ライフサイエンスコーパス: expanded polyglutamine tract

1 with disease caused by ATXN1[82Q] having an expanded polyglutamine tract.

2 plasmids expressing a transcript encoding an expanded polyglutamine tract.

3 pression of mutant ataxin-1 that contains an expanded polyglutamine tract.

4 lve interactions with other proteins via the expanded polyglutamine tract.

5 generation requires expressing ATXN1 with an expanded polyglutamine tract.

6 neurodegenerative disorders associated with expanded polyglutamine tracts.

7 caused by expression of proteins containing expanded polyglutamine tracts.

8 ed in other transgenic models overexpressing expanded polyglutamine tracts.

9 ucts containing SBMA or DRPLA with normal or expanded polyglutamine tracts.

10 N-terminal huntingtin fragments with an expanded polyglutamine tract aberrantly localized to int

11 In contrast, Drosophila expressing an expanded polyglutamine tract alone, or an expanded polyg

12 Previous studies suggest that expanded polyglutamine tracts alter transcription by seq

13 This flexibility is impaired with expanded polyglutamine tracts, and we can detect changes

14 aggregation of the androgen receptor with an expanded polyglutamine tract (AR-polyQ) has been linked

15 asm, N-terminal fragments of huntingtin with expanded polyglutamine tracts are able to accumulate in

16 Expanded polyglutamine tracts are responsible for at lea

17 ataxin-1 SUMOylation in the presence of the expanded polyglutamine tract, ataxin-1[82Q].

18 Here we show that polypeptides containing expanded polyglutamine tracts, but not normal N-terminal

19 A gain of toxic function as a result of an expanded polyglutamine tract can cause the protein hunti

20 Expanded polyglutamine tracts cause huntingtin and other

21 sfolding of huntingtin (HTT) protein with an expanded polyglutamine tract, could also benefit from th

22 Here we show that the expanded polyglutamine tract differentially affects the

23 rotein aggregation diseases is an abnormally expanded polyglutamine tract found in the respective pro

24 d a direct viral approach to locally express expanded polyglutamine tracts fused to the green fluores

25 An expanded polyglutamine tract (>37 glutamines) in the N-t

26 pressing a human huntingtin fragment with an expanded polyglutamine tract (Htn-Q150).

27 huntingtin's protein exon-1 fragment with an expanded polyglutamine tract (Htt-103Q), which is depend

28 It has been suggested that proteins with expanded polyglutamine tracts impair ubiquitin-dependent

29 ington's disease (HD), which is caused by an expanded polyglutamine tract in huntingtin (htt).

30 It is caused by an expanded polyglutamine tract in huntingtin (Htt).

31 ssive neurodegenerative disease caused by an expanded polyglutamine tract in huntingtin protein (Htt)

32 an expanded polyglutamine tract alone, or an expanded polyglutamine tract in the context of the spino

33 Huntington disease derives from a critically expanded polyglutamine tract in the huntingtin (Htt) pro

34 etic neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin protein.

35 Huntington's disease (HD) is caused by an expanded polyglutamine tract in the huntingtin protein.

36 The resulting expanded polyglutamine tract in the N-terminal region of

37 Huntington's disease (HD) is caused by an expanded polyglutamine tract in the protein huntingtin (

38 In addition, the presence of an expanded polyglutamine tract in the SBMA androgen recept

39 inant neurodegenerative disease caused by an expanded polyglutamine tract in the ubiquitously express

40 f CHIP to protect against toxicity caused by expanded polyglutamine tracts in different protein conte

41 he pathway to neuronal dysfunction, while an expanded polyglutamine tract is essential for neuronal d

42 In SCA1, the expanded polyglutamine tract is in the ataxin-1 (ATXN1)

43 Aggregation of expanded polyglutamine tracts is associated with nine di

44 otoxicity induced by Htt proteins containing expanded polyglutamine tracts is likely mediated, at lea

45 ion of the mutant huntingtin protein with an expanded polyglutamine tract plays a central role in the

46 cterized by misfolding and aggregation of an expanded polyglutamine tract (polyQ).

47 ed on identifying the mechanism by which the expanded polyglutamine tract renders a protein toxic to

48 ical features caused by ATXN1[82Q] having an expanded polyglutamine tract, they fail to manifest the

49 The expansion results in an expanded polyglutamine tract, which likely confers a nov

50 es of mutant huntingtin exon 1 containing an expanded polyglutamine tract with 51 residues (mhttQ51),

51 rmal CAG expansion, which translates into an expanded polyglutamine tract within ataxin-3.