in the Precambrian is exceedingly rare.

223 rganometallic cerium(iv) compounds are still exceedingly rare.

224 ization leading to speciation in mammals are exceedingly rare.

225 munodeficient mice; however, metastases were exceedingly rare.

226 stence of mutations in these two genes seems exceedingly rare.

227 c 1946 article describing arterial repair as exceedingly rare.

228 res or fractures of other mid-face bones are exceedingly rare.

229 l examples of versatile metamaterials remain exceedingly rare.

230 s emergence of these structures in nature is exceedingly rare.

231 om living immunocompetent human subjects are exceedingly rare.

232 king examples of exclusive cation-pi bonding exceedingly rare.

233 exist, crippling mitochondrial mutations are exceedingly rare.

234 ed with germline KIT activating mutations is exceedingly rare.

235 recurrence of the same mutation in a sibling exceedingly rare.

236 spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(B

237 DNA phosphoester bonds are exceedingly resistant to hydrolysis in the absence of ch

238 FNAB proved effective and exceedingly safe.

239 sistant to chemical degradation copepods are exceedingly scarce in the geological record with limited

240 Bryostatin 1 is an exceedingly scarce marine-derived natural product that i

241 ges as to secure a meaningful supply of this exceedingly scarce natural product derived from a deep-s

242 ailable potent antibiotic drugs are becoming exceedingly scarce.

243 thin the ER-PM junctions, where they mediate exceedingly selective Ca(2+) entry.

244 PNAs are used as exceedingly selective chemical tools that bind genomic D

245 emonstrate that gapped-DNA cyclization is an exceedingly sensitive and accurate approach for the dete

246 oscopic (frequency resolved) and potentially exceedingly sensitive indicators of interfacial change (

247 s, we determined that ubc4Delta ubc5Delta is exceedingly sensitive to protein translation inhibitors.

248 ur electrophile because the S(VI) Cl bond is exceedingly sensitive to reductive collapse yielding S(I

249 analyse an extended data set that reveals an exceedingly sharp inner boundary for the ultrarelativist

250 isolated in crystalline form owing to their exceedingly short lifetimes, transient (UV-vis) spectra

251 aphic phenotype of the proband, including an exceedingly short QT interval with merging of the QRS an

252 Two exceedingly short synthetic routes to the key intermedia

253 Current incident AVF practice falls exceedingly short years after recommendations were made

254 xpected, the overall fold of Sf-caspase-1 is exceedingly similar to that of the five active caspases

255 This article describes an exceedingly simple and low-cost method for metering the

256 ere we report that an entirely different and exceedingly simple class of materials-doped small-bandga

257 Furthermore, exceedingly slow delivery of toluene from a high molecul

258 hTDG turnover is exceedingly slow for G.T (k(cat)=0.00034 min(-1)) and G.

259 ins grow well on decanoic acid but grow only exceedingly slowly on octanoic acid and fail to grow at

260 much larger length scales, withstanding only exceedingly small compressive forces.

261 ity for analysis of decade-old materials and exceedingly small microdissected tissue fragments.

262 hat can selectively and specifically isolate exceedingly small numbers of circulating tumor cells (CT

263 train amplitudes from a large earthquake are exceedingly small once the waves have propagated more th

264 Chemical information from this exceedingly small organism is usually accomplished by st

265 d identification of molecular partners using exceedingly small sample quantities under physiological

266 ic manifold and is highly accurate, even for exceedingly small sample sizes.

267 ave designed and developed zwitterion-coated exceedingly small superparamagnetic iron oxide nanoparti

268 As the early stages of nucleation involve exceedingly small time and length scales, atomistic comp

269 om an ability to optically isolate and image exceedingly small volume elements made up of the lateral

270 m activity during spontaneous respiration is exceedingly small.

271 elihood in the absence of global warming was exceedingly small.

272 rium substitution on phospholipid mixing are exceedingly small.

273 opose that this property allows TmHU to form exceedingly stable associations in which DNA flanking th

274 ll four phases of molybdenum carbide, and is exceedingly stable in acidic solution.

275 In rabbits, eye position is exceedingly stable in both alert and inattentive states.

276 imeric form and that this multimeric form is exceedingly stable, even to high concentrations of salt

277 f the two components tend to be similar; (c) exceedingly steep concentration gradients, involving sev

278 novirus is unnecessary, vector production is exceedingly straightforward.

279 The effective increase in acidity of an exceedingly strong protic acid is greater for biscoordin

280 cells exposed to 4-HPR should make the drug exceedingly suitable as an anti-HIV therapeutic.

281 aA/PsaB heterodimer has evolved to ensure an exceedingly tight binding interface, thereby rendering t

282 ly by native interactions, knot formation is exceedingly unlikely.

283 or 1000 years, much less 10,000 years, seems exceedingly unlikely.

284 on, an ill-defined quantity in metals--it is exceedingly unusual to find a polar metal that exhibits

285 Fluorescent fusion proteins are exceedingly useful for monitoring protein localization i

286 This HeV sG glycoprotein will be exceedingly useful for structural studies, receptor iden

287 Optical microscopy has been exceedingly useful in imaging cell microarchitecture.

288 rosis (CF) and nosocomial pneumonia could be exceedingly useful, but to date no effective immunothera

289 All-cause postoperative mortality rates are exceedingly variable within resource-constrained environ

290 All-cause postoperative mortality rates are exceedingly variable within resource-constrained environ

291 s of growth in surgical service delivery are exceedingly variable, but the largest growth rates were

292 lly characterized, and demonstrated to be an exceedingly versatile pentafluoroethylating reagent for

293 e robustness of the result implies that even exceedingly weak Ab-mucin affinity can markedly reduce t

294 ing between photons and acoustic phonons-are exceedingly weak in conventional nanophotonic silicon wa

295 lation of serine, threonine, and tyrosine is exceedingly well characterized, the role of histidine ph

296 Transgenic plants grew exceedingly well in soil contaminated with organic (appr

297 al role of microRNAs in plant development is exceedingly well supported; their importance in environm

298 reactants is a liquid, the reaction proceeds exceedingly well without a solvent.

299 mon and important elements in nature, has an exceedingly well-explored phase diagram under pressure,

300 We find that these trajectories are best-and exceedingly well-modeled by the proportional navigation