ライフサイエンスコーパス: exchange factor

1 ne exchange factor, betaPIX (Pak interactive exchange factor).

2 rones, an Hsp40 (J-protein) and a nucleotide exchange factor.

3 he first identified nuclear Hsp70 nucleotide exchange factor.

4 a GTPase activating protein and a nucleotide exchange factor.

5 s RIN3, a RAB5-activating guanine nucleotide exchange factor.

6 some condensation 1 (RCC1), Ran's nucleotide exchange factor.

7 nding partner beta-PIX, a guanine nucleotide exchange factor.

8 of (at least) three Drosophila Arf6 guanine exchange factors.

9 cing the Rac-activating effect of nucleotide exchange factors.

10 ctions with RhoA-specific guanine nucleotide exchange factors.

11 ociated proteins, and Rho guanine nucleotide exchange factors.

12 ominently, G12/13, to Rho guanine nucleotide exchange factors.

13 s involving HSP70 and interacting nucleotide exchange factors.

14 ors, such as Hsp40 J-proteins and nucleotide exchange factors.

15 fic brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1) and JAK1, as potential antivira

16 that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell division control prote

17 of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) sever

18 nst brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG2) that activate AD

19 vels of the Rac activator PIP3-dependent Rac exchange factor-1 (P-REX1) increased in response to PI3K

20 ylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) using the same immortalized hu

21 ptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor directly activated by

22 ated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPases, is required for

23 imulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

24 We determined that the guanine nucleotide exchange factor activity of DOCK8 is essential for the i

25 b exchange depends on the guanine nucleotide exchange factor activity of the Mon1-Ccz1 heterodimer fo

26 gene expression is OGG1's guanine nucleotide exchange factor activity, acquired after interaction wit

27 r Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac regulates podosome for

28 of Cb, which carries the guanine nucleotide exchange factor activity, leads to epilepsy and intellec

29 ess by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates

30 RASGRP1 is an important guanine nucleotide exchange factor and activator of the RAS-MAPK pathway fo

31 on of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signaling as well as on t

32 nd KRAS(G12C) is insusceptible to nucleotide exchange factors and thus trapped in its inactive state.

33 dicator of cytokinesis 4 (DOCK4) is a GTPase exchange factor, and its gene maps to the commonly delet

34 roteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activ

35 hibits RhoA activation by guanine nucleotide exchange factors, and blocks RhoA, but not Rac and Cdc42

36 l GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activating proteins (GAPs)

37 nd P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbetagamma effectors in

38 e ADP ribosylation factor guanine nucleotide exchange factor (ARF-GEF) GNOM.

39 n ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi.

40 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate virtually all traff

41 A-sensitive ADP-ribosylation factor-guanine exchange factors (ARF-GEFs).

42 se-activating proteins (ArfGAPs) and guanine exchange factors (ArfGEFs) that regulate the activity of

43 ein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT-1 and the actin-se

44 protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA and PKG substrates in

45 can interact with the ARF guanine nucleotide exchange factor ARNO, although the C-terminally lacking

46 -protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, interfering RNA or phar

47 re, we demonstrate that the Hsp70 nucleotide exchange factor Bag1 promotes hERG degradation by the ub

48 eracts with p21-activated kinase interacting exchange factor beta (betaPIX) and G protein-coupled rec

49 he b isoform of Rac/Cdc42 guanine nucleotide exchange factor beta-PIX, regulates the activity of Rac1

50 ike pathway, involving the Rac/Cdc42 guanine-exchange factor beta-PIX/PIX-1 and effector PAK1/PAK-1,

51 and its interaction with the PAK-interacting exchange factor-beta (beta-Pix) are required to reconsti

52 ene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x10(-)(4)), also ass

53 ng Scrib from its complex with the Rac/Cdc42 exchange factor betaPIX and decreasing the activity of t

54 to beta-PAK1-interacting guanine-nucleotide exchange factor (betaPIX) and G protein-coupled receptor

55 r Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), and PKA.

56 racting protein (GIT1) and the cdc42 guanine exchange factor, betaPIX (Pak interactive exchange facto

57 Mice lacking Rab-32 or its nucleotide exchange factor BLOC-3 are permissive to S. Typhi infect

58 carrier formation is dependent on the RAB38 exchange factor BLOC-3.

59 brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in a GluN2 subunit-de

60 Arf1 is activated by guanine nucleotide exchange factors, but essential roles for Arf1 GTPase-ac

61 s coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion docking molecule CA

62 explains how KaiA, by acting as a nucleotide exchange factor, can stimulate phosphorylation of KaiC,

63 We show that Nedd8 conjugation and the SR exchange factor Cand1 have a profound effect on shaping

64 increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity combined with increas

65 ein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide exchange on RhoA, t

66 t upon the brain-specific guanine nucleotide exchange factor Collybistin (Cb).

67 protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

68 ases, guanosine triphosphatases, and guanine exchange factors) controlled conversion between conforma

69 tion mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 degradation, and mislo

70 ) and is activated by the guanine-nucleotide exchange factor DENND3.

71 omplex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 results in the loss of m

72 ing Rap guanine nucleotide exchange factor 3/exchange factor directly activated by cyclic adenosine m

73 10 knockout mice lack the guanine nucleotide exchange factor DOCK8 (dedicator of cytokinesis 8), whic

74 mily protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

75 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of both myosin-II act

76 genous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and intersectin (ITSN).

77 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-protein directly activat

78 pression of the bacterial guanine nucleotide exchange factor, EspT.

79 ccharomyces cerevisiae, the Hsp70 nucleotide exchange factor Fes1 is essential for the degradation of

80 ing modulated by Ric8, a nonreceptor guanine exchange factor for [Formula: see text] in Dicty, drives

81 Caenorhabditis elegans the signaling protein Exchange Factor for ARF-6 (EFA-6) is a potent intrinsic

82 ribosylation factor 6 (Arf6) isoform and the exchange factor for Arf6 (EFA6) are known to regulate th

83 It functions as a guanine nucleotide exchange factor for Galphai, Galphaq, and Galpha12/13 an

84 key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mi

85 ule found in all eukaryotes and serves as an exchange factor for Rab-GTPases to regulate diverse cell

86 in protein DENND2B as the guanine nucleotide exchange factor for Rab13 and develop a novel Forster re

87 of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that specifica

88 is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical for NCT activity.

89 RasGRP2 is a guanyl exchange factor for Rap1.

90 se of Kalirin-7 (Kal7), a guanine-nucleotide exchange factor for Rho-like small GTPases critical to m

91 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we report here that SmgGDS

92 Sil1 is a nucleotide exchange factor for the endoplasmic reticulum chaperone

93 Epac, a guanine nucleotide exchange factor for the low molecular weight G protein R

94 1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTPase Ras-related C3

95 thway through Cdc24p, the guanine nucleotide exchange factor for the polarity establishment GTPase Cd

96 cellular protein GBF1, a guanine nucleotide exchange factor for the small cellular GTPase Arf1.

97 ically, alphaPIX, a known guanine nucleotide exchange factor for the small GTPases of the Rho family,

98 FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the small GTPases Rac and Cdc42 and

99 ver, only in the past decade have nucleotide exchange factors for BiP been identified, which has shed

100 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GTPases.

101 ical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 that is putatively in

102 rms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTPases, Rap1 and Rap2

103 ns that function as GEFs (guanine nucleotide exchange factors) for the small GTPase Rab35.

104 ed of the unique modular makeup of guanidine exchange factor Galpha-interacting vesicle-associated pr

105 ine et al. identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress-indu

106 dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimulating its ability

107 uiting its activator, the guanine nucleotide exchange factor GEF-H1.

108 mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expressed in breast can

109 ing inflammation, but its guanine-nucleotide exchange factor (GEF) activators seem dispensable for th

110 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for se

111 is the first for which a guanine nucleotide exchange factor (GEF) activity has been unequivocally as

112 GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vitro and promotes G p

113 find that Bem1 directly augments the guanine exchange factor (GEF) activity of Cdc24.

114 usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs.

115 ation that disrupts DOCK8 guanine nucleotide exchange factor (GEF) activity while sparing protein exp

116 pment that acts as both a guanine nucleotide exchange factor (GEF) and a chaperone for Galpha subunit

117 ling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase activating protein (G

118 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed that I942 and, to

119 d their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which controls integrin end

120 rred independently of the guanine nucleotide exchange factor (GEF) catalytic activity and of the pres

121 activator of Cdc42p, the guanine nucleotide exchange factor (GEF) Cdc24p, which we show also regulat

122 mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicator of cytokinesis 4)

123 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with distinct specificitie

124 n of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.

125 The guanine nucleotide exchange factor (GEF) epithelial cell transforming seque

126 NCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in the olfactory epithel

127 ells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small GTPases, causes a ro

128 ase that functions as a guanosine nucleotide exchange factor (GEF) for ARL3-GDP.

129 Thus, SBDS acts as a guanine nucleotide exchange factor (GEF) for EFL1 promoting its activation

130 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-binding protein partne

131 y of PLC to function as a guanine nucleotide exchange factor (GEF) for Rap1 supports sustained downst

132 in-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characteri

133 exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum t

134 iated protein (GIV, aka Girdin) is a guanine exchange factor (GEF) for the trimeric G protein Galphai

135 radigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G protein Galphai

136 protein Rad24 associates with Cdc42 guanine exchange factor (GEF) Gef1, limiting Gef1 availability t

137 alphai by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known as Girdin), a meta

138 ctivation of Galphai proteins by the guanine exchange factor (GEF) GIV.

139 Importantly, ARL-13 acts as a nucleotide exchange factor (GEF) of ARL-3, while UNC-119 can stabil

140 otein betagamma-regulated guanine nucleotide exchange factor (GEF) of the Rac small GTPase, for its p

141 We find that the guanine nucleotide exchange factor (GEF) of Ypt7 (the Mon1-Ccz1 complex) an

142 ociation inhibitor 1 (GDI1), but not guanine exchange factor (GEF) or GTPase-activating protein (GAP)

143 hanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed in a significant pro

144 tion required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

145 that structurally resembles the Ran guanine exchange factor (GEF) RCC1, but has not previously been

146 ng protein RanGAP1 and the nuclear guanosine exchange factor (GEF) RCC1.

147 ECT-2, the guanine nucleotide exchange factor (GEF) required for RhoA activation, is a

148 The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a cri

149 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates Arf-like protein A

150 cycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates Rab11 in most eukar

151 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein

152 a new subunit of the CCZ1-MON1 RAB7 guanine exchange factor (GEF) that positively regulates RAB7 rec

153 hen detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitated the assembly of

154 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifically activates the Rh

155 The Rac1 guanine nucleotide exchange factor (GEF) Trio is essential for netrin-1-ind

156 ns ortholog of Trio, as a guanine nucleotide exchange factor (GEF) upstream of both CED-10 and MIG-2.

157 However, the guanine nucleotide exchange factor (GEF) which activates Arl3 is unknown.

158 (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, and p115RhoGEF augme

159 H1(-/-)), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limited migration and r

160 ecycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

161 itor state, that the cAMP-dependent Rap1 GTP exchange factor (GEF), Epac, known to down-regulate RhoA

162 As a guanidine exchange factor (GEF), GIV modulates signals initiated b

163 activation by its cognate guanine nucleotide exchange factor (GEF), Rabin8 (by using the Ser111Glu ph

164 sociated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates Galpha activity-in

165 Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadoso

166 We identified the guanine nucleotide exchange factor (GEF), VAV2, as having the greatest loss

167 and function and requires guanine nucleotide exchange factor (GEF)-mediated activation of downstream

168 tastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).

169 IV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).

170 loses the ability to bind guanine nucleotide exchange factor (GEF).

171 f sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and dedicator of cytok

172 a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a Rab-GDP dissociation

173 icrotubule-associated Rho guanine nucleotide exchange factor, GEF-H1, participates in TRPC3-mediated

174 s with protein Blt1p, guanosine triphosphate exchange factor Gef2p, and kinesin Klp8p emerge from con

175 d), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regulator of G protein

176 Guanine nucleotide exchange factors (GEFs) activate and GTPase-activating p

177 e factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho GTPases, leading t

178 y the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (

179 y their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (

180 ors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signall

181 omprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial ce

182 Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomyces cerevisiae that

183 lso act as Galpha-subunit guanine nucleotide exchange factors (GEFs) in vitro.

184 e VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9.

185 1 (ARF1)-GTPase and its effector ARF-guanine-exchange factors (GEFs) of the Brefeldin A-inhibited GEF

186 TPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulati

187 elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio and TIAM-1 promote a

188 GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserved molecular switche

189 Rho GTPases, activated by guanine nucleotide exchange factors (GEFs), are essential regulators of pol

190 ed family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin, Daple, NUCB1 and NU

191 y of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAP

192 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associa

193 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety

194 ctors, both effectors and guanine nucleotide exchange factors (GEFs), showed induction of RAB11B bind

195 er, about the function of guanine nucleotide exchange factors (GEFs), which activate these GTPases, i

196 to oligomerize with ROR2 and recruit guanine exchange factors (GEFs), which activated Rac1 and RhoA;

197 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

198 TPases is governed by Rho guanine nucleotide exchange factors (GEFs).

199 he SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

200 family of Rab-activating guanine nucleotide exchange factors (GEFs).

201 class of enzymes, termed guanine nucleotide exchange factors (GEFs).

202 ER and how it is regulated by the nucleotide exchange factors, Grp170 (glucose-regulated protein of 1

203 li) induce the ADP state, and the nucleotide exchange factors (GrpE in E. coli) induce the ATP state.

204 ways, involving ubiquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/GAP).

205 one, even with the crucial HSP110 nucleotide exchange factor, has poor disaggregation activity in vit

206 calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported prev

207 which indicates superiority of a system with exchange factor if substrate receptors bind substrates a

208 s Tuba), a Cdc42-specific guanine nucleotide exchange factor, in ciliogenesis and nephrogenesis using

209 BIG2 or overexpression of guanine nucleotide-exchange factor inactive mutant, but not wild-type, prot

210 Ric-8b, a guanine nucleotide exchange factor, interacts with Galphaolf and can amplif

211 cribe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with

212 Ras GTPase-activating proteins, Ras guanine exchange factors, kinases, scaffolding or adaptor protei

213 ization is activated by a guanine nucleotide exchange factor known as Dedicator of cytokinesis 2 (DOC

214 pathway involves Trio, a guanine nucleotide exchange factor known to promote cytoskeletal remodeling

215 on was independent of Rac guanine nucleotide exchange factors known to regulate T cell activity.

216 Prominent among these were PAK-interacting exchange factor (known as Pix or RtGEF) and G-protein-co

217 argo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPases RagA and Rab3D.

218 an associated Hsp40, Scj1, and a nucleotide exchange factor, Lhs1, stabilize torsinA and torsinADelt

219 tivated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects of the pivotal seco

220 e ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTERACTOR7/BREFELDIN A

221 tment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115 kDa), a direct tar

222 substrate receptors is mediated by a protein exchange factor named Cand1.

223 We found that nucleotide exchange factor (NEF) Grp170 induces nucleotide exchange

224 demonstrate that the ER-resident nucleotide exchange factor (NEF) Grp170 plays an important role dur

225 tein DNAJB1, and an Hsp110 family nucleotide exchange factor (NEF) provide ATP-dependent activity tha

226 omyces cerevisiae) functions as a nucleotide exchange factor (NEF) to regulate the protein folding ac

227 demonstrate that the ER-resident nucleotide exchange factors (NEFs) Grp170 and Sil1 induce CT releas

228 Nucleotide exchange factors (NEFs) play a crucial role in exchangin

229 linos targeting two other guanine nucleotide exchange factors not known to be in the Cdc42/ciliogenes

230 otein that functions as a guanine nucleotide exchange factor of ADP-ribosylation factors (Arfs), is c

231 Mge1, an evolutionarily conserved nucleotide exchange factor of Hsp70, acts as an oxidative sensor to

232 ect of overproduction of Sse1 - a nucleotide exchange factor of the molecular chaperone Hsp70, and it

233 heterologously expressed guanine nucleotide-exchange factors or of constitutively active (but not wi

234 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary PIP3-stimulated Ra

235 2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.

236 ction for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white adipose t

237 tol 3,4,5-trisphosphate (PIP3)-dependent Rac exchange factor (PREX) family of guanine nucleotide exch

238 nal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synapse number

239 show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is rapidly sequestered t

240 previously identified the guanine nucleotide exchange factor, RAPGEF5.

241 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysregulated homeostatic

242 Active nuclear import of Ran exchange factor RCC1 is mediated by importin alpha3.

243 lear transport of the Ran guanine nucleotide exchange factor RCC1.

244 These guanine nucleotide exchange factors regulate the spatiotemporal dynamics of

245 RETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation of RhoA, which is

246 stimulated, Rap1-specific guanine nucleotide exchange factor required to balance Ras and Rap signalin

247 This study identifies the guanine exchange factor responsible for Rap1b activation during

248 ECT-2, the exchange factor responsible for RhoA activation, is regu

249 The guanine nucleotide exchange factor Rgnef (also known as ArhGEF28 or p190Rho

250 x is a conserved Rho-type guanine nucleotide exchange factor (Rho-GEF) homologous to Beta-PIX and Alp

251 x1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate Rac GTPases to regu

252 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promotes actin polymerizat

253 gnaling homology (RH) Rho guanine nucleotide exchange factors (RhoGEFs) (p115RhoGEF, leukemia-associa

254 LC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to Trio, in a strikin

255 e to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family of proteins involve

256 Rho GTPases are activated by Rho guanine exchange factors (RhoGEFs), but the RhoGEF(s) required f

257 tream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

258 Through its exchange factor role, asparagine regulates mTORC1 activi

259 olled by signaling of the guanine nucleotide exchange factor Rom2, initiating at the plasma membrane.

260 s efficiently activated in vitro by the Sec4 exchange factor, Sec2.

261 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized to gamma-aminobuty

262 Here we demonstrate that BiP's nucleotide exchange factor - Sil1 - can reverse BiP cysteine oxidat

263 an be stimulated by two different nucleotide exchange factors, Sil1 and Lhs1.

264 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is a key promoter of c

265 ted by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos).

266 rted to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its Rac-guanine nucleoti

267 with its association with guanine nucleotide exchange factor SOS1.

268 epression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cells of tr

269 overed that overexpression of the nucleotide exchange factor Sse1 can partially alleviate this toxici

270 Unexpectedly, interaction with the exchange factor TBL1 is required to protect GPS2 from de

271 interact with Zizimin1, a guanine-nucleotide exchange factor that activates Cdc42 and stimulates S863

272 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates heterotrimeric G protein

273 GEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA, a small GTPase prot

274 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPa

275 d destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1.

276 hat GIV is a non-receptor guanine nucleotide exchange factor that activates trimeric G proteins in re

277 a ubiquitously expressed guanine nucleotide exchange factor that functions in signaling pathways reg

278 associated protein (GIV)/girdin, a guanidine exchange factor that links G proteins to a variety of RT

279 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP signaling in various

280 y showed that the GrpE dimer is a nucleotide exchange factor that works by interaction of one of its

281 RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and a

282 in particle (TRAPP) complexes are Rab GTPase exchange factors that share a core set of subunits.

283 Thus, Rho guanine nucleotide exchange factors, the activators of these molecular swit

284 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD-induced increase i

285 proteins and signaling through the G protein exchange factor Tiam1.

286 inase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

287 bitor of the Rac-specific guanine nucleotide exchange factors Tiam1 and Trio (NSC23766).

288 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G pro

289 mily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key components of EphB2 trans-e

290 interact with Dock family guanine nucleotide exchange factors to promote activation of the small GTPa

291 ceptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance the repulsive acti

292 he levels of the Rho-type guanine nucleotide exchange factor Trio, a transcriptional output of BMP-Sm

293 sine phosphatase LAR, and the RAC1 guanidine-exchange factor TRIO.

294 Here we show that RhoG and its exchange factor, Trio, play a role in the regulation of

295 e family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human schizophrenia brai

296 Gtr1 and Gtr2, which work downstream of the exchange factor Vam6.

297 e identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensive screen for human

298 iators promote recruitment of the nucleotide-exchange factor Vav3, which in turn activates small Rho-

299 as is activated by Sos, a guanine nucleotide exchange factor, we modeled the N-Ras-Sos interaction an

300 t the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domain binds to various