ライフサイエンスコーパス: exocrine pancreas

1 ed state and then can form new endocrine and exocrine pancreas.

2 nce of the differentiated state of the adult exocrine pancreas.

3 the absence of differentiated endocrine and exocrine pancreas.

4 that is distinct from those that inhabit the exocrine pancreas.

5 e protein present in zymogen granules of the exocrine pancreas.

6 omas (ACCs) are rare malignant tumors of the exocrine pancreas.

7 -induced rapid gating of water in ZGs of the exocrine pancreas.

8 Acinar cell carcinoma is a rare tumor of the exocrine pancreas.

9 s that are scattered unevenly throughout the exocrine pancreas.

10 tes and differentiation of the endocrine and exocrine pancreas.

11 zymogen granules, the secretory vesicles in exocrine pancreas.

12 uctular epithelial cell populations from the exocrine pancreas.

13 n in the pancreatic secretory granule of the exocrine pancreas.

14 the pancreatic islets while being absent in exocrine pancreas.

15 nd complete neoplastic transformation of the exocrine pancreas.

16 ntracellular cyclic AMP (cAMP) levels in the exocrine pancreas.

17 atic progenitors and derived lineages of the exocrine pancreas.

18 stigated the role of Bmi1 in regeneration of exocrine pancreas.

19 nse hyperactivation and tissue injury of the exocrine pancreas.

20 receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas.

21 evention of alcohol-induced ER stress in the exocrine pancreas.

22 of other diseases, including diseases of the exocrine pancreas.

23 for the injurious effects of low pHe on the exocrine pancreas.

24 vely active form of the GTPase, Kras, in the exocrine pancreas.

25 (ER) is abundant in the acinar cells of the exocrine pancreas.

26 lar structures; such changes were lacking in exocrine pancreas.

27 they expand rapidly to form the bulk of the exocrine pancreas.

28 s important to the proper development of the exocrine pancreas.

29 ymphocytic and plasmacytic infiltrate in the exocrine pancreas.

30 dependence as specific to endocrine, but not exocrine, pancreas.

31 Bmi1 contributes to regeneration of the exocrine pancreas after cerulein-induced injury through

32 inhibition of polyamine biosynthesis reduces exocrine pancreas and beta cell mass, and that these red

33 that would confer dual tissue specificity in exocrine pancreas and cytotoxic T lymphocytes are identi

34 ge-enhanced vacuolization and atrophy of the exocrine pancreas and exhibited keratin hyperphosphoryla

35 ein procolipase, which is synthesized in the exocrine pancreas and gastric mucosa.

36 neighbors, which ultimately give rise to the exocrine pancreas and intestine.

37 RT-PCR analysis of total RNA isolated from exocrine pancreas and islets shows that the gene is expr

38 s a lethal autoimmune syndrome involving the exocrine pancreas and other abdominal organs.

39 Over time, the exocrine pancreas and proximal tubules of the kidney als

40 ties exclusively in secretory organs such as exocrine pancreas and salivary gland that led to early p

41 d the endocrine pancreas but scarcely in the exocrine pancreas and skeletal muscle.

42 In contrast, the exocrine pancreas and the intestinal epithelium dediffer

43 herapy may induce focal proliferation in the exocrine pancreas and, in the context of exocrine dyspla

44 ities, including extensive fibrosis, loss of exocrine pancreas, and islet disorganization.

45 nriched in purified islets compared with the exocrine pancreas, and islet-specific expression of p16I

46 n terminal differentiation of the intestine, exocrine pancreas, and retina.

47 receptors for TNFalpha are expressed in the exocrine pancreas, and whether pancreatic acinar cells r

48 Diseases of the exocrine pancreas are often associated with perturbed di

49 Carcinomas of the exocrine pancreas are poorly understood and have a poor

50 nt in the secretory compartment of the human exocrine pancreas, as judged by immunogold electron micr

51 3 (ST3, matrix metalloproteinase 11) in the exocrine pancreas at metamorphic climax.

52 esulted in a 90% decrease in the size of the exocrine pancreas, because of decreased cellular prolife

53 A genuine understanding of human exocrine pancreas biology and pathobiology has been hamp

54 cytokines induced by viral infection of the exocrine pancreas but not of the beta-cells.

55 Ptf1a morphants lack differentiated exocrine pancreas, but maintain normal differentiation a

56 r the early development of the endocrine and exocrine pancreas, but whether Hh signaling functions in

57 zSMCTn is expressed in exocrine pancreas, but zSMCTe is not.

58 riductal and parenchymal inflammation of the exocrine pancreas by CD4(+) T cells, CD8(+) T cells, and

59 diates basolateral bicarbonate influx in the exocrine pancreas by coupling the transport of bicarbona

60 eatment did not exert any negative effect on exocrine pancreas, by inducing either pancreatic inflamm

61 The exocrine pancreas can give rise to endocrine insulin-pro

62 The exocrine pancreas can undergo acinar-to-ductal metaplasi

63 Expression of the homeobox gene Prox1 in the exocrine pancreas changes throughout development in mice

64 The majority of the exocrine pancreas consists of the secretory acinar cells

65 t1 has a dual role in the development of the exocrine pancreas: controlling cell proliferation and pr

66 and that maintained ductal fluid flow in the exocrine pancreas could delay the onset of CFRD.

67 Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose

68 During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells,

69 Ptf1a is a gene required for exocrine pancreas development and is first expressed as

70 Here, we characterize zebrafish exocrine pancreas development in wild type and mutant la

71 Previous studies have shown that exocrine pancreas development may be modeled in zebrafis

72 were required for pancreatic viability; the exocrine pancreas died in mice that were depleted of DCs

73 netic factors likely influence the extent of exocrine pancreas disease in CF ferrets and have implica

74 Interestingly, prior to major exocrine pancreas disease, CF kits demonstrated signific

75 Although CF kits are born with only mild exocrine pancreas disease, progressive exocrine and endo

76 the needed capacity for organ recovery from exocrine pancreas disease.

77 Although both endocrine and the exocrine pancreas display a significant capacity for tis

78 raumatic brain injury or cardiac arrest; and exocrine pancreas DNA was identified in patients with pa

79 Bmi1 expression was up-regulated in the exocrine pancreas during regeneration after cerulein-ind

80 The exocrine pancreas exhibits a reduction in the synthesis

81 comparatively little is known about how the exocrine pancreas forms.

82 itis is caused by inflammatory injury to the exocrine pancreas, from which both humans and animal mod

83 eatorrhea was induced by embolization of the exocrine pancreas gland and pancreatic duct ligation in

84 Tumors of the exocrine pancreas have a poor prognosis.

85 CACs are a functional component of the exocrine pancreas; however, our fate-mapping results ind

86 nesis and cytodifferentiation of the gut and exocrine pancreas in a primordial state.

87 ated the role of Prox1 in development of the exocrine pancreas in mice.

88 sizes an underappreciated involvement of the exocrine pancreas in the natural course of type 1 diabet

89 ease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats.

90 cer (11)C-hydroxytryptophan in endocrine and exocrine pancreas in vitro and in vivo.

91 of a differentiated acinar phenotype in the exocrine pancreas in vivo.

92 in cey mutants, including HSPCs, the retina, exocrine pancreas, intestine, and jaw cartilage.

93 fore promote a transdifferentiation of adult exocrine pancreas into hepatocyte-like cells, and chroni

94 ing knowledge about normal physiology of the exocrine pancreas is essential for investigations into t

95 The pancreatic anlage that gives rise to the exocrine pancreas is located in the ventral gut endoderm

96 Growth of exocrine pancreas is regulated by gastrointestinal hormo

97 The exocrine pancreas is regulated by various hormonal facto

98 In contrast, exocrine pancreas K8 and K18 are dispensable and are co-

99 They are deeply embedded in the exocrine pancreas, limiting their accessibility for func

100 r tissues, including the heart, vasculature, exocrine pancreas, liver, and central nervous system.

101 The exocrine pancreas, liver, and submandibular glands of th

102 gene, the secretion of human insulin by the exocrine pancreas normalized elevated blood glucose leve

103 the elastase promoter not only protects the exocrine pancreas of a transgenic tadpole from TH-induce

104 The exocrine pancreas of adult mice can be remodeled by re-e

105 y, we report that CD8 T cells infiltrate the exocrine pancreas of diabetic subjects in high numbers a

106 copy and immunohistochemical analysis in the exocrine pancreas of multiorgan donors with T1D (both at

107 the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates.

108 doublet beta cells scattered throughout the exocrine pancreas of the transgenic mice.

109 the effects of constitutive ER stress in the exocrine pancreas of these mice.

110 Exocrine pancreases of transgenic tadpoles expressing a

111 n of the probe, with virtually no binding to exocrine pancreas or stromal tissues.

112 The exocrine pancreas plays an important role in endogenous

113 Cells of the exocrine pancreas produce digestive enzymes potentially

114 adverse actions of sitagliptin treatment on exocrine pancreas raise concerns that require further ev

115 P) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointe

116 After metamorphosis is complete the exocrine pancreas redifferentiates in the growing frog f

117 bryos display accelerated differentiation of exocrine pancreas relative to wild-type clutchmate contr

118 At metamorphosis the Xenopus laevis tadpole exocrine pancreas remodels in two stages.

119 issue was highly selective in the epidermis, exocrine pancreas, renal glomeruli, the red pulp of the

120 This reduces enzyme production by the exocrine pancreas, resulting in digestive insufficiencie

121 The action of several exocrine pancreas secretagogues depends on the second me

122 The liver and exocrine pancreas share a common structure, with functio

123 lete neoplastic transformation of the entire exocrine pancreas shortly after birth.

124 ounts and chemotaxis as well as a diminished exocrine pancreas size in a SRP54-knockdown zebrafish mo

125 Most importantly, the increase in exocrine pancreas size, protein/DNA content, and acinar

126 on factor 1-L complex (PTF1-L) in regulating exocrine pancreas-specific gene expression.

127 Exocrine pancreas-specific overexpression of CN inhibito

128 Thus, LRH-1 is a key regulator of the exocrine pancreas-specific transcriptional network requi

129 rly to the main islet, as well as defects in exocrine pancreas specification and differentiation.

130 s), the membrane-bound secretory vesicles in exocrine pancreas, swell in response to GTP mediated by

131 tudies also reveal the spare capacity of the exocrine pancreas that allows normal growth and developm

132 ctrum of fibro-inflammatory disorders of the exocrine pancreas that includes calcifying, obstructive,

133 on and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreati

134 ancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a m

135 IL-1betaAb treatment also protected the exocrine pancreas; the number of infiltrating macrophage

136 In the exocrine pancreas, these peptides not only regulate norm

137 n order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or

138 Endocrine and exocrine pancreas tissues are both derived from the post

139 om 150 nm in diameter in acinar cells of the exocrine pancreas to 12 nm in neurons.

140 (TH) induces dedifferentiation of the entire exocrine pancreas to a progenitor state.

141 Instead, we found the exocrine pancreas to be the major site of AFGP synthesis

142 that actin-coated secretory vesicles of the exocrine pancreas travel this distance over bundles of s

143 , the predominant cellular alteration in the exocrine pancreas was acinar metaplasia in which individ

144 istorically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pan

145 ue-regulated phosphorylation of hsp27 in rat exocrine pancreas was investigated both in vivo and in i

146 cute inflammatory phase, the recovery of the exocrine pancreas was massively impaired in Postn-defici

147 of Bmi1(-/-) mice were hypoplastic, and the exocrine pancreas was replaced with ductal metaplasia th

148 To address this issue in the exocrine pancreas we analyzed the Bmi1-labeled cell line

149 s with newly diagnosed adenocarcinoma of the exocrine pancreas were compared with 388 general populat

150 rs]) with unresectable adenocarcinoma of the exocrine pancreas were treated, 106 with neutron irradia

151 atin overexpression has minor effects on the exocrine pancreas whereas significant keratin overexpres

152 activity and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancrea

153 G alpha and G beta gamma subunits in the rat exocrine pancreas which is highly specialized for protei

154 Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer

155 lation of differentiated acinar cells in the exocrine pancreas whose derivatives are still present, a

156 is, but also inflammatory destruction of the exocrine pancreas with diffusely up-regulated expression

157 atic capillaries were regularly found in the exocrine pancreas, with small lymphatic vessels located