ライフサイエンスコーパス: executioner

1 digm in which AIF can substitute for caspase executioners.

2 is setting function as downstream cell-death executioners.

3 well known as the core apoptotic cell death executioner, acts in early responses to neuronal injury

4 The executioners are members of a family of proteases founde

5 BHRF1 bound the Executioner Bak and, when cells were cultured without cy

6 ision-making process, by functioning both as executioner by damaging the biomolecules, or as savior b

7 Thus, no single executioner caspase (nor a combination of caspase-3 and

8 ucing factor (AIF) nuclear translocation and executioner caspase 3 activation, in NBD rats.

9 neration, of the cleaved form of the central executioner caspase 3 is inhibited.

10 Given the presence of unusually long executioner caspase 3' UTRs in many metazoans, translati

11 post-mitochondrial signaling responsible for executioner caspase activation is controversial.

12 ints, including mitochondrial fragmentation, executioner caspase activation, and DNA damage, it is as

13 During apoptosis, executioner caspase activity has been considered a point

14 neuronal degeneration is independent of the executioner caspase CED-3, but instead requires the acti

15 Caspase-6 is an executioner caspase found directly regulated by p53, and

16 and its linker to determine the mechanism of executioner caspase inhibition by XIAP.

17 death: at the level of p53/CEP-1 and at the executioner caspase level.

18 rus that attacks lepidopterans, codes for an executioner caspase synthesized by 9 h after infection o

19 Caspase-7 is an executioner caspase that plays a key role in apoptosis,

20 l other DNA viruses, ascoviruses code for an executioner caspase, apparently involved in a novel cyto

21 ection, and the data further showed that the executioner caspase, caspase 3, does not become activate

22 Activation of the executioner caspase, caspase 3, is essential for many fo

23 In contrast, autoactivation of the executioner caspase-3 and -6 zymogens was not detected.

24 epeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7.

25 e EFES is homologous to a loop unique to the executioner caspase-3 and caspase-7 that are targeted by

26 IGF-I blocked activation of the executioner caspase-3 and the intrinsic initiator caspas

27 ivation concomitantly with activation of the executioner caspase-3 as the final step in the toxic cas

28 he apoptogen cytochrome c, and activation of executioner caspase-3 were determined by Western blottin

29 To dissect the nonredundant roles of the executioner caspase-3, -6, and -7 in orchestrating apopt

30 Apoptotic executioner caspase-3, -6, and -7, but not the inflammat

31 the proteolytic activation of the downstream executioner caspase-3.

32 d (iv) activation of initiator caspase-9 and executioner caspase-3.

33 are cleaved by caspases, most of them by the executioner caspase-3.

34 of cytochrome c and Smac, and activation of executioner caspase-3.

35 me c, and subsequently the processing of the executioner caspase-3.

36 for an analogous intermediate of the related executioner caspase-3.

37 We identified executioner caspase-6 as a transcriptional target of p53

38 initiator caspases 1 and 8 but not from the executioner caspase-6.

39 nd pattern of GrB-mediated activation of the executioner caspase-7 in vitro and in vivo.

40 We report here that the apoptotic executioner caspase-7 was activated in the splenocytes o

41 e a caspase cascade involving the downstream executioners caspase-3, -6, and -7.

42 s and their applications to directly monitor executioner (caspase-3 and -7) and initiator (caspase-8

43 Caspase-3 is the key "executioner" caspase, catalyzing the hydrolysis of a mul

44 ns, we have designed an infrared fluorogenic executioner-caspase reporter, which reveals spatiotempor

45 Here, we test directly the role of executioner caspases (caspase-3, -6, and -7) in fiber ce

46 hways converge to activate common downstream executioner caspases (caspase-3, -6, and -7), resulting

47 Activities of executioner caspases (e.g., cas-6 and -3) became elevate

48 eolytic cleavage of apical caspases 8 and 2, executioner caspases 3 and 6, Bid cleavage, and release

49 MP also showed robust and fast activation of executioner caspases and apoptosis, the colorectal cance

50 hondrial factors necessary for activation of executioner caspases and apoptosis.

51 at displays attributes of both initiator and executioner caspases and includes a caspase recruitment

52 ngly suggest that Fas-mediated activation of executioner caspases and induction of apoptosis do not d

53 shion leading to activation of caspase-9 and executioner caspases and, surprisingly, activation of th

54 udy demonstrates the efficiency by which the executioner caspases are activated in vivo.

55 in many metazoans, translational control of executioner caspases by RBPs might be a strategy used wi

56 caspase 8 arose during evolution to trigger executioner caspases directly, circumventing viral suppr

57 Activation of executioner caspases during receptor-mediated apoptosis

58 orted here will enable direct control of the executioner caspases in apoptosis and in cellular differ

59 imaging to observe tangles and activation of executioner caspases in living tau transgenic mice (Tg45

60 eful in assessing the role of inhibiting the executioner caspases in minimizing tissue damage in dise

61 We tested the role of executioner caspases in organelle degradation by examini

62 the peptide linker by caspase-3, one of the executioner caspases involved in apoptosis, results in a

63 ose further processing is mediated by mature executioner caspases rather than initiator caspases.

64 that cleavage of Bid to tBid is mediated by executioner caspases suggests that a self-amplifying fee

65 s (KCs) activating the signaling kinases and executioner caspases that damage KCs, causing their shri

66 rt half-life may inhibit the activity of the executioner caspases toward specific substrates.

67 Executioner caspases were activated in detached pancreat

68 Transcripts for all three executioner caspases were identified in lens fiber cells

69 m activation of caspase-8 but not of distal, executioner caspases, and does not lead to apoptosis.

70 stricts the infection-mediated activation of executioner caspases, and inhibits virus propagation.

71 ssing, caspase-8 can be cleaved by activated executioner caspases, and reports of whether this cleava

72 ds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspase-7, and have

73 aying a nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspase-7, were iden

74 hway downstream of FLICE but upstream of the executioner caspases, caspase-3, -6, and -7.

75 Baculovirus p35, a suicide substrate of executioner caspases, is not cleaved by purified Dredd i

76 r of apoptosis protein (XIAP) suppression of executioner caspases, respectively.

77 aspase p10 subunit for initiator but not for executioner caspases, so that any free p20 formed by dea

78 Upon exposure to executioner caspases, TcapQ(647) was specifically cleave

79 demolition during apoptosis is completed by executioner caspases, that selectively cleave more than

80 We find that unlike the executioner caspases, which are readily activated by int

81 is autoproteolysis, which directly activates executioner caspases-3 and -7, is unknown for the apical

82 ase specificity with the prototype apoptotic executioner caspases-3 and -7, suggesting that caspase-2

83 h regulates the initiator caspase-9, and the executioner caspases-3 and -7.

84 han a proteasome inhibitor at mobilizing the executioner caspases-3 and -7.

85 ded initiator caspases-8 and -10, as well as executioner caspases-3, -6, and -7.

86 on of caspase-8, consequently activating the executioner caspases-3, -6, and -7.

87 937 cells that was preceded by activation of executioner caspases.

88 membrane permeabilization and activation of executioner caspases.

89 se of caspase-8 into the cytoplasm to engage executioner caspases.

90 f imaging, despite the presence of activated executioner caspases.

91 n contributes substantially to inhibition of executioner caspases.

92 te that tau is cleaved at D421 (DeltaTau) by executioner caspases.

93 Caspase-8, an executioner enzyme in the death receptor pathway, was sh

94 tion of apical caspases 8 and 9 and also the executioner enzyme, caspase 3, whereas infection alone h

95 ed that Y-linked genes Zfy1 and Zfy2 act as 'executioners' for this checkpoint, and that wrongful exp

96 ormation from Texas and Virginia showed that executioners had no anaesthesia training, drugs were adm

97 Since the aggression used by executioners is proactive, the execution paradox is solv

98 sible commitment to positive feedback in the executioner module.

99 Caspase-3 is an essential executioner of apoptosis responsible for regulating many

100 Caspase-3 is a main executioner of apoptotic cell death.

101 Importantly, release of an executioner of caspase-independent apoptosis, apoptosis-

102 The C5b-9 complex is the executioner of CDC.

103 which leads to activation of caspase-3, the executioner of cell death.

104 phosphorylation and aggregation of MLKL, the executioner of necroptosis.

105 SARM1 is the central executioner of the axonal degeneration pathway that culm

106 ein 1 (SARM1) is an evolutionarily conserved executioner of this degeneration cascade, also known as

107 The executioners of apoptosis are caspase family proteases.

108 ve overlapping but nonredundant roles as the executioners of apoptosis in humans.

109 Caspases are critical executioners of apoptosis, and living cells prevent thei

110 ptotic proteins, including caspases, the key executioners of apoptosis, and review the nonlethal func

111 ce caspases-3 and -6 are the most downstream executioners of apoptosis, the constitutively active ver

112 s) can bind to and inhibit caspases, the key executioners of apoptosis.

113 tensively studied as critical initiators and executioners of cell death pathways.

114 ccrued to impugn the presenilins (PS) as the executioners of intramembranous processing of APP.

115 Caspases, the executioners of programmed cell death, are normally synt

116 on caspases and their putative role as sole executioners of programmed cell death.

117 d Arl6ip5, Tnfrsf10b, Traf2, and Ubc are key executioners of this program.

118 activates caspase-9 and then caspase-3, the "executioner" of the cell.

119 Caspase-3 carries out the executioner phase of apoptosis, however under special ci

120 ator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km

121 stimulate procaspase activity, showing that executioner procaspase conformational equilibrium can be

122 Mechanistically, B-PAC-1 treatment activated executioner procaspases and not other Zn-dependent enzym

123 including B-PAC-1 (L14R8), convert inactive executioner procaspases to their active cleaved forms by

124 tions demonstrated that direct activation of executioner procaspases via B-PAC-1 treatment bypasses a

125 ted caspase-3 has properties of a cell death executioner protease.

126 of the antiapoptotic protein Bcl-2 and the "executioner" protease caspase-3 in sepsis-induced gut ce

127 ibitor 2A (Spi2A), an inhibitor of lysosomal executioner proteases dependent on transcription factor

128 apoptotic proteins such as the mitochondrial executioner protein BAX.

129 totic Bcl-2-associated X protein (BAX) is an executioner protein of the BCL-2 family that represents

130 induced by different stimuli share a common executioner proteolysis cascade, including caspase-3 and

131 caspases 6 and 7, other important downstream executioners, remained unchanged.

132 r understanding of IRE1alpha as a cell-death executioner, showing that upon ER stress, IRE1alpha degr

133 In plant systems, the identities of the main executioners that orchestrate cell death remain elusive.

134 strates for the cysteine protease cell death executioners, the caspases.

135 PCD through the induction of the cell death executioner VPE.

136 ay into three modules (initiator, amplifier, executioner), we use computer simulation and bifurcation

137 tivation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (