ライフサイエンスコーパス: exocytic

1 mutant SNAP-47 overexpression impaired VAMP7 exocytic activity.

2 These results indicate that the post-exocytic adhesive activity of vWF towards platelets and

3 lysineless Ub-sensitive, whereas retargeting exocytic Ag to the cytosol had the inverse effect.

4 y two independent pathways that use distinct exocytic and cytoskeletal machinery to drive neuritogene

5 Direct observation of individual exocytic and endocytic events showed a higher percentage

6 Using fluorescence imaging of individual exocytic and endocytic events we observed that granules

7 depression, spatially and temporally defined exocytic and endocytic events were introduced.

8 Surprisingly, by tracking individual exocytic and endocytic events, we found that vesicles wi

9 Plant morphogenesis depends on polarized exocytic and endocytic membrane trafficking.

10 ion of the TGN/EE at the intersection of the exocytic and endocytic pathways in plants.

11 roteins direct cargo trafficking through the exocytic and endocytic pathways of eukaryotic cells.

12 P4-ATPases Drs2p and Dnf1p cycle between the exocytic and endocytic pathways, and here we define endo

13 ring cleavage furrow ingression involves the exocytic and endocytic pathways, including endocytic tub

14 addition to the V(o) sector, is required in exocytic and endocytic pathways.

15 pistasis experiments with sensory signaling, exocytic and endocytic proteins further implicate OSTA-1

16 effect of insulin is through changes in the exocytic and endocytic rate constants, k(ex) and k(en).

17 At 40 Hz stimulation, exocytic and endocytic spots did not colocalize.

18 ding the molecular composition of individual exocytic and endocytic structures and their organization

19 tate distributions of proteins at individual exocytic and endocytic structures in the cell.

20 rget MHC-I antigen presentation via both the exocytic and endocytic trafficking pathways.

21 In mutants, components of exocytic and endocytic vesicles, such as Vamp2, Clathrin

22 als on Chs3p responsible for sorting in both exocytic and intracellular pathways by the coats exomer

23 croscopy imaging revealed that vacuoles were exocytic and mediated secretion of beta-hexosaminidase a

24 e mutant GTPases also inhibited targeting of exocytic and recycled vesicles to the pollen tube invert

25 osis of NMDA receptors included both de novo exocytic and recycling events, which were regulated by d

26 ciated with and regulate the function of the exocytic apparatus via phosphorylation of Sec9.

27 emonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartm

28 ate the cellular mechanism for this shift in exocytic behavior.

29 Oocyte maturation in response to the exocytic block induces the MAPK and Cdc25C signaling cas

30 Strong stepwise depolarization evoked an exocytic burst that lasted 10 ms and corresponded to the

31 n 2 (Syt2) functions as a low affinity, fast exocytic Ca(2+) sensor in neurons, where it is activated

32 ic neurotransmitter release, suggesting that exocytic Ca(2+) sensors may possess divergent mechanisms

33 les, consistent with the known dependence of exocytic Ca(2+) signaling on intracellular stores in the

34 phorin receptor, plexin C1 (PLXNC1), and the exocytic calcium sensor, synaptotagmin 7 (Syt7), in thes

35 tory pathway, and the mechanisms involved in exocytic cargo sorting and exit from the Golgi and endos

36 nvolved in the formation of other classes of exocytic carriers and thus appears to proceed via a nove

37 late Golgi cisternae as they dissipate into exocytic carriers.

38 Rab27b, PKA, and MyRIP are components of the exocytic compartment, and that they form a complex invol

39 and the adapter LAT traffic through distinct exocytic compartments, which are released at the immunol

40 direct entry into specialized cAMP regulated exocytic compartments.

41 e has been shown to regulate the motility of exocytic compartments.

42 Interestingly, two exocytic components known to be palmitoylated, cysteine

43 h in genetic interactions with endocytic and exocytic components.

44 romotes RAB4- and RABENOSYN-5-dependent endo/exocytic cycles (EECs) of critical cargos (membrane-type

45 This exocytic defect was selectively rescued by expression of

46 hip14 mutants show exocytic defects at low frequency stimulation and a near

47 Furthermore, the hip14 exocytic defects can be suppressed by targeting CSP to s

48 3 selectively mediates cAMP-stimulated NKCC2 exocytic delivery and surface expression in TALs.

49 there, supporting a symmetrically polarized exocytic delivery model.

50 cts with NKCC2 and mediates its constitutive exocytic delivery to the apical surface.

51 cAMP stimulation enhanced VAMP2 exocytic delivery to the plasma membrane of renal cells,

52 cAMP stimulates NKCC2 exocytic delivery via protein kinase A (PKA), increasing

53 cing VAMP3 in vivo blocks constitutive NKCC2 exocytic delivery, decreasing the amount of NKCC2 at the

54 membrane are maintained by a balance between exocytic delivery, endocytosis, and recycling.

55 P3 is not required for cAMP-stimulated NKCC2 exocytic delivery.

56 and completely blocked cAMP-stimulated NKCC2 exocytic delivery.

57 plasmically-exposed domain, comprise both an exocytic di-acidic signal and an intracellular di-leucin

58 Here, we show that an exocytic domain adjacent to the postsynaptic density (PS

59 icle dynamics and interspersed endocytic and exocytic domains compared with control cells.

60 expression of alphaSyn in yeast impairs late-exocytic, early-endocytic and/or recycling trafficking.

61 BM production along two tissue axes promotes exocytic efficiency, BM remodeling, and organ morphogene

62 jor mechanisms of AMPA receptor trafficking: exocytic/endocytic exchange of surface receptors with in

63 is carried out by a giant kiss-and-run focal exocytic event during which the two membranes are only t

64 The number of AMPARs inserted per exocytic event, estimated using single-molecule analysis

65 quently fuses with the plasma membrane in an exocytic event.

66 e within rapid diffusion distance of a local exocytic event.

67 II cells) allows the detection of individual exocytic events by FM, which can be simultaneously corre

68 In response to a stimulus, exocytic events cluster near ribbons, but show no eviden

69 In this paper, we show that Cdc42 controls exocytic events during phagosome formation.

70 nds assembled SNARE complexes, during single exocytic events in live cells.

71 termine whether Syt VII was required for the exocytic events mediating neurite extension, we followed

72 AMPAR-containing exocytic events occurred under basal culture conditions

73 Here, we directly visualized individual exocytic events of NMDA receptors in rat hippocampal neu

74 ndings identify a novel role for Dyn2 in the exocytic events required for effective NK cell-mediated

75 Two populations of exocytic events were observed; small amplitude events th

76 ssive actin motor, functions in a variety of exocytic events, although the underlying mechanisms are

77 increases in Cm, which represent elementary exocytic events.

78 ource bursts of luminescence consistent with exocytic events.

79 asma membrane and was present at all vesicle exocytic events.

80 dent increase in the frequency of individual exocytic events.

81 ely, but elicited similar numbers of vesicle exocytic events.

82 P, are involved in the regulation of unitary exocytic events.

83 and the cortical localization pattern of the exocytic factors Sec6-Syb1-Exo70.

84 Furthermore, both endocytic and exocytic FgRabs are required for vegetative growth, coni

85 lts support a model whereby insulin promotes exocytic flux primarily by releasing an intracellular br

86 In addition, we found elevated exocytic function in Mecp2(-/y) adrenal chromaffin cells

87 Supporting the connection between Cdc42 and exocytic function, we found that the overproduction of a

88 ress mutants in RHO3 and CDC42 defective for exocytic function.

89 although mitochondrial fusion and regulated exocytic fusion are mediated by distinct sets of protein

90 y different properties of activity-dependent exocytic fusion at the axon and dendrite of cultured hip

91 We directly resolved discrete exocytic fusion events mediating insertion of AMPA-type

92 f the docking/fusion kinetics of hundreds of exocytic fusion events.

93 verslip), an effect previously attributed to exocytic fusion of SGs with the plasma membrane.

94 otransmission involves the calcium-regulated exocytic fusion of synaptic vesicles (SVs) and the subse

95 Neurotransmission depends on the exocytic fusion of synaptic vesicles (SVs) and their sub

96 the luminal acid load that results from the exocytic fusion of zymogen granules is significantly blu

97 dent of SG fusion, suggesting that vesicular exocytic fusion plays a relatively minor role in filopod

98 dynamin/PIP2/BAR assembly that regulates the exocytic fusion pore of dense-core vesicles in cultured

99 es spreading out in the plasma membrane from exocytic fusion sites is unchanged by insulin.

100 evious report suggested these structures are exocytic fusion sites.

101 t into the intracellular events that precede exocytic fusion.

102 timulation increases the fusion frequency of exocytic GLUT4 vesicles by approximately 4-fold, increas

103 gest that the co-localisation of PrP(d) with exocytic granules of the hormone trafficking system may

104 Ca(2+) influx triggered an exocytic increase of vglut1-pHluorin fluorescence at the

105 n, "rafts" represent target microdomains for exocytic insertion and retrieval of "flux proteins", inc

106 dy-state apical surface NKCC2 by stimulating exocytic insertion and that this process is highly depen

107 PKA inhibition blunted cAMP-stimulated exocytic insertion but did not affect the rate of consti

108 ulative apical membrane exocytosis and NKCC2 exocytic insertion in TALs.

109 Both modes of exocytic insertion occurred throughout the dendritic sha

110 We also found constitutive exocytic insertion of NKCC2 in TALs over time, which was

111 These transient changes depend on exocytic LB-PM fusion.

112 Signaling pathways known to directly affect exocytic machinery also regulated KCNQ5 channels, and in

113 accid paralysis by enzymatic cleavage of the exocytic machinery component SNAP25 in motor nerve termi

114 ocrine cells where it functions to prime the exocytic machinery for Ca(2+)-triggered fusion.

115 SNARE proteins are key components of the exocytic machinery in neurons and some secretory cells,

116 changes and coordination of cytoskeletal and exocytic machinery may be used in other physiological co

117 ation between the actin cytoskeleton and the exocytic machinery responsible for fusion of secretory v

118 Munc18-1 is a key component of the exocytic machinery that controls neurotransmitter releas

119 s enhance the functioning of the submembrane exocytic machinery.

120 nsitive factor (NSF), a key component of the exocytic machinery.

121 ve factor (NSF), a critical component of the exocytic machinery.

122 ntaining vacuole labeled with both endo- and exocytic markers.

123 Golgi also suggests a possible recycling or exocytic mechanism for this ligand.

124 st are required for matrix degradation by an exocytic mechanism that involves tubular connections bet

125 trypanosomes use this coupled endocytic and exocytic mechanism to maintain the cell density of its c

126 o specifically stimulate ATP release through exocytic mechanisms.

127 ue to an imbalance between the endocytic and exocytic membrane flow at the front of a migrating cell.

128 lex drives the majority of intracellular and exocytic membrane fusion events.

129 nc18/SNARE interactions and is essential for exocytic membrane fusion.

130 the erythrocyte membrane, with formation of exocytic microvesicles or microparticles and hemolysis,

131 APTA-1 (OGB1), to examine how the balance of exocytic mode changes during a stimulus train.

132 This conversion of exocytic mode may provide insight as to the mechanisms u

133 with AM-EGTA also prevents the conversion of exocytic mode.

134 supersedes stimulus frequency in controlling exocytic mode.

135 f exocytosis, and demonstrate that these two exocytic modes directly affect the throughput of synapti

136 It is shown that these exocytic modes result in distinct postsynaptic consequen

137 of AMPARs, mediated by kinetically distinct exocytic modes that differ in propensity to drive latera

138 We identify two broad dynamic behaviors of exocytic molecules.

139 cle tracking revealed that the endocytic and exocytic mutants she4 and bud6 alter post-Golgi vesicle

140 tion in two transgenic mouse models in which exocytic neurotransmitter release was impaired via condi

141 mpartments and did not colocalize with known exocytic or endosomal compartments.

142 ntaining liposomes with liposomes containing exocytic or endosomal Q-SNAREs and directly interacted w

143 ly, first during their secretion through the exocytic organelles of virus-producing cells, and second

144 the progression of rotavirus proteins in the exocytic pathway and found that VP4 and virion-assembled

145 e released from multivesicular bodies via an exocytic pathway and have the potential for cell-specifi

146 ntly, although the diversion of MHC-I on the exocytic pathway caused a relatively modest reduction in

147 ubunit complexes and trafficking through the exocytic pathway for secretory and cell surface proteins

148 overlap of 2 Rabs, Ypt1p and Ypt32p, on the exocytic pathway in Saccharomyces cerevisiae.

149 A reduced DMS expansion, indicating that the exocytic pathway is essential for DMS biogenesis.

150 esent study was to determine if biosynthetic exocytic pathway is polarized in migrating cells and whe

151 the exocytic pathway, without affecting the exocytic pathway itself.

152 ly measured the average bilayer thickness of exocytic pathway membranes, which contain increasing amo

153 is also sorted from endosomes into a second exocytic pathway through Glut4 storage vesicles (GSVs).

154 y than a protein carried by the conventional exocytic pathway, and no H-Ras was visible on Golgi memb

155 protein targeted to the bud neck through the exocytic pathway, as necessary for actomyosin ring stabi

156 or glycoprotein trafficking within the early exocytic pathway, associates with arenavirus, hantavirus

157 required at the TGN to sort Drs2p out of the exocytic pathway, presumably for delivery to the early e

158 d proteins that are cytoplasmic cargo in the exocytic pathway, without affecting the exocytic pathway

159 partially abrogated by neutralization of the exocytic pathway.

160 is has an impact on later stages of the endo-exocytic pathway.

161 targeting of intracellular Smf1p through the exocytic pathway.

162 sport and the structural organization of the exocytic pathway.

163 ar protein folding and transport through the exocytic pathway.

164 lopes at the intermediate compartment of the exocytic pathway.

165 s, a critical signaling component within the exocytic pathway.

166 ate the release of "gliotransmitters" via an exocytic pathway.

167 llular lysis, they do not follow the classic exocytic pathway.

168 microtubules and through the cell endo- and exocytic pathways can be next visualized via live-cell i

169 The endocytic and exocytic pathways display strong interdependence during

170 Third, the membrane protein biosynthetic and exocytic pathways from the endoplasmic reticulum to the

171 membrane trafficking along the endocytic and exocytic pathways in all eukaryotic cells.

172 nsights into the highly active endocytic and exocytic pathways in the bloodstream form of T. brucei.

173 n extensive convergence of the endocytic and exocytic pathways in this human parasite.

174 Tomosyn negatively regulates SNARE-dependent exocytic pathways including insulin secretion, GLUT4 exo

175 to play a crucial role in the endocytic and exocytic pathways of receptors or receptor/ligand comple

176 ane transport through both the endocytic and exocytic pathways of the host cell.

177 Membrane traffic along the endocytic and exocytic pathways relies on the appropriate localization

178 ynamic interconnection between endocytic and exocytic pathways, viral proteins recovered from the pla

179 Glut4 and the Tf receptor through all three exocytic pathways.

180 vitro to recapitulate the tomosyn-regulated exocytic pathways.

181 ic, at the intersection of the endocytic and exocytic pathways.

182 hile adduct excretion and cell endocytic and exocytic pathways.

183 distinct SM protein involved in nonsynaptic exocytic pathways.

184 icle fusion remain poorly understood in most exocytic pathways.

185 uantal analysis to incorporate endocytic and exocytic phases of single fusion events and uncover auto

186 ments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.

187 sides in the Golgi, RabE(RAB11) localizes to exocytic post-Golgi carriers undergoing transport to the

188 ind that the lungs of mice deficient for the exocytic priming protein Munc13-2 stain prominently with

189 , but the participation of lysosomes in this exocytic process has remained unclear.

190 he leading edge of polarized cells, that the exocytic process is organized into hotspots, and that th

191 tiple putative roles of acidification in the exocytic process.

192 kely contributes to other cell-type-specific exocytic processes such as platelet secretion.

193 Alterations of endo/exocytic proteins have long been associated with maligna

194 the mechanisms underlying the impact of endo/exocytic proteins in cancer, a scenario emerges in which

195 epitope production from model cytosolic and exocytic proteins modified in various ways.

196 at these components are mediated by distinct exocytic proteins.

197 , we provide evidence for the involvement of exocytic Q/t-SNAREs in autophagosome formation, acting i

198 and more variable when GTP hydrolysis of the exocytic Rab is delayed.

199 RAB-3 is an exocytic Rab that plays a modulatory role in synaptic tr

200 We found that AEX-3 regulates another exocytic Rab, RAB-27.

201 and Rab7 but increased localization with the exocytic Rab8.

202 Insulin increased the exocytic rate constant (k(ex)) for both Glut4 and Tf.

203 bly, in unstimulated TUG-depleted cells, the exocytic rate is similar to that in insulin-stimulated c

204 , Sec2p is dephosphorylated very late in the exocytic reaction to facilitate recycling.

205 ulation of gastric parietal cells results in exocytic recruitment of the proton pump (H(+),K(+)-ATPas

206 Here we compare the exocytic release of fluorescently labelled neuropeptide

207 regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 1

208 Neurotransmission is mediated by the exocytic release of neurotransmitters from readily relea

209 thogenesis of Micro syndrome is a failure of exocytic release of ocular and neurodevelopmental trophi

210 l at their host synapses, as revealed by the exocytic release of the dye upon stimulation.

211 is an efficient sensitizer of the neutrophil exocytic response to a second stimulus.

212 The exocytic response was independent of temperature but req

213 Although much is known regarding the exocytic responses of mast cells following allergen/IgE-

214 rt of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain

215 Hence, Syt2 can serve as an exocytic sensor for diverse Ca(2+) signaling systems, an

216 in the cellular redox state may regulate the exocytic signaling pathway.

217 are rapidly and transiently recruited to the exocytic site near the time of membrane fusion.

218 irect information on the utilization of each exocytic site.

219 polarized transport of secretory vesicles to exocytic sites and for exocytosis.

220 First, proteins enriched at exocytic sites are associated with DCVs long before exoc

221 t containers (TCs) from sorting endosomes to exocytic sites at the plasma membrane, and indirect path

222 cling compartments from sorting endosomes to exocytic sites at the plasma membrane.

223 Two subunits, Sec3p and Exo70p, localize to exocytic sites by an actin-independent pathway, whereas

224 uptake, occur at or very near highly active exocytic sites during high-frequency stimulation.

225 withdrawal, increases their concentration at exocytic sites, and dramatically enhances GSIS in vitro

226 sicles toward the cell periphery, docking at exocytic sites, and plasma membrane fusion.

227 nsulin signaling, and traffics with Glut4 to exocytic sites.

228 y, with secretory vesicles accumulating near exocytic sites.

229 coupled receptor (GPCR) and aex-4 encodes an exocytic SNAP25 homologue.

230 8, for the interaction between Sec1p and the exocytic SNARE complex.

231 all the possible topological combinations of exocytic SNARE helices, only one induces efficient fusio

232 critical catalytic link between Netrin-1 and exocytic SNARE machinery in murine cortical neurons.

233 CAPS binding is specific for a subset of exocytic SNARE protein isoforms and requires membrane in

234 t the regulatory factor synip binds to GLUT4 exocytic SNAREs and inhibits the docking, lipid mixing,

235 We observed that Doc2b binds to GLUT4 exocytic SNAREs and potently accelerates the fusion kine

236 Certain topological combinations of exocytic SNAREs result in basal fusion but cannot suppor

237 ubunit tethering complex, interacts with the exocytic SNAREs to mediate vesicle targeting and fusion

238 of hot spots, demonstrating their origin as exocytic sources, not endocytic sinks.

239 t-based prevention and promotion of specific exocytic steps during regulated secretion.

240 We propose that exocytic stimuli activate ARF6, which is required for ac

241 P for GTP in sperm challenged with different exocytic stimuli.

242 termediate endocytic compartments within the exocytic system, indicating an extensive convergence of

243 ndii has one of the most extensive regulated exocytic systems among all unicellular organisms, yet th

244 However, the exocytic targeting factor Rab11 is recruited to the furr

245 ts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent de

246 The EF-hand mutant had no effect on general exocytic traffic.

247 We identified bex5 (for BFA-visualized exocytic trafficking defective), a novel dominant mutant

248 e essential regulators of both endocytic and exocytic trafficking in eukaryotic cells.

249 suggest that the former is related to 1) the exocytic trafficking of and plasma membrane delivery of

250 suggesting a pivotal role of sortilin in the exocytic trafficking of IFN-alpha in pDCs.

251 IRBIT-dependent activation of NHE3 involves exocytic trafficking of NHE3 to the plasma membrane and

252 into fat and muscle cells by increasing the exocytic trafficking rate of the GLUT4 facilitative gluc

253 dhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this p

254 in function is dynamically modulated by endo-exocytic trafficking, however, major mysteries remain ab

255 ecessary for insulin-regulated GLUT4-vesicle exocytic translocation in muscle cells.

256 Insulin causes the exocytic translocation of GLUT4 glucose transporters to

257 ose and muscle cells, insulin stimulates the exocytic translocation of vesicles containing GLUT4, a g

258 Exocytic transmitter release is regulated by the SNARE c

259 e that GRASP55/65 are negative regulators of exocytic transport and that this slowdown helps to ensur

260 tory event that results in the inhibition of exocytic transport of a specific class of Golgi-derived

261 The branching of exocytic transport routes in both yeast and mammalian ce

262 rface glycoprotein, indicating a function in exocytic transport.

263 ole in facilitating the incorporation of the exocytic uroplakin vesicles into the corresponding hinge

264 the clusters are dynamic, appearing when an exocytic vesicle fuses with the plasma membrane and disp

265 Exocytic vesicle fusion requires both the SNARE family o

266 Forceful re-directioning of exocytic vesicle fusion to broader cortical areas induce

267 FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences are l

268 , these components are needed to recycle the exocytic vesicle SNAREs Snc1p and Snc2p from the plasma

269 guanosine triphosphatase Rab13 functions in exocytic vesicle trafficking in epithelial cells.

270 ive map, we find that both calcium-regulated exocytic vesicles (dense core vesicles) and endocytic st

271 REN1 was localized to exocytic vesicles accumulated in the pollen-tube apex, a

272 -alpha, thereby coating TGF-alpha-containing exocytic vesicles and directing these vesicles to the ba

273 he unbiased mapping of 78 proteins at single exocytic vesicles and endocytic structures in neuroendoc

274 sition center on the fusion of Golgi-derived exocytic vesicles and endosomal multivesicular bodies wi

275 ient association of a fraction of GAP43 with exocytic vesicles and motion at a fast axonal transport

276 sicle formation or sorting stage because the exocytic vesicles are properly generated and protein pro

277 mics after Cdk1 inhibition demonstrates that exocytic vesicles are rapidly mistargeted away from the

278 Sorting of plasma membrane proteins into exocytic vesicles at the yeast trans-Golgi network (TGN)

279 itch from approximately 60 nm GSVs to larger exocytic vesicles characteristic of endosomes.

280 g suggests an evolutionary scenario in which exocytic vesicles harboring a venomous secretome assembl

281 In this regard, physiologically docked exocytic vesicles may be anchored by a highly dynamic an

282 By directly studying the constitutive exocytic vesicles of AMPA and GABAA receptors in vitro a

283 The apical accumulation of exocytic vesicles oscillated in phase with, but slightly

284 ved protein complex involved in tethering of exocytic vesicles to the plasma membrane, rescued secret

285 cytial furrows, and mediates the movement of exocytic vesicles to the plasma membrane.

286 Snc1 is a v-SNARE that drives fusion of exocytic vesicles with the plasma membrane, and then rec

287 ering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane.

288 omplex, which mediates docking and fusion of exocytic vesicles with the plasma membrane.

289 ethering complex necessary for the fusion of exocytic vesicles with the plasma membrane.

290 ndent decrease of anterograde trafficking of exocytic vesicles, representing a possible mechanism con

291 GAP43 for global sorting by piggybacking on exocytic vesicles, whereas phosphorylation locally regul

292 each increased the velocity of Rab6 positive exocytic vesicles.

293 ncreases the release of transferrin receptor exocytic vesicles.

294 ired for efficient segregation of cargo into exocytic vesicles.

295 amining the temporal and spatial dynamics of exocytic vesicles.

296 The exocytic vesicular soluble N-ethylmaleimide sensitive fu

297 s in the oocyte has been well characterized, exocytic vesicular traffic is less well understood.

298 Thus, Stx4 defines an exocytic zone that directs membrane fusion for postsynap

299 Endocytic vesicles corral a central exocytic zone, tightening it to a vertex that establishe

300 defects in the organization of endocytic and exocytic zones at the site of growth.