ライフサイエンスコーパス: excitable

1 age, a time point when these cells are most excitable.

2 ormally inhibit fear extinction, become more excitable.

3 l types that are not considered electrically excitable.

4 old for firing, which causes them to be more excitable.

5 Dynamic actin networks are excitable.

6 constitute a general module for establishing excitable actin dynamics in other cellular contexts.

7 of NKCC1, significantly decreases the hyper-excitable action of GABAA receptor signaling and restore

8 To make this photopigment excitable again,all-trans-retinal must be reisomerized t

9 roximal dendrites of GnRH neurons are highly excitable and are likely to be the site of action potent

10 ls into an autonomous source of electrically excitable and conducting cells by stably expressing only

11 dult striatal astrocytes into iDANs that are excitable and correct some aspects of motor behavior in

12 ctive phase, however, these muscles are more excitable and each body bend is accompanied by a calcium

13 medial entorhinal cortex neurons are highly excitable and exhibit a supralinear input-output functio

14 sting that this region of dendrite is highly excitable and may be the site of spike initiation.

15 signaling molecules that play roles in both excitable and nonexcitable cell types and with or withou

16 The extracellular potential of excitable and nonexcitable cells with respect to ground

17 enerally expressed at the plasma membrane of excitable and nonexcitable cells.

18 piking behavior, despite being intrinsically excitable and receiving visuotopically organized synapti

19 Pancreatic beta cells are electrically excitable and respond to elevated glucose concentrations

20 -124-induced neurons (miNs) are functionally excitable and uncommitted toward specific subtypes but p

21 t, with the Purkinje cells being most easily excitable and ventricular cells requiring the highest ir

22 ic GABA(A) receptors were significantly more excitable and were insensitive to the anesthetic propofo

23 The spinal circuitries were more excitable, and behavioural and electrophysiological anal

24 Human alpha-cells are electrically excitable, and blockade of any ion channel involved in a

25 fic chemosensory receptors, are electrically excitable, and modulate serotonin-sensitive primary affe

26 Neurons more active will be more excitable, and thus more responsive to external inputs.

27 in the infarction model, providing a larger excitable area for postshock propagation but smaller tra

28 represent a filamentous actin molecule as an excitable automaton network (F-actin automaton).

29 Excitable behavior arising from positive feedback in Cdc

30 ABA)-mediated inhibition and leads to type I excitable behavior characterized by a continuous decreas

31 s the most complete simulation of a piece of excitable brain matter to date.

32 mia and reperfusion, defining a period where excitable but synaptically silent neurons are present.

33 a bright, engineered, orange-red FP that is excitable by cyan light.

34 singlet oxygen production capability and be excitable by light illuminations with deep tissue penetr

35 The nanoparticles are excitable by red light and emit in the near-infrared spe

36 ory pyramidal neurons is to render them more excitable by reducing the spike afterhyperpolarization a

37 l cellular process particularly important in excitable cell activities such as hearing.

38 Collectively LOTUS-V extends the scope of excitable cell control and simultaneous voltage phenotyp

39 Whether nonexcitable cells may modulate excitable cell function or even contribute to AP conduct

40 s an important but potentially toxic role in excitable cell function.

41 ng variation can be applied to models of any excitable cell.

42 maintain high input resistance in these non-excitable cells also requires the K(+) channel subunits

43 ) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs

44 annels (Kv) are responsible for repolarizing excitable cells and can be heavily glycosylated.

45 teins in biology, regulating the activity of excitable cells and changing in diseases.

46 In humans, ICG labels excitable cells and is routinely visualized transdermall

47 (BK-type) channels, abundantly distribute in excitable cells and often localize to the proximity of v

48 e for understanding electrical signalling in excitable cells and the actions of drugs used for pain,

49 urthermore, we demonstrate that biosynthetic excitable cells and tissues can repair large conduction

50 ds used to assess the electrical activity of excitable cells are often limited by their poor spatial

51 ral patterns of resting potentials among non-excitable cells as instructive cues in embryogenesis, re

52 nd their relation to the normal functions of excitable cells as well as pathophysiology.

53 suppression of high-frequency discharges of excitable cells by local anesthetics (LA) is largely det

54 ion flux and generate electrical signals in excitable cells by opening and closing pore gates.

55 er increase or decrease in calcium influx in excitable cells can be associated with BD.

56 ctrophysiology beyond canonical electrically excitable cells could yield exciting new findings.

57 Potassium (K(+)) exits electrically excitable cells during normal and pathophysiological act

58 hannels, CaV, regulate Ca(2+) homeostasis in excitable cells following plasma membrane depolarization

59 Electrically excitable cells harness voltage-coupled calcium influx t

60 istently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inh

61 versely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum sub

62 urrounding myocytes, suggesting that the non-excitable cells in the scar closely follow myocyte actio

63 hannel function and SOCE in a variety of non-excitable cells including lymphocytes and other immune c

64 is unique to neurons or also occurs in other excitable cells is currently unknown.

65 CaV1 function and suggests a means by which excitable cells may dynamically tune CaV activity.

66 differences between cardiomyocytes and other excitable cells modulate vulnerability to conduction fai

67 The excitable cells of Dictyostelium discoideum show traveli

68 t drives action potential generation in many excitable cells of the brain, heart, and nervous system.

69 t signaling pathways control the activity of excitable cells of the nervous system and heart, and are

70 sequences of such activity in the setting of excitable cells remains the central focus of much of the

71 In non-excitable cells stromal interaction molecule 1 (STIM1) i

72 high frequency oscillating magnetic field on excitable cells such as neurons are well established.

73 nd viability impairment in aggregate-exposed excitable cells such as peripheral neurons and cardiomyo

74 Corticotrophs are excitable cells that receive input from two hypothalamic

75 Corticotrophs are excitable cells that receive input from two hypothalamic

76 In excitable cells these channels are composed of the ion-f

77 nnels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism tha

78 current inhibition that is widely present in excitable cells through modulation of ion channels by sp

79 ulation of K(+) channel inactivation enables excitable cells to adjust action potential firing.

80 brane potential and regulate the response of excitable cells to various stimuli.

81 eld of agonist-activated Ca(2+) entry in non-excitable cells underwent a revolution some 5 years ago

82 dulating the firing patterns of electrically-excitable cells using surface plasmon resonance phenomen

83 es significant thermally mediated effects on excitable cells via basic thermodynamic mechanisms that

84 Indeed, when the ratio of intrinsically excitable cells was increased or decreased, the number o

85 Ventricular myocytes are excitable cells whose voltage threshold for action poten

86 ns, genes that function in multiple types of excitable cells, and genes in the signaling pathway of t

87 vascular smooth muscle tissue, electrically excitable cells, and some tumors.

88 ost of hair cells, as well as those of other excitable cells, are still immature.

89 els is essential for electrical signaling in excitable cells, but the structural basis for voltage se

90 nd light-sensitive ion currents operating in excitable cells, e.g. cardiomyocytes or neurons.

91 In electrically non-excitable cells, for example epithelial cells, this is a

92 niques to follow the activation state of non-excitable cells, including lymphocytes.

93 In excitable cells, ion channels are frequently challenged

94 In many excitable cells, KATP channels respond to intracellular

95 to modulate the plasma membrane potential of excitable cells, mitochondria have thus far eluded optog

96 Electrically excitable cells, such as neurons, exhibit tremendous div

97 In excitable cells, the main mediators of sodium conductanc

98 In non-excitable cells, thiol-oxidizing agents have been shown

99 In excitable cells, voltage-gated sodium (Na(V)) channels a

100 nnels often overlaps in neurons and in other excitable cells.

101 eatly enhances their functional diversity in excitable cells.

102 of action potentials is commonly observed in excitable cells.

103 als in nerve, muscle, and other electrically excitable cells.

104 um (K(+)) channel desirable for silencing of excitable cells.

105 for optogenetic stimulation of electrically excitable cells.

106 ght control of resting membrane potential in excitable cells.

107 s a novel regulator of cell processes in non-excitable cells.

108 critical for proper electrical signaling in excitable cells.

109 rize the voltage dynamics of large groups of excitable cells.

110 tion and propagation of action potentials in excitable cells.

111 Nav) channels propagate action potentials in excitable cells.

112 annel activity to gene expression changes in excitable cells.

113 trigger or modify action potentials (APs) in excitable cells.

114 maintenance of resting membrane potential in excitable cells.

115 ials is important to understand electrically-excitable cells.

116 iming mechanisms across different systems of excitable cells.

117 rol the upstroke of the action potentials in excitable cells.

118 on and propagation of electrical impulses in excitable cells.

119 protein underlying the membrane potential in excitable cells.

120 lectrical signals to biological responses in excitable cells.

121 cal for chemical and electrical signaling in excitable cells.

122 els are crucial for electrical signalling in excitable cells.

123 propagates action potentials in electrically excitable cells.

124 action potentials in nerve, muscle and other excitable cells.

125 t in the amplification of Ca(2+) influx into excitable cells.

126 hibitory effect of many neurotransmitters on excitable cells.

127 o quickly recycle vesicle proteins in highly excitable cells.

128 se intracellular Ca(2+) concentration in non-excitable cells.

129 tial for initiating action potentials within excitable cells.

130 of fundamental activities in other kinds of excitable cells.

131 al, thereby enabling electrical signaling in excitable cells.

132 ng subthreshold oscillations in electrically excitable cells.

133 tion of discrete downstream responses in non-excitable cells.

134 ls, transporters, and signaling molecules in excitable cells.

135 on potentials during electrical signaling in excitable cells.

136 between VGSC activity and gene expression in excitable cells.

137 e quantification of calcium responses in non-excitable cells.

138 ls which leads to physiological signaling in excitable cells.

139 nels widely employed for photostimulation of excitable cells.

140 e primary mechanism for mCa(2+) extrusion in excitable cells.

141 Calcium Entry (SOCE) is well studied in non-excitable cells.

142 rrents and TRPM8-mediated calcium signals in excitable cells.

143 and frequency of action-potential firing in excitable cells.

144 l players in many physiological processes in excitable cells.

145 nderstanding of the role of Kv11 currents in excitable cells.

146 tic changes and the electrical properties of excitable cells.

147 sodium channels (Navs) play crucial roles in excitable cells.

148 nt of intracellular Ca(2+) signaling in many excitable cells; however, the role of this mechanism in

149 se excitation and inhibition of electrically-excitable cellular activity.

150 ro-inflammatory cytokines and promotes hyper-excitable central conditions, a causal relationship betw

151 ackground, and compatibility with blue-light-excitable channelrhodopsins.

152 h demyelinated axons were intrinsically more excitable, characterized by increased spontaneous suprat

153 cial neurons (ANs) is to use oscillatory and excitable chemical systems.

154 This mismatch suggests that apparently excitable cortical neurons (even >1 mm into peri-infarct

155 e results suggest that individuals with more excitable corticospinal pathways are faster to initiate

156 erse roles in neurons, including assembly of excitable domains such as the axon initial segment (AIS)

157 essly interfaced with genetically engineered excitable donor cells expressing inward rectifier potass

158 A sound excitable drug (SED) that is non-cytotoxic to cells is d

159 We surveyed 6 green and 16 red excitable dyes for their suitability in single-molecule

160 of useful dynamical behaviors, including the excitable dynamics also found in the time-resolved "spik

161 Simple models of excitable dynamics on graphs are an efficient framework

162 n networks or the models used for describing excitable dynamics.

163 ng a negative feedback system countering the excitable effects I(NaP); the interrelatedness of I(NaP)

164 statistics can be predicted from an isolated excitable element with rescaled parameters according to

165 the stochastic dynamics of strongly-coupled excitable elements on a tree network.

166 l that sucrose cue exposure recruited a more excitable ensemble in the nucleus accumbens, but not orb

167 Despite being electrically excitable, enteroendocrine cells are generally thought t

168 ity, and a mechanosensory apparatus based on excitable epithelia.

169 mes16 leaves exhibited a strong ultraviolet-excitable fluorescence, which resulted from large amount

170 First, lesions may create an excitable gap vulnerable to invasion by fibrillatory wav

171 nism was light-induced depolarisation of the excitable gap, which led to block of reentrant wavefront

172 easing wavelength and reducing the available excitable gap.

173 f existing wavefronts, rapid closing down of excitable gaps, and successful defibrillation and give g

174 d left ventricle), which rapidly closed down excitable gaps.

175 and validated a computational model of these excitable HEK293 cells (called "Ex293" cells) using exis

176 c sodium channels (BacNav) to create de novo excitable human tissues and augment impaired action pote

177 y to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and o

178 sistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and

179 Notwithstanding endothelia being non-excitable in nature, the hypothesis of Ca(2+)-induced en

180 In basal conditions, MSNs are more excitable in parkinsonian than in sham mice, and excitab

181 The beta cell is electrically excitable; in response to an elevation of glucose, it de

182 physical model in which CMs are mechanically excitable inclusions embedded within the extracellular m

183 Excitable ion channels in stable small pores can serve a

184 the expression of genetically encoded photo-excitable ion channels.

185 h corticotrophs are known to be electrically excitable, ion channels controlling the electrical prope

186 robustly observed in excitable systems with excitable kinetics and with self-diffusion only.

187 The concept of an electrically excitable L-cell provides a basis for understanding how

188 d, chemically, electrically and mechanically excitable materials formulated in the 20th century was,

189 ous pulses of p53, which are triggered by an excitable mechanism during cell-cycle phases associated

190 ns for surface diffusion, pattern formation, excitable media, and bulk-surface coupling are provided

191 stochastic coupled FitzHugh-Nagumo model for excitable media.

192 show theoretically that fundamentally in any excitable medium a region with a propagation velocity fa

193 ortical tissue normally operates as a type I excitable medium but it is locally transformed into a ty

194 Notably, the excitable medium equations exhibit a wider family of sol

195 We present an excitable medium model to simulate the cycling behavior

196 This indicates that blood can function as an excitable medium that conducts traveling waves of coagul

197 rnal current, the model operated as a type I excitable medium that supported propagating waves of gam

198 hich propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagat

199 le wave, much like wave propagation in other excitable medium, e.g., nerve signal transmission.

200 nd small amplitude-the hallmark of a type II excitable medium-yet they also propagate far beyond the

201 n of follicles can be treated as a classical excitable medium.

202 e stimulation site in the manner of a type I excitable medium.

203 neurons transformed the model into a type II excitable medium.

204 al and widely used two-component model of an excitable medium.

205 from the RPE, they are thought to regenerate excitable melanopsin exclusively through RPE-independent

206 ex biophysical dynamics; in this case, of an excitable membrane.

207 types of 5-HT and non-5-HT neurons and their excitable-membrane properties are heterogeneous and over

208 that are ubiquitous in all domains of life, excitable membranes are found almost exclusively in anim

209 iming and waveform of APs generated from two excitable membranes present in each electrocyte.

210 he potential to measure voltage optically in excitable membranes with a combination of high spatial a

211 ost neuronal tissue, exhibiting electrically excitable membranes, synaptic currents, dopamine release

212 protein to control the membrane potential of excitable membranes, the molecular determinants that def

213 -gated potassium channels (K(v) channels) in excitable membranes.

214 on or direct channel block made neurons more excitable, minutes to hours of sustained M-current depre

215 Here we report three new red-excitable monomeric FPs obtained by structure-guided mut

216 find that, despite weighted excitation, more excitable motoneurons are preferentially activated by a

217 Individuals with more excitable motor pathways had faster reaction times and,

218 of inhibition, which is most obvious in more excitable motor pools.

219 tor cortex counteracts an intrinsically more excitable motor system.

220 within M1, possibly to compensate for a more excitable motor system.SIGNIFICANCE STATEMENT This study

221 e resonance of these phasic-firing (type III excitable) MSO neurons and of the model is of particular

222 Gated ion channels are excitable nanopores in biological membranes.

223 The central module is an excitable network that accounts for random migration.

224 A polarization module linked to the excitable network through the cytoskeleton allows unstim

225 hese properties require coupled adaptive and excitable networks.

226 membrane organization occur in fibroblasts, excitable neuroblastoma cells, and Drosophila neurons in

227 nated distal dendritic tree-like arbors with excitable nodes of Ranvier at peripheral and branching n

228 Finally, these pulses are excitable only beyond a threshold for protonation, deter

229 Electrophysiological studies of excitable organs usually focus on action potential (AP)-

230 st, 'Atypical' inhibitory neurons with their excitable phenotype but weak excitatory input may be mor

231 highly reactive radicals, and visible light excitable photocatalysts can provide the required oxidat

232 luminescent Orban transformations, and photo-excitable photochromic and fluorescent species.

233 In addition, excitable pre-OLs receive glutamatergic inputs from neig

234 identified genes likely contribute to unique excitable properties of different groups of neurons in t

235 ross their plasma membrane to maintain their excitable properties under varying environmental conditi

236 y recruited during locomotion have identical excitable properties.

237 A computational model shows that the coupled excitable Ras/F-actin system forms the driving heart for

238 a newly developed FRET donor, monomeric cyan-excitable red fluorescent protein (mCyRFP1), which has a

239 shortest action potential duration and less-excitable region, consistent with drift direction under

240 We show that soft spots, or excitable regions in the materials, correspond to rollin

241 ho activation in adherent cells and proposed excitable Rho signaling networks underlying cell contrac

242 Studies show that an excitable signal transduction network acts as a pacemake

243 tematically more drive to progressively less excitable spinal motoneurons.

244 ong the dendrites, which creates a different excitable state of the dendrites.

245 e that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize ene

246 e typically involved neurons/models (type II excitable, such as the standard Hodgkin-Huxley model) th

247 resent a model of these actin dynamics as an excitable system in which a diffusive, autocatalytic act

248 This coupled excitable system leads to short-lived patches of activat

249 Cardiac tissue is an excitable system that can support complex spatiotemporal

250 es that the segmentation clock behaves as an excitable system, introducing a broader paradigm to stud

251 that activation of Ras and F-actin forms two excitable systems that are coupled through mutual positi

252 t quasi-solitons can be robustly observed in excitable systems with excitable kinetics and with self-

253 l of pattern formation in complex biological excitable systems.

254 rmal method to link genotype to phenotype in excitable systems.

255 ns, have been observed also in dissipative, "excitable" systems, either at finely tuned parameters (n

256 est that VHC neurones are intrinsically more excitable than DHC neurones.

257 MHbVL neurons were more excitable than MHbVC neurons, and they also responded mo

258 istinct properties make URS motoneurons more excitable than other alpha-motoneurons.

259 OFC, these activated GFP+ neurons were more excitable than surrounding GFP- neurons.

260 ii) neurons from SAL-Yoked Tg rats were more excitable than those from SAL-Yoked non-Tg rats, and in

261 Neuronal dendrites are electrically excitable: they can generate regenerative events such as

262 (from remodeling) produced re-entry in more excitable tissue allowing collision of wavefront and bac

263 development of new cell-based therapies for excitable tissue repair.

264 and abnormal conduction in multidimensional excitable tissue, and the methodology of modeling variat

265 bility regions migrated spiral waves to less excitable tissue, where they detached to collide with no

266 ion channels mediate electrical dynamics in excitable tissues and are an important class of drug tar

267 cellular calcium release channels in various excitable tissues and cells such as muscles and neurons.

268 d for non-invasive investigations of diverse excitable tissues and may ultimately be applied for trea

269 eneral mechanism for how nervous systems and excitable tissues can exploit degenerate relationships a

270 onstrated the ability to create biosynthetic excitable tissues from genetically engineered and immort

271 To understand how excitable tissues give rise to arrhythmias, it is crucia

272 ly changed our understanding of electrically excitable tissues in health and disease, paving the way

273 ential that is essential for the function of excitable tissues like cardiac muscle.

274 the upstroke of the action potential in the excitable tissues of nerve and muscle.

275 ucial for regulation of electric activity of excitable tissues such as nerve cells, and play importan

276 l importance of this exquisite modulation in excitable tissues were unknown.

277 patterns of action potential propagation in excitable tissues, such as the brain or heart.

278 fever can negatively impact the function of excitable tissues, such as the heart, producing cardiac

279 dium channels (Navs) play essential roles in excitable tissues, with their activation and opening res

280 d to changes in membrane potential (V(M)) in excitable tissues.

281 e the rapid upstroke of action potentials in excitable tissues.

282 acellular calcium ([Ca(2+)]i) homeostasis in excitable tissues.

283 r supports a nonconducting role for Kv2.1 in excitable tissues.

284 assium efflux and membrane repolarization in excitable tissues.

285 propagation of the action potential through excitable tissues.

286 an regulates the plasmalemmal sodium pump in excitable tissues.

287 n response properties changed from uniformly excitable to differentially plastic.

288 in nesting hippocampal ripples within their excitable troughs, stimulation in-phase with the slow os

289 older neurons appeared to be uniformly less excitable under baseline conditions yet displayed a prev

290 re active or might become intrinsically more excitable under the pathological conditions that produce

291 Using a basic model of discrete excitable units that follow a susceptible - excited - re

292 reactivations of specific memories to their excitable up-phase, thus allowing plastic changes in ext

293 l processes generic to condensed, chemically excitable, viscoelastic materials, although the embryoni

294 Rac explained how CDR actin propagates as an excitable wave, much like wave propagation in other exci

295 occur when the CRU network is monostable and excitable, while long-lasting sparks occur when the netw

296 ensors have several advantages such as being excitable with red light, emitting in the near-infrared

297 KEY POINTS: Optic nerve axons get less excitable with warming.

298 d to high-fat diet for 12-14 weeks were less excitable, with a decreased membrane input resistance an

299 and synthesis of a new type of RE-free, blue-excitable yellow phosphor, obtained by combining a stron

300 ternal quantum yield among all RE-free, blue-excitable yellow phosphors reported to date, with a valu