ライフサイエンスコーパス: exogenous

1 f parathyroid hormone, but administration of exogenous 1,25-dihydroxyvitamin D increased FGF23 levels

2 /11-linked receptors mimicked the effects of exogenous 2-AG and their actions were prevented by inhib

3 in 2OG levels, either by OGDH suppression or exogenous 2OG treatment, resulted in aspartate depletion

4 KD2 and HKE2 Platelets did not form HKs from exogenous 5S-HETE, implying that COX-1 is not involved.

5 Here we investigated the role of exogenous ABA in modulating thrombopoiesis, the process

6 ome dynamics in P. hopeiensis in response to exogenous ABA using Illumina RNA-sequencing.

7 This difference was again countered by exogenous ABA, further indicating regulation of cuticle

8 tatory transmission can also be triggered by exogenous activation of group I mGluRs at the same time

9 Conversely, overexpression of CYP4A or exogenous addition of 20-hydroxyeicosatetraenoic acid pr

10 The exogenous addition of culture medium containing Mcc(ia)

11 Without overexpression of exogenous adipogenic genes, our method recapitulates an

12 lar effects on neurogenesis were observed on exogenous administration of beta-hydroxybutyrate.

13 demonstrate attenuation of PAH severity with exogenous administration of ELA in a rat model.

14 Exogenous administration of HX, GSN, or AAT abrogated th

15 d compelling, cytocompatible, alternative to exogenous administration of MNPs.

16 Exogenous administration of recombinant CCL5 to C3aR-def

17 more recent experimental work suggests that exogenous administration of T rapidly potentiates amygda

18 c-pituitary-adrenal (HPA) axis activation by exogenous adrenocorticotropic hormone (ACTH) in blubber

19 asmatic and endosomal membranes for favoring exogenous Ag access to the cytosol of APCs.

20 cRgamma) elicit proinflammatory responses to exogenous Ags.

21 Mechanistically, addition of exogenous alpha-ketoglutarate replenishes TCA intermedia

22 ) and a kinase (i.e., CblS) that can salvage exogenous alpha-ribazole (alpha-R) from the environment

23 rons resulted in increased susceptibility to exogenous alpha-synuclein fibrils.

24 Our data suggest that exogenous alphaS can seed endogenous cytoplasmic alphaS

25 ck on the amido-Ir-coordinated alkene by the exogenous amine determine the outcome of the reaction.

26 is necessary for GDU1-dependent tolerance to exogenous amino acids, and LOG2 self-ubiquitination was

27 treated human aortic endothelial cells with exogenous amphiphiles, shown previously in model membran

28 scence-based biosensors after addition of an exogenous analyte.

29 m this checkpoint and stimulates delivery of exogenous and endogenous deltaR to the neuronal surface

30 This allows exogenous and endogenous metabolites to be visualized in

31 Many of these pathways are driven by chronic exogenous and endogenous oxidative stress.

32 -MB can be potentially employed to visualize exogenous and endogenous peroxynitrite in RAW264.7 macro

33 these parameters at every step to respond to exogenous and/or endogenic perturbations.

34 Exogenous angiopoietin-1 was required to induce arteriol

35 s through sensitization to endogenous and/or exogenous antibacterial proteins such as lysozyme and co

36 Exogenous application of ABA partially rescued these phe

37 This impairment could be rescued by exogenous application of active MMP-9.

38 Exogenous application of bacterial peptidoglycans restor

39 t V8 protease-mediated integrity damage, and exogenous application of hBD2 was protective.

40 SDE5 expression is rapidly induced by exogenous application of phytohormone salicylic acid (SA

41 Exogenous application of recombinant OsHAD1 protein in g

42 Exogenous application of S100A8 to S100A9 knockout CVB3

43 Next, exogenous application of several aldehydes to siliques i

44 ity, which could be triggered by addition of exogenous arachidonic acid (AA).

45 cycle arrest was reversible at any point by exogenous arginine, suggesting starved T cells remain po

46 retroviral envelope glycoprotein of several exogenous as well as endogenous retroviruses.

47 ession renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo incl

48 und under endogenous attention but not under exogenous attention.

49 Exogenous calcitriol (1,25-dihydroxyvitamin D) and high

50 ny conditions in EDTA-treated samples unless exogenous calcium/magnesium was added at the time of ant

51 ge, which was overcome by the addition of an exogenous carbon source.

52 s come from the regressions of shape on some exogenous cause or effect of form.

53 Specifically, exogenous CCL19 abolished oligodendrocyte precursor cell

54 Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in

55 As seen with administration of exogenous ceramide, AC ablation blocks cell cycle progre

56 Importantly, we demonstrate that trace exogenous chemicals can be detected in fingerprints.

57 Consistently, exogenous chromophore reduces rod responses at bright ba

58 Exogenous ciliary neurotrophic factor (CNTF) administrat

59 Indeed, supplying exogenous citrate significantly enhanced Ga tolerance.

60 ays was demonstrated by supplementation with exogenous CNTF in vitro and siRNA knockdown in vivo.

61 m endogenous viral elements (dsRNA/LRV1), or exogenous coinfection with IFN-inducing viruses, are abl

62 Additionally, exogenous compounds, such as lithium chloride (LiCl), a

63 n vivo but often requires the addition of an exogenous contrast agent that may have limited tissue ac

64 images the ocular vasculature without using exogenous contrast agents, avoiding associated side effe

65 ementations, still require either genetic or exogenous contrast labeling for light microscopy.

66 us allele of ataxin 7 and replace it with an exogenous copy of the gene, highlighting the efficacy an

67 The use of higher concentrations of protein, exogenous cross-linkers, and blending synthetic polymers

68 Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cell

69 Here, we report that spermine acts as an exogenous cue that inhibits V. cholerae biofilm formatio

70 Levels of exogenous Cx30 decayed over time, but were still detecta

71 Here we describe exogenous cycles and endogenous rhythms associated with

72 XAS) to investigate the relationship between exogenous cysteine, cellular metabolism, cellular locali

73 yuc4, and ahp6 mutants are hypersensitive to exogenous cytokinin and 1-napthylphthalamic acid (NPA),

74 Whereas only AFKP80 yielded GDP-d-Arap from exogenous d-Arap, both proteins were able to salvage l-f

75 , are continuously exposed to endogenous and exogenous damaging agents, representing a significant ch

76 Exogenous delivery of polyunsaturated phosphatidylcholin

77 Exogenous desaturated fatty acids inhibit Ubp2 degradati

78 Our data showed that exogenous DHEA significantly downregulated IGF-1 and its

79 ting models that require either insertion of exogenous DNA (knock-in) or replacement of genomic segme

80 e model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer c

81 base lesions induced by both endogenous and exogenous DNA damaging agents.

82 Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA

83 In this system, exogenous DNA loaded with magnetic nanoparticles was del

84 mentosa, and to introduce point mutations or exogenous DNA sequences.

85 ntaining genomic stability in the absence of exogenous DNA-damaging agents is unclear.

86 d decreases apoptosis to both endogenous and exogenous DNA-damaging agents.

87 We apply BLISS to profile endogenous and exogenous DSBs in low-input samples of cancer cells, emb

88 waves were induced by OSI and suppressed by exogenous dysferlin.

89 in common with reparative dentine formation, exogenous elevation of Wnt/beta-catenin signaling can en

90 Addition of exogenous endothelial cells to reconstituted glands rest

91 e of both glucose and citrate that delivered exogenous energy and provided approximately 512 kcal/d.

92 Humans are exposed to multiple exogenous environmental pollutants.

93 radoxical behavior depend on the presence of exogenous environmental variation.

94 d a US9-driven functional assay based on the exogenous enzymatic activity of Tobacco Etch Virus Prote

95 Action of the exogenous enzyme on the dye results in fluorogenic activ

96 ires the use of high temperature mashing and exogenous enzymes to ensure adequate starch conversion.

97 ompounds was not affected by the presence of exogenous enzymes.

98 In the absence of exogenous estradiol, a TD by ACE interaction was observe

99 he sarcoplasmic reticulum membrane and after exogenous expression in COS7 cells in vitro but that the

100 Moreover, exogenous expression of ACTRT1 reduced the in vitro and

101 y mst depletion were dramatically rescued by exogenous expression of an actin member.

102 ptor heterodimerization in vivo Accordingly, exogenous expression of an inactive form of the 5-HT2C r

103 r growth under ambient, but not elevated CO2 Exogenous expression of BASS6 complemented this photores

104 Exogenous expression of GMAP6 protected Huh-7 cells from

105 HNF4G/HNF1A-double-negative prostate cancer, exogenous expression of HNF4G at physiologic levels reca

106 Functionally, exogenous expression of JMJD2B enhanced subcutaneous tum

107 Recent studies have shown that exogenous FA causes only a modest increase in DNA adduct

108 duced hepatic steatosis (a model of enhanced exogenous FA delivery) yet developed steatosis upon indu

109 Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, sof

110 function or the pancreatic development as an exogenous factor, while in adipose HFD's impact roughly

111 ence in men and women points to an effect of exogenous factors with a differential effect on the 2 se

112 oth intracellular metabolism and exposure to exogenous factors.

113 to fix damage resulting from endogenous and exogenous factors.

114 cells, and suggest that CD8(+) TRM cells use exogenous FFAs and their oxidative metabolism to persist

115 mechanical environment, we hypothesized that exogenous forces can be applied for engineering a variet

116 ncy of Fabp4 and Fabp5 (Fabp4/Fabp5) impairs exogenous free fatty acid (FFA) uptake by CD8(+) TRM cel

117 ession in females to male levels phenocopied exogenous GA application with respect to flower developm

118 for the first time our results indicated the exogenous GAs lowered the aerobic metabolism including t

119 ndr2 RNA to specific lineages indicates that exogenous gdf3 is able to fully rescue mutants only when

120 ine had a significantly higher percentage of exogenous gene expression than the healthy liver cells (

121 being the predominant source of contemporary exogenous genetic variants for the populations studied.

122 tly monitor (detect, identify, and quantify) exogenous GHB in almost intact body fluids and its high

123 atterned cell pairing systems, we found that exogenous GJA1-20k expression stabilizes filamentous act

124 dogenous glucagon-like peptide-1 (GLP-1) and exogenous GLP-1 receptor (GLP-1R) agonists are an active

125 w whether it is necessary for the effects of exogenous GLP-1R agonists (GLP-1RA) or endogenous GLP-1

126 ular effects of a mixed meal and infusion of exogenous glucose-dependent insulinotropic polypeptide (

127 r cell renal cell carcinoma (ccRCC), require exogenous glutamine for growth and exhibit reprogrammed

128 All starved cells could oxidize exogenous glutamine, whereas the capacity for oxidizing

129 ever, the amplitudes of current responses to exogenous glycine were significantly reduced.

130 first time on both endogenous (melanin) and exogenous (gold nanorods) absorbers.

131 enough activity to shield the cytoplasm from exogenous H2O2 However, it receives electrons from the q

132 d from convergent (truncated red cluster and exogenous hbn cluster) biosynthetic pathways.

133 Furthermore, the application of exogenous HCT enabled us to show that the activity of pl

134 Perturbing exogenous hepatic FA use modulates both hepatic steatosi

135 Exogenous hormone applications and transgenic rice were

136 ne risk factors and age of administration of exogenous hormones because of concern regarding an incre

137 to investigate and delineate the effects of exogenous hormones, such as androgen, luteotropin, and e

138 and/or proliferate in vivo in the absence of exogenous human cytokines.

139 In ex vivo experiments, exogenous human IL-17c provided directional guidance and

140 onsistent with these results, treatment with exogenous human POT1 protein maintains human HSC activit

141 In contrast, exogenous IFN treatment restricts HRV replication, with

142 Finally, exogenous IFN-alpha did not substantially protect cardio

143 However, augmentation of these responses by exogenous IFN-beta, but not IFN-lambda, protected MCs ag

144 Administration of exogenous IFN-gamma or -alpha to CAST mice before or dur

145 sary for the response to both endogenous and exogenous IFN-lambda.

146 adipogenic differentiation in the context of exogenous, IGF1-modified mRNA stimulation.

147 Exogenous IL-15 exacerbates the severity of sepsis by ac

148 aturation is rescued in vitro by addition of exogenous IL-1beta.

149 Exogenous IL-2 restores the phenotypic changes and overa

150 defect could be readily corrected by adding exogenous IL-2 to the co-cultures.

151 Despite uninhibited alloreactivity, exogenous IL-22 administration posttransplant resulted i

152 Exogenous IL-33 treatment revealed that miR-155 is neede

153 o, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production

154 o models, this study first demonstrated that exogenous IL-6 promoted crypt organoid proliferation and

155 In vitro exogenous IL-6-induced IL-17 production in iTreg cells,

156 activated and expanded indefinitely without exogenous IL2.

157 y in pico-to-micro-molar range, dependent on exogenous imaging agents.

158 as able to discontinue immunosuppression and exogenous immunoglobulin support, with improvement in va

159 macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) access brain tissue from t

160 Exogenous in vivo expression of zTrpa1b in sensory neuro

161 ients' cells, which we confirmed by means of exogenous induction of expression of CD55.

162 nt stem cells (iPSCs) is usually achieved by exogenous induction of transcription by factors acting i

163 a function of the previous spike history and exogenous inputs.

164 STAT1 phosphorylation in response to exogenous interferon (IFN) administration can be inhibit

165 release inhibitors, anti-sense nucleosides, exogenous interferon stimulation, interferon response st

166 y of macrophages is amplified by exposure to exogenous interferon-gamma, which prolongs and heightens

167 ls or lacking IFN-gamma, and was mimicked by exogenous interleukin-15 (IL-15).

168 Current methodologies for the exogenous introduction of synthetic biomolecules often r

169 nosine) failed to produce ITGA4 protein, but exogenous ITGA4-mRNA was detected in transfected MSCs.

170 Exogenous jasmonates are known to trigger ISR by activat

171 been performed ex vivo or in the presence of exogenous labels used to enhance contrast and impart spe

172 We investigated the population dynamics of exogenous Lactobacillus plantarum and its interactions w

173 Confocal microscopy confirmed active exogenous leptin uptake in cultured parathyroid cells.

174 red chemotaxis to CCL19 that was restored by exogenous leukotriene C4 .

175 ooth muscle cells without an increase in the exogenous levels of AngII.

176 bond functionalization does not requires any exogenous ligand to be added, and our mechanism experime

177 BCR ligation by endogenous or exogenous ligands induced the surface expression of the

178 relates with the metal ion's ability to bind exogenous ligands.

179 crophages in the presence and the absence of exogenous lipids, in particular, oleate.

180 rmans-macrophage interaction is modulated by exogenous lipids, providing a new tool for studying nonl

181 s that is both endogenous (nest budding) and exogenous (loss of preferred habitat), resulting in a si

182 Treatment of primary hepatocytes with exogenous LPA blunted glucagon-induced PEPCK expression

183 We demonstrate that exogenous LysoPC drives biosynthesis of the essential me

184 unction is GFR, which is measured either via exogenous markers (eg, DTPA, iohexol), or estimated usin

185 ithin native connective tissue devoid of any exogenous material such as scaffolds or growth factors.

186 Overexpressing exogenous MBNL1 in the DM1 mouse model has been shown to

187 his article discusses various endogenous and exogenous mechanisms whereby transport is controlled in

188 ng mitochondrial DNA (mtDNA) with functional exogenous mitochondria and selection in a restrictive me

189 ermine the intracellular fate of endocytosed exogenous mitochondria in human iPS-derived cardiomyocyt

190 Upon systemic administration, exogenous Mn exhibited varying transport rates and conti

191 The development of exogenous molecules to control stem cell self-renewal or

192 ssive immunization through administration of exogenous monoclonal antibodies (mAbs).

193 Activation of exogenous MrgA1Rs expressed in astrocytes tripled astroc

194 Exogenous MT2 could fully correct abnormally high hepcid

195 Exogenous murine IL-17c pretreatment reduced apoptosis i

196 We found that the exogenous mutant tau protein was restricted in MEC witho

197 fficient and reproducible gene expression of exogenous naked pDNA in human skin using volumes that ar

198 s has been challenging, as overexpression of exogenous NEDD8 can trigger NEDD8 conjugation through th

199 Finally, the administration of exogenous NGF to wild-type mice was found to significant

200 ising from the diffusion-limited reaction of exogenous NO and endogenous superoxide (O2(*-)) produced

201 In this study, we investigated the effect of exogenous NO donor (NaNO2) on corneal wound healing.

202 Exogenous NO in the microenvironment facilitates paracri

203 oxygen consumption after the addition of the exogenous nutrients.

204 , depending on the availability of light and exogenous organic carbon source.

205 duced in young flies by constant exposure to exogenous oxidative stress, and this upregulation is CLO

206 Metabolomic and proteomic data showed that exogenous pABA is used for folate biosynthesis, and lead

207 lular PCSK9, the LDLR-R410S was resistant to exogenous PCSK9-mediated degradation in endosomes/lysoso

208 al under reduced glucose conditions, whereas exogenous PEA15 increases neuronal survival even in the

209 aximal LPS-induced IL-33 expression and that exogenous PGE2 can amplify IL-33 production via EP2 and

210 Plasma leucine concentrations and exogenous phenylalanine appearance rates increased after

211 Plasma exogenous phenylalanine availability over the 5-h postpr

212 cts were only observed in the presence of an exogenous phosphate source.

213 peatedly amplified pine DNA and were free of exogenous plant taxa.

214 e NspS-MbaA signaling system may communicate exogenous polyamine content to the cell to control biofi

215 This phenomenon was replicated by exogenous preexposure to the amino acid D-aspartate (D-A

216 ly reduces the levels of both endogenous and exogenous Premature Termination Codon (PTC)-containing m

217 mice, they survive ex vivo in the absence of exogenous pro-survival cytokine support.

218 nown to regulate alpha-SYN expression; while exogenous promoter-reporter assays failed to reproduce t

219 process initiated by the internalization of exogenous protein aggregates.

220 e-directed mutants, recombinant proteins and exogenous protein overexpression in C. merolae-a new mod

221 changed in putrescine-treated plants, so the exogenous putrescine likely accelerated disease indirect

222 Exogenous pyrimidines reverse DNA damage and rescue grow

223 Exogenous R-spondin administration expands and accelerat

224 We found that exogenous Rad23 increases the toxicity of pathogenic ata

225 P(MeAN) core, which combines the assembly of exogenous reagents in the primary (phenolates) and secon

226 The effects of exogenous reagents on product distributions are consiste

227 with high sensitivity and without the use of exogenous reagents or enzyme amplification steps.

228 le catalyst without the need for addition of exogenous reagents.

229 Administration of exogenous recombinant Sema3E markedly reduced allergen-i

230 med to have ADR, 2 were confirmed as causing exogenous reinfection, and 2 were unrecoverable for geno

231 elope glycoprotein of diverse endogenous and exogenous retroviruses is considered inherently immunosu

232 We show that exogenous Rint1 expression enhances E2-dependent virus r

233 osomal RNA filtering for accurate mapping of exogenous RNAs and summarization based on taxonomy annot

234 in each biofluid, as well as an analysis of exogenous RNAs.

235 Provision of exogenous ROS in the form of H2O2 reversed the necrotic

236 expression of TFPI-2 or after treatment with exogenous rTFPI-2, breast cancer cells exhibited reduced

237 alyzed diamination of the alkene with simple exogenous secondary amines under extraordinarily mild re

238 ted to probe the metabolism of endogenous or exogenous secondary metabolites and facilitates the unta

239 us alpha-syn to a relatively small number of exogenous seeds.

240 pectedly, saliva samples have high levels of exogenous sequence that can be traced to bacteria.

241 e novo serine synthesis, many others rely on exogenous serine for optimal growth.

242 on of a Smoothened agonist or by addition of exogenous Shh, or neutralizing MMP-9 activity, decreased

243 l contagion to find the scenario of smallest exogenous shock that, should it occur, would lead to a g

244 We also study the properties of smallest exogenous shocks as a function of the parameters that de

245 ibution across banks of the size of smallest exogenous shocks we rank banks in terms of their systemi

246 e triggered to migrate out in response to an exogenous signal but then regroup into a neurosphere as

247 However, for exogenous siRNAs it is limited by the rapid removal of t

248 processes, summarizes the current status of exogenous small-molecule inhibitors of RAGE and conclude

249 ASCs are highly dependent on exogenous soluble factors such as interleukin-6 (IL-6) a

250 Exogenous sorbitol application during flower development

251 Accordingly, an exogenous source of alphaKG restored the DNA demethylati

252 Excluding the factor of smoking, an exogenous source of glyoxal, levels of these two cross-l

253 C) might convert to PrP(res) if seeded by an exogenous source of PrP(res) not associated with host ce

254 Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumou

255 y both de novo biosynthesis and recycling of exogenous sphingolipids.

256 Exogenous SPL expression inhibited influenza A virus rep

257 The administration of exogenous stem cells has been investigated in patients s

258 endogenous stimuli in new ways as well as to exogenous stimuli, such as temperature, magnetic field,

259 Exogenous sTNF rapidly and simultaneously induced increa

260 ng the impact of the inoculation of selected exogenous strains on natural strains.

261 n suboptimal, and there is a need to develop exogenous strategies to help regenerate the thymus.

262 nerated both endogenously and in response to exogenous stress, induce point mutations by mis-replicat

263 trins and therefore, they are protected from exogenous stress.

264 g biological vulnerability who experience an exogenous stressor, such as prone/side sleeping or soft

265 protective properties against endogenous and exogenous stressors.

266 we evaluated the oxidation of endogenous or exogenous substrates by cell lines harboring different m

267 ence of Mg(2+) and NAD(+) and the absence of exogenous substrates upon inner membrane pore formation

268 sh interference of endogenous or undesirable exogenous substrates with the cellular capacity of oxidi

269 COX-2, using inhibitors and incubations with exogenous substrates.

270 n infected host cells in the absence of both exogenous sugars and/or amino acids.

271 Importantly, exogenous superoxide addition to CB3-infected NOD.Ncf1(m

272 Exogenous T on its own did not modulate aggressive behav

273 RNAs typically relies on the introduction of exogenous tags.

274 me brains, regulates alternative splicing of exogenous tau exon 10.

275 leviate Tau aggregation without the need for exogenous Tau fibrils.

276 ral RNA synthesis on both the endogenous and exogenous templates.

277 aive CD4(+) T cells, independent of Foxp3 or exogenous TGF-beta.

278 Finally, exogenous TGF-beta1 to -beta3, each restituted the norma

279 We found that exogenous TH precociously activates the beta-cell differ

280 Notably, these functions do not require exogenous thrombomodulin, unlike other anticoagulant thr

281 Importantly, we demonstrated that the exogenous ToV-PLP gene that was inserted into the EVG ge

282 In mice not treated with exogenous tPA, the plasma concentration of endogenous tP

283 , each existing platform relies on a defined exogenous transcription activator capable of binding a u

284 etic landscape which is not achievable using exogenous transfection-based luciferase reporter assays.

285 ter analysis, site-of-action experiments and exogenous transgene expression; and we provide a basic d

286 f DENV structural proteins expressed from an exogenous transgene.

287 In this study, we report that exogenous treatment of flowering Arabidopsis (Arabidopsi

288 iated NET formation was further supported by exogenous treatment with autophagy inducer tamoxifen, wh

289 restart under replication stress elicited by exogenous treatments.

290 latory role and regulates HEV sensitivity to exogenous type I IFN.IMPORTANCE Hepatitis E virus (HEV)

291 itor cerulenin and is rescued by addition of exogenous unsaturated fatty acids.

292 ing daily global weather data, which creates exogenous variation in running among friends, with data

293 d VEGF induction, suggesting that the use of exogenous VEGF expression as a therapeutic for neovascul

294 This finding suggested the possibility that exogenous viral infections could likewise increase patho

295 g wine grapes, tree nuts and tree fruits and exogenous viral pathogens by simulating a horizontal tra

296 morphosis, we found that exposure to OSS and exogenous virus resulted in significantly heightened Bla

297 1 blockade can be rescued by the addition of exogenous wnt3a ligand.

298 In turn, exogenous Wnt5a inhibits CCN1 gene expression, induces E

299 atalyzes the N-methylation of endogenous and exogenous xenobiotics.

300 scenario wherein inappropriate responses to exogenous yet non-pathogen-derived nucleic acids would h