1 the total number of kiwi taxa that currently
exist to 11 and the number that existed just before huma
2 onditions, the open-ring merocyanine (MC(-))
exists to 48% and closes quantitatively by irradiation w
3 n motion and position, no unifying framework
exists to account for these two key features of our visu
4 a solution from the multiple solutions that
exist to achieve any particular task goal.
5 While many strategies
exist to achieve tethering of peptides, protein, and sma
6 Multiple impediments
exist to achieving value, including misaligned patient a
7 However, it is unclear whether mechanisms
exist to actively protect cell identity in response to e
8 mia events, until recently, no precise tools
existed to actively interrogate cardiac dynamics in spac
9 N2O mitigation strategies
exist to address the most significant anthropogenic sour
10 mains a major challenge, and no technologies
exist to adequately interrogate the >1 x 10(6) B cells i
11 Significant barriers
exist to adopting these systems, however, and a diversit
12 Impactful research opportunities
exist to advance understanding of IDPM, and to incorpora
13 Minimal normative baseline data
exist to aid decision making in clinical and athletic se
14 However, limited evidence
exists to aid clinical decision making regarding which p
15 er, there is another family of criteria that
exists to allow the selection of an adequate model: the
16 However, no publicly available tools
exist to analyse single-nucleotide polymorphism (SNP) ca
17 Various software tools
exist to analyze these pooled sequence data, yet little
18 However, no good method
exists to analyze this P-TEFb equilibrium in living cell
19 Few instruments
exist to ascertain the severity of a preschool-aged chil
20 Although powerful tools
exist to assay the spatial and temporal dynamics of prot
21 atrophy and dysfunction, and few techniques
exist to assess diaphragmatic function: the purpose of t
22 rently, few objective and validated measures
exist to assess IHs.
23 However, no agreed measures
exist to assess the scale and scope of the private healt
24 No widely available parameter
exists to assess global lung stress.
25 Insufficient evidence
exists to assess the possible benefits for suicide preve
26 ighlights the significant knowledge gap that
exists to assess the potential human health hazards asso
27 However, no non-invasive technique
exists to assess this key biological process.
28 inimal, and at times contradictory, evidence
exists to associate clinically available factors with ev
29 Several mechanisms
exist to avoid photodamage, which are collectively refer
30 that conserved RNAPII-associated mechanisms
exist to both suppress intragenic cryptic promoters duri
31 Consequently, many modeling frameworks
exist to capture microbial population growth measurement
32 in instrument raw data files, an opportunity
exists to capture this metadata more accurately.
33 While procedures
exist to characterize the viability of cells, most metho
34 ts of most epidemiologic studies, techniques
exist to characterize uncertainty that can be applied to
35 However, little empirical evidence
exists to characterize the potential health benefits fro
36 cause of hypertension, no standard criteria
exist to classify surgical outcomes.
37 in this region, suggesting that a mechanism
exists to cluster myosin XI-associated structures at the
38 The results appear reasonable but no data
exist to compare with except those from dynamical mean-f
39 We propose that this asymmetry
exists to compensate for inherent and variable time dela
40 ike), but no direct experimental observation
exists to confirm this picture.
41 ermatologist's examination, no reliable tool
exists to confirm whether a patient has CLE for use in e
42 This highlights that opportunities
exist to constrain and even reduce the environmental imp
43 Although other methods
exist to control gene expression with light by using spe
44 whether central circuit specializations also
exist to control their propagation through visual pathwa
45 While laboratory practice standards
exist to control this variability, the disparities betwe
46 tical models in small data sets, and methods
exist to correct for this issue.
47 Whereas strategies
exist to correct such inconsistencies during whole-genom
48 ed in space and time, but whether mechanisms
exist to couple the actin and microtubule (MT) cytoskele
49 t is important to understand what mechanisms
exist to curb unwanted activation.
50 No national standardized guidelines
exist to date for venous thromboembolism (VTE) prophylax
51 parative effectiveness studies in hepatology
exist to date, yet a growing number of analyses using na
52 of IBD, no effective antifibrotic therapies
exist to date.
53 ypes in publication quality figures does not
exist to date.
54 cution time the best local search heuristics
existing to date when applied to real data.
55 e and selective vagal deafferentation method
existing to date, to study the consequences of complete
56 No HIV-1 Vif-APOBEC3 costructure
exists to date despite extensive research.
57 ajor heart pathogen against which no therapy
exists to date.
58 study of local ancestry accuracy in Latinos
exists to date.
59 However, no universally accepted criteria
exist to define metabolically healthy obesity.
60 arly-stage IPF remains unclear, limited data
exist to definitively connect abnormal imaging findings
61 No randomized controlled clinical trials
exist to definitively support the efficacy of surveillan
62 ess is not well understood because no method
exists to definitively distinguish regenerated from pree
63 rtive care, but no definitive clinical trial
exists to delineate the role of surgery.
64 Currently, a number of models
exist to describe allosteric behavior, taking into accou
65 clinical importance, but no tools currently
exist to describe the fine spatial organization of myeli
66 ons are not necessarily static, yet few data
exist to describe the natural history of LVEF over time.
67 No systematic algorithms or heuristics
exist to detect and filter batch effects or remove assoc
68 Several algorithms
exist to detect CNVs by analyzing whole genome sequencin
69 Tests
exist to detect endotoxin in bodily fluids, but are expe
70 Different methods
exist to detect FR expression.
71 Whereas many techniques
exist to detect HLA antibodies in the sera of immunized
72 Methods
exist to detect residual confounding in epidemiologic st
73 Currently, no method
exists to detect early tissue damage and enable interven
74 While a large range of techniques
exist to determine a multitude of properties of these pa
75 Although pathologic methods
exist to determine tissue type during surgery, these met
76 Opportunities
exist to develop a cheap assay to sequence a small numbe
77 delines are rescuer focused, the opportunity
exists to develop patient-centered resuscitation strateg
78 ous clinical trials, an enormous opportunity
exists to develop sustained-release, local delivery syst
79 A need
exists to develop trust and effective meaningful collabo
80 However, limited data
exist to directly compare outcomes with belatacept-based
81 rom chiral starting materials, fewer methods
exist to directly synthesize enantioenriched chiral alle
82 Therefore, mechanisms must
exist to distinguish calcium signalling relevant to diff
83 At present, no reliable predictors
exist to distinguish future responders from nonresponder
84 Significant opportunity
exists to document processes of engagement that reflect
85 f the neural tissue in which dendritic trees
exist to drive their generation in silico.
86 eal valid, feasible, and reliable scar scale
existed to effectively assess the quality of postoperati
87 Although strategies
exist to efficiently generate large quantities of expand
88 oints composed of viral and cellular factors
exist to either maintain a latent state or initiate prod
89 These data suggest that an opportunity
exists to employ hospital informatics systems to improve
90 No previously published method
exists to enable comparative analyses of enrichment leve
91 adhere to consensus guidelines, opportunity
exists to encourage better guideline uptake.
92 No early postnatal treatment strategies
exist to enhance neuroprotective potential of microglia.
93 that generate it, suggesting that mechanisms
exist to ensure its maintenance.
94 e first time in human history, the potential
exists to eradicate a chronic viral disease using combin
95 Moreover, mechanisms must
exist to establish and preserve such organization in the
96 Several algorithms currently
exist to estimate expression from the raw amplification
97 st cancers in humans, yet no validated tools
exist to estimate future risks of developing keratinocyt
98 Multiple equations
exist to estimate glomerular filtration rate (GFR); howe
99 At present, no tools
exist to estimate objectively the risk of poor treatment
100 e site and have therefore been postulated to
exist to evade host immunity.
101 l assessment strategies for caregiver burden
exist to evaluate caregivers, their care recipients, and
102 No records
exist to evaluate long-term pH dynamics in high-latitude
103 A number of assessment tools
exist to evaluate the impact of hearing loss, with littl
104 function and in disease; however, few tools
exist to examine the INM in living cells, and the INM-sp
105 n light of sexual dimorphisms in CVD, a need
exists to examine baseline cardiac differences in humans
106 The opportunity
exists to expand screening programs and reduce the incid
107 based on 1D diffusion and/or 3D-DNA looping,
exist to explain how the long-distance interaction betwe
108 though different macroevolutionary scenarios
exist to explain the Triassic origin and subsequent rise
109 is more active than rutile, but no consensus
exists to explain this difference.
110 New opportunities
exist to exploit proteinases as therapeutic targets in p
111 metabolism for this amoeba but the potential
exists to exploit differentially expressed metabolic sig
112 ganic examples are known and strong interest
exists to extend the search for ferroelectric molecular
113 idome, but no automated lipid classification
exists to facilitate this partitioning.
114 ite their immense interest, no simple method
exists to gain insights into their cellular concentratio
115 With MASC, a theoretical footing now
exists to generate and test computationally explicit pre
116 However, no well-defined protocols
exist to guide fluid administration in this treatment.
117 d Laboratory Standards Institute breakpoints
exist to guide interpretation of minocycline susceptibil
118 erefore stringent regulatory pathways do not
exist to guide research and marketing.
119 ants and children, but no objective criteria
exist to guide the diagnosis and treatment of this disea
120 h care spending, although few objective data
exist to guide the prioritization of comparative effecti
121 No prospective, controlled trials
exist to guide therapy.
122 No RCT evidence
exists to guide statin initiation after age 80 years.
123 ase for which, to date, no effective therapy
exists to halt disease progression toward end-stage live
124 tients, and currently no effective treatment
exists to halt its progression.
125 re found in most prokaryotes, an opportunity
exists to harness the endogenous systems as convenient t
126 Currently, no reliable biomarkers
exist to help diagnose the severity of TBI to identify p
127 Thus, new opportunities
exist to help distinguish microglia in the brain and per
128 ssess the risk of the nodule being malignant
exist to help in the stratification of patients.
129 The potential for ACT1
exists to help heal refractory VLUs, but it faces additi
130 omic, communication and governance solutions
exists to help transform management.
131 isability, but few multifactorial algorithms
exist to identify individuals at risk of future work dis
132 Currently, no available methods
exist to identify patients who will respond favorably to
133 sufficiently well by a linear model, methods
exist to identify the number and connectivity of a minim
134 However, few analytical tools
exist to identify which host species are likely to harbo
135 Hence, a pressing need
exists to identify alternative animal models that reflec
136 Little information
exists to identify barriers to participation in pandemic
137 An urgent need
exists to identify more brown planthopper (Nilaparvata l
138 Insufficient research
exists to identify specific population subgroups that ar
139 rting in July 2018, but no measure currently
exists to identify the added sugar content of products a
140 No reliable method presently
exists to identify these lineages or hemilineages unambi
141 is ongoing about whether sufficient evidence
exists to implement CT screening programmes.
142 Multiple actionable opportunities
exist to improve communication in the intensivist-led IC
143 Opportunities
exist to improve hospitals' performance of time-critical
144 ease course, but many symptomatic treatments
exist to improve patients' quality of life.
145 trial population, significant opportunities
exist to improve the quality of cardiovascular secondary
146 Technical options
exist to improve vehicle efficiency through smarter use
147 Multiple strategies
exist to improve violence prevention efforts, and health
148 Therefore a tremendous need
exists to improve current treatment options and to facil
149 The opportunity
exists to improve guideline-concordant testing in patien
150 A pressing need
exists to improve the management of major depression for
151 allow testing of whether fundamental limits
exist to in vitro network complexity.
152 ite these inherent challenges, opportunities
exist to incorporate evidence from emerging data streams
153 Opportunities
exist to incorporate physical and cognitive rehabilitati
154 RC increases among adolescents, a clear need
exists to incorporate messages about condom use specific
155 Strategies
exist to increase access to surgery and to improve commu
156 Few effective community-based interventions
exist to increase HIV testing and uptake of antiretrovir
157 epresents a family of related complexes that
exist to increase the regulatory diversity and gene cont
158 However, the potential
exists to increase PhytOC levels to 1.16-2.17 x 10(6) to
159 ly, we suggest that considerable opportunity
exists to increase the knowledge gained from BAL analyse
160 While many algorithms
exist to infer a gene regulatory network, very few of th
161 in the therapeutic landscape, no robust data
exist to inform on the selection of patients for a speci
162 Limited data
exist to inform policy decisions about the most appropri
163 -free environment, and thus, the possibility
exists to interrogate intermediate and radical species.
164 However, not a single large-scaled study
exists to investigate the optimal positive cutoff point
165 However, limited evidence
exists to justify its costs and associated morbidity.
166 isingly, although little sequence similarity
exists to known insecticidal proteins, efficacy tests us
167 continues to expand globally, opportunities
exist to leverage these technologies to support demand f
168 regulation, no dedicated bioinformatics tool
exists to leverage its advantages.
169 Virally encoded proteins therefore
exist to limit, inhibit or target UDG activity for prote
170 ndicate that specific multisynaptic circuits
exist to link movement, cognition, and affect to the fun
171 f determining whether compensatory processes
exist to maintain performance in the face of fatigue.
172 hat negative regulators of this process also
exist to maintain the critical balance required for figh
173 on and imply that strong selection pressures
exist to maintain the fidelity of the viral genome durin
174 t an optimal concentration of gold nanostars
exists to maximize the enhancement factor (EF), and the
175 Few instruments
exist to measure caregivers' functional status during a
176 A number of innovative methods
exist to measure cell-matrix adhesive forces, but they h
177 vous system circuits as long as methods have
existed to measure them.
178 However, no well-established method
exists to measure solute partition coefficients into pol
179 Several strategies
exist to mitigate As impacts on rice and each has its se
180 and cultural issues, but that opportunities
exist to mitigate its impacts by combining novel technol
181 ting that management opportunities currently
exist to mitigate near-term non-breeding habitat losses.
182 Currently, no therapeutic options
exist to mitigate the pulmonary consequences of alcoholi
183 A wide range of platforms
exist to model and study disorders associated with sudde
184 Multiple approaches
exist to model patterns of space use across species, amo
185 Thus, T-cell autoreactivity
exists to modified islet epitopes that differs in qualit
186 nic diseases, substantial untapped potential
exists to modify the relation between chronological age
187 Therefore, additional mechanisms may
exist to modulate MEK/ERK activity in favor of tumor cel
188 cell adhesion; however, no rigorous approach
exists to monitor and quantify it accurately in the abse
189 However, in most countries, no surveillance
exists to monitor the change in pneumococcal OM incidenc
190 No imaging methodology currently
exists to monitor viable islet mass after clinical intra
191 completely lacking and authorities apply non-
existing to most stringent requirements.
192 cula become progressively integrated, a need
exists to optimize education related to the skin cancer
193 fore not surprising that regulatory circuits
exist to organize the synthesis of ribosomal components.
194 Opportunities
exist to partner with schools to reach most children wit
195 A variety of platforms
exist to phenotype cellular models, including convention
196 not straightforward, as spatial constraints
exist to position the laser beam and the objective lens
197 arget for which clinically available therapy
exists to potentially treat muscular dystrophy in DM1.
198 Both experimental and computational methods
exist to predict pathogenicity of human genetic variatio
199 Although many computational methods
exist to predict plant protein subcellular localization,
200 monitor multiple sclerosis, no imaging tools
exist to predict the evolution of disease and the effica
201 Peripheral tolerance mechanisms
exist to prevent autoimmune destruction by self-reactive
202 ay enter a cell at the same time, mechanisms
exist to prevent infection by subsequent viruses.
203 Moreover, no treatments
exist to prevent the development of epilepsy in those at
204 At present, no effective treatment
exists to prevent its development.
205 l stiffness, and as yet, no clinical therapy
exists to prevent or reverse it.
206 Limited evidence
exists to prevent retained surgical items by using data-
207 characterized in vitro, very few techniques
exist to probe RNA structures inside cells.
208 Various manufacturing techniques
exist to produce double-curvature shells, including inje
209 Additionally, the need
exists to protect consumers who, out of medical or ethic
210 Barriers also
exist to proteins administered through non-parenteral ro
211 Various analytical protocols
exist to provide an offsite analysis, and a point of sit
212 t has been unclear whether parallel pathways
exist to provide protection from FcgammaR ligation by bo
213 number of versatile synthetic routes already
exist) to provide access to complexes of cobalt, which h
214 However, no single tool yet
exists to provide comprehensive alignment-based quality
215 ications in many areas of biology, and tools
exist to quantify organ shape and detect shape differenc
216 However, no high resolution methods
exist to quantify steroids within target tissues.
217 However, simple techniques do not
exist to quantify the contribution of capillary flux to
218 Different algorithms
exist to quantify the total intensity and position of a
219 ancer-related death worldwide, but no models
exist to readily investigate distant metastases that are
220 Although numerous sequence design strategies
exist to realize these assemblies in solution, there is
221 At present, insufficient evidence
exists to recommend supplementation with any vitamin or
222 Several methods
exist to reconstitute membrane proteins in lipid systems
223 ate that two separate but redundant pathways
exist to recruit ESCRT-III proteins to the midbody.
224 ypes, suggesting that activation checkpoints
exist to reduce the initiation of autoreactive B cell re
225 The potential
exists to reduce radiation dose without compromising low
226 tandardized brain tumor imaging protocol now
exists to reduce variability and improve reliability.
227 echanism distinct from the IR-Akt-Foxo1 axis
exists to regulate glucose production.
228 vessels within peripheral nerve endoneurium,
exists to regulate its internal microenvironment essenti
229 t is unknown whether surveillance mechanisms
exist to reinforce this function.
230 At present, few methods
exist to remediate prion-contaminated land surfaces.
231 ods, but currently, no 3D noninvasive method
exists to replace the taking of small paint samples in t
232 If perceptual mechanisms
exist to represent lifelikeness, then observers should b
233 few if any satisfactory long-term solutions
exist to resolve this serious unintended side effect of
234 proteins, indicating that redundant pathways
exist to respond to hepatocyte death.
235 the matrix, we reasoned that mechanisms must
exist to retain low levels of superoxide in other cellul
236 it is less clear where tractable routes may
exist to reverse or inhibit EMT as a strategy for drug s
237 t conversions suggests that kinetic barriers
exist to safeguard cell-type identity.
238 nism, and additional temporal regulators may
exist to sculpt vascular topology.
239 findings indicate that, in vivo, mechanisms
exist to select against aneuploid cells.
240 by TNF-alpha, suggesting that opportunities
exist to selectively activate latent HIV proviruses.
241 Moreover, innate components or pathways
exist to sense membrane fusion upon viral entry into hos
242 It is conceivable that mechanisms
exist to sense these changes and link them to pathways t
243 tely, only a few large experimental datasets
exist to serve as benchmarks for function-related predic
244 tment for SUDs but only if an infrastructure
exists to serve new enrollees.
245 Limited evidence
exists to show that adding a third agent to platinum-dou
246 argue that differences in premotor circuits
exist to simplify the coordination of activity within sp
247 Although no targeted therapy yet
exists to slow renal fibrosis, a number of important rec
248 rain predictions, but significant challenges
exist, to some extent because of the large range of scal
249 Although several methods
exist to study cell migration (such as Boyden chamber as
250 owever, few models of B lymphocyte infection
exist to study immune recognition of such cells.
251 servoir within B lymphocytes, but few models
exist to study KSHV-infected B cells other than the tran
252 standing protein translation, no such probes
exist to study ribosome biogenesis.
253 nd maintenance in vivo, and no cancer models
exist to study the action of IDH2 mutants in vivo.
254 e stenosis, but no approved specific therapy
exists to substantially lower Lp(a) concentrations.
255 However, no convincing evidence
exists to suggest that only single CSCs are representati
256 No evidence
exists to suggest that zoledronic acid improves survival
257 Convincing data now
exist to support a detrimental role for HTRA1 in the pat
258 Few population-based data
exist to support an association.
259 strate that specialized molecular mechanisms
exist to support growth demands in neurons with large de
260 nd clinical evidence and mathematical models
exist to support some aspects of most theories, but evid
261 alternative routes for NAD regeneration must
exist to support the increased glycolytic rate while all
262 Emerging data
exist to support the notion that SRS in combination with
263 No randomized controlled trials
exist to support the use of eculizumab in renal disease.
264 Currently, sufficient data
exist to support the use of lactobacilli as candidates f
265 Few clinical data
exist to support this recommendation.
266 However, scant clinical data
exist to support this target and available data relied o
267 has been undertaken to determine if evidence
existed to support these findings.
268 Sufficient evidence
exists to support clinical recommendations that fructose
269 Reasonably consistent evidence
exists to support higher absolute BMR/RMR and TDEE in pu
270 facility use; however, insufficient evidence
exists to support its use over standard clinical care.
271 While evidence
exists to support the effectiveness of neuraminidase inh
272 te a positive-feedback loop in leukemia that
exists to support the growth and relapse of the disease.
273 ical, paleontological, and isotopic evidence
exists to support the hypothesis that the atmospheric ox
274 However, surprisingly little evidence
exists to support the idea that synaptic plasticity in p
275 Level 1 evidence
exists to support the use of nivolumab as second-line tr
276 ertility prospects, although little evidence
exists to support this assumption.
277 No evidence
exists to support this threshold.
278 Thus, an additional supply pathway(s) must
exist to sustain cone-dependent vision.
279 error-prone, and error-correction mechanisms
exist to switch misaligned chromosomes to the correct, b
280 applications; however, to date, few methods
exist to synthesize or fabricate such materials.
281 A new therapeutic agent now
exists to target further heart rate lowering in patients
282 Limited cellular platforms
exist to test endocrine disrupting chemical-induced deve
283 Several barriers
exist to the development and expansion of palliative car
284 We noted that exceptions
exist to the idea that a higher magnitude of negative ch
285 his review is to highlight the barriers that
exist to the use and availability of AAIs and that preve
286 nity in individuals where immunologic memory
exists to the autoantigen to be expressed.
287 However, barriers
exist to their development in the pediatric population,
288 Few methods
exist to track the sources of DON in watersheds.
289 me domains, indicating that a mechanism must
exist to transfer the growing primer terminus from one s
290 shed research priorities, an opportunity now
exists to translate the call for action into a global de
291 No licensed vaccine or therapeutic
exists to treat MHF, and MARV is therefore classified as
292 uently, no pharmacological therapy currently
exists to treat NASH.
293 currently no approved therapeutic or vaccine
exists to treat or prevent LASV infections.
294 However, no techniques
exist to unambiguously identify these cell types, greatl
295 Limited information
exists to understand resource selection of mule deer in
296 Nevertheless, little data
exist to validate the usefulness of kidney biopsies in t
297 No evidence currently
exists to validate the purported health benefits of bloo
298 Considerable scope
exists to vary the physical and chemical properties of n
299 Few tools
exist to visualize and manipulate neurons that are targe
300 However, no tool
exists to visualize the predicted tolerance of the genom