ライフサイエンスコーパス: exonuclease

1 o that predicted for the activity of a 3'-5' exonuclease.

2 through multiple contacts with the clamp and exonuclease.

3 this work, we show that TREX1 is also a RNA exonuclease.

4 se, duplex-specific nuclease, DNase I, or T7 exonuclease.

5 is unwound by RecQ to create ssDNA for RecJ exonuclease.

6 digestion of lambda-DNA (48.5 kbp) by lambda-exonuclease.

7 uclease and degraded by the XRN1 cytoplasmic exonuclease.

8 enhanced 2.5-fold by incorporating the Trex2 exonuclease.

9 RNA production depends on distributive 3'-5' exonucleases.

10 a phenotype dependent on secreted endo- and exonucleases.

11 photriesters are resistant toward 5'- and 3'-exonucleases.

12 adation of the cleaved fragments by cellular exonucleases.

13 activities of various 3'-end polymerases and exonucleases.

14 y protecting it from phosphatases and 5-to-3 exonucleases.

15 organs and (iii) protects siRNAs from 5-to-3 exonucleases.

16 , we identify potential inhibitors for DEDDh exonucleases.

17 log 3 (Msh3) stimulates 5' to 3' excision by exonuclease 1 (Exo1) from a single-strand break 5' to th

18 Exonuclease 1 (Exo1) is a 5'-->3' exonuclease and 5'-fla

19 Next, MRN loads exonuclease 1 (Exo1) onto the free DNA ends to initiate

20 study, we show that Metnase associates with exonuclease 1 (Exo1), a 5'-exonuclease crucial for 5'-en

21 cleases FANCD2-associated nuclease 1 (FAN1), exonuclease 1 (EXO1), and flap endonuclease 1 (FEN1) pro

22 luding the Bloom syndrome (BLM) helicase and exonuclease 1 (EXO1), play a major role in generating th

23 reaction requiring Msh2-Msh6 (or Msh2-Msh3), exonuclease 1 (Exo1), replication protein A (RPA), RFC,

24 Human exonuclease 1 (hExo1) is a member of the RAD2/XPG struct

25 Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like disease Aicar

26 efects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune conditio

27 Mutations in the human 3' repair exonuclease 1 (TREX1) have been linked to the type I IFN

28 3' repair exonuclease 1 (TREX1) is a known DNA exonuclease involve

29 Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleav

30 S678A cells, there was no phosphorylation of Exonuclease 1 consistent with the defect in HDR.

31 Three-prime repair exonuclease 1 knockout (Trex1(-/-)) mice suffer from sys

32 tudies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, pre

33 lly caused by a mutation in TREX1 (3' repair exonuclease 1).

34 k1 activation following DNA end-resection by Exonuclease 1.

35 ing the extent of resection mediated through Exonuclease 1.

36 end resection in budding yeast cells lacking exonuclease 1.

37 caused by mutations of TREX1 (3-prime repair exonuclease-1).

38 We determined that three-prime repair exonuclease-1, a host 3' to 5' exonuclease, reduced IFN-

39 d of the D12A/D66A mutations, located in the exonuclease active site, approximately 30 A from the pol

40 ransfer, followed by biased binding into the exonuclease active site.

41 e entry path of the primer strand in the PHP-exonuclease active site.

42 It promotes c-NHEJ via helicase and exonuclease activities and inhibits alt-NHEJ using non-e

43 We conclude that the trace exonuclease activities detected in SAMHD1 preparations a

44 ration of a 3' single-strand DNA overhang by exonuclease activities in a process called DNA resection

45 Both endonuclease and exonuclease activities of MRE11 were required for MMEJ,

46 in DNA and have weak endoribonuclease and 3'-exonuclease activities on r8oxoG substrate.

47 is a vertebrate nuclease with both endo- and exonuclease activities that acts on a wide range of nucl

48 n Ku sequesters seDSBs and shields them from exonuclease activities.

49 core of Pol and retains both polymerase and exonuclease activities.

50 SAMHD1 with no dNTPase activity retained the exonuclease activities.

51 th WRN and influences its basic helicase and exonuclease activities.

52 contributions of its polymerase and 3'-->5' exonuclease activities.

53 al VH gene that is often further obscured by exonuclease activity and N-nucleotide addition.

54 type I alkaline nuclease, UL12, has 5'-to-3' exonuclease activity and shares homology with nucleases

55 APE1) prevented TNR expansions via its 3'-5' exonuclease activity and stimulatory effect on DNA ligat

56 However, TREX1 mutants competent for DNA exonuclease activity are also linked to AGS.

57 in remarkable protection of that oligo from exonuclease activity as it remains hybridized to the dsD

58 Thus, the exonuclease activity cannot be associated with any known

59 ing with flap endonuclease 1, the APE1 3'-5' exonuclease activity cleaves the annealed upstream 3'-fl

60 tic analysis of nucleotide incorporation and exonuclease activity for a Family D DNA polymerase from

61 e (PNPase), which is considered the major 3' exonuclease activity in mRNA decay and which is one of f

62 omain of OsCCR4a and OsCCR4b exhibited 3'-5' exonuclease activity in vitro, and point mutation of a c

63 rOsCAF1G, and rOsCAF1H, all exhibited 3'-5' exonuclease activity in vitro.

64 Inactivation of the 3'-5' proof-reading exonuclease activity is also necessary.

65 We conclude that UL12 exonuclease activity is essential for the production of

66 rand displacement synthesis unless its 3'-5' exonuclease activity is removed.

67 However, inactivation of the 3'-5' exonuclease activity is sufficient to allow the polymera

68 Depletion of MRE11 and abrogation of its exonuclease activity negatively impact viral replication

69 Here, we provide evidence that the exonuclease activity of mammalian flap endonuclease (FEN

70 d newly replicated genome is degraded by the exonuclease activity of MRE11, and the fragmented nascen

71 sion site is enlarged into a DNA gap via the exonuclease activity of MRX, which is stimulated by Sae2

72 inant proteins-with CSB able to modulate the exonuclease activity of SNM1A on oligonucleotide substra

73 inutes after UV irradiation and required the exonuclease activity of the double strand break repair n

74 rotects the recessed strand from the 5'-->3' exonuclease activity of the model exonuclease from bacte

75 inhibitors, ATA and PV6R, indeed inhibit the exonuclease activity of the viral protein NP exonuclease

76 n together, our results demonstrate that the exonuclease activity of UL12 is essential for the produc

77 We demonstrate that the exonuclease activity of UL12 is essential for the produc

78 In this communication, we confirm that the exonuclease activity of UL12 is essential for viral repl

79 eavage activity was not required for Exo1 5'-exonuclease activity on the lagging strand daughter DNA,

80 suggest that Metnase enhances Exo1-mediated exonuclease activity on the lagging strand DNA by facili

81 Deleting the 3'-5' proofreading exonuclease activity reduced fidelity twofold.

82 Although the exonuclease activity resides in Pan2, efficient deadenyl

83 vity, but confers on hEXOG a strong 5'-dsDNA exonuclease activity that precisely excises a dinucleoti

84 We now show that inhibition of MRE11 3'-5' exonuclease activity with Mirin reduces the frequency of

85 replication, mediated by an intrinsic 3'-5' exonuclease activity within its PHP domain.

86 Rad51 knockdown required Mre11, but not its exonuclease activity, and PrimPol, a DNA polymerase with

87 omatic mutations in hPol, which decrease its exonuclease activity, are connected with mutator phenoty

88 eliminates ATPase activation and repetitive exonuclease activity, but the ability to support single

89 Purified human Poldelta-R689W has normal exonuclease activity, but the nucleotide selectivity of

90 ffinity, reduced thermostability, diminished exonuclease activity, defective catalytic activity, and

91 exonuclease activity, RecJ can display dsDNA exonuclease activity, degrading 100-200 nucleotides of t

92 9 and showed it to possess a 5' --> 3' ssDNA exonuclease activity, in addition to the previously demo

93 ish that in addition to its well-known ssDNA exonuclease activity, RecJ can display dsDNA exonuclease

94 p-dependent endonuclease activity, but lacks exonuclease activity.

95 nuclease activity and in parallel with MRE11 exonuclease activity.

96 KBM mediates Ku-dependent stimulation of WRN exonuclease activity.

97 tive DNA polymerase with an associated 3'-5' exonuclease activity.

98 ce of which severely diminishes its 3' to 5' exonuclease activity.

99 ics, strand displacement synthesis and 3'-5' exonuclease activity.

100 ' helicase activity and DNA2's 5'->3' ss-DNA exonuclease activity.

101 ssesses single-stranded DNA and/or RNA 3'-5' exonuclease activity.

102 nd selectively reduces WRN helicase, but not exonuclease activity.

103 eplisome, to which it provides an additional exonuclease activity.

104 es both the endonuclease activity and the 5'-exonuclease activity.

105 Exonuclease 1 (Exo1) is a 5'-->3' exonuclease and 5'-flap endonuclease that plays a critic

106 anscriptase (RT) lacks 3' to 5' proofreading exonuclease and can extend mismatches.

107 tion, thereby licensing HR followed by MRE11 exonuclease and EXO1/BLM bidirectional resection toward

108 ed after the primer strand is excised by the exonuclease and returned back to the polymerase active s

109 ork provides important insights into the PHP-exonuclease and reveals unique properties that make it a

110 Its dominant, processive 5'-3' exonuclease and secondary 5'-flap endonuclease activitie

111 revisiae Full-length resection requires Exo1 exonuclease and the DSB-responsive kinase Tel1, but not

112 Here, we show that the 5'-exonuclease and the endonuclease activities co-purify.

113 Third, divalent cation effects on the 5'-exonuclease and the endonuclease parallel one another.

114 hat there is kinetic competition between the exonuclease and the pol II elongation complex.

115 clear division of the RNHL superfamily into exonucleases and endonucleases.

116 nd PNPase is well suited to studies of other exonucleases and helicases.

117 cation and 3' uridylation and thus relies on exonucleases and nucleotidyl transferases.

118 Artemis is a diverse endo- and exonuclease, and creating a unified model for its wide r

119 donuclease, 3'-terminal uridylyltransferase, exonuclease, and ligase activities.

120 The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of

121 complex composed of RET1 TUTase, DSS1 3'-5' exonuclease, and three additional subunits.

122 identified PNLDC1, an uncharacterized 3'-5' exonuclease, as Trimmer in silkworms.

123 o that of wild type enzyme in a conventional exonuclease assay and that in contrast to a D173A active

124 n) in this region, within a gene encoding an exonuclease, associates with parasite recrudescence foll

125 yme was originally identified as a 3' --> 5' exonuclease, but we show here that NrnA is bidirectional

126 Several viral and human DEDDh exonucleases can serve as antiviral drug targets due to

127 ssay that allows the in vitro observation of exonuclease-catalyzed degradation (resection) of telomer

128 These mechanisms employ two types of exonucleases, CCA end addition, tRNA nuclear aminoacylat

129 Chromatin immunoprecipitation-exonuclease (ChIP-exo) analysis shows that Nap1 is requi

130 tif-resolution chromatin immunoprecipitation-exonuclease (ChIP-exo) approach, we find that agonist-li

131 High-resolution exonuclease (ChIP-exo) mapping revealed that the majorit

132 nalysis by the chromatin immunoprecipitation-exonuclease (ChIP-exo) method allowed the identification

133 carried out exclusively by protein-mediated exonuclease cleavage and full-strand desorption.

134 is through activation of the SLX4/MUS81/EME1 exonuclease complex that forms part of the Fanconi anemi

135 ch begins with 5' end resection, mediated by exonuclease complexes, one of which contains Exo1.

136 e associates with exonuclease 1 (Exo1), a 5'-exonuclease crucial for 5'-end resection to mediate DNA

137 This novel p53 activity is lost in the exonuclease-deficient but transcriptionally active p53(H

138 ions (S305R, H932Y, Y951N, and Y955C) and an exonuclease-deficient mutant (D198A/E200A).

139 he observed strand displacement synthesis by exonuclease-deficient Pol epsilon is distributive.

140 oration, and ribonucleotide incorporation by exonuclease-deficient polD.

141 ficient for the nuclear exosome or the 5'-3' exonuclease Dhp1, and also at late stages of meiotic dif

142 niently prepared from PCR products by lambda-exonuclease digestion and streptavidin magnetic bead iso

143 Depletion of PAPD5 or the cytoplasmic exonuclease DIS3L rescues the effect of PARN depletion o

144 aluated the contribution of mutations in the exonuclease domain (exodom) of POLE and POLD1 genes that

145 two KBMs; one at the N terminus next to the exonuclease domain and one at the C terminus next to an

146 Much attention has been focused on POLE exonuclease domain mutations, which occur frequently in

147 ted to carry amino acid substitutions in the exonuclease domain of DNA polymerase epsilon (Polepsilon

148 We also identify Exonuclease domain-containing 1 (EXD1) as a partner of t

149 wing to their lack of a proofreading (3'- 5' exonuclease) domain.

150 SNM1A is a key exonuclease during replication-dependent and transcripti

151 The isolated recombinant exonuclease-endonuclease-phosphatase domain of OsCCR4a a

152 orientation of the C-terminal helix with the exonuclease/endonuclease function and the architecture o

153 the DNA sliding clamp beta, the proofreading exonuclease epsilon and the C-terminal domain of the cla

154 spora crassa Here we show that the conserved exonuclease ERI-1 (enhanced RNAi-1) is a critical compon

155 al and zygotic factors such as the conserved exonuclease ERI-1.

156 Mre11 exonuclease, EXD2, and Exo1 execute resection, and Artem

157 This mutant protein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities

158 ilures, result in substitutions in the 3'-5' exonuclease (Exo) domain of the catalytic subunit of the

159 c.585C>G; H195Q) within the highly conserved exonuclease (Exo) III domain.

160 ion involves phosphorylation of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like k

161 both upstream and in concert with the 5'-3' exonuclease EXO1 in DNA resection, but it remains unclea

162 th several nucleases, including the 5' dsDNA exonuclease EXO1.

163 oth the 5'-3' exonuclease RecJ and the 3'-5' exonuclease ExoI, observations that suggest the importan

164 during RC DNA to CCC DNA conversion, two 3' exonucleases, exonuclease I (Exo I) and Exo III, were us

165 RICE1 exhibited a DnaQ-like exonuclease fold and formed a homohexamer with the activ

166 the observed cleavage patterns, we also used exonuclease footprinting to demonstrate that individual

167 Here, we found that EXO1, an exonuclease for DNA damage repair, is quickly recruited

168 lymerase in this family relies on a built-in exonuclease for proofreading.

169 ase that is distinct from the canonical DEDD exonucleases found in the Escherichia coli and eukaryoti

170 he 5'-->3' exonuclease activity of the model exonuclease from bacteriophage lambda.

171 le possible mechanism by showing that the 3'-exonuclease function of the polymerase is not needed.

172 The PHP-exonuclease has a trinuclear zinc center, coordinated by

173 e identify oligoribonuclease (Orn)-a 3'-->5' exonuclease highly conserved among Actinobacteria, Beta-

174 9 degrees N polD were used to examine 3'-5' exonuclease hydrolysis activity in the presence of Mg(2+

175 Preference for Mn(2+) over Mg(2+) in exonuclease hydrolysis activity is a property unique to

176 to CCC DNA conversion, two 3' exonucleases, exonuclease I (Exo I) and Exo III, were used in combinat

177 plementary strands of aptamer (CSs) complex, exonuclease I (Exo I) and gold electrode.

178 escent probe system that shows resistance to exonuclease I (Exo I) digestion upon binding to ATP mole

179 elective detection of streptomycin, based on exonuclease I (Exo I), complimentary strand of aptamer (

180 f aptamer (CS) conjugate, gold electrode and exonuclease I (Exo I).

181 pe structure on the surface of electrode and exonuclease I (Exo I).

182 etected the activities of two model enzymes, exonuclease I and uracil DNA glycosylase with high sensi

183 Dictyostelium cells disrupted in exonuclease I, a critical factor for HR, are sensitive t

184 berberine, is digested upon the addition of exonuclease I, leading to the release of berberine into

185 A 3' ends from resection by Escherichia coli exonucleases I and III and from end-healing by T4 polynu

186 leic acid self-assembly circuitry and enzyme exonuclease III (Exo III) for the differentiation of sin

187 The enzyme Exonuclease III (Exo III) is a useful tool in this regar

188 ive detection of streptomycin (STR) based on Exonuclease III (Exo III), SYBR Gold and aptamer complim

189 multifunctional dumbbell probe can initiate exonuclease III (Exo III)-aided target recycling amplifi

190 Herein, we report a type of exonuclease III (Exo III)-powered stochastic DNA walker

191 icking endonucleases or sequence independent exonuclease III, lambda exonuclease, RNase H, RNase HII,

192 method involving simultaneous digestion with exonuclease III, which removes linker DNA.

193 CoVs encode a proofreading exonuclease in nonstructural protein 14 (nsp14-ExoN), wh

194 mRNA decay and which is one of four known 3' exonucleases in B. subtilis.

195 r another function of UL12, we introduced an exonuclease-inactivating mutation into the viral genome.

196 Finally, we show that ssDNA exonucleases inhibit natural transformation in Acinetoba

197 nhibition promotes NHEJ in lieu of HR, while exonuclease inhibition confers a repair defect.

198 he resistance of circular dsDNA molecules to exonuclease, internally calibrated with the native plasm

199 nuclease, transforming it from a destructive exonuclease into a recombination-promoting repair enzyme

200 repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the ant

201 a HLM present in yeast Xrn1, the main 5'-3' exonuclease involved in mRNA decay.

202 ition between elongating pol II and the Xrn2 exonuclease is integral to termination of transcription

203 We conclude that the 5'-exonuclease is intrinsic to ARTEMIS, making it relevant

204 The WRN helicase/exonuclease is mutated in Werner syndrome of genomic ins

205 The mechanism of the PHP-exonuclease is not known.

206 Here, we show that this exonuclease is strongly upregulated in human psoriasis,

207 n different biological matrices show that 5'-exonuclease is the most prevalent nuclease activity in e

208 ing subunit of the replisome, the varepsilon exonuclease, is essential for high-fidelity DNA replicat

209 NS-seq depends on the ability of lambda exonuclease (lambda-exo) to efficiently digest parental

210 Redbeta interacts with lambda exonuclease (lambdaexo), the other component of the Red

211 Thus, rational removal of ssDNA exonucleases may be broadly applicable for enhancing the

212 In vitro, this exonuclease mechanism allows FAN1 to excise an ICL from

213 aE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiot

214 ribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome bi

215 determined by chromatin immunoprecipitation-exonuclease methodology (ChIP-exo).

216 In ssDNA exonuclease mutants, one arm of homology can be reduced

217 wild type and approximately 1.75% in nuclear exonuclease mutants.

218 y known RNA viruses to encode a proofreading exonuclease (nsp14-ExoN), as well as other replicase pro

219 Inactivation of the 3' --> 5' proofreading exonuclease of DNA polymerase II did not enable bypass.

220 exonuclease activity of the viral protein NP exonuclease of Lassa fever virus in vitro.

221 processivity factor for Exo1, retaining the exonuclease on DNA for long-range resection.

222 We report the immobilization of lambda-exonuclease onto poly(methylmethacrylate) (PMMA) micropi

223 restriction fragments can be degraded by DNA exonucleases or ligated by T3 and T4 DNA ligases.

224 is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic core.

225 The DEDDh family of exonucleases plays essential roles in DNA and RNA metabo

226 Knockdown of the exosome-associated exonuclease PM/Scl-100, but not the Dis3L2 exonuclease,

227 e common architectural features, such as the exonuclease/polymerase and C-terminal domains (CTDs) of

228 pair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting dam

229 mutations impact APE2 DNA binding and 3'-5' exonuclease processing, and also prevent efficient APE2-

230 In the absence of FANCD2, MRE11 exonuclease-promoted access of FAN1 to stalled forks res

231 rocessed transcripts from degradation by the exonuclease Rat1.

232 Pre-steady-state kinetics showed that the exonuclease rates on single-stranded, double-stranded, a

233 ack processivity and have reduced repetitive exonuclease rates.

234 ct expansion is controlled by both the 5'-3' exonuclease RecJ and the 3'-5' exonuclease ExoI, observa

235 -prime repair exonuclease-1, a host 3' to 5' exonuclease, reduced IFN-beta expression significantly d

236 nding specificity, and protection against 3'-exonucleases relative to regular LNA.

237 V xrRNA structure clarifies the mechanism of exonuclease resistance and identifies features that may

238 Mutations that disrupt the structure affect exonuclease resistance in vitro and sfRNA formation duri

239 mino-LNA-T derivatives induced remarkable 3'-exonuclease resistance.

240 Our work identifies a class of exonucleases responsible for miRNA 3' truncation in vivo

241 ing of Brachyury by ChIP sequencing and ChIP-exonuclease revealed distinct sequence signatures enrich

242 In cells lacking the exonuclease Rex1, scR1 terminates in a longer U5-6 tail

243 ficity endoribonuclease RNase III and the 5' exonuclease RNase J1 are not essential in the Gram-posit

244 at does not involve any of the six 3' --> 5' exonucleases (RNase T, RNase PH, RNase D, RNase BN, RNas

245 sequence independent exonuclease III, lambda exonuclease, RNase H, RNase HII, AP endonuclease, duplex

246 ChIP-exonuclease-sequencing revealed that the +60ZF-DBD was t

247 Furthermore, the PHP-exonuclease shows a striking similarity to E. coli endon

248 erase site and for hydrolytic editing in the exonuclease site.

249 transfer pathway between the polymerase and exonuclease sites displays additional kinetic states not

250 th directions between the polymerase and the exonuclease sites, and we have applied it to determine t

251 transferred between the DNAP polymerase and exonuclease sites, separated by a distance that is typic

252 r strand transfer between the polymerase and exonuclease sites.

253 d exonuclease PM/Scl-100, but not the Dis3L2 exonuclease, slows histone mRNA degradation consistent w

254 two-hybrid approach, we identified the 5'-3' exonuclease SNM1A as one of four strong interacting part

255 The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induce

256 at this activity is redundant with the 5'-3' exonuclease SNM1A.

257 n of a battery of cellular endonucleases and exonucleases, some universal and others present only in

258 destruction is the virally encoded alkaline exonuclease SOX.

259 ene 6 protein of bacteriophage T7 is a 5'-3'-exonuclease specific for dsDNA.

260 core into the active site tunnel of its key exonuclease subunit Rrp44, which acts both as an enzyme

261 ound and DNA-free states of the PolIII-clamp-exonuclease-tauc complex.

262 uents provided greater resistance against 3'-exonucleases than the corresponding (R)-isomers.

263 Mutations in TREX1, a 3' repair exonuclease that degrades cytosolic DNA, cause Aicardi-G

264 TREX1 is an exonuclease that digests DNA in the cytoplasm.

265 replication depends on a proofreading 3'-5' exonuclease that is associated with the replicative DNA

266 Human EXOG (hEXOG) is a 5'-exonuclease that is crucial for mitochondrial DNA repair

267 um tuberculosis (Mtb) uses its intrinsic PHP-exonuclease that is distinct from the canonical DEDD exo

268 e is thought to provide entry for a 5'-to-3' exonuclease that targets RNA polymerase II via the nasce

269 One particular gene, xds, encodes a secreted exonuclease that was previously identified as being indu

270 gest potential lead inhibitors for the DEDDh exonucleases that may pave the way for designing nucleas

271 TREX1 and 2 are exonucleases that repair and degrade DNA.

272 s process, identifying conserved PARN-family exonucleases that trim piRNAs to their mature size in si

273 ucleoplasm, La binds to and protects from 3' exonucleases, the ends of precursor tRNAs, and other tra

274 s (circRNAs) are resistant to degradation by exonucleases, their abundance relative to linear RNAs ca

275 phosphohydrolase (PPH), decapping, and 5'-3' exonuclease (toward 5' monophosphate RNA) activities, wh

276 omplexes using high-throughput sequencing of exonuclease-treated chromatin-immunoprecipitated DNA (Ch

277 tin immunoprecipitation followed by 5'-to-3' exonuclease treatment and then massively parallel DNA se

278 ders that have been traced to defects in the exonuclease TREX1 (DNase III).

279 We show that the DNA exonuclease Trex1 is induced by radiation doses above 12

280 DNA fragments and that the cytoplasmic 3'-5' exonuclease Trex1 is required for their degradation.

281 produce type I IFNs owing to loss of the DNA exonuclease Trex1, inflammatory disease completely depen

282 The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifyi

283 EJ repair event (i.e., expression of the 3' exonuclease Trex2).

284 us subtilis pnpA gene, encoding the major 3' exonuclease turnover enzyme, polynucleotide phosphorylas

285 periments with nucleotide resolution through exonuclease, unique barcode and single ligation), which

286 in in complex with dsDNA, revealing how this exonuclease uses a novel DNA-unwinding mechanism to sepa

287 viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs.

288 also PRNPIP and PINT1), a putative 3'-5' RNA exonuclease, which preferentially associates with DENV-2

289 this requirement is due to cytoplasmic ssDNA exonucleases, which inhibit natural transformation.

290 in repair is removal of the FD by the RecBCD exonuclease, whose entry past the N-protein block is lic

291 PARN is an extensively characterized exonuclease with deadenylation activity that controls mR

292 This reinforced structure blocks the 5'-->3' exonuclease Xrn1 for the production of pathogenic subgen

293 Host cell exonuclease Xrn1 likely loads on the 5' end of viral gen

294 RNA effector pathways and/or the cellular 5' exonuclease Xrn1 were prepared by CRISPR-Cas9 gene editi

295 equently degraded by the cellular 5'-3' mRNA exonuclease Xrn1, thereby suppressing cellular gene expr

296 he cytoplasmic tRNA quality control 5'-to-3' exonuclease Xrn1, which has specificity for RNAs with 5'

297 ating substrates for degradation by the host exonuclease Xrn1.

298 the 5' end and preventing decay mediated by exonuclease Xrn1.

299 f transcription termination asserts that the exonuclease Xrn2 attacks the 5'PO4-end exposed by nascen

300 DcpS requires the contribution of the 5'-3' exonuclease Xrn2.