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1 the total number of kiwi taxa that currently exist to 11 and the number that existed just before huma
2 onditions, the open-ring merocyanine (MC(-)) exists to 48% and closes quantitatively by irradiation w
3 n motion and position, no unifying framework exists to account for these two key features of our visu
4  a solution from the multiple solutions that exist to achieve any particular task goal.
5                        While many strategies exist to achieve tethering of peptides, protein, and sma
6                         Multiple impediments exist to achieving value, including misaligned patient a
7    However, it is unclear whether mechanisms exist to actively protect cell identity in response to e
8 mia events, until recently, no precise tools existed to actively interrogate cardiac dynamics in spac
9                    N2O mitigation strategies exist to address the most significant anthropogenic sour
10 mains a major challenge, and no technologies exist to adequately interrogate the >1 x 10(6) B cells i
11                         Significant barriers exist to adopting these systems, however, and a diversit
12             Impactful research opportunities exist to advance understanding of IDPM, and to incorpora
13              Minimal normative baseline data exist to aid decision making in clinical and athletic se
14                    However, limited evidence exists to aid clinical decision making regarding which p
15 er, there is another family of criteria that exists to allow the selection of an adequate model: the
16         However, no publicly available tools exist to analyse single-nucleotide polymorphism (SNP) ca
17                       Various software tools exist to analyze these pooled sequence data, yet little
18                      However, no good method exists to analyze this P-TEFb equilibrium in living cell
19                              Few instruments exist to ascertain the severity of a preschool-aged chil
20                      Although powerful tools exist to assay the spatial and temporal dynamics of prot
21  atrophy and dysfunction, and few techniques exist to assess diaphragmatic function: the purpose of t
22 rently, few objective and validated measures exist to assess IHs.
23                  However, no agreed measures exist to assess the scale and scope of the private healt
24                No widely available parameter exists to assess global lung stress.
25                        Insufficient evidence exists to assess the possible benefits for suicide preve
26 ighlights the significant knowledge gap that exists to assess the potential human health hazards asso
27           However, no non-invasive technique exists to assess this key biological process.
28 inimal, and at times contradictory, evidence exists to associate clinically available factors with ev
29                           Several mechanisms exist to avoid photodamage, which are collectively refer
30  that conserved RNAPII-associated mechanisms exist to both suppress intragenic cryptic promoters duri
31       Consequently, many modeling frameworks exist to capture microbial population growth measurement
32 in instrument raw data files, an opportunity exists to capture this metadata more accurately.
33                             While procedures exist to characterize the viability of cells, most metho
34 ts of most epidemiologic studies, techniques exist to characterize uncertainty that can be applied to
35           However, little empirical evidence exists to characterize the potential health benefits fro
36  cause of hypertension, no standard criteria exist to classify surgical outcomes.
37  in this region, suggesting that a mechanism exists to cluster myosin XI-associated structures at the
38    The results appear reasonable but no data exist to compare with except those from dynamical mean-f
39               We propose that this asymmetry exists to compensate for inherent and variable time dela
40 ike), but no direct experimental observation exists to confirm this picture.
41 ermatologist's examination, no reliable tool exists to confirm whether a patient has CLE for use in e
42           This highlights that opportunities exist to constrain and even reduce the environmental imp
43                       Although other methods exist to control gene expression with light by using spe
44 whether central circuit specializations also exist to control their propagation through visual pathwa
45          While laboratory practice standards exist to control this variability, the disparities betwe
46 tical models in small data sets, and methods exist to correct for this issue.
47                           Whereas strategies exist to correct such inconsistencies during whole-genom
48 ed in space and time, but whether mechanisms exist to couple the actin and microtubule (MT) cytoskele
49 t is important to understand what mechanisms exist to curb unwanted activation.
50          No national standardized guidelines exist to date for venous thromboembolism (VTE) prophylax
51 parative effectiveness studies in hepatology exist to date, yet a growing number of analyses using na
52  of IBD, no effective antifibrotic therapies exist to date.
53 ypes in publication quality figures does not exist to date.
54 cution time the best local search heuristics existing to date when applied to real data.
55 e and selective vagal deafferentation method existing to date, to study the consequences of complete
56             No HIV-1 Vif-APOBEC3 costructure exists to date despite extensive research.
57 ajor heart pathogen against which no therapy exists to date.
58  study of local ancestry accuracy in Latinos exists to date.
59    However, no universally accepted criteria exist to define metabolically healthy obesity.
60 arly-stage IPF remains unclear, limited data exist to definitively connect abnormal imaging findings
61     No randomized controlled clinical trials exist to definitively support the efficacy of surveillan
62 ess is not well understood because no method exists to definitively distinguish regenerated from pree
63 rtive care, but no definitive clinical trial exists to delineate the role of surgery.
64                Currently, a number of models exist to describe allosteric behavior, taking into accou
65  clinical importance, but no tools currently exist to describe the fine spatial organization of myeli
66 ons are not necessarily static, yet few data exist to describe the natural history of LVEF over time.
67       No systematic algorithms or heuristics exist to detect and filter batch effects or remove assoc
68                           Several algorithms exist to detect CNVs by analyzing whole genome sequencin
69                                        Tests exist to detect endotoxin in bodily fluids, but are expe
70                            Different methods exist to detect FR expression.
71                      Whereas many techniques exist to detect HLA antibodies in the sera of immunized
72                                      Methods exist to detect residual confounding in epidemiologic st
73                         Currently, no method exists to detect early tissue damage and enable interven
74            While a large range of techniques exist to determine a multitude of properties of these pa
75                  Although pathologic methods exist to determine tissue type during surgery, these met
76                                Opportunities exist to develop a cheap assay to sequence a small numbe
77 delines are rescuer focused, the opportunity exists to develop patient-centered resuscitation strateg
78 ous clinical trials, an enormous opportunity exists to develop sustained-release, local delivery syst
79                                       A need exists to develop trust and effective meaningful collabo
80                        However, limited data exist to directly compare outcomes with belatacept-based
81 rom chiral starting materials, fewer methods exist to directly synthesize enantioenriched chiral alle
82                   Therefore, mechanisms must exist to distinguish calcium signalling relevant to diff
83           At present, no reliable predictors exist to distinguish future responders from nonresponder
84                      Significant opportunity exists to document processes of engagement that reflect
85 f the neural tissue in which dendritic trees exist to drive their generation in silico.
86 eal valid, feasible, and reliable scar scale existed to effectively assess the quality of postoperati
87                          Although strategies exist to efficiently generate large quantities of expand
88 oints composed of viral and cellular factors exist to either maintain a latent state or initiate prod
89       These data suggest that an opportunity exists to employ hospital informatics systems to improve
90               No previously published method exists to enable comparative analyses of enrichment leve
91  adhere to consensus guidelines, opportunity exists to encourage better guideline uptake.
92      No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia.
93 that generate it, suggesting that mechanisms exist to ensure its maintenance.
94 e first time in human history, the potential exists to eradicate a chronic viral disease using combin
95                    Moreover, mechanisms must exist to establish and preserve such organization in the
96                 Several algorithms currently exist to estimate expression from the raw amplification
97 st cancers in humans, yet no validated tools exist to estimate future risks of developing keratinocyt
98                           Multiple equations exist to estimate glomerular filtration rate (GFR); howe
99                         At present, no tools exist to estimate objectively the risk of poor treatment
100 e site and have therefore been postulated to exist to evade host immunity.
101 l assessment strategies for caregiver burden exist to evaluate caregivers, their care recipients, and
102                                   No records exist to evaluate long-term pH dynamics in high-latitude
103                 A number of assessment tools exist to evaluate the impact of hearing loss, with littl
104  function and in disease; however, few tools exist to examine the INM in living cells, and the INM-sp
105 n light of sexual dimorphisms in CVD, a need exists to examine baseline cardiac differences in humans
106                              The opportunity exists to expand screening programs and reduce the incid
107 based on 1D diffusion and/or 3D-DNA looping, exist to explain how the long-distance interaction betwe
108 though different macroevolutionary scenarios exist to explain the Triassic origin and subsequent rise
109 is more active than rutile, but no consensus exists to explain this difference.
110                            New opportunities exist to exploit proteinases as therapeutic targets in p
111 metabolism for this amoeba but the potential exists to exploit differentially expressed metabolic sig
112 ganic examples are known and strong interest exists to extend the search for ferroelectric molecular
113 idome, but no automated lipid classification exists to facilitate this partitioning.
114 ite their immense interest, no simple method exists to gain insights into their cellular concentratio
115         With MASC, a theoretical footing now exists to generate and test computationally explicit pre
116           However, no well-defined protocols exist to guide fluid administration in this treatment.
117 d Laboratory Standards Institute breakpoints exist to guide interpretation of minocycline susceptibil
118 erefore stringent regulatory pathways do not exist to guide research and marketing.
119 ants and children, but no objective criteria exist to guide the diagnosis and treatment of this disea
120 h care spending, although few objective data exist to guide the prioritization of comparative effecti
121            No prospective, controlled trials exist to guide therapy.
122                              No RCT evidence exists to guide statin initiation after age 80 years.
123 ase for which, to date, no effective therapy exists to halt disease progression toward end-stage live
124 tients, and currently no effective treatment exists to halt its progression.
125 re found in most prokaryotes, an opportunity exists to harness the endogenous systems as convenient t
126            Currently, no reliable biomarkers exist to help diagnose the severity of TBI to identify p
127                      Thus, new opportunities exist to help distinguish microglia in the brain and per
128 ssess the risk of the nodule being malignant exist to help in the stratification of patients.
129                       The potential for ACT1 exists to help heal refractory VLUs, but it faces additi
130 omic, communication and governance solutions exists to help transform management.
131 isability, but few multifactorial algorithms exist to identify individuals at risk of future work dis
132              Currently, no available methods exist to identify patients who will respond favorably to
133 sufficiently well by a linear model, methods exist to identify the number and connectivity of a minim
134                However, few analytical tools exist to identify which host species are likely to harbo
135                       Hence, a pressing need exists to identify alternative animal models that reflec
136                           Little information exists to identify barriers to participation in pandemic
137                               An urgent need exists to identify more brown planthopper (Nilaparvata l
138                        Insufficient research exists to identify specific population subgroups that ar
139 rting in July 2018, but no measure currently exists to identify the added sugar content of products a
140                 No reliable method presently exists to identify these lineages or hemilineages unambi
141 is ongoing about whether sufficient evidence exists to implement CT screening programmes.
142            Multiple actionable opportunities exist to improve communication in the intensivist-led IC
143                                Opportunities exist to improve hospitals' performance of time-critical
144 ease course, but many symptomatic treatments exist to improve patients' quality of life.
145  trial population, significant opportunities exist to improve the quality of cardiovascular secondary
146                            Technical options exist to improve vehicle efficiency through smarter use
147                          Multiple strategies exist to improve violence prevention efforts, and health
148                  Therefore a tremendous need exists to improve current treatment options and to facil
149                              The opportunity exists to improve guideline-concordant testing in patien
150                              A pressing need exists to improve the management of major depression for
151  allow testing of whether fundamental limits exist to in vitro network complexity.
152 ite these inherent challenges, opportunities exist to incorporate evidence from emerging data streams
153                                Opportunities exist to incorporate physical and cognitive rehabilitati
154 RC increases among adolescents, a clear need exists to incorporate messages about condom use specific
155                                   Strategies exist to increase access to surgery and to improve commu
156  Few effective community-based interventions exist to increase HIV testing and uptake of antiretrovir
157 epresents a family of related complexes that exist to increase the regulatory diversity and gene cont
158                       However, the potential exists to increase PhytOC levels to 1.16-2.17 x 10(6) to
159 ly, we suggest that considerable opportunity exists to increase the knowledge gained from BAL analyse
160                        While many algorithms exist to infer a gene regulatory network, very few of th
161 in the therapeutic landscape, no robust data exist to inform on the selection of patients for a speci
162                                 Limited data exist to inform policy decisions about the most appropri
163 -free environment, and thus, the possibility exists to interrogate intermediate and radical species.
164     However, not a single large-scaled study exists to investigate the optimal positive cutoff point
165                    However, limited evidence exists to justify its costs and associated morbidity.
166 isingly, although little sequence similarity exists to known insecticidal proteins, efficacy tests us
167  continues to expand globally, opportunities exist to leverage these technologies to support demand f
168 regulation, no dedicated bioinformatics tool exists to leverage its advantages.
169           Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for prote
170 ndicate that specific multisynaptic circuits exist to link movement, cognition, and affect to the fun
171 f determining whether compensatory processes exist to maintain performance in the face of fatigue.
172 hat negative regulators of this process also exist to maintain the critical balance required for figh
173 on and imply that strong selection pressures exist to maintain the fidelity of the viral genome durin
174 t an optimal concentration of gold nanostars exists to maximize the enhancement factor (EF), and the
175                              Few instruments exist to measure caregivers' functional status during a
176               A number of innovative methods exist to measure cell-matrix adhesive forces, but they h
177 vous system circuits as long as methods have existed to measure them.
178          However, no well-established method exists to measure solute partition coefficients into pol
179                           Several strategies exist to mitigate As impacts on rice and each has its se
180  and cultural issues, but that opportunities exist to mitigate its impacts by combining novel technol
181 ting that management opportunities currently exist to mitigate near-term non-breeding habitat losses.
182            Currently, no therapeutic options exist to mitigate the pulmonary consequences of alcoholi
183                    A wide range of platforms exist to model and study disorders associated with sudde
184                          Multiple approaches exist to model patterns of space use across species, amo
185                  Thus, T-cell autoreactivity exists to modified islet epitopes that differs in qualit
186 nic diseases, substantial untapped potential exists to modify the relation between chronological age
187         Therefore, additional mechanisms may exist to modulate MEK/ERK activity in favor of tumor cel
188 cell adhesion; however, no rigorous approach exists to monitor and quantify it accurately in the abse
189  However, in most countries, no surveillance exists to monitor the change in pneumococcal OM incidenc
190             No imaging methodology currently exists to monitor viable islet mass after clinical intra
191 completely lacking and authorities apply non-existing to most stringent requirements.
192 cula become progressively integrated, a need exists to optimize education related to the skin cancer
193 fore not surprising that regulatory circuits exist to organize the synthesis of ribosomal components.
194                                Opportunities exist to partner with schools to reach most children wit
195                       A variety of platforms exist to phenotype cellular models, including convention
196  not straightforward, as spatial constraints exist to position the laser beam and the objective lens
197 arget for which clinically available therapy exists to potentially treat muscular dystrophy in DM1.
198  Both experimental and computational methods exist to predict pathogenicity of human genetic variatio
199          Although many computational methods exist to predict plant protein subcellular localization,
200 monitor multiple sclerosis, no imaging tools exist to predict the evolution of disease and the effica
201              Peripheral tolerance mechanisms exist to prevent autoimmune destruction by self-reactive
202 ay enter a cell at the same time, mechanisms exist to prevent infection by subsequent viruses.
203                      Moreover, no treatments exist to prevent the development of epilepsy in those at
204           At present, no effective treatment exists to prevent its development.
205 l stiffness, and as yet, no clinical therapy exists to prevent or reverse it.
206                             Limited evidence exists to prevent retained surgical items by using data-
207  characterized in vitro, very few techniques exist to probe RNA structures inside cells.
208             Various manufacturing techniques exist to produce double-curvature shells, including inje
209                       Additionally, the need exists to protect consumers who, out of medical or ethic
210                                Barriers also exist to proteins administered through non-parenteral ro
211                 Various analytical protocols exist to provide an offsite analysis, and a point of sit
212 t has been unclear whether parallel pathways exist to provide protection from FcgammaR ligation by bo
213 number of versatile synthetic routes already exist) to provide access to complexes of cobalt, which h
214                  However, no single tool yet exists to provide comprehensive alignment-based quality
215 ications in many areas of biology, and tools exist to quantify organ shape and detect shape differenc
216          However, no high resolution methods exist to quantify steroids within target tissues.
217            However, simple techniques do not exist to quantify the contribution of capillary flux to
218                         Different algorithms exist to quantify the total intensity and position of a
219 ancer-related death worldwide, but no models exist to readily investigate distant metastases that are
220 Although numerous sequence design strategies exist to realize these assemblies in solution, there is
221            At present, insufficient evidence exists to recommend supplementation with any vitamin or
222                              Several methods exist to reconstitute membrane proteins in lipid systems
223 ate that two separate but redundant pathways exist to recruit ESCRT-III proteins to the midbody.
224 ypes, suggesting that activation checkpoints exist to reduce the initiation of autoreactive B cell re
225                                The potential exists to reduce radiation dose without compromising low
226 tandardized brain tumor imaging protocol now exists to reduce variability and improve reliability.
227 echanism distinct from the IR-Akt-Foxo1 axis exists to regulate glucose production.
228 vessels within peripheral nerve endoneurium, exists to regulate its internal microenvironment essenti
229 t is unknown whether surveillance mechanisms exist to reinforce this function.
230                      At present, few methods exist to remediate prion-contaminated land surfaces.
231 ods, but currently, no 3D noninvasive method exists to replace the taking of small paint samples in t
232                     If perceptual mechanisms exist to represent lifelikeness, then observers should b
233  few if any satisfactory long-term solutions exist to resolve this serious unintended side effect of
234 proteins, indicating that redundant pathways exist to respond to hepatocyte death.
235 the matrix, we reasoned that mechanisms must exist to retain low levels of superoxide in other cellul
236  it is less clear where tractable routes may exist to reverse or inhibit EMT as a strategy for drug s
237 t conversions suggests that kinetic barriers exist to safeguard cell-type identity.
238 nism, and additional temporal regulators may exist to sculpt vascular topology.
239  findings indicate that, in vivo, mechanisms exist to select against aneuploid cells.
240  by TNF-alpha, suggesting that opportunities exist to selectively activate latent HIV proviruses.
241      Moreover, innate components or pathways exist to sense membrane fusion upon viral entry into hos
242            It is conceivable that mechanisms exist to sense these changes and link them to pathways t
243 tely, only a few large experimental datasets exist to serve as benchmarks for function-related predic
244 tment for SUDs but only if an infrastructure exists to serve new enrollees.
245                             Limited evidence exists to show that adding a third agent to platinum-dou
246  argue that differences in premotor circuits exist to simplify the coordination of activity within sp
247             Although no targeted therapy yet exists to slow renal fibrosis, a number of important rec
248 rain predictions, but significant challenges exist, to some extent because of the large range of scal
249                     Although several methods exist to study cell migration (such as Boyden chamber as
250 owever, few models of B lymphocyte infection exist to study immune recognition of such cells.
251 servoir within B lymphocytes, but few models exist to study KSHV-infected B cells other than the tran
252 standing protein translation, no such probes exist to study ribosome biogenesis.
253 nd maintenance in vivo, and no cancer models exist to study the action of IDH2 mutants in vivo.
254 e stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations.
255              However, no convincing evidence exists to suggest that only single CSCs are representati
256                                  No evidence exists to suggest that zoledronic acid improves survival
257                          Convincing data now exist to support a detrimental role for HTRA1 in the pat
258                    Few population-based data exist to support an association.
259 strate that specialized molecular mechanisms exist to support growth demands in neurons with large de
260 nd clinical evidence and mathematical models exist to support some aspects of most theories, but evid
261 alternative routes for NAD regeneration must exist to support the increased glycolytic rate while all
262                                Emerging data exist to support the notion that SRS in combination with
263              No randomized controlled trials exist to support the use of eculizumab in renal disease.
264                   Currently, sufficient data exist to support the use of lactobacilli as candidates f
265                            Few clinical data exist to support this recommendation.
266                 However, scant clinical data exist to support this target and available data relied o
267 has been undertaken to determine if evidence existed to support these findings.
268                          Sufficient evidence exists to support clinical recommendations that fructose
269               Reasonably consistent evidence exists to support higher absolute BMR/RMR and TDEE in pu
270 facility use; however, insufficient evidence exists to support its use over standard clinical care.
271                               While evidence exists to support the effectiveness of neuraminidase inh
272 te a positive-feedback loop in leukemia that exists to support the growth and relapse of the disease.
273 ical, paleontological, and isotopic evidence exists to support the hypothesis that the atmospheric ox
274        However, surprisingly little evidence exists to support the idea that synaptic plasticity in p
275                             Level 1 evidence exists to support the use of nivolumab as second-line tr
276 ertility prospects, although little evidence exists to support this assumption.
277                                  No evidence exists to support this threshold.
278   Thus, an additional supply pathway(s) must exist to sustain cone-dependent vision.
279 error-prone, and error-correction mechanisms exist to switch misaligned chromosomes to the correct, b
280  applications; however, to date, few methods exist to synthesize or fabricate such materials.
281                  A new therapeutic agent now exists to target further heart rate lowering in patients
282                   Limited cellular platforms exist to test endocrine disrupting chemical-induced deve
283                             Several barriers exist to the development and expansion of palliative car
284                     We noted that exceptions exist to the idea that a higher magnitude of negative ch
285 his review is to highlight the barriers that exist to the use and availability of AAIs and that preve
286 nity in individuals where immunologic memory exists to the autoantigen to be expressed.
287                            However, barriers exist to their development in the pediatric population,
288                                  Few methods exist to track the sources of DON in watersheds.
289 me domains, indicating that a mechanism must exist to transfer the growing primer terminus from one s
290 shed research priorities, an opportunity now exists to translate the call for action into a global de
291           No licensed vaccine or therapeutic exists to treat MHF, and MARV is therefore classified as
292 uently, no pharmacological therapy currently exists to treat NASH.
293 currently no approved therapeutic or vaccine exists to treat or prevent LASV infections.
294                       However, no techniques exist to unambiguously identify these cell types, greatl
295                          Limited information exists to understand resource selection of mule deer in
296                    Nevertheless, little data exist to validate the usefulness of kidney biopsies in t
297                        No evidence currently exists to validate the purported health benefits of bloo
298                           Considerable scope exists to vary the physical and chemical properties of n
299                                    Few tools exist to visualize and manipulate neurons that are targe
300                             However, no tool exists to visualize the predicted tolerance of the genom

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