ライフサイエンスコーパス: exosome

1 o transfer via extracellular vesicles (e.g., exosomes).

2 is linked to RNA degradation by the nuclear exosome.

3 , since they are rapidly degraded by the RNA exosome.

4 ily RNA-binding protein Mmi1 and the nuclear exosome.

5 pidly degraded in the nucleus by the nuclear exosome.

6 Rrp44 and Rrp6 within the 11-subunit nuclear exosome.

7 be a conserved feature of the eukaryotic RNA exosome.

8 polymerase PAPD5 and degraded by the nuclear exosome.

9 dependencies on elements within the nuclear exosome.

10 ing protein Mmi1 and degraded by the nuclear exosome.

11 erived factor (PEDF) on the outer surface of exosomes.

12 nd 8) Perspectives in the theranostic use of exosomes.

13 alanine-rich kinase (SPAK) in human urinary exosomes.

14 f miRs 1, 133a, and 133b in myofiber-derived exosomes.

15 matic subjects compared to healthy controls' exosomes.

16 istration of normal, but not ADicerKO, serum exosomes.

17 protein markers, indicating an enrichment in exosomes.

18 selectively enriching Ag within immunogenic exosomes.

19 y recruit neutrophils as compared to control exosomes.

20 stemic dissemination of small-RNA-containing exosomes.

21 hysiological extracellular vesicles, such as exosomes.

22 vironment are the nano-sized vesicles called exosomes.

23 d fatty acid composition of the two types of exosomes.

24 m cells or through time-varying release from exosomes.

25 NK-92 cells do not internalize AML exosomes.

26 compared to the basolateral plasma membrane exosomes.

27 mmunoblot) indicated that most serum EV were exosomes.

28 to small extracellular vesicles (EVs) called exosomes.

29 it markers and size profiles consistent with exosomes.

30 haracterization, and function of circulating exosomes; 3) The role of exosomes in acute lung injury;

31 is and growth are suppressed by impaired RNA exosome activity.

32 These exosomes alone can activate human brain microvascular en

33 studies have focused on determining how the exosome, along with associated cofactors, achieves the d

34 were identified within HEK293T cell EVs and exosomes, among the most abundant being transcripts cont

35 The proteomes of these exosome and dense EVs preparations suggest that epitheli

36 However, the role of RNA exosome and its RNA processing activity on DNA mutagenes

37 fabrication, membrane-protein interactions, exosome and virus detection and analysis, and probing nu

38 20 aM or 9500 exosomes in 50 muL) for intact exosomes and 3-5 picomolar for internal exosomal synteni

39 CrkI-containing microvesicles (distinct from exosomes and apoptotic bodies), which induce proliferati

40 nal epithelial cells were exposed to urinary exosomes and cellular exosomal uptake was confirmed; the

41 at VPS4 activity is important for generating exosomes and ectosomes, thereby generally implicating th

42 Extracellular vesicles (EVs), including exosomes and microvesicles, are 30-800 nm vesicles that

43 a different biophysical interaction between exosomes and MVs with SAM AuNIs.

44 stinctive membrane property of tumor-derived exosomes and MVs, but also facilitate the development of

45 lycans were chemically released from urinary exosomes and profiled, revealing some unusual structures

46 m associates with metalloprotease-containing exosomes and stimulates their secretion.

47 aco-2 cells increased the levels of released exosomes and their expression of CD133.

48 ) on the characteristics of monocyte-derived exosomes and their influence on HIV-1 replication.

49 terminology that encompasses microparticles, exosomes, and apoptotic bodies) are emerging as a novel

50 nd two subpopulations of small EVs including exosomes, and dense EVs, were purified and processed for

51 ripts involved in endocytosis, extracellular exosomes, and metal ion binding are differentially expre

52 enriched in small ncRNAs, such as miRNAs in exosomes, and precisely processed tRNA and Y RNA fragmen

53 Exosomes are a subclass of extracellular vesicles involv

54 Circulating levels of exosomes are associated with the onset and clinical cour

55 Exosomes are both active in mediating intracellular comm

56 Tumor exosomes are emerging as antitumor immunity regulators;

57 Exosomes are emerging mediators of intercellular communi

58 Exosomes are extracellular nanosized vesicles with lipid

59 Exosomes are extracellular vesicles (EVs) that play a ce

60 Exosomes are generated within endosomes and released whe

61 the resistant cancer cells and the secreted exosomes are intricately associated with the reduction i

62 Our study shows that exosomes are involved in fine-tuning intercellular commu

63 Exosomes are involved in intercellular communication.

64 Exosomes are lipid vesicles derived from cellular multiv

65 Exosomes are membrane enclosed nano-sized vesicles activ

66 It is unclear whether RNA-containing exosomes are mobile genetic signals regulating epithelia

67 Exosomes are small extracellular vesicles (EVs), release

68 Exosomes are small membrane vesicles (30-100nm in diamet

69 Exosomes are vesicles released by many eukaryotic cells;

70 Exosomes are viral-like particles from endosomal origin

71 The potential of exosomes as a novel therapeutic is also discussed.

72 dients are more stable when secreted through exosomes as compared with direct secretion.

73 Furthermore, the validation of an exosome-associated biomarker in the blood of patients pr

74 ervous system, resulting in the elevation of exosome-associated immunostimulatory endogenous danger/d

75 d mass spectrometry identified low-abundance exosome-associated proteins and protein complexes, some

76 -infected hepatocytes given that blockade of exosome-associated TGF-beta or inhibition of exosome rel

77 previously demonstrated that suppression of exosomes at the distal tumor site of pancreatic ductal a

78 Exosome based screening of key HPVOPC associated molecul

79 EVs used in this study are referred to as A1-exosomes because of their robust antiinflammatory proper

80 physiological and pathological mechanisms of exosome biogenesis, protein trafficking, and signal tran

81 d a role for active Ras protein signaling in exosome biogenesis, we found that GTP binding of K-Ras w

82 natural cargo delivery functions of natural exosomes, biomimetic synthetic strategies are exploited

83 A structure of a twelve-subunit nuclear Mpp6 exosome bound to RNA shows the central region of Mpp6 bo

84 -terminal fragment (CTF) content in secreted exosomes, but had minimal effects on APP lysosomal degra

85 in samples of apical plasma membrane-derived exosomes, but not in basolateral plasma membrane exosome

86 rogate the action-at-a-distance signaling of exosomes by UV irradiation, demonstrating that RNA is cr

87 Moreover, they show that exosomes can constitute a novel vehicle for haptenated p

88 Mpp6-exosomes can recruit Mtr4, while Mpp6 and Rrp47 each con

89 Astrocytic exosomes carry heat shock proteins that can reduce the c

90 Cancer exosomes carry malignant information in the form of prot

91 ed that LV-FKRP cells were driven to release exosomes carrying FKRP.

92 Secreted exosomes carrying lipids, proteins, and nucleic acids co

93 Here we demonstrate that CDC-secreted exosomes (CDCexo) recapitulate the cardioprotective effe

94 ls in exponential growth phase released 220 exosomes/cell in culture medium.

95 Mtr4 recruitment domain next to Rrp6 and the exosome central channel.

96 strate the biomarker potential of transplant exosome characterization for providing a noninvasive win

97 binding sites for RNA polymerase II and the exosome cofactors Mtr4 (TRAMP complex) and Nab3 (NNS com

98 Exosomes, compared with MVs, produced a distinguishable

99 mined (i.e., nanoparticle tracking analysis) exosome concentration analysis, lysing, and subsequent i

100 manner which is then independent of absolute exosome concentration and sample preparation.

101 Exosomes constitute an emerging biomarker for cancer dia

102 MPCs secrete exosomes containing miR-206, which represses Rrbp1, a ma

103 gether, these studies show that ATMs secrete exosomes containing miRNA cargo.

104 es release extracellular vesicles, including exosomes containing miRs, upon activity.

105 atory responses by triggering the release of exosomes containing unshielded RNAs that activate patter

106 Strikingly, exosomes containing vsRNAs, purified from haemolymph of

107 hows the central region of Mpp6 bound to the exosome core, positioning its Mtr4 recruitment domain ne

108 Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease

109 Our results suggest that EVs and exosomes could play a role in the purging and intercellu

110 Exosome cytokine content was analysed by Cytokine Arrays

111 Exosome deficiency uncouples chromatin targeting of the

112 ediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.

113 These poly(I:C) exosomes demonstrate enhanced trafficking to the node an

114 Exosome-dependent intercellular communication is an emer

115 The exosome-depleted supernatant of ML had no effect on in v

116 Exosomes derived from all nephron segments are present i

117 in the absence of antigens, whereas control exosomes derived from antigen-stimulated CTLs did not.

118 The goal of this study was to understand if exosomes derived from high-metastatic cells may influenc

119 n of p38/Stat pathways in T-cells exposed to exosomes derived from HIV-1 infected DCs.

120 ed total protein and antioxidant capacity in exosomes derived from HIV-1-infected and uninfected macr

121 Exosomes derived from normal fibroblast-like mesenchymal

122 We are the first to show that exosomes derived from poly(I:C) stimulated cells induce

123 study was to investigate differences between exosomes derived from the apical plasma membrane and bas

124 , molecular and biogenesis machinery between exosomes derived from these two immune cell types.

125 f sialic acid decorated apoptotic bodies and exosomes derived from tumors.

126 sis that extracellular vesicles (EV, largely exosomes) derived from these cells are the therapeutic e

127 Importantly, the uptake of exosomes, derived from IL-2 stimulated CD4+ T cells, eff

128 Molecular analysis of exosomes detected the presence of fibronectin and galect

129 Associated exosome detection limits are 1.9 x 10(5) particles mL(-1

130 the noncoding RNA processing function of RNA exosome determine the strand-specific distribution of DN

131 The distribution of FKRP protein boosted by exosomes determined its restoration within muscle tissue

132 the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells h

133 ere, we review the emergent functions of RNA exosome during CSR, SHM, and other chromosomal alteratio

134 LMP1-modified exosomes enhance the growth, migration, and invasion of

135 Immunoisolation of CD63-positive exosomes exhibited accumulation of LMP1 in this vesicle

136 opy confirmed the presence of plasma-derived exosomes (EXOs) isolated by differential centrifugation.

137 erived extracellular nanovesicles resembling exosomes from an H-RasV12 myr-Akt mouse model for GBM ar

138 of 10(11) ssODNs for those associating with exosomes from breast cancer patients or controls.

139 s aggregates, causing decreased secretion of exosomes from cultured astrocytes.

140 We isolated exosomes from daily urine samples in 25 patients undergo

141 emonstrated that miR-19a carried through the exosomes from HCV-infected hepatocytes activates HSC by

142 More important, exosomes from IL-12-stimulated CTLs directly activated b

143 we will focus on the current advances in the exosomes from iPSC derivatives and discuss their therape

144 ranscripts of AMR-associated genes in plasma exosomes from kidney transplant patients.

145 We provide evidence that salivary exosomes from mice with PDAC exhibit a suppressive effec

146 omes, but not in basolateral plasma membrane exosomes from mouse cortical collecting duct cells.

147 AuNIs) can be used to detect and distinguish exosomes from MVs isolated from A-549 cells, SH-SY5Y cel

148 In contrast, here we show that exosomes from poorly metastatic melanoma cells can poten

149 uctures and biochemical studies of RNA bound exosomes from S. cerevisiae revealed that the Exo9 centr

150 Moreover, exosomes from the metastatic line (SW620Exos) exhibited

151 to cause endothelial hyperpermeability than exosomes from the non metastatic line (SW480Exos).

152 he proteins packaged within the two types of exosomes from the same cells.

153 Here we show that exosomes from TLR stimulated cells can largely recapitul

154 ither in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor i

155 Collectively, these results imply that exosomes from uninfected cells activate latent HIV-1 in

156 t knowledge on the role of microvesicles and exosomes from various cellular origins in angiogenesis,

157 This defect was rescued by bone marrow exosomes from WT, but not miR-155(-/-), cells, suggestin

158 e focused on biomarker discovery rather than exosome function.

159 These finding imply that exosomes function to promote T cell immunity during a ba

160 stems and is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently d

161 Congenital mutations in RNA exosome genes are associated with neurodegenerative dise

162 ments revealed that intravenous injection of exosomes harvested after T/HS, but not before shock, cau

163 llular communication; whether the release of exosomes has an effect on the exosome donor cells in add

164 Extracellular vesicles (EVs), such as exosomes, have been identified as regulators of vascular

165 Extracellular vesicles, including exosomes, have immediate potential for serving as biomar

166 tablish that SRC stimulates the secretion of exosomes having promigratory activity on endothelial cel

167 Circulating exosome holds great potentials as biomarker for diagnosi

168 ed to define the global RNA profile of serum exosomes in 19 RRMS patients (9 in relapse, 10 in remiss

169 rticles mL(-1) (equivalent to 320 aM or 9500 exosomes in 50 muL) for intact exosomes and 3-5 picomola

170 iatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion injury.

171 xosomes in acute lung injury; 4) The role of exosomes in acute cardiac injury; 5) The role of exosome

172 omes in acute cardiac injury; 5) The role of exosomes in acute kidney injury; 6) The role of exosomes

173 tion of circulating exosomes; 3) The role of exosomes in acute lung injury; 4) The role of exosomes i

174 urrounding the significance of LMP1-modified exosomes in cancer, very little is understood about the

175 l cells, signifying an important role of CAF exosomes in chemotherapeutic drug resistance.

176 Uptake profile of fluorescent-labelled exosomes in epithelial cells was assessed by flow cytome

177 Though studies have implicated a role for exosomes in HIV-1 pathogenesis, their mechanisms are not

178 and provides novel insight into the role of exosomes in hMSC paracrine-mediated effects on contracti

179 ement cascade pathway and the involvement of exosomes in mid-secretory endometrial functions.

180 role of bronchoalveolar lavage fluid (BALF) exosomes in patients with sarcoidosis and to find candid

181 Exosomes in postshock mesenteric lymph are key mediators

182 han nCPCs, aCPC-derived TCM, or nCPC-derived exosomes in recovering cardiac function, stimulating neo

183 However, roles for endogenously produced exosomes in regulating immune cell functions in vivo are

184 somes in acute kidney injury; 6) The role of exosomes in sepsis; 7) Limitations of exosome isolation

185 However, the role of exosomes in smoking-mediated HIV-1 pathogenesis is unkno

186 A leading role exists for cancer exosomes in specific aspects of tumor progression: modul

187 in vitro Here, we assess the function of ML exosomes in the development of T/HS-induced ALI and the

188 Herein, we analyzed the role of exosomes in the differentiation of HT29 cells.

189 ive studies aimed at elucidating the role of exosomes in the molecular pathophysiology of retinal dis

190 l address the functions attributed to cancer exosomes in these three aspects of cancer biology, highl

191 The packaged material within exosomes includes proteins and lipids, but the molecular

192 In addition, epithelial cell-derived exosomes induced endothelial cell proliferation and ex v

193 proteins, B cell depletion did not alter the exosome-induced CTL response.

194 tic knockout of TLR4 completely abolished ML exosome-induced cytokine production in macrophages.

195 ation in the exosomal donor cells instead of exosomes, inhibiting tumour progression.

196 ively, these findings show the potential for exosome inhibitors as treatment options alongside chemot

197 transplanted tissues release donor-specific exosomes into recipient circulation and that the quantit

198 Conversely, injection of astrocytic exosomes into the striatum of HD140Q KI mice reduces the

199 The nuclear exosome is a key factor for pre-rRNA processing through

200 The eukaryotic RNA exosome is a well-conserved protein complex with ribonuc

201 The eukaryotic RNA exosome is an essential and conserved protein complex th

202 The nuclear RNA exosome is an essential multi-subunit complex that contr

203 The eukaryotic RNA exosome is an essential, multi-subunit complex that cata

204 Release of exosomes is affected by differentiation of colon cancer

205 rovide evidence that IN administration of A1-exosomes is efficient for minimizing the adverse effects

206 suggesting that uptake of miR-155-containing exosomes is important for a proper LPS response.

207 scle-specific miRNAs are encapsulated within exosomes isolated from DM1 patients.

208 We show that exosomes isolated from pre-therapy plasma of the AML pat

209 ole of exosomes in sepsis; 7) Limitations of exosome isolation protocols; and 8) Perspectives in the

210 Compared to liposomes, the engineered exosomes (known as iExosomes) target oncogenic KRAS with

211 -3 in those derived from DCs, whereas T-cell exosomes lacked these molecules.

212 membrane components to escape the cell in an exosome-like particle.

213 viral siRNAs (vsRNA), which are secreted in exosome-like vesicles.

214 findings demonstrate that epithelial-derived exosomes may be involved in corneal wound healing and ne

215 mmarizes how these multifaceted functions of exosomes may promote development and/or progression of c

216 esults indicate that epithelial cell-derived exosomes mediate communication between corneal epithelia

217 S-induced ALI and the role of TLR4 in the ML exosome-mediated inflammatory response.

218 Our results implicated a novel mechanism of exosome-mediated intercellular communication in the acti

219 teins, we show that Rrp47 and Mpp6 stimulate exosome-mediated RNA decay, albeit with unique dependenc

220 il signal relay that focuses on LTB4 and its exosome-mediated secretion.

221 networks, only TGF-alpha stimulation causes exosome-mediated secretion.

222 Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involve

223 Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiqu

224 ed by differentiation of colon cancer cells; exosomes might be used by differentiating cells to get r

225 To assess the value of exosome miRNAs as biomarkers for T1DM, miRNA expression

226 icle we report the first characterization of exosomes miRNAs from human synovial fluid.

227 E7 protein was detectable in the circulating exosomes of numerous HPVOPC subjects.

228 Exosomes of severe asthmatic subjects' fibroblasts showe

229 codynamics successfully predicted effects of exosomes on intercellular drug transfer, cytotoxicity of

230 arify the regulatory mechanism of microglial exosomes on neuronal inflammation in TBI, we focused on

231 nor cells and cytotoxicity of PTX-containing exosomes on Recipient cells.

232 resent in apoptotic bodies, necrotic debris, exosomes or even release of non-vesicular antigen from i

233 ession levels of the remaining candidates in exosomes, plasma and tissue samples from CRC patients an

234 These results show that liver-derived exosomes play a pivotal role in the accumulation of Tfr

235 Recent studies have shown that exosomes play a vital role in cell-to-cell communication

236 ired for the sorting of selected miRNAs into exosomes, plays a role in the sorting of highly abundant

237 WT) hematopoietic cells or administration of exosomes produced by GM-CSF-expanded bone marrow cells.

238 trafficking and LMP1-mediated enhancement of exosome production and may play further roles in limitin

239 gether, our study finds that Rab27-dependent exosome production contributes to homeostasis within the

240 g complex required for transport)-associated exosome proteins Vps4a and Alix.

241 st of membrane vesicles containing serum and exosome proteins, including albumin, fetuin-A, apolipopr

242 ncreases recruitment range and show that the exosomes provide a time delay mechanism that regulates t

243 The A1-exosomes reached the hippocampus within 6 h of administr

244 exosome-associated TGF-beta or inhibition of exosome release abrogated Tfr expansion.

245 To better decipher the exosome release pathways involved, we used siRNA to supp

246 Inhibition of monocyte exosome release reverses endothelial cell activation and

247 emcitabine-exposed CAFs with an inhibitor of exosome release, GW4869, significantly reduces survival

248 d that ESCRT II and IV significantly control exosome release.

249 but not Ser20-->Glu20) rescues the impaired exosomes release induced by PKM2 knockdown.

250 ->Ala95) significantly reduces PKM2-mediated exosomes release whereas expression of selective phospho

251 the formation of the SNARE complex to allow exosomes release.

252 To evaluate the role of exosomes released by bronchial fibroblasts on epithelial

253 Pure sensory neuron-derived exosomes released by capsaicin are readily phagocytosed

254 We observed that exosomes released during a mouse M. tuberculosis infecti

255 Exosomes released from cells with different phenotypes e

256 ing growth factor beta (TGF-beta)-containing exosomes released from HCV-infected hepatocytes given th

257 and concentration of apical and basolateral exosomes remained relatively stable across 3 different t

258 AML exosomes reprogram NK-92 cells, interfering with their a

259 e BCR, but not circulating Ab, in DC-derived exosome responses.

260 ressed and secreted by promastigotes via the exosome route.

261 In prior work, we found that semen exosomes (SE) from healthy donors who do not use illicit

262 Exosomes secreted by mouse corneal epithelial cells were

263 Microvesicles such as exosomes secreted from the iPSC-derived cardiomyocytes e

264 Exosomes, secreted by several cell types, including canc

265 at nano-sized extracellular vesicles, called exosomes, secreted into ML after trauma/hemorrhagic shoc

266 nduced endoplasmic reticulum stress enhanced exosome secretion by beta-cells; induced exosomal releas

267 ulators; however, their effects on secondary exosome secretion by distal organs have not been explore

268 ockout (Rab27DKO) mice that are deficient in exosome secretion have a chronic, low-grade inflammatory

269 alphaB-crystallin in astrocytes to decrease exosome secretion in the HD brains, contributing to non-

270 e way for understanding how stress regulates exosome secretion under pathophysiological conditions.

271 on is both necessary and sufficient to cause exosome secretion without affecting the endoplasmic reti

272 During exosome secretion, phosphorylated PKM2 serves as a prote

273 100-A9 expression, NF-kappaB activation, and exosome secretion.

274 ents identified mostly RNase H-resistant but exosome-sensitive RNAs that mapped to both DNA strands a

275 led to a marked decrease in transplant islet exosome signal along with distinct changes in exosomal m

276 Proteins involved in the immune response and exosome signalling were significantly enriched in the in

277 lipids, but the molecular comparison within exosome subtypes is largely unknown.

278 nd the specific and stronger binding between exosome surface protein and the aptamer displaces aptame

279 Assessing exosome surface proteins provides a powerful means of id

280 Metastatic cancers produce exosomes that condition pre-metastatic niches in remote

281 DC, and KLH was concentrated specifically in exosomes that were a uniquely effective source of Ag in

282 In the presence of exosomes, the non-specific and weaker binding between ap

283 The characteristics of exosomes, their associated cargo (nucleic acids, protein

284 able PTX concentrations, the contribution of exosomes to active drug efflux increased with drug conce

285 After exosome transfer to immune cells, unshielded RN7SL1 driv

286 of the stress response and that circulating exosomes transporting immunomodulatory signals, may play

287 Capsids, carboxysomes, exosomes, vacuoles and other nanoshells easily self-asse

288 for T1DM, miRNA expression in plasma-derived exosomes was measured.

289 in mediating CTL responses to B cell-derived exosomes was ruled out using DHLMP2A mice, which lack se

290 ltured BV2 microglia in vitro The microglial exosomes were collected for miRNA microarray analysis, w

291 Exosomes were isolated from the culture medium of drug-t

292 Exosomes were isolated from the culture-conditioned medi

293 Exosomes were obtained from culture media of primary bro

294 In contrast, CTL responses to DC-derived exosomes were significantly inhibited within Ab-deficien

295 onstrate that skeletal muscle fibers release exosomes which can exert biologically significant effect

296 ontains elevated levels of immunosuppressive exosomes which interfere with anti-leukemia functions of

297 in human T1D, GAD65, IA-2, and proinsulin in exosomes, which are taken up by and activate dendritic c

298 Exosomes, which are vesicles produced through the format

299 ll-cell communication, supported by syntenin exosomes, which is likely to contribute to tumor-host in

300 gs of islet and renal transplantation, donor exosomes with respective tissue specificity for islet be