ライフサイエンスコーパス: exochelin

1 nfluence of polarity on the iron affinity of exochelins.

2 um secretes iron-binding siderophores called exochelins.

3 gh-affinity iron-binding siderophores called exochelins.

4 Desferri-exochelin 772SM (D-EXO), a highly diffusible, lipophilic

5 The ability of desferri-exochelin 772SM to reversibly block the growth of VSMC i

6 entration of a novel iron chelator, desferri-exochelin 772SM, reversibly arrests the growth of human

7 This study supports the concept that exochelins acquire iron for M. tuberculosis by removing

8 Desferri-exochelins also removed iron, but at a slower rate, from

9 ium tuberculosis all produce the same set of exochelins, although the relative amounts of individual

10 ferric chelating substances that are termed exochelin (an excreted product) and mycobactin (a cell-a

11 le alkyl side chain on the core structure of exochelins and mycobactins, the principal determinant of

12 approach to identify those genes involved in exochelin biosynthesis and transport in Mycobacterium sm

13 gous to peptide synthetases, indicating that exochelin biosynthesis occurs by a nonribosomal mechanis

14 genes, fxbB and fxbC, which are required for exochelin biosynthesis.

15 ped the 5' region of the previously reported exochelin biosynthetic gene fxbA and contained three ope

16 ormyltransferase, an essential enzyme in the exochelin biosynthetic pathway.

17 Thus, highly diffusible desferri-exochelins block injury caused by .OH production and hav

18 The finding that ferri-exochelins but not iron transferrin transfer iron to myc

19 Purified ferri-exochelins, but not iron transferrin, transferred iron t

20 mutagenesis techniques were used to generate exochelin-deficient mutants of Mycobacterium smegmatis s

21 The water-soluble exochelins differ from each other and from water insolub

22 rfusion after a period of ischemia, desferri-exochelins dramatically improved systolic and diastolic

23 the ABC transporter ExiT is responsible for exochelin excretion.

24 the purification and characterization of the exochelin family of molecules.

25 The exochelins from M. avium have previously been reported t

26 the cell wall underscores the importance of exochelins in iron acquisition.

27 The lipophilic desferri-exochelin is effective more rapidly and at a 10-fold low

28 that the peptide backbone of the siderophore exochelin is synthesized in part by enzymes resembling n

29 Exochelin is the primary extracellular siderophore of My

30 h no apparent cytotoxicity suggests that the exochelin may be useful as a therapeutic agent to limit

31 although the relative amounts of individual exochelins may differ.

32 erophore produced by Mycobacterium neoaurum, exochelin MN (ExoMN), is reported along with its pK(a) v

33 Exochelin MN has two hydroxamic acid groups and an unusu

34 The first total synthesis of exochelin MN is described along with rationally designed

35 Exochelin MN is of particular interest as it can efficie

36 In addition, a plausible mechanism for exochelin MN-mediated iron(III) transport was proposed.

37 In contrast, uptake of the exochelin MS, the main siderophore of M. smegmatis, was

38 Exochelins of different polarity exchanged iron equally

39 In this study, we have characterized the exochelins of Mycobacterium bovis, the causative agent o

40 ty, requiring both supplemental iron and the exochelin pathway to acquire it.

41 In the iron-free state, exochelins prevented .OH formation.

42 Desferri-exochelins prevented oxidative injury to cultured cardia

43 mong these mycobacteria, the total amount of exochelins produced is greatest in M. tuberculosis, inte

44 A 10.1 kb SacI fragment restored exochelin production to the other transposon mutant (LUN

45 ansposition mutant strains were deficient in exochelin production.

46 Purified desferri-exochelins rapidly removed iron from human transferrin,

47 f growth-synchronized VSMC with the desferri-exochelin results in down-regulation of cyclin E/ Cdk2 a

48 Exochelins, siderophores of Mycobacterium tuberculosis,

49 conditions is specifically dependent on the exochelin synthesis and uptake pathways, and the strong

50 excreted mycobactin, although both excreted exochelin (the mycobacterial peptido-hydroxamate siderop

51 the possibility that the transfer iron from exochelins to mycobactins was influenced by their polari

52 The capacity of various desferri-exochelins to protect myocytes from oxidative injury var

53 e have investigated the capacity of purified exochelins to remove iron from host high-affinity iron-b

54 the capacity of novel iron chelators called "exochelins" to prevent reperfusion injury.

55 orter proteins, which are likely involved in exochelin transport.

56 ation and RNA transcription are inhibited in exochelin-treated cells, but protein synthesis is not.

57 e pathways, and the strong defect of an iron-exochelin uptake mutant suggests a regulatory role of ir

58 t had lost the ability to produce or secrete exochelin were identified.

59 Mycobacteria secrete the siderophore exochelin when grown under iron-limiting conditions.

60 e abundant quantities of siderophores called exochelins, which have the capacity to scavenge iron fro