ライフサイエンスコーパス: exemplify

1 tuted and tetrasubstituted ketene aminals is exemplified.

2 gG1s within the same spiked sample were also exemplified.

3 e chiral isochromene products have also been exemplified.

4 trinsically disordered proteins and probably exemplifies a common strategy used by the cell to respon

5 Therefore, the otic vesicle case exemplifies a generic morphogenetic process where spatia

6 mployment of two distinct endocytic pathways exemplifies a mechanism wherein cells in tissues leverag

7 Moreover, the Nop9 structure exemplifies a new class of Pumilio repeat proteins.

8 d systems approach targeting connected nodes exemplifies a novel precision medicine strategy providin

9 Our work exemplifies a powerful strategy to gain rapid insight in

10 kers at international scientific conferences exemplifies a present-day discussion topic usually occur

11 Metformin exemplifies a promising new class of antiplatelet agents

12 This compound exemplifies a second generation of non-covalent NAAA inh

13 The bacterial flagellum exemplifies a system where even small deviations from th

14 The Neuse River, North Carolina, U.S., exemplifies a typical de facto potable reuse scenario, w

15 laxy community, we believe that the app also exemplifies a useful way of exploiting mobile interfaces

16 DraRnl exemplifies a widely distributed Rnl5 family of nick-sea

17 Vaccinating decisions exemplify a complex, coupled system where vaccinating be

18 We exemplify a metastructure-based implementation by combin

19 We exemplify a plethora of subsurface, i.e., "in-chip" micr

20 Our results exemplify a very counterintuitive feature of non-Hermiti

21 ch the scaffolds can be further modified are exemplified according to the biological properties of th

22 del protein of a spectrin tandem repeat that exemplified an intuitive stability profile based on the

23 Pepper & Nettle's paper exemplifies an emerging resistance against an exclusive

24 Herein, we exemplify an "Inverse Drug Discovery" strategy in which

25 We exemplify an application of stock demographics by charac

26 ckerins interacting with adaptor scaffoldins exemplify an evolutionary pathway developed by R. flavef

27 of the large signal gain in the devices and exemplifying an important design strategy that enables h

28 This work exemplifies as a cautionary tale how a more potent inhib

29 The results showed that healthy controls exemplified better cognition than patients in both gende

30 attenuates fungal pathogenicity and growth, exemplifying bidirectional cross-kingdom RNAi and sRNA t

31 Their versatility is exemplified by (1) [2+n]-cycloadditions (n = 3, 4) by th

32 on of novel hydroxamic acid LpxC inhibitors, exemplified by 1, where cytotoxicity against mammalian c

33 Axially chiral biaryls, as exemplified by 1,1'-bi-2-naphthol (BINOL), are key compo

34 ich is then changed to a 1D elastic crystal, exemplified by 4-bromophenyl 4'-chlorobenzoate, by intro

35 benzimidazole-based direct AMPK activators, exemplified by 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-

36 attention is paid to the square-planar case, exemplified by [Cu(CF3)4](-), in which Snyder had the fo

37 The application of the optimization model is exemplified by a case aimed at determining the environme

38 six electroactive groups at its vertices, as exemplified by a facile synthesis of a representative he

39 n effort using 9, we further improved LLE as exemplified by a much more druglike analog 26.

40 veal an abundance of Gly/Ala/Ser/Thr repeats exemplified by a prominent, previously unidentified, 43

41 The usefulness of this resource has been exemplified by a search for all potential transcription

42 f simple observations made >40 years ago, as exemplified by a study performed by Anderson, Brown, and

43 perties such as subcellular localization, as exemplified by a ubiquitin-binding domain in Salmonella

44 c populations (including subclones) has been exemplified by acute promyelocytic leukemia, where succe

45 s of these Endo-S2 glycosynthase mutants was exemplified by an efficient glycosylation remodeling of

46 he usefulness of this synthetic strategy was exemplified by an efficient synthesis of the glycopeptid

47 This is exemplified by analyzing distinct features in the electr

48 between innate and adaptive immunity is best exemplified by antigen presentation.

49 These compounds, exemplified by APS-2-79, modulate KSR-dependent MAPK sig

50 This was further exemplified by aromaticity analysis of the heterolytic h

51 s play a vital role in cellular processes as exemplified by assembly of the intricate multi-enzyme ce

52 The macrocyclic FXIa series, exemplified by compound 16, had a FXIa Ki = 0.16 nM with

53 h activity in biochemical and plasma assays, exemplified by compound 40.

54 D abolish constraint from un-liganded LBD as exemplified by constitutively active AR variants (AR-Vs)

55 modular reactivity of these intermediates is exemplified by cross-coupling reactions, enabling regioc

56 nt to the induction of allergic inflammation exemplified by diminished airway eosinophilia, type 2 cy

57 lyltriflates, which are prepared in situ, is exemplified by dipolar cycloaddition reactions with nitr

58 le (epigenetic) regulation of transcription, exemplified by DNA methylation.

59 This is exemplified by Dscam1 and Dscam2, which together repel d

60 pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication.

61 This is exemplified by employing the genome sequence to clone an

62 This effect is well exemplified by energy storage systems, in which structur

63 Macrolide antibiotics, exemplified by erythromycin, bind the 50S subunit with n

64 ly or late components of glucose metabolism, exemplified by fluorine 18 ((18)F) fluorodeoxyglucose (F

65 ate in cancer initiation and progression, as exemplified by frequent mutations in genes encoding prot

66 This is particularly exemplified by giant pandas.

67 clear classification is still needed, as is exemplified by glycoside hydrolase family-3 (GH3) protei

68 ntrol and high end group fidelity is further exemplified by in situ block copolymerization upon seque

69 Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexano

70 teract covalently with cysteine residues, as exemplified by its effect on NF-kappaB, the inhibition o

71 The adamantane compounds, exemplified by JNJ303, are highly potent gating modifier

72 class of function-blocking anti-beta1 mAbs, exemplified by Lia1/2, could not disrupt IFCs.

73 progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphob

74 This is exemplified by limits of detection of 1.2%, 1.0%, and 1.

75 The natural analogues of such systems are exemplified by nastic plant motions, where a variety of

76 al statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Lo

77 yn), often resulting in motor dysfunction as exemplified by Parkinson's disease (PD).

78 man colonic Bacteroides species are glycans, exemplified by pectins, a network of covalently linked p

79 (Abeta) plaque-associated neuronal lipids as exemplified by performing high-resolution MALDI-IMS with

80 The importance of the developed method was exemplified by performing the reaction sequence on gram

81 izing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab

82 rapid changes in cell shape are perhaps best exemplified by phagocytes, such as neutrophils.

83 cquire a spectrum of activation status, best exemplified by pro-inflammatory (M1) and anti-inflammato

84 Heavy metal layers, exemplified by Pt, are known to play a significant role

85 during controlled persistent infections, as exemplified by rare HIV-infected individuals who control

86 exhibits typical RNA helicase activities, as exemplified by RNA-dependent ATPase activity and unwindi

87 e extended to the remodeling of proteins, as exemplified by RNase.

88 eta-hydroxy-beta-trifluoromethyl ynamides is exemplified by selective transformations to chiral Z- an

89 This is exemplified by single-wall carbon nanotubes, which exhib

90 performance of the tripeptide substrates is exemplified by specific fluorescence detection of thromb

91 a proof of concept, its application has been exemplified by staining Abeta plaques in slices of brain

92 ze, structure, and coding capacity [3-5], as exemplified by Sulcia muelleri, a nutritional endosymbio

93 umping dsDNA into a preformed protein capsid exemplified by tailed bacteriophages and herpesviruses.I

94 In addition, we describe novel probe uses, exemplified by the addition of a total of 1052 SNP probe

95 peptides to ion channel homology models, as exemplified by the alpha-GID:alpha4beta2 nAChR complex,

96 resolved liquid extraction surface sampling exemplified by the analysis of propranolol and its hydro

97 This limitation is exemplified by the antigen receptors of jawed vertebrate

98 stions in influenza A virus (IAV) ecology is exemplified by the apparent disappearance of highly path

99 ed for the production of androgens, has been exemplified by the approval of abiraterone for the treat

100 phase of physiological B12 absorption, best exemplified by the autoimmune disease pernicious anemia.

101 protein transporters in lipidic mesophases, exemplified by the bacterial ClC exchanger from Escheric

102 de the first direct evidence for one cohort, exemplified by the beetle Darwinylus marcosi, family Oed

103 n understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhib

104 In these reactions, exemplified by the Bergman cyclization (BC), two bonds a

105 generation of native-like trimer immunogens, exemplified by the BG505 SOSIP.664 construct, induces na

106 This is well exemplified by the Ca(2+)-dependent inactivation of L-ty

107 conjugates in a satisfying overall yield was exemplified by the case of trypanothione disulfide (TS2)

108 This is exemplified by the CFTR promoter that in different cell

109 ent in the corresponding metal complexes, as exemplified by the chromium series, and the effect of th

110 variety of probes, drugs and other cargos as exemplified by the conjugation and delivery of the model

111 This is exemplified by the continued controversy over the source

112 One such influence is exemplified by the Crabtree effect (the glucose-mediated

113 ally useful, patient-centred classifiers, as exemplified by the CRC intrinsic signature (CRIS), which

114 As exemplified by the CXC chemokine genes clustered on chro

115 e use of difluoromethylene cap analogues was exemplified by the development of 19F NMR assays for Dcp

116 ing such pathways holds clinical promise, as exemplified by the development of bromodomain and extra-

117 ecroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP-deficien

118 By contrast, in the ADP-bound state, exemplified by the Escherichia coli Hsp70 DnaK, the inte

119 he rapid preparation of bioactive amines, as exemplified by the facile synthesis of anabasine and (-)

120 This is exemplified by the fact that only histone H3 and the pla

121 izing forces in nature is the hydrogen bond, exemplified by the folded secondary, tertiary, and highe

122 rganization of the respective organelles, as exemplified by the fragmentation of the Golgi apparatus

123 tional platform to build artificial cells as exemplified by the in vitro transcription in "nucleus" l

124 functionalization of bioactive heterocycles exemplified by the methylation of the antifungal agent v

125 tinct temporal profiles post-elutriation, as exemplified by the observation of the maturation of a se

126 tuational threat of economic uncertainty (as exemplified by the poverty rate, the housing vacancy rat

127 This ability is exemplified by the preparation of a series of new BODIPY

128 These compounds, here exemplified by the purple-colored anthocyanins, are accu

129 ontrivial, a well-established notion that is exemplified by the quantum Hall effect and topological i

130 seases are a major public health concern, as exemplified by the recent devastating Ebola virus (EBOV)

131 As exemplified by the regulation of PALB2 by ATR, ATR promo

132 secondary structures in the viral genome, as exemplified by the RNA bacteriophage MS2 and as proposed

133 ers has transformed cardiovascular medicine, exemplified by the routine assessment of troponin, for b

134 and chemoreceptors from an orthologous group exemplified by the Salmonella McpC protein.

135 g adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (Sd

136 ed with the synthesis of certain peptides is exemplified by the so-called "difficult peptides", a con

137 uentially directed disulfide bond formation, exemplified by the synthesis of four-disulfide bond-cont

138 A) combined with peptide-centric scoring, as exemplified by the technique SWATH-MS, has emerged as a

139 mmune systems for therapeutic gain, are well exemplified by the urological malignancies of renal, bla

140 lipid-enclosed compartments in the dark, as exemplified by their retention in the interior of erythr

141 ng T. gondii infection are Th1 polarized, as exemplified by their T-bet, CXCR3, and IFN-gamma express

142 metabolic regulators to their effectors, as exemplified by TORC1, whose inhibition in exponentially

143 equivalent number of peptides as pepsin, as exemplified by using the two model systems tetrameric hu

144 zation of main chain fluorinated monomers as exemplified by vinylidene fluoride (VDF) and for the syn

145 The concept of optimal stomatal behavior, exemplified by woody plants shifting along a continuum o

146 This was exemplified by young CpG rich lineage-restricted repeat

147 ow-voltage circuit integration, as this work exemplifies by demonstrating high-performance analog dif

148 lected key examples from the literature that exemplify critical concepts and place a special emphasis

149 We exemplify current developments in structure-guided targe

150 The simulated data exemplifies datasets with varying degrees of common stru

151 Using 5 common anticancer drugs, we exemplified detection of differential proteome stress be

152 This work exemplifies dual recovery of precious Au and fabrication

153 This is best exemplified during humoral immune response when an expan

154 lasmonic entities via a virtual middle state exemplify electron-based population transfer, but their

155 It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordi

156 by promoter DNA methylation, and as such it exemplifies epigenetic regulation of metastatic breast c

157 lyzing 46 common flavones and flavanones and exemplified for four plant extracts.

158 completely automated process trace analytics exemplified for the analysis of a CO2 stream in a produc

159 ural changes in cellular gene expression, as exemplified for the cell cycle in the yeast S. cerevisia

160 Accordingly, PduL and Pta exemplify functional, but not structural, convergent evo

161 demonstrate this technique's generality, we exemplify further studies on a range of pyridazine, pyri

162 anostructures for biomedical applications is exemplified here as photodynamic therapy of malignancies

163 This is exemplified here by real-time profiling of oxygen and gl

164 The approach exemplified here for the Mediterranean Sea, revealing pr

165 This is exemplified here in the case of acetate bound to Au(110)

166 aining activity and specificity for binding, exemplified here with DNA sensors.

167 phosphatase was previously unappreciated and exemplifies how a phospho-network is precisely controlle

168 The LPA locus link with cardiovascular risk exemplifies how detailed metabolic profiling may inform

169 The HPV field exemplifies how long-term funding for basic research has

170 This study exemplifies how poor nutritional condition can aggravate

171 ccumulation of redox equivalents, because it exemplifies how the buildup of charge can be avoided yet

172 The results exemplify how detailed metabolic characterization of gen

173 These findings exemplify how gradients of chemoattractive factors such

174 fers from other measures of correlation, and exemplify how it can reveal shared covariance between hi

175 These findings exemplify how negative selection and subtle enzyme chang

176 In one patient, we also exemplify how our growth prediction model can be used fo

177 and insulin receptor tyrosine kinases (RTKs) exemplify how receptor location is coupled to signal tra

178 Our data exemplify how receptors increase their functional repert

179 Finally, we exemplify how the distributions generated by our method

180 and function of d-LDH in the plant cell and exemplify how the plant mitochondrial respiratory chain

181 We exemplify how this approach facilitates scrutinizing put

182 cities to that of the biosynthetic pathways, exemplify how transporter substrate specificities origin

183 small repository of complex molecules, thus exemplifying how substituted [3]dendralenes could be dep

184 toluminescence spectroscopy of this material exemplifies hysteretic photochromic switching (HPS) betw

185 target reactivity remains a key concern, as exemplified in a recent clinical report describing fatal

186 pposed to A-DNA in the dehydrated state, are exemplified in a series of studies that show: (1) improv

187 Next, the utility of DCFH2 was exemplified in a variety of cell-free and in vitro redox

188 etwork invariants between mouse and macaque, exemplified in graph motif profiles and connection simil

189 D) which is arranged as a dimer of dimers as exemplified in homomeric structures, but no high-resolut

190 The versatility of the approach is exemplified in its extension to the synthesis of 1,3-rel

191 rbohydrate-specific adaptive immune response exemplified in our previous study can be applied to the

192 of them display a profuse stem nodulation as exemplified in the African Aeschynomene afraspera.

193 This is exemplified in the American Midwest by efforts aimed at

194 This is exemplified in the assessment of acute abdominal pain, i

195 Our integrative network-based methodology, exemplified in the case of E2F1-induced aggressive tumor

196 th transport of the protein to processes, as exemplified in the hippocampal neuropil layers and weakl

197 This is perhaps best exemplified in the layering, or lamination, of the retin

198 donors and acceptors, and its versatility is exemplified in the one-pot synthesis of a trisaccharide.

199 The method is exemplified in the rapamycin biosynthetic gene cluster w

200 val conditions for both protecting groups is exemplified in the rapid and efficient synthesis of Lys3

201 the formed beta-amino substituted ketones is exemplified in the total synthesis of sphingolipid HPA-1

202 etones possessing alpha,beta-unsaturation is exemplified in the total synthesis of the quinolizidine

203 Such distinctions are exemplified in the vertebrate retina.

204 se gel thinning rate up to a factor two, and exemplifies interferometry as a powerful tool to quantif

205 Development of a flow-cell apparatus further exemplifies its suitability toward PAT measurements, inc

206 rtain rate and coefficient of variation) and exemplify its ability to achieve precise and reliable sp

207 We exemplify its application with analyses of saturation mu

208 To exemplify its use in crop research, we developed a flexi

209 We then discuss studies that exemplify Mac-1's pro-inflammatory versus regulatory rol

210 This approach was exemplified on QiShenYiQi Pills using thrombin and angio

211 The capacity of this approach is exemplified on various 3D models including adherent/susp

212 To exemplify our approach we designed two epitope ensemble

213 We exemplify our method with three biologically important p

214 We exemplify our strategy by oligomeric state characterizat

215 ing protein-protein association equilibrium, exemplifying possible interactions taking place in crowd

216 MNs with therapeutics have been proposed and exemplified, predominantly for hydrophilic drugs and par

217 ctories, we generated molecular fingerprints exemplifying propensities of protein-ligand interactions

218 ion-dependent behavior of the capsule colony exemplifies quorum-sensing behavior.

219 n time, and offense at 2 urban agencies that exemplify specialty and traditional probation.

220 The cheetah Acinonyx jubatus exemplifies such a species and faces extreme challenges

221 The North American Great Plains exemplify such intraplate earthquake localization, with

222 uantum transition in an atom of antihydrogen exemplifies tests of fundamental symmetries such as char

223 It exemplifies that even closely related, congeneric specie

224 Our findings exemplify that precise quantification using the perceive

225 ting FLOWERING LOCUS T in different manners, exemplifying that different MCTPs additively regulate a

226 These are unprecedented findings, exemplifying that the quantitative imaging method demons

227 We exemplified the applicability of the model using EGFR-ge

228 The Zika virus crisis exemplified the risk associated with emerging pathogens

229 and selective antagonists for the hA3AR, and exemplifies the benefits of a joint theoretical-experime

230 combination, this in vitro experiment better exemplifies the broad applicability of this synthetic sy

231 e tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer

232 This study exemplifies the complex relationship between microbial c

233 Our study exemplifies the continued importance of WGS in detecting

234 llow escape from antibody neutralization and exemplifies the interplay between antigenicity and HBGA

235 This study thus exemplifies the plasticity, dynamics, and novelty of reg

236 This study therefore both exemplifies the potential of a novel formulation for coa

237 Ovarian cancer exemplifies the potential value of genetic testing and t

238 This aspect of our study exemplifies the promise of future widespread resequencin

239 Recent research exemplifies the repertoire of regulatory strategies empl

240 avior of H2A.Z at their +1 nucleosome, which exemplifies the requirement of this histone for transcri

241 This work exemplifies the technological potential of atomically th

242 SLK transplantation exemplifies the trade-off between the principles of util

243 usly supported by retrospective analyses and exemplifies the value of international collaboration in

244 the cell cycle using therapeutic inhibitors exemplify the 'pushmi-pullyu' effect of disrupted DNA re

245 Furthermore, we exemplify the above discoveries with materials ranging f

246 To exemplify the application of the flowchart, valleytronic

247 We exemplify the approach for both nuclear magnetic resonan

248 as birds or reptiles, suggesting that it may exemplify the basal layout from which vertebrate pallial

249 Altogether, these results exemplify the capability of the linker installation meth

250 These patterns exemplify the complex nature of evolutionary changes dur

251 s of PRC2 in the formation of three lineages exemplify the complex outcomes that the lack of PRC2 can

252 Overall, the findings exemplify the creative solutions that the human immune s

253 together with charge transport measurements exemplify the efficient alloying of the anionic sublatti

254 We discuss how amyloid materials exemplify the emergence of function from protein self-as

255 These two new types of oleosin-LDs exemplify the evolutionary plasticity of oleosins-LDs in

256 endent affinity in IgG-FcRn interactions and exemplify the important and often ignored role of intrin

257 We exemplify the method with an investigation of the Bi2Sn2

258 Here, we exemplify the novel 'Transgene Repression In vector Prod

259 -specific sequences in imputation panels and exemplify the power gains afforded by population isolate

260 ess to GPCR structure resolution efforts and exemplify the practical application of structural inform

261 The sealing partners of the Netsilik Inuit exemplify the problem with their account.

262 ent checkpoint kinase 1 (Chk1) inhibitors to exemplify the protocol.

263 n, both to capture how well laboratory lines exemplify the species they represent and to inform on mo

264 desirable to focus on certain cell types to exemplify the underlying growth mechanisms.

265 developments by highlighting few cases that exemplify the uniqueness of NMR in providing atomic reso

266 We exemplify the usage of samExploreR by studying the influ

267 n changes for a couple of candidate genes to exemplify the utility of our analysis of position effect

268 ly all canonical human gene products, and we exemplify the utility of these data in several applicati

269 We exemplify the utility of this approach on several non-es

270 st full view of a class I cytokine receptor, exemplifying the architecture of more than 40 different

271 of the calcium signatures are not intuitive, exemplifying the importance of mathematical modelling ap

272 porosimetry, we define a digital rock model exemplifying the key structural elements of these carbon

273 ation, depending on the lipid probe, clearly exemplifying the limitation of lipid labelling.

274 reticulate evolution have occurred in Avena, exemplifying the long-term persistence of tetraploids an

275 d ferromagnetic-like state in the nickelate, exemplifying the potential of correlated interfaces to d

276 that were sensitive to XMD8-87 and XMD16-5, exemplifying the potential utility of these compounds ac

277 ansferred this approach to various proteins, exemplifying the universal applicability of our new prep

278 overies has been largely platform dependent, exemplifying the usefulness of applying different genomi

279 liability and uncertainty discourses in MFA, exemplifying the usefulness of the approaches in policy

280 e molecular targets for Affimer selection to exemplify their use in common molecular and cellular app

281 al changes occurring during evolution and to exemplify these by detailed examples.

282 We exemplify these strategies using study data collected as

283 Coffee production exemplifies this issue, because large losses in areas su

284 The mammalian X chromosome exemplifies this structure-function relationship.

285 or small-molecule inhibitor discovery and to exemplify this approach in the development of inhibitors

286 We exemplify this mechanism by simulating how smoking behav

287 We exemplify this technique for the Au-Cu-Si system, where

288 ro, 3-dimensional, blood-brain barrier model exemplifies tight-junction integrity.

289 This technique was exemplified using a radio ((14)C) isotopologue and a sta

290 a beam in an arbitrary spatial-mode basis - exemplified using Hermite-Gaussian and radial Laguerre-G

291 The usefulness of PlantMAT is exemplified using ultrahigh-performance liquid chromatog

292 As exemplified, we started from the integrated disposal of

293 This is exemplified with (i) The H2O2-mediated oxidation of dopa

294 OF-MS), exceptional measurement precision is exemplified with independent epidemiological sample sets

295 erapeutic capabilities will be explained and exemplified with seminal and cutting-edge in vivo studie

296 The efficiency of this workflow is exemplified with the analysis of six fractions of increa

297 ility to simplify retrosynthetic analysis is exemplified with the preparation of 16 different natural

298 Exemplified with urate oxidase (UOx), the enzyme used fo

299 Exemplified with Zika virus detection, we show the appli

300 ually, the potential of fecal lipidomics was exemplified within a clinical context of type 2 diabetes