ライフサイエンスコーパス: excision repair

1 thymine DNA glycosylase (TDG)-dependent base excision repair.

2 to 30 nucleotides during base or nucleotide excision repair.

3 for transcription initiation and nucleotide excision repair.

4 s of homologous recombination and nucleotide excision repair.

5 ative products 5fC and 5caC, initiating base excision repair.

6 ug by removal of the damages with nucleotide excision repair.

7 ons more commonly associated with nucleotide excision repair.

8 d by DNA glycosylases that initiate DNA base excision repair.

9 n-coupled repair, a subpathway of nucleotide excision repair.

10 ng activity of AID when it overwhelms uracil excision repair.

11 than two nucleotides during long-patch base excision repair.

12 ption factor and an accessory factor in base excision repair.

13 cytidine deaminase, and an inhibitor of base excision repair.

14 atch base excision repair and ribonucleotide excision repair.

15 apyrimidinic lyase activity to initiate base excision repair.

16 ch could influence the ability of nucleotide excision repair.

17 DNA lesion bypass, extension of D-loops, or excision repair.

18 ential roles in transcription and nucleotide excision repair.

19 A glycosylase (TDG) in conjunction with base excision repair.

20 zaki fragment maturation and long patch base excision repair.

21 amptothecin, suggesting a role in nucleotide excision repair.

22 uring DNA lagging strand maturation and base excision repair.

23 bstrate for transcription-coupled nucleotide excision repair.

24 al burden increased with impaired nucleotide excision repair.

25 des that are released from the genome during excision repair.

26 kDa, TFIIH is also essential for nucleotide excision repair.

27 ch are removed from the genome by nucleotide excision repair.

28 ions, but through BER rather than nucleotide excision repair.

29 and trigger transcription-coupled nucleotide excision repair.

30 y discovered fidelity checkpoint during base excision repair.

31 with shielding of platinum-DNA adducts from excision repair.

32 ally all DNA damages processed by nucleotide excision repair.

33 nly altered in the absence of ribonucleotide excision repair.

34 However, ATMIN also has a role in base excision repair, a process that has been demonstrated to

35 n of the overall mechanism of ribonucleotide excision repair across domains of life.

36 ociated with reduced cellular ribonucleotide excision repair activity and increasedDNAdamage.

37 4-CSN complex, thereby regulating nucleotide excision repair and cell death.

38 ylase (TDG) plays critical roles in DNA base excision repair and DNA demethylation.

39 rcc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.

40 ear protein, participates in both nucleotide excision repair and mRNA transcription.

41 y uracil DNA glycosylase (UNG)-mediated base-excision repair and MSH2-mediated mismatch repair (MMR)

42 his severe phenotype involved defective base excision repair and non-homologous end-joining, pathways

43 their proposed biological functions in base excision repair and nonhomologous end joining.

44 njugates, which can be subject to nucleotide excision repair and replication bypass.

45 Pol epsilon participates in short-patch base excision repair and ribonucleotide excision repair.

46 s with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) an

47 This review focuses on the classical base excision repair and strand incision pathways in eukaryot

48 which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the

49 versatile factor involved in both nucleotide excision repair and transcriptional coactivation as a cr

50 of DNA single-strand break repair, DNA base excision repair, and cell survival.

51 io reflects a natural step during nucleotide excision repair, and given that the germline is set asid

52 methyl-directed mismatch repair, nucleotide excision repair, and homologous recombination.

53 pecific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations ca

54 enome repair-specific elements of nucleotide excision repair, and suggests that TCR is a major force

55 te that together these factors constitute an excision repair apparatus capable of repairing damaged b

56 Mismatch and base-excision repair are important in the somatic expansion o

57 oupled DNA repair (TCR) branch of nucleotide excision repair, are hypersensitive to cisplatin-induced

58 ur expectation, impairment of ribonucleotide excision repair, as well as virtually all other DNA repa

59 Here we used the in vivo excision repair assay developed in our laboratory to dem

60 the enzymes involved in base and nucleotide excision repair (BER and NER).

61 lacking the H2A and H3 N-tails rescues base excision repair (BER) activity but not MMS sensitivity.

62 d cytidine deaminase (AID) and requires base excision repair (BER) and mismatch repair (MMR).

63 ted DNA sequences and the efficiency of base excision repair (BER) and RER enzymes (OGG1, MUTYH, and

64 ses and their inefficient processing by base excision repair (BER) are among the factors suggested to

65 in promoter-coding strands, initiating base excision repair (BER) by 8-oxoguanine DNA glycosylase (O

66 ase beta (Pol beta) plays a key role in base excision repair (BER) by filling in small gaps that are

67 NEIL1 DNA glycosylase, which initiates base excision repair (BER) by removing damaged DNA bases.

68 Base Excision Repair (BER) efficiently corrects the most comm

69 Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, eff

70 s with a key mitochondrial-specific DNA base excision repair (BER) enzymes, namely EXOG and DNA polym

71 ry results on recognition of 5'-AODN by base excision repair (BER) enzymes.

72 ygous germline nonsense mutation in the base-excision repair (BER) gene NTHL1.

73 that are supposed to be substrates for base excision repair (BER) in the framework of active demethy

74 ligonucleotide fragments in addition to base excision repair (BER) incision products.

75 n the absence of APTX activity, blocked base excision repair (BER) intermediates containing the 5'-AM

76 Base excision repair (BER) is an essential DNA repair pathway

77 Base excision repair (BER) is one of several DNA repair pathw

78 Base excision repair (BER) is one of the most frequently used

79 Furthermore, base excision repair (BER) is responsible for causing CAG rep

80 Base excision repair (BER) is the major cellular pathway resp

81 Base excision repair (BER) is the predominant pathway for cop

82 Abortive ligation during base excision repair (BER) leads to blocked repair intermedia

83 Analysis of these maps revealed that base excision repair (BER) of alkylation damage is significan

84 Base excision repair (BER) of an oxidized base within a trinu

85 demonstrated to initiate prereplicative base excision repair (BER) of oxidized bases in the replicati

86 iring oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing questio

87 The base excision repair (BER) pathway is mainly responsible for

88 Additionally, we find that the base excision repair (BER) pathway is required to maintain ex

89 The DNA base excision repair (BER) pathway is the frontline mechanism

90 Repair of these lesions via base excision repair (BER) pathway maintains genomic fidelity

91 inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a form

92 The base excision repair (BER) pathway repairs oxidized lesions i

93 eta (Pol beta), a key enzyme in the DNA base excision repair (BER) pathway, is pivotal in maintaining

94 (hUNG) perform the initial step in the base excision repair (BER) pathway.

95 cytotoxic abasic lesions as part of the base excision repair (BER) pathway.

96 te active DNA demethylation through the base-excision repair (BER) pathway.

97 osylases catalyze the first step of the base excision repair (BER) pathway.

98 oguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.

99 ase (APE1), which functions through the base excision repair (BER) pathway.

100 Base excision repair (BER) processes non-helix distorting les

101 beta (Polbeta), known as a key nuclear base excision repair (BER) protein, in mitochondrial protein

102 Base excision repair (BER) recognizes and repairs minimally h

103 d mutation, it is unknown if subsequent base excision repair (BER) steps function on replication-asso

104 for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polymerase

105 ation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA gl

106 eacetylases contribute to DNA repair by base excision repair (BER), nucleotide excision repair (NER),

107 whether Rev1 could also be involved in base excision repair (BER).

108 (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).

109 maged DNA bases is vitally important in base excision repair (BER).

110 reactive DNA repair intermediate during base excision repair (BER).

111 ajority of these lesions are subject to base excision repair (BER).

112 ) patients is influenced by IFN-induced base excision repair (BER).

113 coupling factor whereas UvrD plays a role in excision repair by aiding the catalytic turnover of exci

114 entosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recrui

115 demonstrate that a modest decrement in base excision repair capacity can render the brain more vulne

116 ests a more ancestral form of ribonucleotide excision repair compared with the eukaryotic pathway.

117 f DNA damage the yeast Rad4-Rad23 nucleotide excision repair complex binds to the promoters of certai

118 the xeroderma pigmentosum C (XPC) nucleotide excision repair complex.

119 into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent componen

120 In excision repair, coupled incisions are made in the damag

121 spective studies indicate that expression of excision repair cross complementing group 1 (ERCC1) prot

122 hydrophobic interaction interface of ERCC1 (excision repair cross-complementation group 1) and XPF (

123 elicase-like gene (WRN, encoding T705I), and excision repair cross-complementation group 6 (ERCC6, en

124 80% of cases are caused by mutations in the Excision Repair Cross-Complementation group 6 gene (ERCC

125 ur, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which enco

126 ouble-strand breaks (DSBs) by the nucleotide excision repair endonucleases XPF and XPG.

127 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epi

128 sense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 (NEI

129 al of methylated cytosines requires the base excision repair enzyme TDG, but the mechanism by which T

130 e DNA glycosylase) is one such silenced base excision repair enzyme that can restore DNA integrity.

131 eviously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2) and

132 at is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase beta.

133 on-associated demethylation promoted by Base Excision Repair enzymes further modifies methylation of

134 but independent of the essential nucleotide excision repair factor XPA.

135 Here we have used purified core nucleotide excision repair factors (RPA, XPA, XPC, TFIIH, XPG, and

136 during replication, or incorrect nucleotide excision repair following oxidative damage.

137 In contrast, even though nucleotide excision repair gene homologs have been found in plants,

138 Additionally, mutations in a base-excision-repair gene (SMUG1) correlate with a C-to-T mut

139 Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1(/-)) show numerous acc

140 Human nucleotide excision repair generates two incisions surrounding the

141 the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-induced direc

142 lesion sites in the global genome nucleotide excision repair (GG-NER) pathway.

143 Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting nucleotide l

144 hanism may also be operative in related base excision repair glycosylases and provides a critical fra

145 found in plants, the mechanism of nucleotide excision repair has not been investigated.

146 aled no particular sensitivity to nucleotide excision repair, homologous recombination repair, or pos

147 homologs of HUS1, CHK2), nucleotide and base excision repair (homologs of XPF, XPC and AP-endonucleas

148 Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the r

149 Nucleotide excision repair in Escherichia coli is stimulated by tra

150 8-N3]T* lesions are substrates of nucleotide excision repair in human cell extracts.

151 strates for transcription-coupled nucleotide excision repair in human cells.

152 ique allows for quantitative measurements of excision repair in human cells.

153 ision repair system in E. coli by nucleotide excision repair in humans.

154 In the absence of additional factors, base excision repair in NCPs will stall at the gap-filling st

155 photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsis and rice.

156 ed a potential role for canonical nucleotide excision repair in the removal of ribonucleotides from D

157 -negative manner and impairs long-patch base excision repair in vitro and in vivo.

158 r studying the mechanism of human nucleotide excision repair in vivo.

159 n mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned whether Re

160 ey are efficiently removed by ribonucleotide excision repair initiated by RNase H2 cleavage.

161 Nucleotide excision repair is a major DNA repair mechanism in all c

162 Nucleotide excision repair is an important and highly conserved DNA

163 that, for poxviruses, DNA synthesis and base excision repair is coupled.

164 oxidation damage to the NER proteome and DNA excision repair is impaired in extracts prepared from FI

165 Base excision repair is initiated by DNA glycosylases that re

166 iates both ATR-CHK1 signaling and nucleotide excision repair is replication protein A, and we find th

167 These results suggest that nucleotide excision repair is unlikely to play a major role in the

168 scription-coupled excision repair or general excision repair isolated the contribution of each pathwa

169 recognized by Fanconi anemia and nucleotide excision repair machinery, although the mechanisms of th

170 hat in humans gBGC is not caused by the base-excision repair machinery.

171 ic if not properly removed by the nucleotide excision repair machinery.

172 Here we present the excision repair maps for CPDs and BPDE-dG adducts genera

173 lications suggests that errors in nucleotide excision repair may be resolved via a similar, but disti

174 y four of the following pathways: nucleotide excision repair, mismatch repair, base excision repair,

175 resolution genome-wide assay for mapping DNA excision repair named eXcision Repair-sequencing (XR-seq

176 oped a method for genome-wide mapping of DNA excision repair named XR-seq (excision repair sequencing

177 Global nucleotide excision repair (NER) and transcription-coupled DNA repa

178 and cdA are repaired by the human nucleotide excision repair (NER) apparatus.

179 Given the use of nucleotide excision repair (NER) as a backup pathway for RER in RNa

180 35), a modification that enhances nucleotide excision repair (NER) by facilitating recruitment of the

181 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1)

182 TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to impaired tran

183 ficiently repaired by a dedicated Nucleotide Excision Repair (NER) enzyme.

184 milar to OmegaXaV motifs found in nucleotide excision repair (NER) factors and transcription factors

185 y-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase

186 Nucleotide excision repair (NER) is a conserved and versatile DNA r

187 Nucleotide excision repair (NER) is a highly conserved pathway that

188 Nucleotide excision repair (NER) is an evolutionarily conserved mec

189 Nucleotide excision repair (NER) is responsible for the removal of

190 Nucleotide excision repair (NER) is the key DNA repair system that

191 lding protein in the multiprotein nucleotide excision repair (NER) machinery.

192 with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet been identifie

193 n another DNA repair pathway, the nucleotide excision repair (NER) pathway, which may exhibit a disco

194 ve diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs DNA damage

195 uld be subjected to repair by the nucleotide excision repair (NER) pathway.

196 est known for its function in the nucleotide excision repair (NER) pathway.

197 the repair of DNA damage via the nucleotide excision repair (NER) pathway.

198 protein that participates in the nucleotide excision repair (NER) pathway.

199 Nucleotide excision repair (NER) plays a vital role in platinum-ind

200 Nucleotide excision repair (NER) protects against sunlight-induced

201 Nucleotide excision repair (NER) proteins have been found to play a

202 We find that the nucleotide excision repair (NER) proteins UvrA, UvrB, and UvrC, but

203 , we measured the distribution of nucleotide excision repair (NER) rates for UV-induced lesions throu

204 Nucleotide excision repair (NER) removes chemically diverse DNA les

205 Nucleotide excision repair (NER) removes these photoproducts, but w

206 eld mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signa

207 bility of 26 proteins involved in nucleotide excision repair (NER) under normal growth conditions.

208 changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombination (HR)

209 Nucleotide excision repair (NER), interstrand cross-links repair (I

210 ir by base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), non-homolo

211 nts for assessing the activity of nucleotide excision repair (NER), the most versatile DNA repair pro

212 extracts yields a characteristic nucleotide excision repair (NER)-induced ladder of short dual incis

213 event required for cAMP-enhanced nucleotide excision repair (NER).

214 cancers, is primarily repaired by nucleotide excision repair (NER).

215 ential for both transcription and nucleotide excision repair (NER).

216 c UVB-induced DNA photolesions by nucleotide excision repair (NER).

217 caused by exposure to UV light is nucleotide excision repair (NER).

218 (XPA) mice that are deficient in nucleotide excision repair (NER).

219 otide excision repair, mismatch repair, base excision repair, nonhomologous end joining, homologous r

220 non-homologous end-joining (cku-80) or base excision repair (nth-1, exo-3), the Fanconi-related prot

221 In humans, short-patch base excision repair of 8-oxoG:dA base pairs requires human D

222 purine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse puri

223 sylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out nucl

224 ntially expressed in testes, uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastran

225 known if histone acetylation modulates base excision repair of DNA lesions in chromatin.

226 in mammalian cells, and a key factor in base-excision repair of DNA.

227 sis for understanding the mechanisms of base excision repair of ICLs.

228 l roles in both transcription and nucleotide excision repair of nuclear DNA, however, whether or not

229 pair of double-strand DNA breaks and in base excision repair of oxidized guanine residues (8-oxoguani

230 nzymes have been known only to initiate base excision repair of small adducts by extrusion from the D

231 c48 segregase complex, leads to impaired DNA excision repair of UV lesions.

232 ls defective in either transcription-coupled excision repair or general excision repair isolated the

233 does not involve mismatch repair, nucleotide excision repair, or transcription, processes that are kn

234 plex is one of the key factors of nucleotide excision repair participating in the primary DNA damage

235 Conversely, inhibiting the base excision repair pathway accentuated NAD decline in respo

236 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil DNA g

237 by DNA glycosylases, which initiate the base excision repair pathway by locating and excising aberran

238 grity and define the specificity of the base excision repair pathway for discreet, detrimental modifi

239 ls, NMPs are repaired by the multi-step base excision repair pathway initiated by human alkyladenine

240 itro and in vivo and a robust ribonucleotide excision repair pathway is critical to keeping incorpora

241 The DNA base excision repair pathway is the main system involved in t

242 utilizes DNA glycosylases found in the base excision repair pathway to excise the modification.

243 We tested if inhibiting the ribonucleotide excision repair pathway would exacerbate the smc6 mutant

244 the LigC complex is directly involved in an excision repair pathway(s) that repairs DNA damage with

245 ERCC2 is indispensable for nucleotide excision repair pathway, and its functional polymorphism

246 e protein homeostasis network and nucleotide excision repair pathway, as a modifier of the toxicity o

247 ific sub-branch of the DNA damage nucleotide excision repair pathway, termed transcription-coupled re

248 Specifically, we show that the base excision repair pathway, the main pathway utilized for t

249 glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism fo

250 s also has an adverse effect on the DNA base excision repair pathway, the major DNA repair system tha

251 he lesion has been excised by the nucleotide excision repair pathway, while others participate in tra

252 sential role in DNA repair in the nucleotide excision repair pathway.

253 )-induced DNA damage is repaired by the base excision repair pathway.

254 nine glycosylase 1 (OGG1)-initiated DNA base excision repair pathway.

255 process of transcription-coupled nucleotide excision repair plays a role in the removal of epsilonC

256 he lesion site after processing via the base excision repair process.

257 d by modulating the initial step of the base excision repair process.

258 The nucleotide excision repair protein complex ERCC1-XPF is required fo

259 tures and interactions with other nucleotide excision repair protein factors of the two enzymes.

260 CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to int

261 disposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational footprint

262 A feature of many base excision repair proteins is that they contain [4Fe4S] cl

263 ropriate DNA lesions also interact with base excision repair proteins, we investigated whether CREB1

264 indication of the versatility of these base excision repair proteins.

265 n repair by aiding the catalytic turnover of excision repair proteins.

266 Ribonucleotide excision repair (RER) removes ribonucleoside monophospha

267 ucleotides must be removed by ribonucleotide excision repair (RER).

268 epaired by RNase H2-dependent ribonucleotide excision repair (RER).

269 they are rapidly repaired by ribonucleotide excision repair (RER).

270 repair maps of the human genome obtained by excision repair sequencing to gain insight into factors

271 mapping of DNA excision repair named XR-seq (excision repair sequencing).

272 We have termed this method translesion excision repair-sequencing (tXR-seq).

273 assay for mapping DNA excision repair named eXcision Repair-sequencing (XR-seq) and have now used XR

274 ecently, we reported that as measured by the excision repair-sequencing (XR-seq), UvrD plays no role

275 is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision

276 efficiently targeted by the human nucleotide excision repair system in vitro or in cultured human cel

277 ss mutations in components of the nucleotide excision repair system.

278 dducts in TGCT cells by using the human TGCT excision repair system.

279 th impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B, D, F, and

280 equires the transcription-coupled nucleotide excision repair (TC-NER) factor Cockayne syndrome group

281 eficient in transcription-coupled nucleotide excision repair (TC-NER) or global genomic NER (GG-NER).

282 its role in transcription-coupled nucleotide excision repair (TC-NER), contains a ubiquitin-binding d

283 Initiating base excision repair, TDG removes thymine from mutagenic G .:

284 ption-blocking adducts to undergo more rapid excision repair than adducts located elsewhere in the ge

285 ide Retrieval Assay" designed to measure DNA excision repair that is capable of quantifying the rate

286 and well-conserved sub-pathway of nucleotide excision repair that preferentially removes DNA lesions

287 mispaired A giving way to the canonical base excision repair that ultimately restores undamaged guani

288 d for both transcription-coupled and general excision repair, the earliest repair occurred preferenti

289 zymes that perform the initial steps of base excision repair, the principal repair mechanism that ide

290 that beyond the known pathways, such as base excision repair, the process of transcription-coupled nu

291 we show that E-cadherin promotes nucleotide excision repair through positively regulating the expres

292 to current ideas, that cellular uracil base excision repair (UBER) enzymes target and cleave A3G-edi

293 DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1% of th

294 polymerase X family that is involved in base excision repair, uses a processive hopping search mechan

295 e report the sequence specificity of BPDE-dG excision repair using tXR-seq.

296 in removal of photo-damage (e.g. nucleotide excision repair uvrABC, recombinases recBCD and resolvas

297 to extend from 8-oxoG during long-patch base excision repair was unknown.

298 all DNA-templated processes, including base excision repair where Pol beta catalyzes two key enzymat

299 ntaining CRE by UNG2 and, therefore, to base excision repair, whereas UNG2 exposure prevented CREB1 b

300 ious reports have shown that both nucleotide excision repair, which is the sole pathway in humans for