ライフサイエンスコーパス: excessive

1 increased titers of serum autoantibodies and excessive accumulation of B cells.

2 ayed hair growth, progressive hair loss, and excessive accumulation of dermal cholesterol, triglyceri

3 It is characterised by excessive accumulation of extracellular matrix (ECM) pro

4 ogression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) pro

5 onstrating a negative feedback loop limiting excessive accumulation of iron-response element RNA-bind

6 In glycophytes, excessive accumulation of Na(+) is accompanied by K(+) d

7 Therapy inhibited excessive accumulation of Tfh cells coexpressing IL-21 a

8 e embryonic brain from environmental stress, excessive activation impairs critical developmental even

9 om mechanical microvessel obstruction and an excessive activation of immune cells leading to patholog

10 among RT neurons is important for preventing excessive activation of RT neurons, which can be respons

11 d by early life stress (ELS), which produces excessive activation of stress response systems broadly

12 Excessive activation of the NLR family pyrin domain cont

13 RL3(GCL) to prevent it from participating in excessive activities.

14 Excessive activity of striatal-enriched protein tyrosine

15 aces inhibits in vitro cell migration due to excessive adhesion.

16 ation: pressure to be clinically productive, excessive administrative responsibilities, difficulty ob

17 Voluntary prolonged and excessive alcohol consumption in a 2-bottle choice proce

18 s to test the hypothesis that TLR4 regulates excessive alcohol consumption in different species and d

19 Here, we report that excessive alcohol consumption increases the translation

20 BACKGROUND & AIMS: Chronic, excessive alcohol consumption leads to alcoholic liver d

21 kinase-3beta signaling dramatically reduced excessive alcohol consumption, as did selective inhibiti

22 termining which neuroimmune pathways mediate excessive alcohol drinking and these findings will help

23 rther support for a neuroimmune mechanism of excessive alcohol drinking.

24 to oncology providers about the influence of excessive alcohol use and cancer risks and treatment com

25 ther these can be used as the biomarkers for excessive alcohol use.

26 be more related to tumorigenesis rather than excessive aldosterone production.

27 8)Ga-HZ220 was blocked significantly with an excessive amount of GRP antagonists.

28 The mildly acidic levels associated with excessive amounts of ammonia can promote high rates of S

29 e maximum limits (MLs) with the exception of excessive amounts of Cu and Zn in one sample.

30 s and bone healing, potentially by producing excessive amounts of Dipeptidyl peptidase-4, a protease

31 This overlap and excessive amounts of kinematics or coordination units ma

32 Fibrosis with excessive amounts of type I collagen is a hallmark of ma

33 Excessive AMPylation also abolished HSP70-dependent infl

34 Here, we show that excessive AMPylation by a constitutively active Fic(E247

35 e among the immune cells that can drive this excessive and detrimental inflammation.

36 Together, our findings implicate both excessive and reduced Trio activity and the resulting sy

37 ion disrupts signaling events and results in excessive angiogenic cell proliferation and plexus forma

38 reover, Birc2 (cIAP1) inactivation generates excessive apoptosis leading to vesicoureteral reflux in

39 ignals regardless who gives them but without excessive arousal as measured in the amygdala.

40 portant implications for disorders marked by excessive avoidance.

41 -system components that govern addiction and excessive behavior and suggests that alterations in the

42 cting domain, or phosphorylation site causes excessive binding of RAD51 to CFS loci and impairs CFS e

43 In the presence of excessive blasts and other poor prognostic factors, hypo

44 Obstetrics complications and excessive bleeding during delivery contributed to nearly

45 TRF prevents excessive body weight gain, improves sleep, and attenuat

46 the altered metabolic environment related to excessive body weight might bear consequences on the WJ

47 Excessive bone resorption by osteoclasts (OCs) can resul

48 ncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of

49 esemble wild ancestors, and breeders avoided excessive branching because of low fertility.

50 l knee extension assistance could reduce the excessive burden placed on the knee extensor muscles as

51 cone membrane excitability, thereby limiting excessive Ca(2+) influx at subthreshold potentials or du

52 y types of embryonic neurons, acts to reduce excessive Ca(2+) influx through Cav channels and thus pe

53 otect neurons by supplying ATP and adsorbing excessive Ca(2+), or kill neurons by releasing proapopto

54 population groups continue to experience an excessive cancer burden when compared with other populat

55 kidneys with IRI, which was associated with excessive caspase-3 activation.

56 Proinflammatory cytokine overproduction and excessive cell death, coupled with impaired clearance of

57 imental impact of DNA damage associated with excessive cell division.

58 ne is often depleted at tumor sites owing to excessive cellular consumption and poor vascularization.

59 These may be important in ensuring that excessive chloride secretion, with the accompanying loss

60 Our results suggest excessive cholinergic stimulation has detrimental effect

61 utcomes in heart failure, an entity in which excessive chronic inflammation may play a pivotal role.

62 terneurons and principal cells and resultant excessive circuit sensitivity and output.

63 rly understood; however, chronic exposure to excessive circulating serotonin is considered one of the

64 result of dysregulated wound healing, where excessive collagen and extracellular matrix proteins are

65 cell transplantation (HSCT) associated with excessive complement activation, likely triggered by end

66 n produce results that are biased or require excessive computational requirements.

67 Although excessive consumption of alcoholic beverages is commonly

68 Cartilage injury induced by acute excessive contact stress is common and mostly affects yo

69 rimarily due to Rho kinase (ROCK) controlled excessive contractile myosin-II activity and not to elev

70 Focal epilepsy involves excessive cortical activity that propagates both locally

71 ine and leads to potential patient harms and excessive costs in health care.

72 (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysi

73 ay also moderate the pathological effects of excessive cytokine production during sepsis.

74 erations, which resulted in dampening of the excessive cytokine production.

75 metabolic pressure secondary to exposure to excessive daily caloric intake and overnutrition.

76 of functional dystrophin protein results in excessive damage from normal muscle use due to the compr

77 o determine the safety and efficacy of LT on excessive daytime sleepiness (EDS) associated with PD.

78 L1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR-OPHN1) and a compo

79 ye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of mu

80 n SWS, reproducing, respectively, narcolepsy excessive daytime sleepiness and poor sleep quality.

81 ported sleep duration, insomnia symptoms and excessive daytime sleepiness in the UK Biobank (n = 112,

82 atory down-regulation, presumably to prevent excessive de novo lipogenesis in adipose tissue.

83 s a physiological down-regulation to prevent excessive de novo lipogenesis.

84 A hallmark of muscle atrophy is the excessive degradation of myofibrillar proteins primarily

85 Nevertheless, excessive dendrite growth, infinite relative dimension c

86 in cortical glutamatergic neurons results in excessive dendritic outgrowth within 24 h, resembling th

87 match between LIB and LIC and can avoid the excessive depletion of electrolyte during the charge pro

88 Airway remodelling with excessive deposition of extracellular matrix (ECM) and l

89 Excessive deposition of type I collagen causes fibrotic

90 Excessive divergence tone may be responsible, but breakd

91 e, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects.

92 poptosis after ionizing radiation because of excessive DNA damage.

93 hrenia, whereas psychosis is associated with excessive dopamine release in the striatum.

94 alcohol-attributable admission or death for excessive drinkers was increased (hazard ratio 6.12, 95%

95 Excessive drinking to intoxication is the major behavior

96 Unlike this excessive drinking, for which treatments exist, compulsi

97 in the negative emotional state that drives excessive drinking.SIGNIFICANCE STATEMENT The central am

98 biosynthesis, in fibrogenic cells to prevent excessive ECM deposition.

99 However, excessive ECM remodeling can cause fibrosis of the TM as

100 : both energy deficiency (acute fasting) and excessive energy storage (high-fat diet-induced obesity)

101 uces AI-resistant cell survival by eliciting excessive EnR stress and also depletes ERalpha expressio

102 alpha expression and signaling by preventing excessive EnR stress.

103 to be an important mechanism for preventing excessive environmental stimulation from overloading sha

104 vities of mEC layer II neurons would provide excessive excitatory input to the hippocampus and contri

105 wing in reaction to persistent antigen; yet, excessive expansion reduces memory potential and impairs

106 also produced in response to infection, and excessive exposure reduces HSC repopulation capacity.

107 proactive stance by the Society to minimize excessive exposure to alcohol has important implications

108 ch higher oxidation states are reached after excessive exposure to cellular oxidants, and accumulate

109 experience the potential health risks due to excessive exposure to the heavy metals from the leather

110 und to have a significant role in preventing excessive external rotation and hyperextension of the kn

111 Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tiss

112 the effector cells of fibrosis that produce excessive extracellular matrix (ECM) proteins.

113 Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contribut

114 in resident cardiac fibroblasts for fibrotic excessive extracellular matrix gene expression and binds

115 oids are pathological scars characterized by excessive extracellular matrix production that are prone

116 f metabolic resistance, and vulnerability to excessive fear memory formation and reveal that ghrelin

117 ting, overfilled intestines, abdominal pain, excessive feces, steatorrhea, and malnutrition.

118 s of a TAAR1 agonist, RO5256390, in multiple excessive feeding-related behaviors induced by limiting

119 d population of iSPNs, which often displayed excessive firing rates and aberrant phase-locked firing

120 rovide a novel therapeutic target to control excessive fission and associated mitochondrial deficits.

121 Excessive fluid therapy in patients with sepsis may be a

122 eight loss, adequate hydration, avoidance of excessive fluids, and regular voiding intervals that red

123 own whether patients' behaviour results from excessive focus on rewards, insensitivity to punishment,

124 Excessive glucocorticoid exposure has been shown to be d

125 We found that excessive glutamate transmission upregulated mRNA expres

126 thin 24 h, resembling the changes induced by excessive glutamate transmission.

127 rbing the expression levels of FGFs/FGFRs by excessive glutamatergic neurotransmission could lead to

128 n and providing enzymatic protection against excessive GR activation in obesity.

129 hypertrophy and proliferation, resulting in excessive granuloma formation in vivo.

130 ine, a serotonin reuptake inhibitor, reduces excessive grooming, hyperanxiety and social behavioral i

131 a and found that it was sufficient to induce excessive grooming.

132 cessive GWG, both high pre-pregnancy BMI and excessive GWG influence perinatal outcomes.

133 Women with excessive GWG showed increased length of gestation, birt

134 hanghai area are overweight/obese or exhibit excessive GWG, both high pre-pregnancy BMI and excessive

135 Excessive haemorrhage at cesarean section requires donor

136 r subjects with MCI were excluded because of excessive head motion (ie, > 0.8 mm translation per repe

137 ing, thus preventing the damaging effects of excessive heat.

138 ical current loop with a major risk of local excessive heating, burn injury, and fire.

139 ic ductal adenocarcinoma is characterized by excessive hyaluronan (HA) accumulation in the tumor micr

140 Admixtures with excessive hypotonicity (sodium = 103 mEq/L), in contrast

141 Identification of excessive IFN-gamma production by blood and lymph node-d

142 tly supports humoral immunity by suppressing excessive IFN-gamma, which induces T-bet expression in B

143 We show here that lipin-2 controls excessive IL-1beta formation in primary human and mouse

144 ted in thymic and splenic hypertrophy, while excessive IL-22 induced atrophy in these lymphoid organs

145 Excessive IL-6 production is associated with activation

146 Inhibiting GrmA reduced excessive IL-8 and MCP-1 synthesis in aging to levels si

147 a dynamic modulator of stroke response, and excessive immune cell accumulation in the cerebral vascu

148 ious life-threatening condition caused by an excessive immune response to infection.

149 gulatory T cells, which function to suppress excessive immune responses, ameliorated blood-brain barr

150 f incarcerated men, and raises concerns that excessive incarceration could harm entire communities an

151 bed as cautious and hesitant, manifesting an excessive indecisiveness that hinders efficient decision

152 IkappaBalpha, and consequently protects from excessive inflammation and acute shock in vivo.

153 1 cells, which are important for controlling excessive inflammation and autoimmune responses.

154 uced ample amounts of IL-10 which controlled excessive inflammation and the mice treated with IL-10-d

155 fact underscored by the devastating toll of excessive inflammation at the cornea - blindness.

156 nnate immune system is tightly regulated, as excessive inflammation can lead to organ failure and dea

157 Excessive inflammation in the skin early after antigen c

158 This may be a significant contributor to excessive inflammation seen in Irgm1-deficient mice in d

159 ar, and several models are proposed, such as excessive inflammation, a second-hit insult, or an imbal

160 ective in limiting symptoms that result from excessive inflammation.

161 e oxidative stress appeared, followed by the excessive inflammation.

162 Inhibiting the excessive inflammatory response is essential for improvi

163 voids the potential negative consequences of excessive insulin release into the systemic arterial cir

164 heightened motivation for palatable food; 2) excessive intake; and 3) increased food seeking when foo

165 Loss of podocytes can occur as a result of excessive intracellular calcium influx, and we have prev

166 Excessive intronic length and silencer density tend to d

167 ) protect against infections and cancer, but excessive IRF3 activation and type I IFN production caus

168 with the ENaC inhibitor, benzamil, reversed excessive K(+) wasting.

169 ng and inefficient walking pattern marked by excessive knee flexion that worsens with age.

170 risk factors and elucidate the mechanisms of excessive lactate production.

171 Here, we hypothesized that excessive leukocyte invasion leads to heart failure and

172 at limit ICAM-1-mediated adhesion to prevent excessive leukocyte transmigration remain unknown.

173 ely in industrial processes, the exposure to excessive levels could alter the biochemical cycles of l

174 Excessive levels of Abeta disrupt excitatory synaptic tr

175 The other "Buyid silks" showed excessive levels of amino acid racemization not only for

176 eveloped adverse ventricular remodeling with excessive levels of the ER regulatory C/EBP homologous p

177 able interfacial contacts, and strategies of excessive Li and better interfacial engineering need to

178 yanobacterial photosynthetic apparatus under excessive light conditions, undergoes significant rearra

179 uptake, further protecting macrophages from excessive lipid accumulation.

180 An excessive lipogenic flux due to chronic dietary stimulat

181 o reject results from climate models with an excessive liquid-water-path response.

182 ad service lines (LSLs) often results in the excessive long-term release of lead particulates due to

183 Excessive lymphangiogenesis is associated with cancer pr

184 suggest that both massive lymphocytosis and excessive lymphocyte activation could contribute to mass

185 Both massive lymphocytosis and excessive lymphocyte activation could contribute to mass

186 3 (MHV-3)-induced fulminant hepatitis due to excessive macrophage-dependent inflammation.

187 In agreement with excessive manganese accumulation was the impaired motor

188 V) created a senescence-like state caused by excessive MAPK signaling.

189 Excessive matrix Ca(2+) concentrations, especially when

190 Excessive matrix metalloproteinase (MMP) activity is eme

191 lung injury caused by bacterial pathogens or excessive mechanical ventilation.

192 diated restriction of ARF3 expression limits excessive megaspore mother cell formation non-cell-auton

193 istered both locally and orally and inhibits excessive melanin via melanocyte.

194 However, if an obstacle's resistance is excessive, Mfd dissociates the RNAP, clearing the DNA fo

195 Loss of NEK6 function led to excessive microtubule waving and distortion, implying th

196 Excessive miR-27 expression in murine T cells severely i

197 hied heart not only prevents cell death from excessive mitochondrial depolarization but also activate

198 Excessive mRNA translation downstream of group I metabot

199 In disease-mimicking dhc-1 alleles, excessive MT growth and collapse occur at the dendrite t

200 lasm now having a biological basis for their excessive myeloproliferation.

201 o the sarcolemma as the primary mechanism of excessive myocellular lipid import.

202 to the superhydrophilic surface property and excessive nanoscale nucleation sites created by the nano

203 and epithelial dysregulation, accompanied by excessive necroptotic cell death and a reduced number of

204 id negative cues in MDD, which could lead to excessive negative focus.

205 tor co-repressor 1 (NCoR1) in T cells causes excessive negative selection to reduce mature thymocyte

206 luding cystic fibrosis, are characterized by excessive neutrophil infiltration into the airspace.

207 that FACs are utilized mainly for removal of excessive nitrogen in generalists but for nitrogen assim

208 Excessive nucleotide-binding oligomerization domain-like

209 NA sequencing (HTS) technologies generate an excessive number of small DNA segments -called short rea

210 ystem conditions, for example, by preventing excessive nutrient input to lakes and reservoirs.

211 Excessive or nonresolving innate immune activation can l

212 Excessive or overly restrictive eligibility criteria can

213 Excessive or sustained ROS production, however, when exc

214 one loss, reduction in vessel perfusion, and excessive osteoclastogenesis in the femoral head.

215 Rod basal outer disks displayed excessive outgrowth, and cone outer segments were curved

216 Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecule

217 type plants impaired growth, suggesting that excessive PEX1 can be detrimental.

218 Excessive placental inflammation is associated with seve

219 tive stress: diabetes, obesity, smoking, and excessive pollution.

220 glucose intolerance in muscle and the liver, excessive postprandial excursion of plasma glucose and i

221 al insulinemia and glycemia after correcting excessive postprandial hyperglycemia using treatment wit

222 amplitudes of miniature EPSCs indicative of excessive postsynaptic excitation.

223 idence-based pain management and to decrease excessive prescribing that may leave unused opioids avai

224 30% is related to waste, inefficiencies, and excessive prices; health disparities are persistent and

225 -1(-/-) mice, these mice did not generate an excessive primary CD4 TFH cell response nor an enhanced

226 y1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity

227 ey effector cells in SSc responsible for the excessive production of collagen and the development of

228 Liver fibrogenesis is associated with excessive production of extracellular matrix by myofibro

229 Excessive production of paramagnetic free radicals in no

230 s combined with genetic tests show that this excessive proliferation depends on the synergistic induc

231 F-, and ribosome-related gene sets, promoted excessive proliferation, and led to retinoblastoma with

232 s well as fully reversing EA2 mutant-induced excessive proteasomal degradation of CaV2.1 WT subunits.

233 Skeletal muscle atrophy due to excessive protein degradation is the main cause for musc

234 /2- and PI3K-mediated signalling, attenuates excessive protein synthesis and corrects dendritic spine

235 core phenotypes in the Fmr1(-/y), including excessive protein synthesis, exaggerated mGluR-LTD, and

236 Excessive proteolysis during dry-cured ham processing ma

237 an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) pr

238 When RADX is inactivated, excessive RAD51 activity slows replication elongation an

239 ER and ERL1 redundantly suppressed excessive radial growth of the hypocotyl vasculature dur

240 Excessive reactive oxygen species (ROS) can damage prote

241 Additionally, an rpaA mutant accumulates excessive reactive oxygen species (ROS) during the day a

242 pecific apoptosis induction by YC-1 involved excessive reactive oxygen species (ROS) generation.

243 Ischemic stroke results in excessive release of glutamate, which contributes to neu

244 ense, deregulated inflammasome responses and excessive release of inflammatory cytokines and danger s

245 myocardium, protected the myocardium against excessive remodeling in response to mild pressure overlo

246 Excessive remodeling of the ECM is a hallmark of a varie

247 myocardium, protected the myocardium against excessive remodeling of the pressure-overloaded heart.

248 rget for treating disorders characterized by excessive repetitive behaviors.

249 y enhancing activity in this pathway reduced excessive repetitive grooming in the mutant mice.

250 Risk ratios and the relative excessive risk due to interaction and 95% confidence int

251 nt antioxidant, significantly eliminated the excessive ROS and suppressed autophagy, indicating that

252 Excessive ROS damages chloroplasts and reduces photosynt

253 A delicate balance between needed versus excessive ROS production distinguishes health from an ar

254 g in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac l

255 n may provide novel clues on how to suppress excessive RyR2 Ca(2+) release by manipulating the CaM-Ry

256 were performed in the same vessel, avoiding excessive sample handling and reducing energy expenditur

257 In distinction to this developmental role, excessive SC mTORC1 activity stimulates myelin growth, e

258 Wound fibrosis (i.e., excessive scar formation) is a medical problem of increa

259 teinases would be more effective in treating excessive scarring than modulation of either therapeutic

260 mitative scratching in normal mice observing excessive scratching in genetically modified demonstrato

261 types from generation to generation requires excessive scrolling back and forth.

262 Excessive secretion of glucagon, a functional insulin an

263 Excessive sedentary time is ubiquitous in developed nati

264 Excessive sedentary time is ubiquitous in Western societ

265 The sensor showed perfect sensitivity, excessive selectivity and stability for longer period of

266 of TNFalpha in PGRN knockout mice abolished excessive self-grooming and the associated hyperexcitabi

267 It determined high asthma risk through excessive sIgE production and directly affected impaired

268 hat among all features of severe atopy, only excessive sIgE production early in life affected asthma

269 43 in astrocytes throughout the brain causes excessive sleepiness and fragmented wakefulness during t

270 2.0 to -25.6]; 13 trials, 543 participants), excessive sleepiness assessed by ESS score (WMD, -2.0 [9

271 ms were also associated with reduced AHI and excessive sleepiness.

272 SMS deficiency leads to excessive spermidine catabolism, which generates toxic m

273 ion interrupts this transport in response to excessive sphingomyelin production.

274 -) mice display reduced barrier function and excessive Src-related tyrosine phosphorylation of the ad

275 ropose that Rad53 prevents the generation of excessive ssDNA under replication stress by coordinating

276 e extension assistance favorably reduced the excessive stance-phase knee extensor moment present duri

277 energy induced by acute food deprivation and excessive storage of energy by high-fat diet feeding dam

278 rogression, two pathologies characterized by excessive stromal expansion, we used mouse models to cha

279 MP signaling within nerve terminals, driving excessive synaptic growth.

280 In TbRAP1-depleted cells, expression of excessive TbRNaseH1, which cleaves the RNA strand of the

281 the VCP/E3 ligase complex, thereby limiting excessive TGF-beta response.

282 However, late in the disease, excessive TH17 responses may be disadvantageous by contr

283 mice show strong eosinophilic infiltration, excessive Th2 polarization, marked airway hyperresponsiv

284 fatal inflammatory disease characterized by excessive TH2-type-dominant responses.

285 rately detect harmful forms of OTV including excessive tidal volumes and common forms of patient-vent

286 ffective immune response that does not cause excessive tissue damage, and this study identifies NO as

287 This finding indicates that limiting the excessive TLR4-mediated proinflammatory response in EBOV

288 cytosis of apoptotic cells, which stimulated excessive TNF-alpha secretion predominantly from dendrit

289 Inflammation is driven by excessive transmigration (diapedesis) of leukocytes from

290 -DOTA-Bn only), leading to euthanasia due to excessive tumor burden, whereas 10 of 10 complete respon

291 rough evidence-based strategies that prevent excessive use of alcohol; * Provide education to oncolog

292 Excessive V in air and water has potential, but poorly d

293 mutated corresponding protospacers, while an excessive variety of spacers dilutes the number of the C

294 nt deletion of Vegfr2 prevented VEGF-induced excessive vascular leakage in mice lacking Vegfr3.

295 scular endothelial cells, thereby preventing excessive vascular permeability.

296 Excessive ventilation led to better arterial oxygenation

297 Excessive ventilatory response in this group was associa

298 tipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes.

299 y lead to their decision-making deficits and excessive worry about everyday problems by disrupting th

300 nt of confounding variables and accommodates excessive zero observations; and it incorporates taxonom