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1 ) proteins play essential roles in regulated exocytosis.
2 f digestive enzymes relies on SNARE-mediated exocytosis.
3 recise role of Munc18-2 during lytic granule exocytosis.
4 eptibilities for undergoing Ca(2+)-dependent exocytosis.
5 flux mechanism reliant upon synaptic vesicle exocytosis.
6 tyle synapses are specialized for continuous exocytosis.
7 the plasma membrane and facilitates insulin exocytosis.
8 endocytic pathway to the Golgi for reuse in exocytosis.
9 ers, does not enhance granule recruitment or exocytosis.
10 ances stored in their granules via regulated exocytosis.
11 ed whether FTY720 has an effect on regulated exocytosis.
12 for the proteins essential for lytic granule exocytosis.
13 arization-evoked Ca(2+)-influx and beta-cell exocytosis.
14 of the RRP; that is, the sustained or tonic exocytosis.
15 ory effect of TBC1D10A overexpression on WPB exocytosis.
16 creen to identify Rab pathways affecting WPB exocytosis.
17 also acidification of vesicles destined for exocytosis.
18 ng local actin network in the final stage of exocytosis.
19 tified as priming factors in SNARE-dependent exocytosis.
20 ,5-bisphosphate [PI(4,5)P2] is essential for exocytosis.
21 eleased by cells through membrane budding or exocytosis.
22 e of Syn-2 in insulin secretory granule (SG) exocytosis.
23 c protein known to regulate synaptic vesicle exocytosis.
24 iosynthesis, signal transduction, or insulin exocytosis.
25 nregulated upon triggering calcium-dependent exocytosis.
26 ight facilitate fusion pore formation during exocytosis.
27 ut had no effect on the rate or extent of SV exocytosis.
28 del's molecular predictions for differential exocytosis.
29 r Ca(2+) signaling and depolarization-evoked exocytosis.
30 cretion by tethering vesicles at the site of exocytosis.
31 ls the availability of synaptic vesicles for exocytosis.
32 2 domain-mediated dimer in regulated vesicle exocytosis.
33 tagmin (syt)-1, a Ca(2+) sensor for neuronal exocytosis.
34 e hormones are secreted by regulated vesicle exocytosis.
35 steps that precede Ca(2+)-triggered vesicle exocytosis.
36 , providing a new tool for studying nonlytic exocytosis.
37 1 and 2 (RIM1/2) are essential regulators of exocytosis.
38 domains functions as a Ca(2+) sensor for SG exocytosis.
39 by an amount that, on average, was close to exocytosis.
40 er, is sufficient to trigger RRP but not SRP exocytosis.
41 near-complete block in secretagogue-induced exocytosis.
42 when deposited in the plasmamembrane during exocytosis.
43 at ACAP2 acts as a negative regulator of WPB exocytosis.
44 f genes involved in lysosomal biogenesis and exocytosis.
45 ency characterized by impaired lytic granule exocytosis.
46 r contents outside of the cell via lysosomal exocytosis.
47 ed into the plasma membrane during regulated exocytosis.
48 c exocytosis while having no effect on lytic exocytosis.
49 uired for vesicle docking and priming during exocytosis.
50 sosomal enzymes and SNAP23-mediated lysosome exocytosis.
51 lete fusion at a rate close to fast neuronal exocytosis.
52 nnel clustering at granules and ablated fast exocytosis.
53 and G-protein-coupled receptors to modulate exocytosis.
54 ules and rendered them more prone to undergo exocytosis.
56 (CCK-8), including 1) amylase secretion, 2) exocytosis, 3) intracellular Ca(2+) responses, 4) cytopl
58 ped remarkable frequency-dependent tuning of exocytosis: accurate low-latency encoding of onset and o
60 nhibits Ca(2+)-dependent presynaptic vesicle exocytosis, also blocked Ca(2+)-dependent postsynaptic A
61 euronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not cl
63 is essential for efficient Ca(2+)-triggered exocytosis and actively promotes membrane fusion as well
67 esicles was an early event mediated by focal exocytosis and coincided with the recruitment of transfe
70 rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the
73 ecliptic pHluorin (SEP) enables detection of exocytosis and endocytosis, but its performance has not
74 s or antibodies allows visualization of both exocytosis and endocytosis, constituting new bright sens
75 e is determined by a dynamic balance between exocytosis and endocytosis, which can often be regulated
76 tant for the coordination of endocytosis and exocytosis and have an impact on stomatal function, gas
78 he dynamics of many key proteins involved in exocytosis and identify a rapidly recruited dynamin/PIP2
79 we show that PI(4,5)P2 uncaging potentiates exocytosis and identify synaptotagmin-1 (the Ca(2+) sens
80 antly enlarged lytic granules with defective exocytosis and impaired integrity of endolysosomal compa
83 namics are regulated by membrane supply from exocytosis and membrane demand from furrow ingression.
85 ing molecular machinery involved in lysosome exocytosis and PM repair (PMR) is poorly understood.
86 bbon synapses, thereby synchronizing vesicle exocytosis and promoting high-fidelity information trans
88 uli that elicit high calcium levels increase exocytosis and retrieval rates in AWC(ON), generating di
89 channels alter the rate of synaptic vesicle exocytosis and thereby enhance neurotransmitter release?
90 explore the role played by PDH in mast cell exocytosis and to determine whether MITF is localized in
92 ntify synaptotagmin-1 (the Ca(2+) sensor for exocytosis) and Munc13-2 (a vesicle priming protein) as
94 hored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD gr
97 secretory protein synthesis and processing, exocytosis, and homeostasis of the endoplasmic reticulum
99 ocesses, including cytokinesis, endocytosis, exocytosis, and organelle trafficking, in the model fung
100 smembrane ion conductances (i.e., channels), exocytosis, and rho/rac signaling, which regulates the a
102 Here, we show that excess granules evading exocytosis are degraded via direct fusion with lysosomes
103 otic tethering complex, coregulates targeted exocytosis as an effector of small GTPases in polarized
104 on of macromolecules in neurons and suggests exocytosis as cellular target for its therapeutic revers
105 ich is fundamental for maintaining regulated exocytosis, as depletion of membranal PIP2 abolishes CDO
106 GTPase Arf6, supported histamine-evoked WPB exocytosis, as shown by knockdown and overexpression of
107 lso active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab
108 attachment protein receptor (SNARE)-mediated exocytosis, assembled SNARE complexes and vesicles adjac
110 onses were accounted for by efficient apical exocytosis at physiologic doses of both agonists and by
113 th is dependent on the size of the region of exocytosis at the tip and that diffusion-based growth wo
115 inhibiting peptide, whereas a later phase of exocytosis, attributable to the recruitment and subseque
116 cated SNAP25 proteins sustain a low level of exocytosis but are unable to support serotonin-mediated
118 lease, and overexpression inhibits regulated exocytosis, but previous work has failed to identify a c
119 proteins, BAIAP3 functions indirectly in DCV exocytosis by affecting DCV maturation through its role
120 that both SNAP-25B mutations impair synaptic exocytosis by destabilizing SNARE assembly, rather than
121 the central small amino acids is crucial for exocytosis by influencing the molecular re-arrangements
123 d that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor
125 gs indicate that Munc13-4 supports acute WPB exocytosis by tethering WPBs to the plasma membrane via
126 e report here a surprisingly strong block of exocytosis by the slow Ca(2+) buffer EGTA (10 mM) in bas
127 ng strength between calcium channels and the exocytosis calcium sensor at inner hair cell synapses ch
129 dicate that enhanced release of BDNF through exocytosis caused by activation of VDCCs and subsequent
130 e spatial coupling between Ca(2+) influx and exocytosis changes from nanodomain in low-frequency tune
131 into the mechanism of multigranular compound exocytosis commonly observed in various secretory cells.
132 nd chc mutants have impaired endocytosis and exocytosis compared with the wild type, indicating a lin
133 " events, "kiss-and-run" and "kiss-and-stay" exocytosis, confirming that the device has adequate sens
136 as levels of Munc13-4 decrease, the rate of exocytosis declines first, and then the total amount of
142 mplex that mediates vesicle tethering during exocytosis, directly interacts with the t-SNARE protein
143 domain of Munc13, enhances calcium-dependent exocytosis downstream of vesicle priming, revealing a no
145 tosis is considered the most massive mode of exocytosis, during which the membranes of secretory gran
147 tically significant data on the frequency of exocytosis events (Rexocytosis, t(-1) m(-2)) with tradit
148 synthesis caused massive spontaneous vesicle exocytosis, followed by arrested endocytosis, accounting
149 les of endothelial cells that undergo evoked exocytosis following intracellular Ca(2+) or cAMP elevat
150 voirs need to be recruited, possibly through exocytosis, for large active deformations to occur.
151 owed that HCN1 channels restrict the rate of exocytosis from a subset of cortical synaptic terminals
152 r of SNARE complex formation failed to block exocytosis from either pool, suggesting that these two v
153 eudotyped HIV.GFP led to increased lysosomal exocytosis from mouse astrocytes and human astrocytes.
155 P reduced oxidative stress, enhanced insulin exocytosis, improved apoptosis, and improved engraftment
156 s, including neutrophils, Munc13-4 regulates exocytosis in a Rab27a-dependent manner, but its possibl
158 anisms orchestrating transient and sustained exocytosis in auditory inner hair cells (IHCs) remain la
159 failed to rescue vesicle docking and evoked exocytosis in CAPS-depleted cells, showing that CAPS res
161 e that microdomain coupling is important for exocytosis in high-frequency hair cells, suggesting a no
162 how that actin filament disruption increases exocytosis in IHCs and that actin filaments most likely
163 Gipc3 disruption enhanced Ca(2+) influx and exocytosis in IHCs, reversed the spatial gradient of max
164 To test this hypothesis, we monitored zinc exocytosis in individual mouse eggs following parthenoge
166 1 (KCNB1) facilitates depolarization-induced exocytosis in INS 832/13 cells and beta-cells from human
167 mbrane fusion and also increases the rate of exocytosis in isolated nerve terminals, neuromuscular ju
169 n tag allow direct visualization of integrin exocytosis in live cells and revealed targeted delivery
172 cerbate SV endocytosis but impairs sustained exocytosis in MB neurons and alters specific motor funct
173 or role, Munc13-4 is essential for regulated exocytosis in MCs, and that this MC effector response is
176 cles that fuse with the plasma member during exocytosis in neurons and endocrine secretory cells.
177 um-dependent regulation of secretory vesicle exocytosis in neurons and neuroendocrine cells, but the
179 ucleotide signaling with Ca(2+)-dependent TV exocytosis in parietal cells, providing a regulatory mec
182 lts support a model in which stimulus-evoked exocytosis in retinal ribbon synapses is SNARE-dependent
183 However, the mechanisms that control WPB exocytosis in the final stages (including the docking, p
184 he cement glands supports the involvement of exocytosis in the secretion of the permanent adhesives.
185 area previously characterized as the site of exocytosis in the tobacco pollen tube, while NtEXO70B1 s
186 FAK activity blocks elevated frequencies of exocytosis in vitro and elevated axon branching in vitro
187 a loss of CAPS function in regulated vesicle exocytosis, indicating that dimerization is essential fo
188 These compounds, named Nexinhibs (neutrophil exocytosis inhibitors), inhibit exocytosis of azurophili
197 nectin-containing vesicles, that adiponectin exocytosis is stimulated by cAMP-dependent mechanisms, a
199 ferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic reticulum (
200 a 62% decrease in the rate constant of Glut4 exocytosis (kex), although Rab10 knockdown also caused a
201 c13-4-deficient MCs was limited to regulated exocytosis, leaving other MC secretory effector response
202 secretory granule release by binding to the exocytosis machinery, an effect that is enhanced by prio
204 ation nearly abolishes depolarization-evoked exocytosis (measured by membrane capacitance) and hormon
205 elease from the urothelium through vesicular exocytosis mechanisms with minimal contribution from pan
208 riggered secretion from a compound to a full exocytosis mode, in which SGs individually fuse with the
209 a identify Rab35 as a novel regulator of WPB exocytosis, most likely acting through the downstream ef
210 racellular ATP in the control of adiponectin exocytosis needs to be revised to include an additional
212 n that adiponectin is secreted via regulated exocytosis of adiponectin-containing vesicles, that adip
213 edundant Ca(2+)-sensors for Ca(2+)-dependent exocytosis of AMPA receptors during LTP, and thereby del
214 acellular killing could be attributed to the exocytosis of antimicrobial components present in neutro
215 (neutrophil exocytosis inhibitors), inhibit exocytosis of azurophilic granules in human neutrophils
216 Our findings suggest that activity-dependent exocytosis of Cathepsin B from lysosomes regulates the l
219 reased in HD astrocytes, suggesting that the exocytosis of dense-core vesicles is impaired by mHtt in
222 n by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) towar
224 voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic
225 he SNARE protein Vamp-7 to promote the local exocytosis of lysosomes at the immune synapse, which is
226 DCC) signaling at the BM breach site directs exocytosis of lysosomes using the exocyst and SNARE SNAP
228 taxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE
230 nd-phase GSIS attributed to the reduction of exocytosis of predocked and newcomer insulin secretory g
231 This recruitment corresponds to directed exocytosis of recycling endosomes (REs) containing these
232 ced first-phase GSIS, selective reduction of exocytosis of short-dock (but not no-dock) newcomer SGs
233 spines is activity-dependent and results in exocytosis of syt-IV-containing vesicles in the spine he
236 al transfer occurred through actin-dependent exocytosis of the late endosome in a vasodilator-stimula
241 ited a reduction in pathological basolateral exocytosis of ZGs resulting from a decrease in fusogenic
242 Munc18c-shRNA-treated) exhibit normal apical exocytosis of zymogen granules (ZGs) in response to phys
243 either from an intracellular reserve pool by exocytosis or from nearby extra-synaptic receptors pre-e
244 Although not required for normal platelet exocytosis or hemostasis, VAMP-3(-/-) mice had less plat
246 infectious cycle, we postulated that the VZV exocytosis pathway following secondary envelopment may c
250 bited histamine-evoked, Ca(2+)-dependent WPB exocytosis, presumably by inactivating the target Rab GT
253 the doc2a gene, encoding a calcium-sensitive exocytosis regulator, a genetic interaction not previous
254 ly expressed in tip-growing cells, exhibited exocytosis-related functional effects in pollen tubes de
255 nsional electrochemical imaging recording of exocytosis release between the electrodes within this ar
258 se from ribbon synapses via Ca(2+)-triggered exocytosis requires tight coupling of L-type Ca(2+) chan
259 terminals deficient in either endocytosis or exocytosis revealed an acid efflux mechanism reliant upo
260 gs to produce the first model of adiponectin exocytosis/secretion that combines all mechanistic knowl
262 tional chemical synapses in synaptic vesicle exocytosis.SIGNIFICANCE STATEMENT RAB3A-interacting mole
263 ether, our data present the first neutrophil exocytosis-specific inhibitor with in vivo anti-inflamma
265 eretofore-unrecognized regulator of compound exocytosis that is essential for SNAP23-mediated granule
267 as a physiological regulator of endothelial exocytosis through reorganizing local actin network in t
268 that Rab10 is an AS160 substrate that limits exocytosis through the highly insulin-responsive special
269 m PKC-dependent activation and AMPA receptor exocytosis, thus enhancing PV neuronal inhibition to exc
270 have a low Ca(2+) buffer capacity to sustain exocytosis, thus making them more prone to Ca(2+)-induce
271 ts and by apical blockade and redirection of exocytosis to the basolateral plasma membrane at suprama
272 ux significantly suppresses NNK-induced IGF2 exocytosis, transformation and tumorigenesis of lung epi
273 nin levels modulate Ca(2+)-dependent insulin exocytosis under conditions of glucose, GLP-1, or KCl st
274 n of ceramide pathways and calcium sensitive exocytosis underlies seizures and large body size associ
276 To explore this possibility, we modeled exocytosis using plasma membrane SNARE-containing planar
277 docytosis was not affected by a reduction of exocytosis using the light chain of botulinum toxin C, n
280 The process for lipid modulation of nonlytic exocytosis was associated with actin changes in macropha
282 By contrast, a third, slower component of exocytosis was blocked by the peptide, as was the functi
283 slides were optimized, and neurotransmitter exocytosis was evoked by injecting solutions with elevat
284 ological relevance of our findings, compound exocytosis was observed in thrombi formed after severe l
287 L-cell level, first-phase forskolin-induced exocytosis was reduced to basal (P < 0.05) and second-ph
290 ore a potentially significant role of 5RK in exocytosis, we next amperometrically analyzed catecholam
292 he fast and sustained components of synaptic exocytosis were revealed by membrane capacitance measure
293 ein without impairing its ability to inhibit exocytosis when overexpressed, indicating a selective de
294 current view is that caseins are secreted by exocytosis, whereas milk fat globules are released by bu
295 NUT expression also reduces the frequency of exocytosis, whereas the overexpression of VNUT drastical
296 ations before neuronal loss is impairment of exocytosis, which may contribute to eventual neurodegene
297 significantly increased the rate of nonlytic exocytosis while having no effect on lytic exocytosis.
298 lls for which localized Ca2+ influx triggers exocytosis with high probability and minimal latency.
299 electrode row, a one-dimensional imaging of exocytosis with submicrometer resolution was accomplishe
300 of the Sec3-Sso2 interaction in cells blocks exocytosis without affecting the function of Sec3 in ves
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