ライフサイエンスコーパス: exert their

1 We also show that LCUFAs exert their action independently of their cellular uptak

2 citing mucosal lesions as long as the toxins exert their action on the epithelium.

3 nce more than 40% of the drugs on the market exert their action through these proteins.

4 T2D loci (FTO, IRS1, KLF14 and PPARG) which exert their action via IR.

5 mechanism through which endocrine disruptors exert their action.

6 ork to understand how dietary phytochemicals exert their actions by binding to many functionally dive

7 e POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.

8 GLP-1 and GIP exert their actions predominantly through unique G prote

9 or molecules through which these medications exert their actions remain poorly characterized.

10 However, how deacetylated FoxO exert their actions remains unclear.

11 paradigm that multiple seminal proteins can exert their actions through a multistep, multicomponent

12 However, it is unknown whether they exert their actions through shared regulatory mechanisms

13 g a neural mechanism through which SSRIs may exert their actions.

14 nia and Parkinson disease, and also to drugs exerting their actions via these sites.

15 ogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense str

16 The compounds exert their activities on insects through neurotoxic eff

17 their antimalarial action and therefore may exert their activity by compromising Plasmodium mitochon

18 The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyaci

19 Similar to AlkB, these homologues exert their activity on nucleic acids, although for some

20 e deacetylases both in vitro and in vivo and exert their activity through locus-specific alterations

21 h what degree of specificity CheR paralogues exert their activity.

22 mework for understanding how different ADAMs exert their adhesive function and shedding activities.

23 rough which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be eluc

24 In conclusion, wine compounds may exert their anti-inflammatory activity by reducing PAF l

25 NSAIDs exert their anti-inflammatory and antitumor effects prim

26 e molecular mechanisms by which NBD peptides exert their anti-inflammatory effects in cells.

27 Statins exert their anti-inflammatory effects on the vascular wa

28 pathways in which statins are implicated and exert their anti-inflammatory effects, and we focus spec

29 ic studies that suggest that these compounds exert their anti-trypanosomal effects, at least in part,

30 Interferons (IFNs) exert their anti-viral effects by inducing the expressio

31 ghly potent, broad-spectrum antibiotics that exert their antibacterial activity by selectively target

32 f action studies revealed these compounds to exert their antibacterial effects, at least in part, thr

33 lasses of naturally occurring antimicrobials exert their antibiotic activity by specifically targetin

34 target for developing therapeutic drugs that exert their anticancer activities by producing massive c

35 ecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping T

36 ction studies indicated that these compounds exert their anticancer activity through inhibition of tu

37 How DNA methylation inhibitors exert their anticancer effects in patients is not well u

38 In cell culture, MTAs exert their anticancer effects primarily by causing mito

39 rugs that specifically target alpha2-GABAARs exert their antihyperalgesic effect through enhanced spi

40 nic AMPs bind negatively charged bacteria to exert their antimicrobial activity.

41 xes currently studied in anticancer research exert their antiproliferative activity, at least partial

42 These drugs exert their antiproliferative effects by creating intras

43 These electrophilic compounds are likely to exert their antitrypanosomal activity via inhibition of

44 e and related immunomodulatory drugs (IMiDs) exert their antitumor effects remains unclear.

45 the host factors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate

46 ass of drugs used in the treatment of HIV-1, exert their antiviral effects.

47 IFITMs typically exert their antiviral function by inhibiting the entry o

48 out the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP.

49 Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors.

50 e effector molecules of host immunity, which exert their bactericidal effects through damaging pathog

51 ough the mechanisms through which probiotics exert their beneficial effects are largely unknown.

52 symptoms of depression, and that treatments exert their beneficial effects by abolishing these biase

53 Mechanistically, MSCs exert their beneficial effects by release of paracrine f

54 However, the mechanisms by which omega-3s exert their beneficial effects has not been fully explor

55 g lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion

56 stent with the idea that these interventions exert their beneficial effects, in part, by modulation o

57 n probiotic adaptation in the host and while exerting their beneficial effects.

58 cant mechanistic insight into how cyclotides exert their bioactivities.

59 ctins are carbohydrate-binding proteins that exert their biological activity by binding to specific c

60 stablished as stress signaling proteins that exert their biological effect by degrading the bacterial

61 hin the native cytoplasm where they normally exert their biological effect.

62 al through the JAK/STAT signaling pathway to exert their biological effects.

63 Many RNA molecules exert their biological function only after folding to un

64 al products that recognize RNA specifically, exert their biological functions by binding to prokaryot

65 To exert their biological functions, basophils need to be e

66 compartments are of paramount importance to exert their biological functions.

67 unknown mechanisms used by these proteins to exert their biological functions.

68 and paralogs ensures that miRNAs efficiently exert their biological impact.

69 ole in worsening dysfunction of the other by exerting their biologically harmful effects, leading to

70 of ITCs, which in part may explain how they exert their cancer-preventive effects.

71 methods based on auto-encoder algorithm can exert their capability in knowledge learning in order to

72 e-derived peptides, like ZIP, are thought to exert their cellular action primarily by inhibiting PKC

73 og P < 1.9) from hydrophobic substances that exert their chaotropic activity, by proxy, from within t

74 s whereby lycopene and other carotenoids may exert their chemoprotective effects, we and others perfo

75 These data reveal that PUFA may exert their clinical effects via their capacity to regul

76 onstitute effective cell therapy for OI, but exert their clinical impact by different, complementary

77 rently accepted notion that hybrid NO-NSAIDs exert their cytoprotective effects by releasing NO.

78 t amyloid fibrils and oligomers assemble and exert their cytotoxic effect at cellular membranes, rath

79 To exert their cytotoxic effect, these prodrugs need to be

80 ompounds (e.g., quinazolinediones, QDs) that exert their cytotoxic effects by modulating ROS-mediated

81 ies have suggested that thiopurine drugs may exert their cytotoxic effects partly through binding of

82 h the cytosol of mammalian cells, where they exert their cytotoxic effects.

83 ing indirect evidence suggests that MTAs may exert their cytotoxicity in human tumors by interfering

84 are internalized to intracellular space and exert their cytotoxicity via an unknown mechanism.

85 and the mechanisms by which antidepressants exert their delayed clinical efficacy.

86 oxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host n

87 olecular mechanisms by which these mutations exert their deleterious effects on the glomerulus remain

88 oth hyperglycemia and increased RAS activity exert their deleterious effects, highlighting the therap

89 These cells exert their detrimental functions by promoting tumor gro

90 pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarize

91 ular mechanisms by which association signals exert their effect and (2) suggests that salt sensitivit

92 d mechanism through which dominant mutations exert their effect and cause disease.

93 ession, yet the rules by which these regions exert their effect are poorly understood.

94 is-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors.

95 s linked to the protective variant rs2647012 exert their effect by a cis-regulatory mechanism involvi

96 These Abs likely exert their effect by activating antiviral effector cell

97 , we found that doxycycline and rifamycin SV exert their effect by binding to oligomeric species both

98 class of putative physiological activators, exert their effect by changing membrane properties, lead

99 RGS proteins exert their effect by directly binding to the activated

100 Epigenetic modifications may exert their effect independently or complementary to gen

101 Epigenetic modifications may exert their effect independently or complementary to gen

102 he mechanism by which most sequence variants exert their effect on blood cell formation remains elusi

103 Phospholipids could exert their effect on membrane protein topology either d

104 ealed how common cancer-associated mutations exert their effect on telomerase after cells differentia

105 f the c-myc IRES and in vitro these proteins exert their effect synergistically to stimulate IRES act

106 trophic cardiomyopathy (HCM) are proposed to exert their effect through gain of function for missense

107 We show that imidazopyrazines exert their effect through inhibitory interaction with t

108 How exactly they exert their effect, in particular in patients with low c

109 impair peripheral allergen sensitization but exerted their effect at the lung allergen challenge phas

110 Myelin-specific Foxp3(+) Tregs exerted their effect both by diminishing Ag-bearing infl

111 tion and it was not known whether these SNPs exerted their effect on adiposity by affecting FTO or ne

112 mune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and I

113 st home successfully to the genital tract to exert their effector function and decrease C. trachomati

114 then reactivated to remain in the tissue and exert their effector function only if they encounter the

115 To better understand how these factors exert their effects and shape glial expression programs,

116 s are needed to understand how these factors exert their effects and to determine if these factors ar

117 , although the mechanisms through which they exert their effects are complex, affect all four domains

118 Furthermore, the compounds exert their effects at the alpha2-adrenoceptor both in v

119 and/or contraceptive drugs across the BTB to exert their effects at the immune-privileged site.

120 er's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in

121 Drugs of abuse exert their effects by exploiting natural neurobiologica

122 Cytotoxic drugs that cause CIPN exert their effects by increasing oxidative stress, whic

123 diac surgery, but it is unclear whether they exert their effects by modifying the myocardial redox st

124 SSRIs may exert their effects by remediating emotion regulatory br

125 Recent evidence shows that many MAPs exert their effects by selectively binding to distinct c

126 fter treatment, which suggests that they may exert their effects by the modulation of acute inflammat

127 hat one of the mechanisms by which helminths exert their effects involves the lymphocyte- and STAT6-d

128 and GPR103 form functional hetero-dimers to exert their effects involving activation of ERK1/2.

129 he mechanisms through which anticancer drugs exert their effects is essential to improve combination

130 olecular mechanism through which these drugs exert their effects is largely undefined.

131 How these polymorphisms exert their effects is poorly understood.

132 We further showed that Cav-1 and LRP6 exert their effects on Akt and glycolytic activities by

133 previously intractable human diseases but to exert their effects on cellular RNA processing they must

134 hich variants underlying association signals exert their effects on disease.

135 Easter, Snake, and Gastrulation Defective to exert their effects on dorsal-ventral patterning.

136 In other cell types, coronins exert their effects on lamellipodia dynamics by an inhib

137 re no longer necessary but might continue to exert their effects on recipient cells.

138 he pathogenic or dominant negative mutations exert their effects on some non-native intermediate form

139 precursor cells, but it is unclear how they exert their effects on stem cells, progenitor cells, or

140 General anesthetics exert their effects on the central nervous system by act

141 Thyroid hormones exert their effects through alpha (TRalpha1) and beta (T

142 enetic predispositions to obesity may partly exert their effects through appetitive traits reflecting

143 of large amounts of PGs, such as PGE2, that exert their effects through EP receptors and other intra

144 own to demonstrate that transport inhibitors exert their effects through inhibition of FABPs, thereby

145 s that the neuroblastoma-associated variants exert their effects through loss or gain of protein-prot

146 a majority of disease-associated variants to exert their effects through pancreatic islet dysfunction

147 Whether these additional gene products exert their effects through the CCK2 receptor or a separ

148 butyrylated lower molecular mass hyaluronans exert their effects through the TLR-4 receptor system.

149 that even seemingly intuitive mutations can exert their effects through unforeseen and complex inter

150 factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces.

151 ric modulators are ligands for proteins that exert their effects via a different binding site than th

152 that have been functionally dissected, most exert their effects via a direct interaction with either

153 In vitro studies have shown that plexins exert their effects via an intracellular R-Ras/M-Ras GTP

154 h it was generally assumed that H(2)S and NO exert their effects via separate pathways, the results o

155 These mutations exert their effects via the RAS/MAPK and the PI3K/AKT pa

156 They exert their effects via their binding to the active site

157 Here we show that RAF inhibitors exert their effects via two distinct allosteric mechanis

158 dentify two mechanisms that ILC3s utilise to exert their effects within intestinal tissue.

159 -based phenotypic screening strategies might exert their effects would be highly augmented by new app

160 gress has been made in understanding how LTs exert their effects, and a broader appreciation for the

161 urveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular me

162 a likely mechanism by which these compounds exert their effects.

163 rmacological and psychological interventions exert their effects.

164 to provide insight into how corticosteroids exert their effects.

165 both drugs share a binding pocket in SUR1 to exert their effects.

166 itself, we studied whether iron or TGF-beta exerted their effects through alternative mechanisms, su

167 he effect of KCNE3 on KCNQ1 channels, mainly exerting their effects by an electrostatic interaction w

168 ase risk may result from regulatory variants exerting their effects only in the presence of immune st

169 After exerting their effects, they are eliminated in the urine

170 gs are diffused from the carrier systems and exert their efficacies under various clinical conditions

171 efects of hypoxia sensing and EPOR mutations exert their EPO hypersensitivity.

172 wever, little is known about how EMILINs may exert their extracellular functions.

173 ns are not sufficient for glucocorticoids to exert their full anti-inflammatory effects and suggest t

174 d by the anti-diabetic sulfonylurea drugs to exert their full glucose-lowering effects.

175 Frequently, proteins do not exert their full potential as monomers but rather underg

176 secondary cell wall thickening, but how they exert their function and how their expression is regulat

177 types in genome-wide association studies may exert their function by altering expression of eQTL gene

178 In human neutrophils, PSMs exert their function by binding to the formyl peptide re

179 They exert their function by delivering bacterial effector pr

180 Hox proteins exert their function by interaction with TALE transcript

181 The channels partly exert their function by varying their conductance throug

182 mato leaf dissection, require Tf activity to exert their function in the basal part of the leaf.

183 hether the mechanism by which these proteins exert their function is conserved across phyla and their

184 A variety of biologically active peptides exert their function through direct interactions with th

185 N-1/Nrf1, ATG-18/WIPI1/2 and ATG-16.2/ATG16L exert their function through the DAF-16/FOXO transcripti

186 Riboswitches exert their function through the interplay of alternativ

187 ing list of cellular processes in which PKDs exert their function via phosphorylation of various subs

188 d not express TNFRp75, IFN-gamma, or IL-4 to exert their function.

189 mo-vascular precursors which require S1P1 to exert their functions and are essential for cardiac morp

190 maturation in the developing lymph gland and exert their functions both in a cell-autonomous and non-

191 Since miRNAs exert their functions by regulating the expression of th

192 RecQ helicases exert their functions by using the free energy of ATP hy

193 the prevailing view that individual kindlins exert their functions in a cell type-specific manner mus

194 gene regulatory networks through which they exert their functions, and their physiological integrati

195 Sirt1, -6, and -7 exert their functions, predominantly, through a direct e

196 ues to generate the final output in order to exert their functions.

197 fection to uncover when, where, and how they exert their functions.

198 tissues in which susceptibility genes might exert their functions.

199 (lncRNAs) are constrained to the nucleus to exert their functions.

200 (caspofungin, micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the syn

201 r mechanisms through which Ikaros and Aiolos exert their growth inhibitory effect remain to be determ

202 These nucleosides exert their growth inhibitory effect via a dramatic incr

203 ines, that likely require MyD88 signaling to exert their growth-promoting activity, are prevented.

204 We hypothesized that AGPs exerted their growth promoting effect by altering gut mi

205 rticipate directly in aortic wall repair but exerted their healing properties through paracrine mecha

206 One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous aro

207 hitosan and digestion resistant maltodextrin exert their hypolipidemic activity by different mechanis

208 pecialized cell population highly adapted to exert their immune functions in the vascular network of

209 fector T cells; however, where and how Tregs exert their immunomodulatory effects remain poorly under

210 Regulatory T cells (Tregs) exert their immunosuppressive activity through several i

211 pathogens (bacterial drivers or alpha-bugs) exert their influence at low abundance by modulating bot

212 Sphingadienes exert their influence by blocking Akt translocation from

213 They exert their influence by guiding mRNA cleavage, translat

214 signals in a spatially restricted manner and exert their influence in a regionally selective manner.

215 mune diabetes, but when, where, and how they exert their influence in this context are questions stil

216 signals in a spatially restricted manner and exert their influence locally.

217 ons and functional variants within STS might exert their influence on ADHD vulnerability, and disorde

218 As a consequence, these factors also exert their influence on catalysis by profoundly influen

219 olecular basis through which these exposures exert their influence on children's health.

220 Just where and how predictive systems exert their influence remains poorly understood.

221 e affinity of the TolB-ColE9 complex, do not exert their influence through long-range electrostatic e

222 nes, yet the extent to which recurrent SCNAs exert their influence through rearrangement of cis-regul

223 translational regulators of gene expression, exerting their influence by selectively targeting mRNAs

224 ponses, mitochondrial activity, and satiety, exerting their influence through signaling systems inclu

225 t and receptor-independent channel activity, exerting their influence, at least in part, by enhancing

226 Both of these factors appear to exert their influences within the first few years of lif

227 mechanism through which palytoxin congeners exert their inhalatory toxicity is still unknown, this r

228 ing pathway suggested that the compounds may exert their inhibitory activity on tumor cells through i

229 These receptors exert their inhibitory effect by shunting excitatory cur

230 icate that GIIA sPLA(2) selective inhibitors exert their inhibitory effects by binding to the hGIIA s

231 of the ovarian cycle during which estrogens exert their inhibitory feedback, it is required for the

232 pathway indicated that these drugs might be exerting their inhibitory effects on IRF3 via PI3K signa

233 Drugs of abuse exert their initial reinforcing effects by triggering su

234 Sulfonylurea derivatives exert their insulinotropic effect by binding to the SUR1

235 rther reveals that EPAC2-specific inhibitors exert their isoform selectivity through a unique mechani

236 The mechanisms by which TFR cells exert their key immunoregulatory functions are largely u

237 uch as exercise and caloric restriction, may exert their known health benefits through the autophagy

238 gulated in their subcellular localization to exert their local function.

239 eg depletion mouse model, we found that Treg exert their main suppressive activity in the first 2 d a

240 ntly, we examined whether BDZ agonists could exert their modulatory effect by displacing the equilibr

241 ust both fold into a stable conformation and exert their molecular function.

242 ever, the mechanism by which these oligomers exert their neurotoxic effect remains unknown.

243 verstimulated ionotropic glutamate receptors exert their neurotoxic effects in part by overactivation

244 may be a new mechanism by which certain DTCs exert their neurotoxic effects.

245 Whether AgRP neurons exert their orexigenic actions, at least in part, by inh

246 How they exert their pathogenic effect has, however, endorsed con

247 in neurodegeneration and that LRRK2 and tau exert their pathogenic effects through independent mecha

248 tributes substantially to how these variants exert their pathogenic effects.

249 stinal barrier and reach the blood stream to exert their physiological action.

250 Dinucleoside polyphosphates, Np(n)N', exert their physiological effects via P2 receptors (P2Rs

251 It is thought that PP-IPs exert their pleiotropic effects as allosteric regulators

252 rotease inhibitors of the Bowman-Birk family exert their potential chemopreventive and/or therapeutic

253 protective against colorectal cancer and may exert their preventative effects via modulation of the W

254 Our results demonstrate that MAPCs exert their primary effects in the periphery and provide

255 LL3 and MLL4 that are found in cancers could exert their properties through malfunction of these Trr/

256 cancer-associated mutations in MLL3 and MLL4 exert their properties through the malfunction of Trr/ML

257 c agents require activation of GCLC to fully exert their protective effect.

258 oxic HDAC(s) that these inhibitors target to exert their protective effects has not been resolved.

259 timately reach the cytosol, where the toxins exert their protein synthesis-inhibitory activity by dep

260 Isoflavones may exert their putative protective effects by stimulating b

261 than a tetramer and that neither ADP nor ATP exert their regulatory effects by altering the oligomeri

262 regulator, and precisely how these proteins exert their regulatory effects on cupA gene expression i

263 odels for how PigR and the MglA-SspA complex exert their regulatory effects.

264 hma, but the anatomic location in which they exert their regulatory function and the mechanisms contr

265 ne the anatomic location at which Treg cells exert their regulatory function in the sensitization and

266 Recent findings have shown that NATs can exert their regulatory functions by acting as epigenetic

267 ation, when these molecules are available to exert their regulatory functions on the cell genome and

268 and functionally similar 14-3-3 isoforms may exert their regulatory potential on p53 through differen

269 In the thymus, the recirculating cells exerted their regulatory function by inhibiting interleu

270 elevant effector through which beta-agonists exert their relaxant effects.

271 idence supports the paradigm that stem cells exert their reparative and regenerative effects, in larg

272 We conclude that cis-expressed ligands exert their repressive effect on Notch signaling in case

273 of the dlPFC during controllable pain, both exerting their respective effects via the anterior insul

274 Finally, we provide evidence that DN1s exert their roles in MSDR and SLR via distinct signaling

275 lar and TMJ development and allows HS-PGs to exert their roles via regulation of Ihh signaling topogr

276 line suggests that rhodium metalloinsertors exert their selective biological effects on MMR-deficien

277 Out-of-pocket expenses exert their severity predominantly on those with the mos

278 dary organizers are established and how they exert their signaling functions.

279 in E3 ligases (CRL4s) were recently shown to exert their specificity through the binding of various s

280 1 cells, a subset of T regulatory cells that exert their suppressive activity through IL-10 secretion

281 These proteins exert their suppressive effects through the inhibition o

282 is how these different populations of Tregs exert their suppressive function in vivo.

283 kocytes--possess all of these properties and exert their targeting ability through cellular membrane

284 Benzodiazepines (BZDs) exert their therapeutic actions by binding to the GABA(A

285 seful in determining whether KOR antagonists exert their therapeutic effects by preventing the develo

286 Yet, precisely how this and related drugs exert their therapeutic effects remains controversial.

287 chanisms by which these different treatments exert their therapeutic effects.

288 mingly limited "hit-and-run" mode to quickly exert their therapeutic impact, mediated by several mech

289 er stress conditions, allowing the toxins to exert their toxic effect.

290 classes of insecticides world-wide and they exert their toxic effects through interactions with the

291 (PD), although the mechanisms by which they exert their toxicity are not completely understood.

292 n viruses hijack this dislocation pathway to exert their toxicity or to infect cells.

293 of (GR)50, suggesting that (PR)50 and (GR)50 exert their toxicity through partially distinct mechanis

294 ndicating that selenide and selenomethionine exert their toxicity via distinct mechanisms.

295 iption factors, such as NF-kappaB and STAT3, exert their tumor-promoting activity at least in part th

296 PHLPP1 and PHLPP2 phosphatases exert their tumor-suppressing functions by dephosphoryla

297 dings imply that proto-oncogenic eIFs likely exert their tumorigenic function by regulating/altering

298 current understanding of how biased ligands exert their unique pharmacology, and how research into G

299 It is believed that adult-born neurons exert their unique role in information processing due to

300 asked whether or not these two neurotrophins exert their unique roles on the gustatory system by regu