ライフサイエンスコーパス: excision

1 rates of repeat excision (referred to as re-excision).

2 rives-growth model and real plants following excision.

3 margins positive for cancer that required re-excision.

4 teractions at position 70, required for NRTI excision.

5 chondrocytes, using "Cre-loxP"-mediated gene excision.

6 s to fill in the gaps resulting from mispair excision.

7 me editing and concurrent scarless transgene excision.

8 for promoting integration and for inhibiting excision.

9 icient TDG enzymatic turnover following base excision.

10 as identified over time for abdominoperineal excision.

11 slightly smaller than those found in staged excision.

12 (2) wide local excision, and (3) whole organ excision.

13 , margins were clear after 5 mm or less in 8 excisions (3.0%) and after 10 mm or less in 141 excision

14 margins were clear after 5 mm or less in 232 excisions (41.1%) and after 10 mm or less in 420 excisio

15 Patients underwent total mesorectal excision 5-10 weeks after radiotherapy completion.

16 isions (3.0%) and after 10 mm or less in 141 excisions (52.2%).

17 sions (41.1%) and after 10 mm or less in 420 excisions (74.5%).

18 cleral limbal dissection owing to wide tumor excision (8 vs 7; P = .12), were comparable.

19 essential for splicing, generating after its excision, a newly formed canonical intron defined as 'ex

20 hanism) or confer an ATP-mediated nucleotide excision activity that removes the inhibitor from the 3'

21 3) and, to a lesser extent, Ile(75) suppress excision activity when TAMs are present in the HIV-2 RT.

22 D67N/K70R/S215Y HIV-2 RT lacks ATP-dependent excision activity, and recombinant virus containing this

23 Organ-preservation alternatives are local excision alone for very early tumors, chemoradiation fol

24 at minimal risk of recurrence after surgical excision alone.

25 iCre) that is frequently used to mediate the excision and loss of loxP-flanked DNA sequences in a rap

26 ts impact on survival after abdominoperineal excision and pelvic exenteration for primary or recurren

27 localization, and removal, along with target excision and rates of repeat excision (referred to as re

28 r during DNA replication by coordinating the excision and re-synthesis of a long tract of the newly-r

29 The excision and reintegration of transposable elements (TEs

30 O binding are not essential for TDG-mediated excision and repair of 5-carboxylcytosine bases.

31 0.50 to 1.0 mm thin melanoma undergoing wide excision and surgical evaluation of regional LNs were in

32 onjunctival lymphoma occurred 6 months after excision and the MALT lymphoma remained indolent during

33 reported to correlate with size of cervical excision and therefore balancing the risk of adequate tr

34 line reported no past history of skin cancer excisions and no more than five destructively treated ac

35 utilizing FGS: (1) debulking, (2) wide local excision, and (3) whole organ excision.

36 n 19,607 participants after abdominoperineal excision, and 30 studies reporting on 1326 participants

37 persistence, or lysis, concomitant with ICE excision, and likely, ICE loss or replication.

38 of UNG2, reduces the rate of in vitro uracil excision, and slows UNG2 dissociation from chromatin aft

39 erable breast cancer, had undergone complete excision, and were due to receive adjuvant chemotherapy.

40 emoradiotherapy followed by total mesorectal excision at our institution during 1993 to 2008 were ide

41 s with CM who had been treated with surgical excision between 2006 and 2011.

42 rmed by a histopathologic examination of the excision biopsy specimen.

43 This was followed by an excision biopsy.

44 ed 'Boolean logic and arithmetic through DNA excision' (BLADE), to engineer genetic circuits with mul

45 h2-MutS homolog 3 (Msh3) stimulates 5' to 3' excision by exonuclease 1 (Exo1) from a single-strand br

46 who underwent breast lesion localization and excision by using the Savi Scout surgical guidance syste

47 s but increased single-joint T-cell receptor excision circle content and CD31(+) naive CD4(+) T cells

48 signal-joint/DbetaJbeta T-cell rearrangement excision circles (sj/beta-TREC ratio) overcomes this lim

49 Neonates with cCMV had fewer TCR excision circles in their blood than non-infected contro

50 nal joints on Igkappa-deleting recombination excision circles, genomic intron recombination signal se

51 CMV: deltaRec-psiJalpha signal joints on TCR excision circles, intron recombination signal sequence k

52 where the standard approach is wide surgical excision combined with radiotherapy and/or (neo)adjuvant

53 of the tissue, and the quality of mesorectal excision (complete, nearly complete, or incomplete).

54 ssential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic

55 sential for transcription-coupled nucleotide excision DNA repair.

56 he efficacy of extralevator abdominoperineal excision (ELAPE) regarding local recurrence rates within

57 The necessary margin of excision for cutaneous melanomas greater than 2 mm in th

58 emoradiotherapy followed by total mesorectal excision for locally advanced rectal cancer, patients wh

59 rectal excision or tumor-specific mesorectal excision for rectal cancer between April 2009 and April

60 that the use of a pelvic drain after rectal excision for rectal cancer did not confer any benefit to

61 one of the major complications after rectal excision for rectal cancer.

62 expert consensus opinion recommends surgical excision for therapeutic management.

63 ive resection margins after abdominoperineal excision [hazard ratio (HR) 2.64, P < 0.01; HR 3.70, P <

64 he ends of SB transposons excised by a K248A excision(+)/integration(-) transposase variant are proce

65 ctive in all recombination reactions tested: excision, integration, and dual recombinase-mediated cas

66 Excision is an early step in GI mobilization, producing

67 risk for achieving a noncomplete mesorectal excision is significantly higher in patients undergoing

68 Rectal resection with mesorectal excision is the mainstay treatment for rectal cancer.

69 Surgical excision is the treatment of choice for this benign cond

70 Upon excision, it leaves a short DNA footprint that can creat

71 ere reported in 35 (8%) patients in the 1 cm excision margin group and 65 (15%) patients in the 3 cm

72 vic exenteration instead of abdominoperineal excision may improve resection margins.

73 primers, enabling further primer elongation (excision mechanism).

74 IV-2 RT residues impeding the development of excision-mediated NRTI resistance.

75 rgical delay, defined as definitive surgical excision occurring more than 6 weeks after melanoma diag

76 ere eligible if women underwent treatment by excision of a histologically confirmed CIN2+ lesion, wit

77 Four years later, he underwent excision of a raised pigmented skin lesion on his left c

78 ors, chemoradiation followed by either local excision of a small tumor remnant or, when there is a co

79 enzymes perform two essential functions: 1) excision of a unit length genome from the concatemer (ge

80 was "severely atypical." Instead of surgical excision of all HRLs, if those categorized with the mode

81 jo, Calif) reflector-guided localization and excision of breast lesions by analyzing reflector placem

82 que non-base-flipping mechanism that enables excision of bulky lesions more commonly associated with

83 ed reduced PRMT5-mediated H4R3me2s following excision of Cdc73 placing this histone modification down

84 Incomplete excision of cervical precancer is associated with therap

85 Here, we used excision of chromosomal regions as circular "loop outs"

86 Excision of CSM reduces re-excision rates by more than 5

87 tep of the BER pathway, i.e. recognition and excision of DNA lesions.

88 (>100-kb) synthetic DNA, through the in vivo excision of double-stranded DNA from an episomal replico

89 with regard to surveillance versus surgical excision of HRLs.

90 quired for heterochromatin-dependent precise excision of IES residing within exons of functionally im

91 on required for RNA transcript synthesis and excision of incorrect nucleotides after misincorporation

92 The excision of introns from pre-mRNA is an essential step i

93 Cre-dependent genetic excision of KOR from dopaminergic, but not serotonergic

94 He underwent re-excision of melanoma but 2 months later developed a new

95 ter misincorporation, and 3) proofreading by excision of misincorporated bases.

96 al-based reaction pathway cleanly results in excision of most atoms of a specific guanosine nucleosid

97 o frozen sections associated with the staged excision of NMSC was performed from September 8, 2008, t

98 The mean time interval between surgical excision of OSSN and onset of LSCD was 8 weeks (median,

99 l dissection of >/=6 clock hours during wide excision of OSSN can cause LSCD.

100 Concomitant p-SLET after surgical excision of OSSN prevents LSCD in cases requiring extens

101 (hysterectomy, curettage, ovary excision, or excision of ovarian cysts).

102 Conditional excision of PMIX revealed its crucial role in invasion,

103 e study was to compare costs associated with excision of routine cavity shave margins (CSM) versus st

104 n Sde2 activation both result in inefficient excision of selected introns from a subset of pre-mRNAs.

105 FEN1 also failed to provide excision of the 5'-adenylated BER intermediate in mitoch

106 ollowed by elective open cholecystectomy and excision of the fistula tract.

107 tions resulting in virus gene expression and excision of the integrated viral genome resulting in rea

108 This morphologic change led to the excision of the lesion.

109 The child underwent total excision of the lesion.

110 Total excision of the nail unit followed by a full-thickness s

111 thout bone invasion treated by wide surgical excision of the nail unit followed by full-thickness ski

112 ies of patients has shown that wide surgical excision of the nail unit was associated with a low rate

113 To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft

114 rectal cancer is a radical total mesorectal excision of the rectum, and although this provides excel

115 in cells results in the modification and/or excision of the segment of viral DNA, leading to replica

116 Similarly, excision of the short-period CK1epsilon tau mutation spe

117 nisation to 25.9% [22.3-29.6] for large loop excision of the transformation zone) and increased by th

118 After excision of the tumor, WDS ceased and gastric acid secre

119 that carry out site-specific integration and excision of their viral genomes.

120 2) provides reversibility, thus allowing the excision of undesired sequences.

121 Patients who underwent total mesorectal excision or tumor-specific mesorectal excision for recta

122 less important for DDFI than completeness of excision or, where appropriate, chest-wall radiotherapy.

123 al treatment (hysterectomy, curettage, ovary excision, or excision of ovarian cysts).

124 Mutations of the excision pathway such as M41L, D67N, K70R, or S215Y (kno

125 ith a median age at the time of first staged excision procedure of 65 years (range, 20-94 years) part

126 Loop electrosurgical excision procedure rates within 5 years were 20.0% highe

127 disease, and biopsy or loop electrosurgical excision procedure rates.

128 biopsies and 20.0% more loop electrosurgical excision procedures were performed.

129 and psaA-i2, splice in trans, and thus their excision process resembles the nuclear spliceosomal spli

130 , patients often experience high rates of re-excision, radical resections, and overtreatment.

131 dian 76 vs 66 min, P < 0.01), but a lower re-excision rate for positive margins (13/119 = 10.9% vs 32

132 extensive treatment and a lower annual mean excision rate for suspicious lesions in specialized surv

133 Re-excision rates and complications were recorded.

134 g developed to reduce positive margin and re-excision rates and will be compared with the diagnostic

135 Excision of CSM reduces re-excision rates by more than 50%.

136 of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcome, and decrease h

137 ons with acceptable margin positivity and re-excision rates.

138 eir binding affinity, DNA incorporation, and excision rates.

139 ong with target excision and rates of repeat excision (referred to as re-excision).

140 ure with an aim to reveal whether incomplete excision, reflected by presence of precancerous tissue a

141 d cytidine deaminase (AID) and requires base excision repair (BER) and mismatch repair (MMR).

142 in promoter-coding strands, initiating base excision repair (BER) by 8-oxoguanine DNA glycosylase (O

143 Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, eff

144 that are supposed to be substrates for base excision repair (BER) in the framework of active demethy

145 ligonucleotide fragments in addition to base excision repair (BER) incision products.

146 n the absence of APTX activity, blocked base excision repair (BER) intermediates containing the 5'-AM

147 Base excision repair (BER) is one of the most frequently used

148 Furthermore, base excision repair (BER) is responsible for causing CAG rep

149 Base excision repair (BER) is the predominant pathway for cop

150 Analysis of these maps revealed that base excision repair (BER) of alkylation damage is significan

151 The base excision repair (BER) pathway is mainly responsible for

152 Additionally, we find that the base excision repair (BER) pathway is required to maintain ex

153 Repair of these lesions via base excision repair (BER) pathway maintains genomic fidelity

154 The base excision repair (BER) pathway repairs oxidized lesions i

155 ase (APE1), which functions through the base excision repair (BER) pathway.

156 oguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.

157 (hUNG) perform the initial step in the base excision repair (BER) pathway.

158 Base excision repair (BER) processes non-helix distorting les

159 beta (Polbeta), known as a key nuclear base excision repair (BER) protein, in mitochondrial protein

160 Base excision repair (BER) recognizes and repairs minimally h

161 d mutation, it is unknown if subsequent base excision repair (BER) steps function on replication-asso

162 for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polymerase

163 ation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA gl

164 eacetylases contribute to DNA repair by base excision repair (BER), nucleotide excision repair (NER),

165 reactive DNA repair intermediate during base excision repair (BER).

166 ajority of these lesions are subject to base excision repair (BER).

167 ) patients is influenced by IFN-induced base excision repair (BER).

168 whether Rev1 could also be involved in base excision repair (BER).

169 the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-induced direc

170 Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting nucleotide l

171 Global nucleotide excision repair (NER) and transcription-coupled DNA repa

172 Given the use of nucleotide excision repair (NER) as a backup pathway for RER in RNa

173 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1)

174 Nucleotide excision repair (NER) is a highly conserved pathway that

175 Nucleotide excision repair (NER) is the key DNA repair system that

176 lding protein in the multiprotein nucleotide excision repair (NER) machinery.

177 ve diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs DNA damage

178 protein that participates in the nucleotide excision repair (NER) pathway.

179 uld be subjected to repair by the nucleotide excision repair (NER) pathway.

180 Nucleotide excision repair (NER) plays a vital role in platinum-ind

181 , we measured the distribution of nucleotide excision repair (NER) rates for UV-induced lesions throu

182 changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombination (HR)

183 ir by base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), non-homolo

184 extracts yields a characteristic nucleotide excision repair (NER)-induced ladder of short dual incis

185 caused by exposure to UV light is nucleotide excision repair (NER).

186 (XPA) mice that are deficient in nucleotide excision repair (NER).

187 event required for cAMP-enhanced nucleotide excision repair (NER).

188 c UVB-induced DNA photolesions by nucleotide excision repair (NER).

189 non-homologous end-joining (cku-80) or base excision repair (nth-1, exo-3), the Fanconi-related prot

190 Ribonucleotide excision repair (RER) removes ribonucleoside monophospha

191 th impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B, D, F, and

192 to current ideas, that cellular uracil base excision repair (UBER) enzymes target and cleave A3G-edi

193 DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1% of th

194 n of the overall mechanism of ribonucleotide excision repair across domains of life.

195 rcc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.

196 ear protein, participates in both nucleotide excision repair and mRNA transcription.

197 their proposed biological functions in base excision repair and nonhomologous end joining.

198 s with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) an

199 which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the

200 te that together these factors constitute an excision repair apparatus capable of repairing damaged b

201 Mismatch and base-excision repair are important in the somatic expansion o

202 coupling factor whereas UvrD plays a role in excision repair by aiding the catalytic turnover of exci

203 ests a more ancestral form of ribonucleotide excision repair compared with the eukaryotic pathway.

204 into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent componen

205 spective studies indicate that expression of excision repair cross complementing group 1 (ERCC1) prot

206 ur, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which enco

207 al of methylated cytosines requires the base excision repair enzyme TDG, but the mechanism by which T

208 on-associated demethylation promoted by Base Excision Repair enzymes further modifies methylation of

209 but independent of the essential nucleotide excision repair factor XPA.

210 during replication, or incorrect nucleotide excision repair following oxidative damage.

211 Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the r

212 Nucleotide excision repair in Escherichia coli is stimulated by tra

213 In the absence of additional factors, base excision repair in NCPs will stall at the gap-filling st

214 photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsis and rice.

215 -negative manner and impairs long-patch base excision repair in vitro and in vivo.

216 Nucleotide excision repair is a major DNA repair mechanism in all c

217 oxidation damage to the NER proteome and DNA excision repair is impaired in extracts prepared from FI

218 iates both ATR-CHK1 signaling and nucleotide excision repair is replication protein A, and we find th

219 recognized by Fanconi anemia and nucleotide excision repair machinery, although the mechanisms of th

220 ic if not properly removed by the nucleotide excision repair machinery.

221 Here we present the excision repair maps for CPDs and BPDE-dG adducts genera

222 In humans, short-patch base excision repair of 8-oxoG:dA base pairs requires human D

223 sylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out nucl

224 ntially expressed in testes, uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastran

225 in mammalian cells, and a key factor in base-excision repair of DNA.

226 sis for understanding the mechanisms of base excision repair of ICLs.

227 nzymes have been known only to initiate base excision repair of small adducts by extrusion from the D

228 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil DNA g

229 grity and define the specificity of the base excision repair pathway for discreet, detrimental modifi

230 itro and in vivo and a robust ribonucleotide excision repair pathway is critical to keeping incorpora

231 the LigC complex is directly involved in an excision repair pathway(s) that repairs DNA damage with

232 Specifically, we show that the base excision repair pathway, the main pathway utilized for t

233 glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism fo

234 s also has an adverse effect on the DNA base excision repair pathway, the major DNA repair system tha

235 he lesion has been excised by the nucleotide excision repair pathway, while others participate in tra

236 process of transcription-coupled nucleotide excision repair plays a role in the removal of epsilonC

237 The nucleotide excision repair protein complex ERCC1-XPF is required fo

238 CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to int

239 disposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational footprint

240 A feature of many base excision repair proteins is that they contain [4Fe4S] cl

241 n repair by aiding the catalytic turnover of excision repair proteins.

242 repair maps of the human genome obtained by excision repair sequencing to gain insight into factors

243 dducts in TGCT cells by using the human TGCT excision repair system.

244 ption-blocking adducts to undergo more rapid excision repair than adducts located elsewhere in the ge

245 ide Retrieval Assay" designed to measure DNA excision repair that is capable of quantifying the rate

246 and well-conserved sub-pathway of nucleotide excision repair that preferentially removes DNA lesions

247 e report the sequence specificity of BPDE-dG excision repair using tXR-seq.

248 in removal of photo-damage (e.g. nucleotide excision repair uvrABC, recombinases recBCD and resolvas

249 to extend from 8-oxoG during long-patch base excision repair was unknown.

250 all DNA-templated processes, including base excision repair where Pol beta catalyzes two key enzymat

251 In excision repair, coupled incisions are made in the damag

252 that beyond the known pathways, such as base excision repair, the process of transcription-coupled nu

253 polymerase X family that is involved in base excision repair, uses a processive hopping search mechan

254 n mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned whether Re

255 We have termed this method translesion excision repair-sequencing (tXR-seq).

256 ecently, we reported that as measured by the excision repair-sequencing (XR-seq), UvrD plays no role

257 ch are removed from the genome by nucleotide excision repair.

258 ions, but through BER rather than nucleotide excision repair.

259 and trigger transcription-coupled nucleotide excision repair.

260 y discovered fidelity checkpoint during base excision repair.

261 with shielding of platinum-DNA adducts from excision repair.

262 nly altered in the absence of ribonucleotide excision repair.

263 thymine DNA glycosylase (TDG)-dependent base excision repair.

264 to 30 nucleotides during base or nucleotide excision repair.

265 ally all DNA damages processed by nucleotide excision repair.

266 s of homologous recombination and nucleotide excision repair.

267 for transcription initiation and nucleotide excision repair.

268 ons more commonly associated with nucleotide excision repair.

269 cytidine deaminase, and an inhibitor of base excision repair.

270 kDa, TFIIH is also essential for nucleotide excision repair.

271 Additionally, mutations in a base-excision-repair gene (SMUG1) correlate with a C-to-T mut

272 tablets; reduction in the number of surgical excisions required per year before, during, and after tr

273 ents, tissue growth persists following notch excision, showing that this model is insufficient to exp

274 Truncations, N-terminal methionine excision, signal peptide removal, and some post-translat

275 Immediately after excision, specimens were imaged intraoperatively in an i

276 These observations imply that pre-excision step(s) during OGG1 initiated BER evoked by ROS

277 nt is controversial and can include surgical excision, stereotactic radiosurgery and embolization.

278 the international transanal Total Mesorectal Excision (taTME) registry for benign and malignant recta

279 Staged excision techniques have been described to treat these c

280 Donor corneas, independent of excision techniques or preservation method, with donor a

281 specifically to the Muta1 ends and catalyzes excision through double strand breaks (DSB) and the join

282 e-guided needle biopsy that require surgical excision to be distinguished from HRLs that are at low r

283 s - 250 mum in size before endoscopic tumour excision to reduce intra-operative bleeding.

284 stem segments were rehydrated with H2O after excision, vessel refilling occurred rapidly (<1 h).

285 Excision was curative without recurrence.

286 (nearly complete and incomplete) mesorectal excision was reported in 179 (13.2%) of 1354 patients un

287 resection margin rates for abdominoperineal excision were 14.7% and 24.0% for pelvic exenteration.

288 vities of pol beta lyase and FEN1 nucleotide excision were able to remove the 5'-AMP-dRP group in mit

289 tudies and pathologic analyses from surgical excision were reviewed when available.

290 al resection margin, and complete mesorectal excision) were eligible for inclusion.

291 ive study used 133 DSCMs from 64 Mohs tissue excisions, which included clear margins, residual BCC, o

292 ence surgery for tumor debulking, wide local excision, whole-organ resection, and peritoneal metastas

293 4.02) cm2 and the mean (SD) area of surgical excision with clear margins was 7.74 (5.28) cm2.

294 margin to clearance end points using staged excision with comprehensive hematoxylin-eosin-stained pe

295 Staged excision with comprehensive hematoxylin-eosin-stained pe

296 Staged excision with comprehensive permanent section margin con

297 All patients underwent tumor excision with navigated intraoperative US guidance with

298 Thirty-eight underwent mastectomy/wide excision with partial skin resection ("conservative") an

299 For patients undergoing abdominoperineal excision with positive resection margins, the reported t

300 Currently, wide local excision (WLE) is the standard of care.