ライフサイエンスコーパス: exocrine cell

1 ndscape of human pancreatic alpha, beta, and exocrine cells.

2 soforms play a regulatory role in pancreatic exocrine cells.

3 ha, 105 beta, 6 delta endocrine cells and 47 exocrine cells.

4 inhibition of redifferentiation into mature exocrine cells.

5 ntling of the secretory apparatus of diverse exocrine cells.

6 ull biogenesis of the secretory machinery in exocrine cells.

7 d concurrently with an abnormal increment of exocrine cells.

8 or bud gives rise to the pancreatic duct and exocrine cells.

9 dermal cells that give rise to endocrine and exocrine cells.

10 ecrete zymogen granules in pancreatic acinar exocrine cells.

11 In the exocrine cells, a rapid efflux of radioactivity was obse

12 also expressed insulin mRNA, and pancreatic exocrine cells and ducts were identified within the neop

13 critical to normal organelle localization in exocrine cells and highlight the critical importance of

14 4 may play a role in the efflux of cAMP from exocrine cells and neurokinin receptors are important in

15 the epithelium gives rise to both epithelial exocrine cells and non-epithelial endocrine cells.

16 ne is a limiting step in fluid production in exocrine cells and often involves functionally linked Cl

17 eins in the cell cycle control of pancreatic exocrine cells and the regulation of pancreatic beta cel

18 nt precursor potential resides within mature exocrine cells, and that this potential is regulated by

19 The pancreatic exocrine cells are selectively affected in these four mu

20 n and possible mTORC2 activation occurred in exocrine cells but not in beta cells of the Pdk1-deficie

21 Exocrine cells can release significant amounts of Ca2+ v

22 protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterati

23 njury and repair, we demonstrate that mature exocrine cells, defined by expression of an Elastase1 pr

24 regut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation e

25 n essential role in pancreatic endocrine and exocrine cell development and maintenance of adult islet

26 s throughout pancreas ontogeny by preventing exocrine cell differentiation of multipotent pancreatic

27 that would normally express ptf1a and become exocrine cells, express the endocrine marker Isl1, indic

28 Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas

29 eas development is critical to endocrine and exocrine cell fate.

30 Goblet cells are highly polarized exocrine cells found throughout the small and large inte

31 ranscription factor that may be important to exocrine cell function is Mist1, a basic helix-loop-heli

32 Ae2 HCO(3)(-) transport metabolon in parotid exocrine cell function.

33 acute inflammatory stress by locking damaged exocrine cells in a permanently de-differentiated state.

34 a) that reprograms differentiated pancreatic exocrine cells in adult mice into cells that closely res

35 Pancreatic exocrine cells in E2f1-/-E2f2 mutant mice become increas

36 mob-1 protein was localized to exocrine cells in pancreata of diseased animals.

37 The endocrine and exocrine cells in the adult pancreas are not static, but

38 Reprogramming of pancreatic exocrine cells into cells resembling beta cells may prov

39 We propose that the lysosomal defect in the exocrine cells is caused by the combination of increased

40 m cells gives rise to separate endocrine and exocrine cell lineages.

41 the 52-week study showed an increase in the exocrine cell mass in liraglutide-dosed animals, with no

42 ase appears to predominate, such as sites of exocrine cell migration, secretion, renewal, and inflamm

43 PKD3 is the predominant isoform expressed in exocrine cells of the mouse and human pancreas, whereas

44 he eye, ductile cells of the salivary gland, exocrine cells of the pancreas, mucosal cells of the sto

45 s of vesicular monoamine transporters in the exocrine cells of the pancreas.

46 also increases beta-cell replication but not exocrine cell or hepatocyte replication.

47 Pancreatic exocrine cell plasticity can be observed during developm

48 d with incretin therapy, with both increased exocrine cell proliferation (P < 0.0001) and dysplasia (

49 We demonstrate that surviving pancreatic exocrine cells repress the terminal exocrine gene progra

50 Some exocrine cells secrete caveolin-1 in a regulated manner.

51 uring mid-pancreogenesis, both endocrine and exocrine cells simultaneously arise from the SOX9(+) epi

52 ues, we also show that the ability of mature exocrine cells to accomplish pancreatic regeneration is

53 rotein-coupled receptors (GPCR) in polarized exocrine cells to address the questions of how luminal t

54 he nongenetic conversion of human pancreatic exocrine cells to endocrine cells is novel and represent

55 iated by initial dedifferentiation of mature exocrine cells to generate a population of nestin-positi

56 development, in the progression from normal exocrine cells to metastatic PDA.

57 ss and increase susceptibility of pancreatic exocrine cells to other metabolic stressors.

58 Stimulus-secretion coupling in pancreatic exocrine cells was studied using dissociated acini, prep

59 (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellul

60 ts in two related, but functionally distinct exocrine cells, were studied to gain insight into how th