ライフサイエンスコーパス: exert its

1 ium pamoate, which has also been proposed to exert its action via compromising mitochondrial function

2 ochemical studies demonstrated this class to exert its action via single-strand cleavage rather than

3 re the expression of a global mechanism that exerts its action across the entire visual field.

4 We also show that ASIC1a exerts its action in hippocampal LTP through multiple me

5 usly unknown layer of antiviral defense that exerts its action on epithelial surfaces before the clas

6 al inhibitors, that this derivative probably exerts its action through Kv channels.

7 F2357 is a potential anti-fibrotic drug that exerts its action via activation of Id3, a downstream ta

8 e-dependent learning rule, in which dopamine exerts its action via D1 and D2 dopamine receptors in a

9 Nicotine exerts its actions by binding to neuronal nAChRs that co

10 rleukin-6, but also suggest that this factor exerts its actions through a receptor system that requir

11 the absence of PKCzeta, suggesting that ZIP exerts its actions via additional cellular targets.

12 d neurotrophic factor family of ligands that exerts its actions via Ret tyrosine kinase and GFRalpha2

13 In PI/galactosylceramide mixtures, DAG may exert its activation role through the generation of smal

14 in vitro and in vivo Mechanistically, PPARD exerted its activity in a DNA binding-dependent and liga

15 The antimicrobial peptide nisin exerts its activity by a unique dual mechanism.

16 egulator of cardiomyocyte hypertrophy, which exerts its activity by suppressing the MAPK signaling pa

17 Ab1 exerts its activity through direct and indirect (antithr

18 We also demonstrate that PACAP in the CeA exerts its anorectic effects via local melanocortin and

19 The data suggest that SsnB may exert its anti-angiogenic properties in part by downregu

20 One mechanism used by Fh12 to exert its anti-inflammatory effect is binding to the CD1

21 Mechanistically, PO exerted its anti-inflammatory function through AMP-activ

22 B13 exerted its anti-invasive and antitumor effects against

23 We now show that NF-kappaB exerts its anti-inflammatory activity by inducing delaye

24 in breast cancer and to elucidate how RK-33 exerts its anti-neoplastic effects.

25 ts suggest a novel mechanism(s) by which HNK exerts its anti-tumor activity through the inhibition of

26 ein that must localize to the nucleoplasm to exert its antiangiogenic and tumor suppressive effects.

27 Mechanistic studies indicated that CTSH exerts its antiapoptotic effects through decreased JNK a

28 alysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biol

29 tigated the molecular mechanisms by which it exerts its anticancer effects.

30 t this novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity by a mechanism differe

31 e findings suggest that cannabidiol could be exerting its anticonvulsant effects, at least in part, t

32 We tested the hypothesis that ranolazine exerts its antidiabetic effects by inhibiting glucagon r

33 ported into the cytoplasm of these fungi and exerts its antifungal activity on intracellular targets.

34 IL-28A exerts its antiinflammatory effect by restricting recrui

35 s taken up specifically by target cells, and exerts its antileukemia effects largely by restoring the

36 Our data support a model in which KAE609 exerts its antimalarial activity by directly interfering

37 Lacticin 3147 may exert its antimicrobial effect by several mechanisms.

38 ogether, these data suggest that alpha-PanAm exerts its antimicrobial activity by direct competition

39 PL-deficient mice revealed that this protein exerts its antineoplastic function through the regulatio

40 The results suggested that D5 exerts its antiproliferative action by dampening microtu

41 Mfn2 exerts its antiproliferative effect by acting as an effe

42 Nociceptin exerts its antistress effect by counteracting the functi

43 tion in the presence of cellular thiols, LNM exerts its antitumor activity by an episulfonium ion-med

44 Together, these results demonstrate that JA exerts its antitumor activity by targeting SF3B1 and SF3

45 However, how PG545 exerts its antitumor effect remains incompletely defined

46 n actually exploits radical SAM chemistry to exert its antiviral activity.

47 r, the cell(s) upon which IFN-lambda acts to exert its antiviral effects is unclear.

48 We sought to determine how RNase L exerts its antiviral activity during influenza virus inf

49 Furthermore, it is not clear whether MxA exerts its antiviral activity in a monomeric and/or mult

50 Furthermore, we determined that EFTUD2 exerts its antiviral activity mainly through governing i

51 revious studies showed that ZAPL (PARP-13.1) exerts its antiviral activity via its N-terminal zinc fi

52 These results suggest that Ifit2 exerts its antiviral effect mainly at the level of viral

53 In searching for mechanisms how TRIM14 exerts its antiviral function we found that TRIM14 inter

54 , we identified the mechanism by which PACAP exerts its anxiogenic and pro-depressant effects, via th

55 cell division and proliferation, PDCD5 might exert its apoptotic function at least in part through in

56 Here we show that TriA1 exerts its bactericidal effect by binding to the bacteri

57 Nicotine exerts its behavioral and additive actions through a fam

58 Cocaine exerts its behavioral stimulant effects by facilitating

59 cal SCI and provides evidence that DHA could exert its beneficial effects in SCI via enhancement of n

60 This provides direct evidence that DHA could exert its beneficial effects in spinal cord injury via n

61 diabetes and that costimulation blockade may exert its beneficial therapeutic effect via modulation o

62 lar mechanisms by which shock wave treatment exerts its beneficial effects.

63 Aldosterone exerts its best known sodium homeostasis actions by cont

64 show that shuttling is important for RLIM to exert its biological functions, as alveolar cell surviva

65 scussion of the mechanisms by which selenium exerts its biological activity.

66 SP released from the peripheral nerves exerts its biological and immunological activity via hig

67 , the active constituent of Cannabis sativa, exerts its biological effects in part through the G-prot

68 lamic neurons and the biliary epithelium and exerts its biological effects on cholangiocytes by inter

69 nt modulator of nociceptive transmission and exerts its biological effects through interactions with

70 BDNF exerts its biological functions through its receptor Trk

71 res and maintains its distinct phenotype and exerts its border function.

72 which dopamine gates locomotion and cocaine exerts its canonical stimulant response.

73 ealed, for the first time, that arsenite may exert its carcinogenic effect by targeting cysteine resi

74 study provides a novel mechanism by which HN exerts its cardioprotective and neuroprotective effects.

75 Mechanistically, TAK1 exerts its cardioprotective effect through activation of

76 alpha-granules to platelet surfaces where it exerts its catalytic activity.

77 of HSJ1 to bind ubiquitylated clients and to exert its chaperone activity.

78 aken together, our data indicate that NMNAT2 exerts its chaperone or enzymatic function in a context-

79 Earlier work showed that TUDC exerts its choleretic properties in the perfused rat liv

80 rcuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known

81 rcuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known

82 The protein exerts its control through interactions with the initiat

83 Our data support a model in which H2S exerts its cytoprotective effect on ISR signaling by ind

84 mine the underlying mechanism(s) by which PT exerts its cytotoxic effects in CRC cells.

85 ing numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controllin

86 an unexpected, cell-autonomous feature that exerts its detrimental, highly aggressive growth potenti

87 At which subcellular site(s) Nef exerts its different functions and how kinetics of membr

88 These findings thus illustrate PFOS exerts its disruptive effects on Sertoli cell function d

89 appreciation of how and in what contexts p53 exerts its diverse effects remains unclear.

90 he specificity of ZIP, as it was reported to exert its effect also in PKMzeta knock-out mice.

91 Although BMI1 is known to exert its effect in the nucleus via repression of 2 pote

92 EA appears to exert its effect on Ewing cells through a decrease in ph

93 MN1), and we provide evidence that STAT3 may exert its effect on the HCV life cycle by way of positiv

94 s, indicating that therapeutic NAc-DBS might exert its effect through antidromic stimulation.

95 t HSP90 inhibition in anticancer therapy can exert its effect through inhibition of multiple kinases

96 d H2 receptor agonists showed that histamine exerted its effect by activating the H1 receptor.

97 We found that miR-132 exerted its effect on aging HSCs by targeting the transc

98 arrest and cardiopulmonary resuscitation by exerting its effect via the perivascular pool of aquapor

99 o hexamer led us to conclude that the former exerts its effect allosterically.

100 We show that 16:4(n-3) exerts its effect by activating splenic F4/80(+)/CD11b(l

101 SFDA approved "epigenetic drug", Decitabine, exerts its effect by hypomethylating DNA, demonstrating

102 rated understanding of how the lipid bilayer exerts its effect has remained elusive.

103 st that energy balance and metabolism status exerts its effect in a specific carcinogenesis pathway t

104 ne insertion, but the mechanism by which ERK exerts its effect is unknown.

105 In contrast, BRCA2 exerts its effect on HR in human cells together with HsR

106 mutants, consistent with the notion that Lh3 exerts its effect on neural crest cell migration by regu

107 cal and developmental mechanisms by which FA exerts its effect on NTDs, characterized mouse models ar

108 GD1a exerts its effect on OPCs by inducing their proliferatio

109 ression, our results suggest that the capsid exerts its effect on transcription in cis.

110 It exerts its effect through the specific binding to the se

111 These data suggest that NMI exerts its effect through tumor-targeted delivery of a M

112 ithout involving the DNA repair pathways and exerts its effect via suppression of CDC25 phosphatase S

113 To determine where dopamine exerts its effect, we limited expression of dopamine sig

114 fy the molecular mechanism of how glypican 4 exerts its effect.

115 suggest that affirmation of core values may exert its effects by allowing at-risk individuals to see

116 tant huntingtin [mHtt]), which is thought to exert its effects in a cell-autonomous manner.

117 Methylphenidate is thought to exert its effects on cognition and emotion through limbi

118 However, we provide evidence that C1 may exert its effects only indirectly, namely via inducing C

119 ells and must be transported out of cells to exert its effects through activation of 5 specific cell

120 Here, testosterone may exert its effects through androgen receptor-mediated mec

121 Classically, Epac1 is thought to exert its effects through binding of cAMP leading to a c

122 side cells and therefore must be secreted to exert its effects through these receptors.

123 E139 has been reported to exert its effects via enhancement of extracellular GABA

124 uclear factor kappaB (NF-kappaB) pathways to exert its effects, although the signal transduction mech

125 tral regulator HilD was essential for Pat to exert its effects.

126 RGS7 exerted its effects by controlling morphine-induced chan

127 om multiple intestinal cell compartments and exerted its effects on DCs and T cells, the latter being

128 -expressing stem cells in crypts, but rather exerted its effects on intermediate progenitors, in part

129 d discrepancy, PF analysis revealed that FED exerted its effects through multiple JAK2-independent me

130 Cholesterol exerts its effects and is, itself, regulated in large pa

131 humans but the exact mechanisms by which it exerts its effects are unspecified.

132 We have previously shown that C/EBPalpha exerts its effects by regulating microRNAs (miRs) such a

133 effects, which can last several months, and exerts its effects by specifically cleaving and inactiva

134 s demonstrate that modafinil at least partly exerts its effects by targeting intrinsic functional rel

135 ediction of bacterial species in which ppGpp exerts its effects by targeting RNAP.

136 Until now it was not known whether GABA exerts its effects in plants through the regulation of c

137 of the mechanisms by which GLP-1R activation exerts its effects in preventing or arresting experiment

138 S1P exerts its effects in S1P receptor-independent manner.

139 igated the molecular mechanisms by which NLK exerts its effects in SBMA.

140 g of the mechanisms by which phosphorylation exerts its effects is lacking.

141 Positive end-expiratory pressure exerts its effects keeping open at end-expiration previo

142 of vitamin D3, is a pleiotropic hormone that exerts its effects on a wide range of tissues, resulting

143 WASP exerts its effects on actin dynamics through a multisubu

144 Data suggest that BPA exerts its effects on amelogenesis by disrupting normal

145 However, it remains unclear whether MSA exerts its effects on cancer prevention by influencing a

146 JAK2V617F exerts its effects on cell growth via janus kinase-signa

147 re detailed knowledge about how hyperthermia exerts its effects on chemotherapy may illuminate ways t

148 In sum, our results suggest that TMEM106B exerts its effects on FTLD-TDP disease risk through alte

149 of USP19-ER, suggesting strongly that USP19 exerts its effects on fusion through its effects on UPR

150 HA exerts its effects through four known G-protein-coupled

151 of Lane et al. that successful psychotherapy exerts its effects through memory reconsolidation.

152 amic deep brain stimulation in tremor likely exerts its effects through modulation of both olivocereb

153 (LE-135) studies further confirmed that ATRA exerts its effects through RAR-beta.

154 A drug exerts its effects typically through a signal transducti

155 drolysis mutants, we show that, although ATP exerts its effects via binding AAA1, ADP effects are med

156 LRH-1 exerts its effects via multiple signaling networks.

157 HuMC function, the mechanisms by which IL-6 exerts its effects, and the relationship of these findin

158 We show that YY1 exerts its effects, in part, by promoting B-cell surviva

159 d by which astrocyte [Ca(2+)]i is raised and exerts its effects.

160 rganisms, it is less clear how oncogenic Ras exerts its effects.

161 oxide (H2O2) and the mechanism by which Cx43 exerts its effects.

162 firm the mechanism through which resveratrol exerts its effects.

163 ATRA-PLLA microparticles exerted its efficacy likely through degrading Pin1 and i

164 rmed that the beta-glucan-containing vaccine exerted its enhanced activity by virtue of dendritic cel

165 rase component that exists as a homodimer to exert its epigenetic function.

166 ns as a motor or as an actin cross-linker to exert its essential role is disputed [1, 4, 5].

167 analyses suggest that Wise requires Lrp4 to exert its function and that, together, they have a role

168 th ZapB and requires the presence of ZapB to exert its function in division.

169 minimal distance required for HSET/KIFC1 to exert its function, highlighting a biphasic model for ce

170 V-9 needs to be cleaved at its C terminus to exert its function.

171 al differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear por

172 Uromodulin mainly exerts its function as an extracellular matrix whose ass

173 CLUH exerts its function by controlling the stability and tra

174 MLL4 exerts its function by regulating transcriptional progra

175 We demonstrated that miR-204 exerts its function by targeting genes involved in tumor

176 sms by which the ASC/caspase-1/IL-1beta axis exerts its function in hepatic IRI.

177 How TIM4 exerts its function is unclear, and conflicting data hav

178 ghly interconnected miRNA regulatory network exerts its function less through any individual link and

179 th characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncoge

180 It exerts its function, at least in part, through repressin

181 actual plant body part in which a transcript exerts its function.

182 Importantly, AtCPSF100 was found to exert its functions through the change of poly(A) sites

183 To exert its functions, monomers of NM II assemble into bip

184 ivates the expression of its target genes to exert its functions.

185 both as a neurotransmitter and as a hormone, exerting its functions via dopamine (DA) receptors that

186 tions about how this epigenetic modification exerts its functions and how organisms discriminate cyto

187 SA exerts its functions by interacting with protein targets

188 al mechanisms as to how linear polyubiquitin exerts its functions distinctly from those of other ubiq

189 T-cell tolerance, although how beta-catenin exerts its functions remains incompletely understood.

190 is a general mechanism by which progesterone exerts its genome-independent action and primes sperm fo

191 PII-transcribed genes, suggesting that RECQ5 exerts its genome-stabilizing effect by acting at sites

192 dulation depended on the baseline SSA level, exerting its greatest effect on neurons with intermediat

193 the molecular mechanisms employed by YAP to exert its growth and oncogenic functions, and suggest st

194 se in vitro results argued that the antibody exerted its growth-retarding effect by acting on the cat

195 s the TEAD1-YAP1 transcriptional complex and exerts its growth inhibitory control through its evoluti

196 Their findings indicate that p53 may exert its "guardian of genome" duties at least in part v

197 grity of the brain histamine system to fully exert its hypophagic effect and that the oxytocin neuron

198 ent on a cognate, Ag-specific interaction to exert its immunomodulatory effects on arthritis developm

199 teroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine.

200 x; however, the mechanism by which the motif exerts its immunosuppressive activity is yet to be deter

201 ivities suggested to us that DeltaEGFR might exert its influence through pleiotropic effectors, and w

202 rther mechanistic studies revealed that SHP2 exerted its influence partly by regulating the abundance

203 Ikaros exerts its influence on the chromatin remodeling of thes

204 uron activity, but the circuitry by which it exerts its influence remains poorly described.

205 is how early in the visual system attention exerts its influence.

206 olecular events during which the acidic loop exerts its influence.

207 nsp1 interacts with distinct host factors to exert its inhibitory activities.

208 gma(54) targets different regions in RNAP to exert its inhibitory function.

209 ATP exerted its inhibitory effect through the activation of

210 nt BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent bond

211 cAMP for the same binding region; rather, it exerts its inhibitory action through an allosteric mecha

212 us studies have therefore suggested that MT2 exerts its inhibitory effect by inactivating HJV.

213 NRG exerts its inhibitory effects on PKD1 through Rac1/NADPH

214 ome VEGF is delivered to the surroundings to exert its known biological actions.

215 ll the yeast host, indicating that the toxin exerts its lethality through its enzyme activity.

216 it has been widely held that streptolysin S exerts its lytic activity through membrane disruption, i

217 is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with s

218 Interestingly, STS exerted its metabolic benefit through sex-specific mecha

219 s an underlying mechanism for brain GLP-1 in exerting its metabolic functions.

220 We demonstrate that miR-22 exerts its metastatic potential by silencing antimetasta

221 s exploits pre-existing chromatin looping to exert its multimodal role.

222 linker histone H1, similar to core histones, exerts its multiple biological functions through indepen

223 We propose that GABA exerts its multiple physiological effects in plants via

224 standing of the mechanisms through which PAG exerts its negative-regulatory role in TCR signaling.

225 Sp8 exerts its neural patterning activities by acting as a t

226 The homodimer NGF (nerve growth factor) exerts its neuronal activity upon binding to either or b

227 It has been hypothesized that carnosine may exert its neuroprotective activities through the histidi

228 CA appears to exert its neuroprotective effects through inhibition of

229 Evidence suggests it exerts its neuroprotective effects through several pathw

230 Abeta may exert its neurotoxic effects via multiple mechanisms and

231 elucidate possible mechanism(s) by which Se exerts its neurotoxicity.

232 of the V3 loop and suggest that the antibody exerts its neutralization effect by blocking the corecep

233 tope in the so-called "rim" domain of AT and exerts its neutralizing effect through a dual mechanism.

234 tastasis-associated phosphatase, is known to exert its oncogenic functions through activation of PI3K

235 Mechanistically, ATDC exerted its oncogenic effects by suppressing miR-29 and

236 results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downr

237 The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repres

238 ed by BCAT1 knockdown, indicating that BCAT1 exerts its oncogenic function through BCAA production in

239 Mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets

240 These results suggest that the CNV may exert its opposing influences through mechanisms that in

241 Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypot

242 tative RT-PCR analyses revealed that adjudin exerted its otoprotective effects by up-regulating the l

243 in apoptosis and the mechanism by which PS1 exerts its pathogenic effects.

244 Glucagon exerts its physiological functions through activation of

245 Pioglitazone exerted its positive effect by inhibition of glycogen sy

246 Sugar exerts its potent reinforcing effects via both gustatory

247 found in red wine that has been suggested to exert its potential health benefit through the activatio

248 urthermore, the exact mechanism by which NCX exerts its potentially proarrhythmic effect, ie, by prom

249 Each ligand exerted its predominant influences on thrombin and also

250 BIM exerts its pro-death function via its alpha-helical BH3

251 cific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of

252 on which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, sin

253 IL-17A exerts its pro-tumorigenic activity through its type A r

254 VEGF, sphingosine-1-phosphate also seemed to exert its proangiogenic effects by stimulating direction

255 ollectively, the data indicate that TGF-beta exerts its profibrotic action in vitro and in vivo via i

256 investigated the mechanism by which TGF-beta exerts its profibrotic effects and specifically the role

257 We conclude that NT exerts its proinflammatory and proangiogenic effects dur

258 Instead, IL-4 exerts its proliferative actions via IL-4Ralpha in hepat

259 stasis; however, the mechanism by which CAIX exerts its prometastatic function is not well understood

260 wledge of the mechanisms by which the plasma exerts its promising anti-cancer effects.

261 urther study demonstrated that hepatic SR-BI exerts its protection against sepsis through its role in

262 tablished role in neutralization of LPS, HDL exerts its protection against sepsis through promoting L

263 d T cells defined the mechanism by which EP2 exerted its protective effect.

264 ifferentiation protein 2 (MD-2) in vitro and exerts its protective antifungal activity in vivo throug

265 This finding suggests that ETA exerts its protective effect by boosting PE through the

266 low us to propose a mechanism by which Psb28 exerts its protective effect on the RC47 intermediate.

267 -induced itch supports the notion that IL-31 exerts its pruritic effect indirectly via keratinocytes

268 icotinic acetylcholine receptors (nAChRs) to exert its psychoactive effects.

269 or of IFN signaling, which was also shown to exert its regulatory function in an isopeptidase-indepen

270 The data suggest that the Y chromosome might exert its regulatory functions through epigenetic mechan

271 importance, we show that NC1 domain peptide exerted its regulatory effect by disorganizing actin mic

272 ion with PigR and support the idea that PigR exerts its regulatory effects through an interaction wit

273 bserved in cd69(-/-) mice, showing that CD69 exerts its regulatory function within the lymphocyte com

274 an intermediary regulator through which agr exerts its regulatory function.

275 MITF exerts its regulatory functions through its association

276 wth inhibitor in the central nervous system, exerting its repulsive activity by binding the Neogenin

277 Morphine exerts its rewarding actions, at least in part, by inhib

278 CUL3 exerts its roles by pairing with approximately 90 distin

279 The protein exerts its scavenging action by hydrolyzing oxidized nuc

280 We propose that Jmjd6 exerts its splice modulatory function by interacting wit

281 The cis-elements through which each homolog exerts its splicing activities are likely to be highly s

282 hat may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activit

283 ing as opposed to visual processing, that it exerts its strongest influence on spatial choices when d

284 ic suppressor of inflammatory responses that exerts its suppressive function by regulating transcript

285 Capsaicin exerts its therapeutic action by ablating the TRPV1-SP n

286 is (ECP) is thought to contribute to how ECP exerts its therapeutic effect in patients with chronic g

287 t can manipulate when, where, and how a drug exerts its therapeutic effect.

288 Our data suggest that anti-CD48 mAb exerts its therapeutic effects by both limiting CD4(+) T

289 thway is a novel mechanism by which ketamine exerts its therapeutic effects on stress-induced cogniti

290 onsequently, we hypothesize that deguelin is exerting its toxic effect on nematodes as a modulator of

291 CBT-I may exert its treatment effects on PI by reducing hyper-resp

292 OX2, KLF4, and MYCN, indicating that LXN may exert its tumor-suppressive function by altering the ste

293 Therefore, we propose that JNK signaling exerts its tumor suppressive function in the pancreas by

294 The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibi

295 Mechanistically, miR-203 exerts its tumor-suppressive effect by directly targetin

296 Overall, our work indicates that TIF1gamma exerts its tumor-suppressive functions in part by promot

297 ome epithelioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dediffe

298 l slow-wave-activity; (2) armodafinil cannot exert its wake-promoting effects when PZ(Vgat) neurons a

299 e shown that lorcaserin acts in the brain to exert its weight-reducing effects, but this has not yet

300 These data suggest that lorcaserin exerts its weight-reducing effects by decreasing attenti