ライフサイエンスコーパス: exocyclic

1 arly critical residue in AIP-II, however, is exocyclic.

2 The trans-4-hydroxynonenal (HNE)-derived exocyclic 1, N(2)-dG adduct with (6S,8R,11S) stereochemi

3 and the lack of cross-link formation by the exocyclic 1,N(2)-dG adduct of (6R,8S,11R) stereochemistr

4 ccordingly, the chemistry of the HNE-derived exocyclic 1,N(2)-dG adduct of (6S,8R,11S) stereochemistr

5 rmation of the interstrand cross-link by the exocyclic 1,N(2)-dG adduct of (6S,8R,11S) stereochemistr

6 Only the HNE-derived exocyclic 1,N(2)-dG adduct of (6S,8R,11S) stereochemistr

7 acrolein- and the 6R-crotonaldehyde-derived exocyclic 1,N(2)-dG adducts form interstrand N(2)-dG:N(2

8 Moreover, as compared to the exocyclic 1,N(2)-dG adducts of acrolein and crotonaldehy

9 ponding acrolein- and crotonaldehyde-derived exocyclic 1,N(2)-dG adducts undergo ring-opening to N(2)

10 yguanosine to HNE yields four diastereomeric exocyclic 1,N(2)-dG adducts.

11 dation in cells, reacts with DNA to form two exocyclic 1,N2-propanodeoxyguanosine (PdG) adducts.

12 its two gamma positions to form the isomeric exocyclic (1-exo) and endocyclic (1-endo) dienolates.

13 benzo-[a]pyrene 7,8-diol 9,10-epoxide by the exocyclic 2-amino group of deoxyguanosine at specific po

14 lized through the intermediacy of an unknown exocyclic [7,10:1,5]patchoul-4(12)-ene (15-d(1)), which

15 ehyde and is known to react with DNA forming exocyclic acrolein-deoxyguanosine adducts (Acro-dG).

16 analyses show that the hydrogenation of the exocyclic activated C horizontal lineC double bond has a

17 s of this class includes the position of the exocyclic acyl group, the prenylation grade of the core,

18 thynyl]phenyl rod that is separated from the exocyclic acylcarbonyl of the DAG-lactone core by a spac

19 The exocyclic adduct 3,N(4)-etheno-2'-deoxycytidine (epsilon

20 is necessary to promote ring-opening of the exocyclic adduct in duplex DNA.

21 The benzetheno exocyclic adduct of the cytosine (C) base (pBQ-C) is a p

22 ethyl)-3,N(4)-etheno-C (8-HM-epsilonC) is an exocyclic adduct resulting from the reaction of dC with

23 M(1)dG is an exocyclic adduct that undergoes ring-opening in duplex D

24 stress that reacts with guanine to form the exocyclic adduct, pyrimido[1,2- alpha]purin-10(3H)-one (

25 Thus, the biotransformation of exocyclic adducts may lead to an additional class of bio

26 n DNA lesions and the enzyme, the effects of exocyclic adducts on DNA cleavage mediated by human topo

27 Together, these data suggest that multiple exocyclic adducts undergo oxidation and glycolytic cleav

28 DNA bases leading to the formation of bulky exocyclic adducts.

29 mation) and to simultaneous formation of the exocyclic alkene double bond.

30 Finally, exploitation of the exocyclic alkene installed in the piperidine-forming rea

31 e RT dNTP binding site that accommodates the exocyclic alkene moiety of ETV was predicted, establishi

32 urred with complete regioselectivity via the exocyclic alkene.

33 ated with alkene transposition to afford the exocyclic alkene; alternatively, the reactivity of the c

34 he 3,3-difluoro-2,4-dione intermediates gave exocyclic alkenes that underwent hydrogenation accompani

35 losing metathesis to afford the synthesis of exocyclic allylic amines from their endocyclic precursor

36 ment with allylic transposition yielding the exocyclic allylsilane 3a with excellent diastereoselecti

37 ray crystal structure of DHO showed that the exocyclic alpha-carboxylate of dihydroorotate is bound t

38 region in the resulting product contains an exocyclic amide positioned alpha to the peptide backbone

39 sely, adding the equivalent of adenine's C-6 exocyclic amine (N-6) to 1- and 3-deazapurines also enha

40 For substrates with purines at -1, an exocyclic amine at C2 on the nucleobase promotes cleavag

41 e local DNA environment and proximity of the exocyclic amine determine the selectivity for reaction w

42 o metabolic activation by N-oxidation of the exocyclic amine group to produce N-hydroxylated metaboli

43 h bioactivate HAAs by N-hydroxylation of the exocyclic amine group; the resultant N-hydroxy-HAA metab

44 at lacks the N4 amino group, implicating the exocyclic amine in critical interactions in the active s

45 terification rate, implying that the guanine exocyclic amine is not a critical determinant of DNA cle

46 the addition of a dimethylallyl group to the exocyclic amine nitrogen (N6) of A(37) in several tRNA s

47 specially sensitive to changes involving the exocyclic amine of A756; by contrast, the cleavage activ

48 a combination of hydrogen bonding to the N6 exocyclic amine of adenosine and steric exclusion of the

49 A pair is in an imino conformation where the exocyclic amine of G contributes approximately 1.4 kcal/

50 ronment and provided a rationale for how the exocyclic amine of nucleobase 8 promotes productive, in-

51 a polyethylene glycol linker attached to the exocyclic amine of PreQ1.

52 th steps; moreover, proton transfer from the exocyclic amine of protonated C75 to the nonbridging oxy

53 drogen bond between the formyl group and the exocyclic amine of the 3'-neighbor adenine stabilizes th

54 en bonding between the formyl oxygen and the exocyclic amine of the 3'-neighboring adenine stabilizin

55 esence of a unique hydrogen bond between the exocyclic amine of the inhibitor and threonine 106 which

56 phospholane approach, which does not require exocyclic amine protection of the nucleobase, has been s

57 through hydrogen bond formation between the exocyclic amine protons of G(7) and the (iPr)Th nitrogen

58 denosine receptor (A3AR) agonists lacking an exocyclic amine resulted from an unexpected reaction dur

59 One proton of its exocyclic amine was approximately 2.8 A from an oxygen o

60 other rigid nucleoside analogues lacking an exocyclic amine were prepared.

61 can partially compensate for the lack of an exocyclic amine, an otherwise important contributor to r

62 e pi-stacking surface and introduction of an exocyclic amine.

63 lves condensation of the dialdehyde with the exocyclic amine.

64 m correlation (NOESY-HSQC) NMR, in which the exocyclic amines at X(7) or Y(19) were (15)N-labeled.

65 tabolized into diol epoxides that react with exocyclic amines in DNA.

66 use of N-dimethoxytrityl protection for the exocyclic amines of adenine and cytosine.

67 ine (Dma), which we show to remain intact on exocyclic amines of adenine bases while other bases carr

68 The exocyclic amines of cytosine, adenine, and guanine were

69 hat binds the AIP thiolactone ring while the exocyclic amino acid tail interacts with loop 1 to facil

70 the determination of the contribution of the exocyclic amino group "N2" of the guanine base to nucleo

71 no selective, total syntheses of the stable exocyclic amino group adducts formed by the single-elect

72 Meanwhile, purine nucleosides with an exocyclic amino group could be obtained easily by simple

73 The primary (15)(V/K) arising from the exocyclic amino group for wild-type cytidine deaminase a

74 Evidently, tertiary interactions with the exocyclic amino group of a G in a single G.A pair can in

75 observed a distance between fluorine and the exocyclic amino group of A that is consistent with a H-b

76 ard nucleotide purine, hydrogen replaces the exocyclic amino group of A.

77 be formed in the major groove of DNA via the exocyclic amino group of adenine (N(6)-dA).

78 which supports that the deprotonation at the exocyclic amino group of cytosine cation radical is esse

79 hed that cross-linking had occurred with the exocyclic amino group of deoxyguanosine.

80 tral G clearly shows the crucial role of the exocyclic amino group of G in sequence-specific recognit

81 (DE) adducts of benzo[a]pyrene (BaP) at the exocyclic amino group of G(+1) block cleavage at a prefe

82 )-anti-benzo[a]pyrene diol epoxide, with the exocyclic amino group of guanine ((+)-trans-anti-[BP]-N(

83 the two enantiomers of anti-B[a]PDE with the exocyclic amino group of guanine ([BP]G adduct).

84 ne diol epoxide, which can attack DNA at the exocyclic amino group of guanine to form the major (+)-t

85 h DNA predominantly by trans addition at the exocyclic amino group of guanine to yield 10S (+)- and 1

86 forms adducts via its C14 position with the exocyclic amino group of guanine.

87 -7,8,9,10-tetrahydrobenzo[a]pyrene, with the exocyclic amino group of guanine.

88 etermined that the hydrogen bond between the exocyclic amino group of guanosine and the 2'-hydroxyl g

89 o probe the putative interaction between the exocyclic amino group of the guanosine nucleophile and t

90 nd DNA-DNA cross-links via reaction with the exocyclic amino group on a nearby 2-deoxyguanosine or 2-

91 try analysis revealed that Scabin labels the exocyclic amino group on guanine bases in either single-

92 X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding

93 ocket and steric exclusion of the guanine N2 exocyclic amino group.

94 tribution of the hydrogen bond involving the exocyclic amino group.

95 imino nitrogen hydrogen bonded to the A(16) exocyclic amino group.

96 ed via its N3 atom to its proximal guanine's exocyclic amino group.

97 cedes the abstraction of the proton from the exocyclic amino group.

98 introduced by means of a ring closure of the exocyclic amino groups of a pyrimidinone using [13C]sodi

99 e normal purines via steric clashes with the exocyclic amino groups of adenine and guanine.

100 ntaining intrastrand cross-links between the exocyclic amino groups of adjacent deoxyguanosines has b

101 It reacts with exocyclic amino groups of DNA nucleobases and forms addu

102 in antagonist CGS15943 1 overlapped, and the exocyclic amino groups of each were H-bonded to the side

103 distortions of the DNA duplexes, because the exocyclic amino groups of flanking guanines on both stra

104 ronmental carcinogen benzo[a]pyrene), to the exocyclic amino groups of guanine or adenine in oligonuc

105 zo[a]pyre ne {B[a]P DE-2 (2)} at C-10 by the exocyclic amino groups of protected purine nucleosides i

106 enanthrene, reacts with DNA primarily at the exocyclic amino groups of purines, forming B[c]PhDE-DNA

107 sented here show that M(1)dG and its stable, exocyclic analog 1,N(2)-propanodeoxyguanine (PdG), arres

108 and the convenient functionalization of both exocyclic and indole nitrogen atoms.

109 M(1)dG paired with thymine is exocyclic and poses a stronger block to transcription th

110 tailed investigation of the influence of the exocyclic base adduct on the overall helical structure a

111 ed the possibility that structurally similar exocyclic base adducts may be good candidates for enzyma

112 ggested in previous computational studies on exocyclic bond cleavage of carbohydrates.

113 oted more ozone reactions with the remaining exocyclic bond of oxidized limonene products in the SOA

114 xial and equatorial silyloxy groups with the exocyclic bonds eclipsed.

115 riety of substrates, including monoalkyl and exocyclic bridged adducts.

116 nal monomer, contains both a highly reactive exocyclic C horizontal lineC bond and a highly stable fi

117 e E or E,E configuration with respect to the exocyclic C horizontal lineC bond is stabilized by inter

118 etween the electron donor groups (oxygen and exocyclic C horizontal lineC double bond) and CH bonds o

119 ose predictable conformational biases on the exocyclic C-5-C-6 bond, as determined by (1)H-(1)H and (

120 that is coupled with the fragmentation of an exocyclic C-C bond.

121 tributed to a rotation around one of the two exocyclic C-C bonds bridging phenol and imidazolinone gr

122 was observed for couplings less sensitive to exocyclic C-O bond conformation.

123 sugars for the most part) suggests that the exocyclic C-O bond in acetate esters of cyclic alcohols

124 tion toward the eclipsed conformation of the exocyclic C-O bond.

125 nd transition states for rotation around the exocyclic C==N bond, electrocyclic ring closure, and los

126 r-catalyzed addition of ZnEt2 (ZnBu2) to the exocyclic C=C bond of pentafulvenes C5H4(=CHAr) (Ar=2-Me

127 nt route to 2-ketosugars glycosylated at the exocyclic C1 position.

128 ) with 2'-deoxyinosine (dI), which lacks the exocyclic C2 amino group present in dG, also prevented D

129 By contrast, the exocyclic C3 unsaturated compounds are less active.

130 of NAD(P)H is transferred to the unsaturated exocyclic C6 carbon of HMMF, resulting in a cyclic achir

131 Ammonolysis of the exocyclic carbethoxymethyl substituent and ester protect

132 The second oxidation event occurs at the exocyclic carbon adjacent to the N(6) atom of adenine.

133 rization to occur, while substitution at the exocyclic carbon atom has an impact on the reaction path

134 Therefore, the exocyclic carbon is not involved in the reduction of mol

135 dding electron-withdrawing CF3 groups to the exocyclic carbon of this meta-disubstituted benzyl catio

136 Substitution of both oxygen atoms in the exocyclic carbonyl groups of the thymine chromophore by

137 Core characteristics of the series are an exocyclic carbonyl moiety as a hydrogen bond acceptor an

138 to utilize multiple J-couplings sensitive to exocyclic CH(2)OH conformation, the ensemble of experime

139 ulfide bond were observed in addition to the exocyclic cleavages typically seen from CID of [M + nH](

140 2 dihedral, and a greater sampling of non-TG exocyclic conformations, particularly the GG conformatio

141 Due to the small 12-membered ring and exocyclic constraints, conformational interconversions c

142 This exocyclic control element also contributes to the increa

143 The exocyclic control element is employed along with a strat

144 ns suggest that substituents proximal to the exocyclic COOH group (i.e., the C4-O4 bond) influence th

145 This analysis shows that the exocyclic coordination of first-row transition metals (T

146 rates a mixture of 3E- and 3Z-olefins of the exocyclic-Delta(3),Delta(5)-dihydrohydroxyphenylpyruvate

147 uted cyanoolefins BTF and TCNE to add to the exocyclic diene portion of 1-isopropenyl-1,3-cyclopentad

148 ient of 0.5, these results indicate that the exocyclic dienolate is 3.0 kcal/mol more stable than its

149 mammalian cells, reacts with DNA to form an exocyclic DNA adduct, 3H-8-hydroxy-3-(beta-D-2'-deoxyrib

150 pair by Escherichia coli AlkB dioxygenase of exocyclic DNA adducts 3,N(4)-ethenocytosine, 1,N(6)-ethe

151 Exocyclic DNA adducts are formed from metabolites of che

152 thenoguanine (N(2),3-epsilonG) is one of the exocyclic DNA adducts produced by endogenous processes (

153 Acrolein reacts with DNA bases forming exocyclic DNA adducts, such as gamma-hydroxy-1,N(2)-prop

154 mary, our data suggest that acrolein-induced exocyclic DNA lesions can be bypassed by mitochondrial D

155 ts that type II topoisomerases interact with exocyclic DNA lesions in physiological systems.

156 A cyclic compound with an exocyclic double bond (6) was synthesized and was found

157 (E)-7 to the 1 alpha-allylic alcohol with an exocyclic double bond (E)-8.

158 The rigid E-geometry of the exocyclic double bond allowed a more efficient binding c

159 In the first, the exocyclic double bond introduced during EtAlCl2-promoted

160 re made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene

161 n addition, gem-dimethyl substitution on the exocyclic double bond of the 2-methyleneaziridine is tol

162 nduced enzyme catalyzes the reduction of the exocyclic double bond of the highly reactive precursor 4

163 tes to afford spirocyclic products having an exocyclic double bond on the newly formed ring.

164 ing nitrogen with concurrent formation of an exocyclic double bond to an alpha-carbon of the ring.

165 nd carboxyl group (6) as substituents at the exocyclic double bond was synthesized in the form of the

166 consisting of (1) oxidative cleavage of the exocyclic double bond, (2) stereoselective alpha-methyla

167 ylene in a formal [2+2] cycloaddition at the exocyclic double bond, followed by retroelectrocyclizati

168 nce of addition/elimination reactions at the exocyclic double bond.

169 macrocycle is linked with a TIPS-substituted exocyclic double bond.

170 lkylation to close a 7-membered ring with an exocyclic double bond.

171 t generating tetracyclic compound 13 with an exocyclic double bond.

172 we synthesized two new nitroxides bearing an exocyclic double bond: 4-methoxycarbonylmethylidene-2,2,

173 pinene and terpinine, where the isomers with exocyclic double bonds are more highly retained than tho

174 afforded calixarene 11 with a pair of distal exocyclic double bonds at the bridges.

175 lded calixarene derivatives possessing three exocyclic double bonds at the bridges.

176 ion of water yielded calixarene 8 possessing exocyclic double bonds at two adjacent bridges.

177 thiomorpholinochlorin with acid converts the exocyclic double bonds to direct links to the ortho-posi

178 The results indicate that the exocyclic, double bonded sulfur atom in rhodanines and t

179 ) have been synthesized from the reaction of exocyclic enaminoketones 8 with amines or metalloenamine

180 three major products were identified as the exocyclic, endocyclic, and 4(20)-methylene 7-fluoroverti

181 ho-quinone methide and L-lactic-acid-derived exocyclic enol ether.

182 alkynyl alcohols to yield the corresponding exocyclic enol ethers.

183 -2-cycloalkenones (COMCs) to highly reactive exocyclic enone alkylating agents.

184 That the exocyclic enone is formed by nonstereospecific ketonizat

185 GSH reacts at the exomethylene carbon of the exocyclic enone, displacing the first GSH to give the fi

186 thylene carbon) gives stereorandomly labeled exocyclic enone.

187 e or free in solution, to a glutathionylated exocyclic enone.

188 s MCF-7wt breast tumors, indicating that the exocyclic enones are the actual cytotoxic species.

189 nd the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7

190 g product profiles which include the desired exocyclic ether, a SiMe(3)-eliminated exocyclic ether, a

191 esired exocyclic ether, a SiMe(3)-eliminated exocyclic ether, and the SiMe(3)-O-functionalized substr

192 y because of the tetrahedral geometry of the exocyclic ethyl carbon atoms.

193 LYP/6-31+G(d,p) levels show the formation of exocyclic ethylenes to proceed (a) on the singlet surfac

194 closing metathesis strategy to install the Z exocyclic ethylidene side chain of streptazolin.

195 ded structures but also the incorporation of exocyclic functionalities as N-substituents.

196 enerated by thiyl radical addition to C4'C5' exocyclic glycals has been re-examined and found to be a

197 zaadenine, and hypoxanthine) and N-3 and the exocyclic group at C-4 of a pyrimidine.

198 s between the equivalent of both N-1 and the exocyclic group at C-6 of a purine NTP (2-fluoroadenine,

199 rate puckering conformations and the role of exocyclic groups have not yet been thoroughly addressed.

200 Furthermore, exocyclic groups in pyrimidines 1-2 nucleotides 5' of th

201 losing base pair showed that the presence of exocyclic groups in the major groove of purines 3' to th

202 These calculations demonstrate that exocyclic groups must be explicitly considered when exam

203 These results identify exocyclic groups of purines in the major groove downstre

204 ructure and to evaluate the influence of the exocyclic groups, Density Functional Theory (DFT) calcul

205 ayers and GT conformation in solvent-exposed exocyclic groups.

206 etries and all possible conformations of the exocyclic groups.

207 ramolecular interactions between consecutive exocyclic hydroxyl groups, which are stable in nonpolar

208 on and nearby protons and carbons within the exocyclic hydroxymethyl group (CH(2)OH) of each compound

209 g agent capable of reacting with DNA to form exocyclic hydroxymethyl-substituted ethenobases.

210 s were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.

211 the resulting product further oxidizes to an exocyclic iminium ion (by the perferryl-oxygen complex);

212 osite strands are linked via a single shared exocyclic imino group.

213 udies show that the site of reduction is the exocyclic ketone group of the tetrahydrocorphin.

214 Therefore, it is concluded that these exocyclic lesions act by accelerating the forward rate o

215 eske aromatic oxygenases, DMO oxygenates the exocyclic methyl group, rather than the aromatic ring, o

216 in the two resulting diols, unmasking of an exocyclic methylene group at C-11, and stereocontrolled

217 Only then was the exocyclic methylene group unmasked via elimination.

218 replacing the 2'-oxygen atom in LNA with an exocyclic methylene group.

219 al and carboxylic acid analogs containing an exocyclic methylene instead of an epoxide, indicating th

220 the 2'-deoxyuridine-5'-monophosphate (dUMP) exocyclic methylene intermediate.

221 ]pyridin-2(3H)-ones, as these substrates are exocyclic methylene lactamyl Michael acceptors.

222 d at different positions with respect to the exocyclic methylene.

223 ucleophilic attack of beta-ME on the dUMP C5 exocyclic methylene.

224 l positioned to transfer hydride to the dUMP exocyclic methylene.

225 ske non-heme iron oxygenase that performs an exocyclic monooxygenation, incorporating O(2) into a sid

226 ter metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four

227 Further support for the importance of the exocyclic N(2)-amino group in this reaction was provided

228 ed of a 2-deoxyribose adduct attached to the exocyclic N(2)-amino group of dG.

229 mutagenicity of trans-opened adducts at the exocyclic N(2)-amino group of guanine by the (+)-(7R,8S,

230 obenzo[a]pyr ene is covalently bonded to the exocyclic N(6)() amino group of the central deoxyadenosi

231 e 2-deoxyribose residue was connected to the exocyclic N(6)-amino group of dA.

232 ompounds was synthesized by derivatizing the exocyclic N-atom at the 3-position of the lead.

233 dia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.

234 group substitution at G33 indicates that its exocyclic N2 interacts directly with the scissile phosph

235 erase RNA, is further hypermethylated at the exocyclic N2 of the guanosine to create a trimethylguano

236 trans isomers at the 9,10 positions) by the exocyclic N2-amino group of O6-allyl-3',5'-di-O-(tert-bu

237 In contrast, the unmethylated cytosine's exocyclic N4 amino group (NH2) and its ring carbon C5 at

238 s binding of the C5 base takes place via the exocyclic N4 site, resulting in the anti-cytosine rotame

239 methylation by Erm methyltransferases of the exocyclic N6 of A2058 (E. coli numbering) that forms the

240 enantiomeric duplexes, thus establishing the exocyclic nature of the lesion.

241 ic NH group at the 4-position, as well as an exocyclic NH group linked to the 3-position of the benzo

242 e-dependent concerted frequency shifts of dA exocyclic NH(2) and dT C4=O vibrational modes suggest th

243 nd allows the complementary synthesis of the exocyclic nitrile product shown, and we demonstrate cont

244 ate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of nucleobases.

245 nes/guanidines only systems which possess an exocyclic nitrogen atom are considered.

246 The exocyclic nitrogen atom preferably bonds to electrophile

247 n bonds with the 1-carboxylate of NOG and N4 exocyclic nitrogen of cytosine, respectively.

248 akes a hydrogen-bonding interaction with the exocyclic nitrogen of the adenine ring, had minimal effe

249 The intermediate product is formed with exocyclic nitrogen.

250 gues M-2/3/4 contain either an endocyclic or exocyclic olefin as the pro-Michael acceptor.

251 obtained by hydrogenation of the C(4')-C(5') exocyclic olefin has been shown to be (R) at the C(4') n

252 on takes place, and the configuration of the exocyclic olefin is likely to be Z.

253 Intermediate exocyclic olefins were prepared by Wittig-type reactions

254 bis-alpha,beta-epoxides via the oxidation of exocyclic olefins.

255 If the double bond is exocyclic or the compound itself is acyclic, ozonolysis

256 l hydrogen atoms on each cage with the empty exocyclic orbitals on B12 of the other cage was found.

257 ine 99 (Y99) to interact with the equatorial exocyclic oxygen atom of cAMP.

258 res highlight the critical importance of the exocyclic oxygen's interaction with the invariant argini

259 for removing promutagenic alkyl lesions from exocyclic oxygens located in the major groove of DNA, i.

260 e-determining step, involves breaking of the exocyclic P-O bond where a metal-ligated water molecule

261 We have developed biologically active small exocyclic peptide mimetics that disable apoptotic functi

262 In the two cAMP-binding sites of RIalpha, exocyclic phosphate oxygens of cAMP were identified to m

263 Exocyclic radical reductions were thoroughly investigate

264 endence of the potency on a basic (Arg, Lys) exocyclic residue that addressed the S1' binding pocket,

265 double bond to a single bond in the 5-member exocyclic ring and are formed by chloroethyl nitrosourea

266 , these products compete with intramolecular exocyclic ring formation by meso-phenyl ring addition, w

267 This orientation places the exocyclic ring in a collision-free empty pocket of the p

268 This lesion contains an exocyclic ring obstructing the Watson-Crick hydrogen-bon

269 The exocyclic ring of M(1)dG opens to the acyclic N(2)-OPdG

270 erved for the free-base derivative, with the exocyclic ring-containing dimerization product isolated

271 re stable tert-butyl alcohol, intramolecular exocyclic ring-quenching is observed in 51% yield with n

272 resence of meta and para substituents in the exocyclic ring.

273 conjugation between the sigma orbital of the exocyclic Si-C bond and the pi orbital of the oligoaryle

274 e allene unit, while the (Z)-geometry of the exocyclic stannylvinylidene is a consequence of the syn-

275 versing the R'' and R' groups, complementary exocyclic stereocontrol can be achieved.

276 esponding interaction of the electronegative exocyclic substituent with O5 (exo-anomeric effect).

277 sted of a benzimidazole ring with one or two exocyclic substituent(s) that are either electron-donati

278 ndence of the potency upon the nature of the exocyclic substituent.

279 The compounds vary in the size of their exocyclic substituents, which range from hydrogen to iod

280 re and bearing different substituents at the exocyclic sulfur has been prepared.

281 tRNA2(Gln) transcripts demonstrates that the exocyclic sulfur moiety improves tRNA binding affinity t

282 ibition and (2) a fourth anchor point on the exocyclic tail needed for receptor activation.

283 Ps consist of a thiolactone macrocyle and an exocyclic "tail", both of which are important for functi

284 hing either the E or Z stereochemistry of an exocyclic tetrasubstituted alkene.

285 lic boronic esters which lead to acyclic and exocyclic tetrasubstituted homoallylic alcohols.

286 dditionally, this transformation produces an exocyclic, tetrasubstituted alkene through which the bic

287 enters are bridged by tecton AMT through the exocyclic thiol and amino linkage.

288 nce caused by the different placement of the exocyclic thymine methyl groups.

289 n to investigate the effects of water on the exocyclic torsional surface.

290 ic ring of the C-2 protecting group with the exocyclic triple bond and the oxocarbenium ion.

291 imple methylene group (i.e., a homologue) or exocyclic unsaturation between the thiazolidine ring and

292 otonation followed by desilylation generates exocyclic unstabilized ylides that undergo cycloaddition

293 is formed by only three amino acids, with an exocyclic ureido phenylalanine moiety at its C-terminus.

294 The corresponding exocyclic variant, which would provide 1-aminotetralin d

295 microbe-specific glycans, indicated that the exocyclic vicinal diol coordinates to a protein-bound ca

296 that hIntL-1 binds microbial glycans bearing exocyclic vicinal diol groups.

297 ranges to the cyclopropene product, or to an exocyclic vinyl bicyclo[3.3.0]octane.

298 Another set of exocyclic vinyl sulfones prepared from 3-O-methylated- a

299 he order of O > NH congruent with S, whereas exocyclic (Y) substituents increase it in the order of C

300 The exocyclic (Z)-alkene found in the majority of the pumili