ライフサイエンスコーパス: exotoxin

1 the remaining 25-kDa portion of Pseudomonas exotoxin.

2 of IL-13 and a truncated form of Pseudomonas exotoxin.

3 wo unrelated toxins, anthrax and Pseudomonas exotoxin.

4 d that it decreases the release of pyocyanin exotoxin.

5 coccal superantigen, streptococcal pyrogenic exotoxin.

6 -4 is fused to a mutated form of Pseudomonas exotoxin.

7 a colonization factor, and cholera toxin, an exotoxin.

8 ells reflects the action of a potent protein exotoxin.

9 /CaM-dependent kinase kinase and the anthrax exotoxin.

10 ety (IL-4) and a mutated form of Pseudomonas exotoxin.

11 IgG) and IgG antibody levels to 11 S. aureus exotoxins.

12 mammals are not the primary targets of these exotoxins.

13 prevent synthesis of Gram-positive bacterial exotoxins.

14 a family of exotoxins called staphylococcal exotoxins.

15 entral cell-binding component of the anthrax exotoxins.

16 ggregates on the HVEC surfaces, and produced exotoxins.

17 homology with known Streptococcus pyrogenic exotoxins.

18 cidogenesis but not by production of protein exotoxins.

19 required for the secretion of antiphagocyte exotoxins.

20 ivate several classes of unrelated bacterial exotoxins.

21 rains are attributed to higher prevalence of exotoxins.

22 lation of IL-31 receptor with staphylococcal exotoxins.

23 lation of IL-31 receptor with staphylococcal exotoxins.

24 in response to bacterial pathogens and their exotoxins.

25 or with a truncated fragment of Pseudomonas exotoxin 38 are able to specifically kill tumors in vitr

26 The catalytic moiety of Pseudomonas exotoxin A (domain III or PE3) inhibits protein synthesi

27 by a number of virulence factors, including exotoxin A (ETA) and the type III cytotoxins (ExoS, ExoT

28 Exotoxin A (ETA) is the most toxic virulence factor of P

29 termed diphtheria toxin (DT) and Pseudomonas exotoxin A (ETA) sensitivity required gene 1 (DESR1), en

30 ysaccharide (LPS), phosholipase C (PLC), and exotoxin A (ETA) were evaluated for their ability to ind

31 e cholera toxin (CT), Pseudomonas aeruginosa exotoxin A (ETA), and ricin, move from the plasma membra

32 NF2, which harbors exotoxin A (exoA) gene, was highly virulent when injecte

33 d a truncated form of Pseudomonas aeruginosa exotoxin A (IL13-PE38QQR) was developed for the targeted

34 s, a nontoxic form of Pseudomonas aeruginosa exotoxin A (ntPE), Bacillus globigii, Mycoplasma hyopneu

35 composed of a nontoxic form of P. aeruginosa exotoxin A (ntPE), where the C-terminal loop amino acid

36 Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that com

37 Pseudomonas exotoxin A (PE) inhibits protein synthesis by NAD-depend

38 Pseudomonas exotoxin A (PE) is a bacterial toxin that arrests protei

39 A number of toxins, including exotoxin A (PE) of Pseudomonas aeruginosa, kill cells by

40 lating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE).

41 Both are fused to a fragment of Pseudomonas exotoxin A (PE38) to create immunotoxins.

42 Fv fused to a 38-kDa fragment of Pseudomonas exotoxin A (PE38).

43 ell fused to a 38-kDa portion of Pseudomonas exotoxin A (PE38).

44 The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavag

45 eriae toxin (DT), and Pseudomonas aeruginosa exotoxin A (PEA).

46 (rPA), or recombinant Pseudomonas aeruginosa exotoxin A (rEPA).

47 eractions, including streptococcal pyrogenic exotoxin A (scarlet fever toxin) and two uncharacterized

48 ced M1 SF370 strain: streptococcal pyrogenic exotoxin A (SpeA) and a streptodornase D (SdaD) homologu

49 erotoxin B (SEB) and streptococcal pyrogenic exotoxin A (SPEA) delivered through the intranasal route

50 on of immunoreactive streptococcal pyrogenic exotoxin A (SpeA) increased.

51 Vbeta8-targeting SAg streptococcal pyrogenic exotoxin A (SpeA), or active immunization with either wi

52 joined to a truncated portion of Pseudomonas exotoxin A (termed PE38) have been evaluated in clinical

53 at the P. aeruginosa translational inhibitor Exotoxin A (ToxA), which ribosylates elongation factor 2

54 itor cycloheximide, saponin, and Pseudomonas exotoxin A additionally confirmed that the resistance wa

55 Exotoxin A also prevented the transporter associated wit

56 f prophages encoding streptococcal pyrogenic exotoxin A and extracellular DNases and (2) the reciproc

57 w for penetration of streptococcal pyrogenic exotoxin A and possibly viable streptococci.

58 (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids an

59 Production of streptococcal pyrogenic exotoxin A by Streptococcus pyogenes was unaffected by a

60 that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory

61 h intratumoral injections of IL4-Pseudomonas exotoxin A experienced complete disappearance of establi

62 Interestingly, exotoxin A expression was unaffected in these mutants.

63 of the superantigen streptococcal pyrogenic exotoxin A from 90.9 +/- 12.7 ng/mL with the control fib

64 surface epitope, and the enzymatic domain of exotoxin A from Pseudomonas aeruginosa.

65 a PtxR as a transcriptional activator of the exotoxin A gene toxA.

66 xin in which a truncated form of Pseudomonas exotoxin A is joined to the variable region of a broadly

67 Streptococcal pyrogenic exotoxin A levels at 9 hrs were 19.9 ng/mL in the contro

68 rence in circulating streptococcal pyrogenic exotoxin A levels between the groups.

69 fic polysaccharide conjugated to recombinant exotoxin A of Pseudomonas aeruginosa (O157-rEPA) was saf

70 idate consisting of a genetically detoxified exotoxin A of Pseudomonas aeruginosa covalently linked t

71 Clostridium difficile, diphtheria toxin, and exotoxin A of Pseudomonas aeruginosa; however, this is t

72 th oprI primers, 11 of 13 were positive with exotoxin A primers, and 10 of 13 were positive with algD

73 ers for gyrB or oprI, 98% were positive with exotoxin A primers, and 90% were positive with algD prim

74 gyrB or oprI primers, 96% were positive with exotoxin A primers, and 92% were positive with algD prim

75 ribed human diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1 and that DPH4 enc

76 SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen.

77 etween the rise of anti-cell lysate and anti-exotoxin A titer and a WCXR score of 5 or more (P =.24 a

78 y antibodies (VHH) conjugated to Pseudomonas exotoxin A to deplete myeloid cells in vitro and in vivo

79 ciated with bacterial challenge, and reduced exotoxin A toxicity.

80 electin targeting domain, (ii) a Pseudomonas exotoxin A translocation domain, and (iii) a NF-kappaB E

81 portion of the bacterial protein Pseudomonas exotoxin A which consists of the toxin moiety of the RIT

82 or control cells with saporin or Pseudomonas exotoxin A whose intracellular mechanism of activation i

83 srupt T-cell epitopes in GFP and Pseudomonas exotoxin A without disrupting function.

84 ocation and enzymatic domains of Pseudomonas exotoxin A), showed limited promise in initial clinical

85 nly partially dependent upon it (Pseudomonas exotoxin A).

86 receptor-binding domain (Ia) of Pseudomonas exotoxin A, AdPEDI-(Abeta1-6)(11), is effective in induc

87 17.8, 24.2, and 70.9 months for cell lysate, exotoxin A, and elastase, respectively.

88 proteins: recombinant Pseudomonas aeruginosa exotoxin A, and ovalbumin, using amide, hydrazone, or th

89 era toxin, ricin, and Pseudomonas aeruginosa exotoxin A, are transported to the lumen of the endoplas

90 ice from lethal challenge with streptococcal exotoxin A, as well as from lethal GAS bacterial infecti

91 oding TonB, alkaline protease,PrpL protease, exotoxin A, as well as fumarase C, Mn-dependent superoxi

92 rived from the bacterial protein Pseudomonas exotoxin A, as well as to the model Ag keyhole limpet he

93 toxin, cholera toxin, Pseudomonas aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.

94 sed to PE38, a 38-kDa portion of Pseudomonas exotoxin A, has produced many complete remissions in dru

95 helin Fab fused to domain III of Pseudomonas exotoxin A, in which immunogenic B-cell epitopes are sil

96 including Sic, SpeB, streptococcal pyrogenic exotoxin A, Mac protein, and streptococcal phospholipase

97 ticulin, domain II of Pseudomonas aeruginosa exotoxin A, or the sorting signal of the lysosome-associ

98 invasive virulence factors, including T3SS, exotoxin A, protease IV, and TFP.

99 albumin, recombinant Pseudomonas aeruginosa exotoxin A, recombinant B. anthracis protective antigen

100 syndrome toxin-1 and streptococcal pyrogenic exotoxin A, respectively, across porcine vaginal mucosa

101 e, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T, U, or Y.

102 Exogenous Pseudomonas aeruginosa Exotoxin A, which inhibits protein translocation from th

103 y of a recombinant cytotoxin IL4-Pseudomonas exotoxin A, which is composed of a targeting moiety (IL-

104 cer cells joined to a portion of Pseudomonas exotoxin A, which kills the cell.

105 ne via the endocytosed translation inhibitor Exotoxin A, which leads to an increase in ZIP-2 protein

106 d ENaC activation and Pseudomonas aeruginosa exotoxin A-induced cell death.

107 portion of the bacterial protein Pseudomonas exotoxin A.

108 he cytotoxic effects of diphtheria toxin and exotoxin A.

109 he prophage encoding streptococcal pyrogenic exotoxin A.

110 diphtheria toxin and Pseudomonas aeruginosa exotoxin A.

111 the SpeA4 variant of streptococcal pyrogenic exotoxin A.

112 fused to a truncated portion of Pseudomonas exotoxin A.

113 ctors, namely pyoverdine, PrpL protease, and exotoxin A.

114 ds to CD22 fused to a portion of Pseudomonas exotoxin A.

115 ti-CD22 Fv fused to a portion of Pseudomonas exotoxin A.

116 stent with this hypothesis, we found that C3 exotoxin (a Rho-specific inhibitor) and HA1077 (an inhib

117 d by treatment with Clostridium botulinum C3 exotoxin, a specific inactivator of RhoA family members.

118 Unlike the acute effects of superantigen exotoxins absorbed through the gut or vaginal mucosa, li

119 pre-existing neutralizing Abs to Pseudomonas exotoxin, allowing RIT treatment.

120 (S. aureus) that produce the staphylococcal exotoxin alpha-toxin.

121 asured humoral responses to 2 staphylococcal exotoxins, alpha-hemolysin (Hla) and Panton-Valentine le

122 MRSA exotoxins also caused neutrophil (polymorphonuclear leuk

123 Consistent with these results, C3 exotoxin, an inhibitor of RhoA activation, significantly

124 Inhibition of Rho with C3 exotoxin and a dominant negative Rho adenovirus and inhi

125 d the cytotoxic action of native Pseudomonas exotoxin and enhanced SS1P toxicity on several human cel

126 antigen and a fusion protein of Pseudomonas exotoxin and lethal factor was tested for anti-lung canc

127 tes examined produce one or more heat-labile exotoxins and may suggest that M. ovis plays a role in t

128 cts, lytic agents, numerous types of protein exotoxins, and bacteriocins.

129 oxin-1 (TSST-1), and streptococcal pyrogenic exotoxins] and anthrax toxin are bioterrorism agents tha

130 sease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (E

131 lls from the lytic effects of three of these exotoxins: anthrolysin O (ALO), listeriolysin O, and pne

132 Immunotoxins derived from Pseudomonas exotoxin are antibody-toxin fusion proteins that inhibit

133 The genes that encode these exotoxins are commonly found in bacterial viruses (bacte

134 that target the cytotoxic effects of anthrax exotoxins are needed.

135 Prior studies suggest Staphylococcus aureus exotoxins are not produced when the organism is cultured

136 Host mechanisms that protect against such exotoxins are poorly understood.

137 We also show that Prymnesium exotoxins are released independently of contact toxicity

138 Catalytic rate enhancements by the bacterial exotoxins are small, and thus transition-state analogues

139 munity, but is also accelerated by bacterial exotoxins as a mechanism of immune evasion.

140 Infochemicals and exotoxins associated with P. aeruginosa are capable of c

141 ne protease known as streptococcal pyrogenic exotoxin B (SpeB) is a key virulence factor that is prod

142 Streptococcal pyrogenic exotoxin B (SpeB) is a protease secreted by group A stre

143 Streptococcal pyrogenic exotoxin B (SpeB) is an extracellular cysteine protease

144 The streptococcal pyrogenic exotoxin B (SpeB) is an important virulence factor of gr

145 racellular protease, streptococcal pyrogenic exotoxin B (SpeB), capsular hyaluronic acid, and protein

146 ar toxins, including streptococcal pyrogenic exotoxin B (SpeB), have been implicated in pathogenesis.

147 complement (Sic) and streptococcal pyrogenic exotoxin B (SpeB).

148 ns, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB).

149 plasmin receptor and streptococcal pyrogenic exotoxin B are currently considered major putative nephr

150 The exotoxin-based genotyping method was able to discriminat

151 SS1P, a Pseudomonas exotoxin-based immunotoxin, was chosen because it is now

152 or the inhibitors 1-butanol, Y-27632, or C3 exotoxin before stimulation with the cholinergic agonist

153 injury and mortality through the delivery of exotoxins by the type III secretion system (TTSS).

154 crystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) re

155 the phage-associated streptococcal pyrogenic exotoxin C (SpeC).

156 n-like proteins, which belong to a family of exotoxins called staphylococcal exotoxins.

157 Several staphylococcal exotoxins can act as superantigens and/or antigens in mo

158 The bacterial exotoxins, cholera toxin (CT), pertussis toxin (PT), and

159 anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activ

160 d/or Shiga toxin 2 (Stx2), both of which are exotoxins comprised of active (A) and binding (B) subuni

161 eurotoxin SP-PE35, a substance P-Pseudomonas exotoxin conjugate, selectively targets striatal choline

162 , an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell li

163 on of CaM between two domains of the anthrax exotoxin (d) binding of Ca2+ ions to only one EF-hand pa

164 This 'Trojan Horse' mechanism of exotoxin delivery into predator cells allows intoxicatio

165 duces a potent bacteriophage-encoded protein exotoxin, diphtheria toxin (DT), which causes the sympto

166 that, in addition to Stx, the phage-encoded exotoxin, diphtheria toxin (Dtx) expressed by Corynebact

167 g that intoxication of Acanthamoeba by these exotoxins does not require a receptor.

168 ion of hyaluronic acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exot

169 cytotoxic strains use this system to secrete exotoxin (Exo)U and ExoT causing cytotoxicity and inhibi

170 ere assayed in vitro for secretion of type 3 exotoxins (ExoU, ExoT, and ExoS).

171 C3 exotoxin, expression of dominant negative RhoA, and inhi

172 t the site of the intramuscular injection of exotoxins from an invasive M-type 1 GAS, which caused a

173 tissue destruction, we investigated whether exotoxins from MRSA could stimulate formation of PNAs in

174 human IL-13 and a derivative of Pseudomonas exotoxin, from days 38 to 44 after the conidia challenge

175 ric anthrax toxin lethal factor, Pseudomonas exotoxin fusion protein, was extremely toxic to mice, ca

176 iated isolates typically possessed different exotoxin gene profiles (eg, Panton Valentine leukocidin

177 Phage-carried exotoxin genes are widespread in the environment and are

178 ized by its ability to internalize bacterial exotoxins, GPI-linked proteins, and extracellular fluid.

179 represent a non-functional heavy atom in an exotoxin group that has diverged from related bacterial

180 Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding doma

181 Exotoxins have been implicated in the pathogenesis of th

182 ver toxin) and two uncharacterized pyrogenic exotoxin homologues, all phage-associated.

183 s blooms coupled with the presence of potent exotoxins; however, no chemical standards are currently

184 Additional exotoxin identification studies of USA200 strain [S. aur

185 uman IL-13 and a mutated form of Pseudomonas exotoxin (IL-13-PE) might affect pathological features o

186 n protein comprised of IL-13 and Pseudomonas exotoxin (IL13-PE) on the development of pulmonary granu

187 IL-13 and a truncated version of Pseudomonas exotoxin (IL13-PE), the proliferation of primary usual i

188 IL-13 and a truncated version of Pseudomonas exotoxin (IL13-PE), which targets and kills IL-13 recept

189 be useful in the management of Gram-positive exotoxin illnesses; its action appears to be membrane st

190 n composed of IL-4 and truncated Pseudomonas exotoxin in animal models of pancreatic ductal adenocarc

191 evels of the anthrax protective antigen (PA) exotoxin in biological fluids, we have developed a metal

192 first gene in this operon (rtxA) encodes an exotoxin in vibrios, while other genes code for proteins

193 reus can elaborate a variety of superantigen exotoxins in "carrier" or "pathogenic" states.

194 The expression of type 3 secretion system exotoxins in bacteremic isolates of P. aeruginosa confer

195 However, the role of these staphylococcal exotoxins in disease pathogenesis remains unclear.

196 strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.

197 ibosylation of RhoA by Clostridium botulinum exotoxin inactivated RhoA signaling and resulted in the

198 ins, leading to inhibition of staphylococcal exotoxins, included the two-component system SrrA-SrrB.

199 in vivo production of potent staphylococcal exotoxins, including Panton-Valentine leukocidin (PVL) a

200 in composed of IL-13 and mutated Pseudomonas exotoxin induced specific killing of IL-13Ralpha2(+) tum

201 markable features describing how a bacterial exotoxin induces virulence exclusively in specific cells

202 a 'Trojan Horse', carrying genes encoding an exotoxin into target organisms.

203 gy of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to

204 HNP-1 to HNP-3 to inhibit so many different exotoxins is proposed.

205 ch of these, the production of sophisticated exotoxins is the main cause of disease.

206 he prophage encoding streptococcal pyrogenic exotoxin K (SpeK) and extracellular phospholipase A(2) (

207 Bacterially derived exotoxins kill eukaryotic cells by inactivating factors

208 H. pylori secretes a pore-forming exotoxin known as vacuolating toxin (VacA).

209 anthrax toxin is the toxic component of the exotoxin (lethal toxin) secreted by toxic strains of Bac

210 he cell-binding component of the two anthrax exotoxins: lethal toxin (LeTx) and edema toxin.

211 ands in S. aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S.

212 cal superantigens, designated staphylococcal exotoxin-like (SET) proteins.

213 We suggest that such exotoxins may have evolved for the purpose of bacterial

214 g a mutated human IL-13 fused to Pseudomonas exotoxin (mhIL-13-PE) that specifically binds to IL13Ral

215 These results reveal how the exotoxin of an intracellular pathogen engages host pathw

216 Many exotoxins of Gram-positive bacteria, such as superantige

217 Exotoxins of Staphylococcus aureus belong to a family of

218 the ability of GML to inhibit the effects of exotoxins on mammalian cells and prevent rabbit lethalit

219 Inhibition of RhoA activity with C3 exotoxin or a dominant-negative RhoA blocks AMPH-induced

220 ment with Clostridium botulinum exoenzyme C3 exotoxin or expression of dominant negative RhoA blocks

221 complement-related membrane attack complex, exotoxins, or cytotoxic T cells.

222 oding a 38-kDa truncated form of Pseudomonas exotoxin (PE38) to generate the IT 8H9(scFv)-PE38.

223 (IL-13) and a truncated form of Pseudomonas exotoxin (PE38QQR).

224 Tetanus neurotoxin (TeNT) is an exotoxin produced by Clostridium tetani that causes para

225 Pertussis toxin (PTX) is an AB5-type exotoxin produced by the bacterium Bordetella pertussis,

226 This report identifies a new exotoxin produced by this organism, termed SpyA, for S.

227 we examined the early role played by another exotoxin produced by this pathogen, adenylate cyclase to

228 tending toxins (CDTs) are tripartite protein exotoxins produced by a diverse group of pathogenic Gram

229 This is primarily due to the pathogenic exotoxins produced by Bacillus anthracis as well as othe

230 Interestingly, only exotoxins produced by bacteria internalized by the Acant

231 LKT), which is a member of the RTX family of exotoxins produced by many gram-negative bacteria.

232 Among the exotoxins produced by Staphylococcus aureus and Streptoc

233 GAS SAgs, namely the streptococcal pyrogenic exotoxins produced by the globally disseminated M1T1 GAS

234 Exotoxin production by both methicillin-resistant and me

235 bin (as low as 1 mug/mL) inhibited S. aureus exotoxin production while increasing production of prote

236 ability of alpha and beta globin to inhibit exotoxin production.

237 s virulence factors, including siderophores, exotoxin, proteases and haemolysin.

238 ructural rearrangement of sub-domains of the exotoxin protective antigen (PA).

239 hion and that a chimeric 5-Helix/Pseudomonas exotoxin protein recognizes cells expressing Env from a

240 us pyogenes (GAS) express superantigen (SAg) exotoxin proteins capable of inducing lethal shock.

241 Among these, the redox active exotoxin pyocyanin (PCN) is produced in concentrations u

242 h-killing P. shumwayae do not secrete potent exotoxins; rather, fish mortality results from micropred

243 g from many bacterial diseases are caused by exotoxins released by the bacteria.

244 six genes (rtxACHBDE), where rtxA encodes an exotoxin, rtxC encodes an RtxA activator, rtxH encodes a

245 hages were prestimulated with staphylococcal exotoxins (SEB, alpha-toxin) to up-regulate the IL-31 re

246 The exotoxins secreted by B. anthracis use capillary morphog

247 Exotoxins secreted by bacteria take advantage of the hos

248 ct of SpeB on the activity of superantigenic exotoxins secreted by M1T1 GAS isolates.

249 his paper describes a biosensing concept for exotoxins secreted by Staphylococcus aureus and Pseudomo

250 Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptoc

251 lates into 22 distinct subgroups, designated exotoxin sequence types (ETST), while the standard seven

252 ed in pathogenesis (e.g., staphylocoagulase, exotoxin, Ser-Asp fibrinogen-binding bone sialoprotein-b

253 The bacterial exotoxin Shiga toxin is endocytosed by mammalian host ce

254 rulence factors, the streptococcal pyrogenic exotoxin (Spe) A and the cysteine protease SpeB, was rec

255 Streptococcal pyrogenic exotoxin (Spe) B, a streptococcal cysteine protease, is

256 superantigen (ssa), streptococcal pyrogenic exotoxins (speC, speH, and speI), and DNases (spd1 and s

257 lammatory cytokines following staphylococcal exotoxins' stimulation in human macrophages.

258 Bacterial exotoxins, such as Escherichia coli heat-labile enteroto

259 zolid resulted in significant suppression of exotoxin synthesis and improved survival outcomes in a r

260 coccal enterotoxin B (SEB), a shock-inducing exotoxin synthesized by Staphylococcus aureus, is an imp

261 nteracts with the type III-secreted effector exotoxin T (ExoT) and plays a key role in vivo in limiti

262 tokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner.

263 The exotoxins TcdA and TcdB are the major virulence factors

264 The disease is caused mainly by two exotoxins, TcdA and TcdB, produced by the bacteria.

265 idium difficile infections are caused by two exotoxins, TcdA and TcdB, which target host colonocytes

266 major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the pr

267 se symptoms are caused by the two homologous exotoxins, TcdA and TcdB.

268 rcularly permuted human IL-4 and Pseudomonas exotoxin termed IL4(38-37)-PE38KDEL, or IL-4 cytotoxin.

269 ny pathogenic gram-positive bacteria release exotoxins that belong to the family of cholesterol-depen

270 s (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especiall

271 ubstrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans.

272 us has numerous virulence factors, including exotoxins that may increase the severity of infection.

273 Staphylococcal enterotoxins are superantigen exotoxins that mediate food poisoning and toxic shock sy

274 esumably through the release of allelopathic exotoxins that offer advantages for Prymnesium in its in

275 ed and seems to be not valid for the anthrax exotoxin, the CaM-regulated K+-channel and possibly also

276 s from environmental exposure to Pseudomonas exotoxin, the component of the RIT that elicits the neut

277 Of these exotoxins, the superantigens (SAg) are likely most patho

278 a and P. shumwayae reportedly secrete potent exotoxins thought to cause fish lesion events, acute fis

279 ents using constitutively active Cdc42 or C3 exotoxin to inhibit Rho GTPase supported a role of Rho G

280 atory and skin infections, produces numerous exotoxins to establish infection.

281 particular toxin, allowing bacteria-bearing exotoxins to kill a broader spectrum of predators, incre

282 The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced

283 C. difficile releases 2 structurally similar exotoxins, toxin A and toxin B, animal experiments sugge

284 CDAD pathology is induced by two exotoxins, toxin A and toxin B, which have been shown to

285 the T3SS apparatus itself, independently of exotoxin translocation.

286 ensitive) or their endotoxins (LTA + PGN) or exotoxins (TSST-1).

287 or a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus syste

288 A T3SS effector, exotoxin U (ExoU), can inhibit activation of the NLRC4 i

289 eria expressed the phospholipase A2 effector Exotoxin U (ExoU).

290 were tested for the genes encoding S. aureus exotoxins using polymerase chain reaction (PCR).

291 ously we found that pertussis toxin (PT), an exotoxin virulence factor produced by Bordetella pertuss

292 o determine whether pertussis toxin (PT), an exotoxin virulence factor produced exclusively by Bordet

293 ples of chemical entities designed to target exotoxin virulence factors from important human bacteria

294 hich point both IgG titers against S. aureus exotoxins were determined, and the functionality of the

295 Exotoxins which belong to the family containing the RTX

296 tibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in host response.

297 tor of the geranylgeranylation of Rho; by C3 exotoxin, which inactivates Rho; and by the adenoviral e

298 Transport of Pseudomonas exotoxin, which is transported to the ER by binding to t

299 ins is the NAD(+)-dependent ADP-ribosylating exotoxins, which include pertussis, cholera, and diphthe

300 ective antigen component of the B. anthracis exotoxin with high affinity and conjugated to polyethyle

301 Exotoxin Y (ExoY) is a type III secretion system effecto