ライフサイエンスコーパス: experimental animal

1 ve differed by study, age at evaluation, and experimental animal.

2 tes to these differences using the rat as an experimental animal.

3 y has been advanced greatly using rodents as experimental animals.

4 focused on polyclonal antibody responses in experimental animals.

5 dministered (99m)Tc-MAG3 and (99m)Tc-DTPA in experimental animals.

6 significantly different between control and experimental animals.

7 significantly different between control and experimental animals.

8 nvironment and the motor capabilities of the experimental animals.

9 ivalent glycemic control in both control and experimental animals.

10 ponses, and increased addiction behaviors in experimental animals.

11 eptive itch through studies using humans and experimental animals.

12 t variations in pathogenicity for humans and experimental animals.

13 ne candidates against pneumonic tularemia in experimental animals.

14 furthermore, it had no apparent toxicity in experimental animals.

15 ulnerability to drug addiction in humans and experimental animals.

16 regulatory T cells (Tregs) prevents GVHD in experimental animals.

17 ate with chronic pain symptoms in humans and experimental animals.

18 ditioned media of Abeta-secreting cells into experimental animals.

19 la and converge with connectivity studies in experimental animals.

20 ng and prolong maximal lifespan up to 60% in experimental animals.

21 ured cells as well in the blood and urine of experimental animals.

22 in networks, which have been studied only in experimental animals.

23 ression of cytokines, eventually killing the experimental animals.

24 and consistently increase insulin action in experimental animals.

25 idly and reliably visualize blood vessels in experimental animals.

26 idely distributed pattern of synapses in our experimental animals.

27 in and destroy hypoxic regions of tumors in experimental animals.

28 nd causes Q fever in humans and pathology in experimental animals.

29 i muscle confirm the androgenic treatment in experimental animals.

30 etic triterpenoids to prevent lung cancer in experimental animals.

31 firmed successful yet mild infections in all experimental animals.

32 ect regenerative growth of the myocardium in experimental animals.

33 s they generate potent anti-tumor effects in experimental animals.

34 and major catecholamines in brain tissue of experimental animals.

35 tion relapsing fever (RF) in both humans and experimental animals.

36 otein that inhibits the action of insulin in experimental animals.

37 ern blot (WB) analysis in brain samples from experimental animals.

38 naphylaxis have been clearly demonstrated in experimental animals.

39 s can be recognized by the immune systems of experimental animals.

40 inhibitors against coronavirus infection in experimental animals.

41 d antitumor efficacy against glioblastoma in experimental animals.

42 administration of either APC or Seprafilm to experimental animals.

43 ected by prenatal stress is possible only in experimental animals.

44 pression in diseased cells from patients and experimental animals.

45 T cell depletion can prevent hypertension in experimental animals.

46 roduce most of the typhoid fever symptoms in experimental animals.

47 ons can be propagated in cell culture and in experimental animals, affording both in vitro and in viv

48 man lung cell injury in vitro and protecting experimental animals against lethal S. aureus pneumonia.

49 fic monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (

50 monary artery endothelial cells (HPAECs) and experimental animals [AMPK subunit alpha-deficient mice

51 y liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies.

52 Supporting a causal role of disturbed sleep, experimental animal and human studies have found that sl

53 Experimental animal and human studies that have probed t

54 hibitors, this article reviews the available experimental animal and human trial evidence that provid

55 The parallel between experimental animal and observational human data lends s

56 dy is an effective therapy against plague in experimental animals and could be developed as a rapidly

57 variety of techniques, caused loss of ICC in experimental animals and demonstrated the critical physi

58 Hyperoxia contributes to lung injury in experimental animals and diseases such as acute respirat

59 Super-low-dose endotoxemia in experimental animals and humans is linked to low-grade c

60 way of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly unde

61 well as the diminished adiposity observed in experimental animals and humans.

62 ts for the different foam cell phenotypes in experimental animals and humans.

63 e CD8+ T-cell and B-cell immune responses in experimental animals and humans.

64 in the development of intestinal adenomas in experimental animals and in adenomas and colorectal canc

65 usively estrogen-dependent mammary tumors in experimental animals and in having E4 region-encoded ope

66 Increased levels of 20-HETE in experimental animals and in humans are associated with h

67 sed risk of cancer at several organ sites in experimental animals and in humans.

68 f the processing activity in the vitreous of experimental animals and in patients with PVR.

69 g, cytokine-associated, flu-like syndrome in experimental animals and in patients, but the underlying

70 es acute inflammation and fluid secretion in experimental animals and patients with C difficile infec

71 e incorporated into future vaccine trials in experimental animals and possibly in humans.

72 factor for hepatocellular carcinoma (HCC) in experimental animals and reveal opposing roles for the n

73 iogenesis and improve insulin sensitivity in experimental animals and, while overcoming hepatic steat

74 over the past 15 years on prebiotics through experimental, animal and human studies, with the aim to

75 nd characterized thousands of epidemiologic, experimental animal, and mechanistic studies, and addres

76 kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic app

77 vergent pharmacokinetics exist in humans and experimental animals, and one reason for these variation

78 ts of serotonin on dopaminergic circuitry in experimental animals, and preclinical findings have impl

79 type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determin

80 However, recent findings in experimental animals appear controversial.

81 ish correlation, not causation, and existing experimental animal approaches alter multiple components

82 Prion incubation periods in experimental animals are known to vary inversely with ex

83 Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying d

84 ghrelin levels were measured in control and experimental animals as a change from baseline ghrelin v

85 d human sera, validating the use of nonhuman experimental animals as a model for determining antigeni

86 cine immunogenicity had not been assessed in experimental animals because fHbp binds human fH specifi

87 e cell wall of M. tuberculosis isolated from experimental animals because of the low amounts of bacte

88 iphenyl were examined based on evidence from experimental animal bioassays and mechanistic studies.

89 In experimental animals, BPA increases embryo implantation

90 gene product expression that is sustained in experimental animals but not in human subjects.

91 Several extrahepatic sites were tested in experimental animals, but many have practical limitation

92 ults in long-term expression of transgene in experimental animals, but only short-term expression in

93 d retinal photoreceptor damage in humans and experimental animals, but the mechanism(s) remain unclea

94 s contribute to alcohol-related behaviors in experimental animals, but their potential role in humans

95 adiposity and systemic insulin resistance in experimental animals, but what maintains eosinophils in

96 d as a headache trigger and can be evoked in experimental animals by electrical or chemical stimulati

97 In recent years, studies carried out in experimental animals by morphological and physiological

98 animal care and use committee and adhered to experimental animal care guidelines.

99 ion of lens calcium occurs in both human and experimental animal cataracts, and opacification may res

100 ]methionine administered intraportally to an experimental animal; clarification of the intracellular

101 y a few nucleotides become more prevalent in experimental animal colonies.

102 AP was at the edge of detection, and in some experimental animals, completely eradicated.

103 Although experimental animal data for hypothermia have been promi

104 Aging of experimental animals demonstrated that constitutive reac

105 ad lib chow control animals, the results for experimental animals demonstrated that fetal exposure si

106 Some humans and experimental animals develop both humoral and cell-media

107 control animal received a shock whenever the experimental animal did, regardless of its own gill posi

108 Monocytes isolated from septic patients and experimental animals display a "deactivated" phenotype,

109 n animals ?" and to rate the strength of the experimental animal evidence.

110 asites of both sexes recovered from infected experimental animals exhibit vivid fluorescence througho

111 In addition, experimental animals exhibited significant downregulatio

112 al analysis of the literature for humans and experimental animals exposed to certain environmental ch

113 s will be necessary to further explore these experimental animal findings.

114 bbit (Oryctolagus cuniculus) is an important experimental animal for studying human diseases, such as

115 modified by learning shifted over time: the experimental animals had a larger increase in the freque

116 Compared to their matched controls, experimental animals had decreased posttransplant marker

117 Decades of work in experimental animals has established the importance of v

118 s, plus preliminary evidence of virulence in experimental animals, has suggested that ST131's epidemi

119 Many cancer immunotherapies developed in experimental animals have been tested in clinical trials

120 Studies of neuropsychological patients and experimental animals have demonstrated that the striatum

121 Studies in experimental animals have provided evidence that consump

122 onsistent with this general rule, studies in experimental animals have shown that broadly neutralizin

123 ons on the development of most behaviours in experimental animals housed in spatially enriched caging

124 come highly instrumental to induce tumors in experimental animals in a tissue-specific manner with th

125 icrobial activity against M. tuberculosis in experimental animals in vivo.

126 first examination of Myh9 kidney disease in experimental animals, in the context of recent findings

127 is review summarizes key recent studies from experimental animals, in vitro models, and human cohorts

128 imaging of healthy volunteers, and work with experimental animals including lesion studies, imaging a

129 Experimental animals infected by Trypanosoma cruzi showe

130 cterium tuberculosis bacteria in established experimental animal infections are acid-fast negative, c

131 Additionally, experimental animal investigations show that neuropathic

132 elopmental basis of teratogenic exposures in experimental animals is an important approach to underst

133 In experimental animals, M. tuberculosis infects no fewer t

134 a C protein elicits protective antibodies in experimental animals, making beta C protein an attractiv

135 In experimental animals, maternal diet during the periconce

136 e a human metabolic disease is induced in an experimental animal model by human hepatocyte transplant

137 These ligands were tested in an experimental animal model containing tumors that express

138 Clinical, in-vitro and experimental animal model evidence continues to mount in

139 To review the clinical, in-vitro and experimental animal model evidence for the pathogenicity

140 iniature pigs in the world and is used as an experimental animal model for life science research.

141 g disease in mice provides a highly relevant experimental animal model for multiple sclerosis.

142 ammatory demyelinating disease, providing an experimental animal model for multiple sclerosis.

143 h Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis

144 to mediate collagen Ab-induced arthritis, an experimental animal model of immune complex-induced join

145 This daring conclusion that is based on an experimental animal model should now be confirmed in hum

146 is lacking, non-randomized observational and experimental animal model studies were used.

147 this review we focus on several widely used experimental animal model systems to highlight differenc

148 es in suppressing tumor cell regrowth in two experimental animal model systems.

149 Thus, in this experimental animal model, a high-titer vaccine-induced

150 Miniature pigs have been used as an experimental animal model, but they are still large and

151 In an experimental animal model, we show that in vitro knockdo

152 mechanisms underlying these events using an experimental animal model, we show that inflammation may

153 y counteracted acute lung eosinophilia in an experimental animal model.

154 ing microembolization to migraine aura in an experimental animal model.

155 Analysis of these gene products in experimental animal models and cell systems has led to a

156 Experimental animal models and epidemiological data indi

157 ng in pain conditions.SIGNIFICANCE STATEMENT Experimental animal models and human psychophysical stud

158 g to the changes observed with aging in both experimental animal models and humans.

159 Drawing from experimental animal models and observational human studi

160 stroke pathology has been underestimated in experimental animal models and this may have contributed

161 Experimental animal models are indispensable to the fiel

162 Studies in humans and experimental animal models are revealing the genetic and

163 in, DJ-1, PINK-1 and LRRK2) and studies from experimental animal models has provided crucial insights

164 Several lines of evidence in experimental animal models have indicated the central ro

165 Previous studies in experimental animal models have reported that administra

166 Experimental animal models of AKI demonstrate that renal

167 iting cardiomyocyte apoptosis in 2 different experimental animal models of AMI.

168 he functions of natural killer (NK) cells in experimental animal models of atherosclerosis, it is not

169 pidemiologic studies, with some support from experimental animal models of atherosclerosis.

170 The most commonly used experimental animal models of CHIKV infection are mice a

171 responses are present in cells derived from experimental animal models of diabetes.

172 he sympathetic nervous system alterations in experimental animal models of hypertension.

173 and Rhizopus oryzae has been demonstrated in experimental animal models of infection.

174 ded evidence of such processes in humans and experimental animal models of insulin-resistant diabetes

175 Immunologic studies involving experimental animal models of L. tropica infection are v

176 linical studies of liver disease and certain experimental animal models of liver injury conspicuously

177 cularization and pulmonary hypertension in 2 experimental animal models of PAH in vivo Up-regulation

178 In experimental animal models of sepsis telavancin was show

179 Experimental animal models of type 1 diabetes mellitus (

180 Genome-wide association studies and experimental animal models point at a central role of th

181 Many fail because experimental animal models poorly predict human xenobiot

182 Furthermore, arguments based on experimental animal models suggest a critical role of th

183 Recent studies involving experimental animal models suggest a role of the gut mic

184 Observational human studies and experimental animal models suggest that childhood exposu

185 Previous results from experimental animal models suggest that post-TBI hypergl

186 Accumulated evidence from experimental animal models suggests that neuronal loss w

187 We review the recent clinical trials and experimental animal models that provide evidence in supp

188 grating patient-based data with results from experimental animal models to gain deeper understanding

189 cilitates studies in platelets obtained from experimental animal models without the need of special d

190 In experimental animal models, administration of talactofer

191 sceptibility, the necessity for adjuvants in experimental animal models, and the often paradoxical ef

192 malformations have been produced in multiple experimental animal models, by perturbing selected molec

193 In experimental animal models, chronic stress leads to neur

194 , explanted and biopsied human material, and experimental animal models, have demonstrated that liver

195 Due to the paucity of experimental animal models, little is known about how ho

196 Importantly, in experimental animal models, low dietary potassium intake

197 dvanced, at least in part, due to the use of experimental animal models, particularly the model of ce

198 ition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identif

199 t and growth of carcinogen-induced tumors in experimental animal models, results from human studies a

200 As with all experimental animal models, they are flawed in one way o

201 iding effective reduction of tumor burden in experimental animal models.

202 nset is limited by the lack of adjuvant-free experimental animal models.

203 ber D (NKG2D) mediates antitumor immunity in experimental animal models.

204 been developed for use in the clinic and in experimental animal models.

205 has been hindered by a paucity of tractable experimental animal models.

206 echanisms greater than that anticipated from experimental animal models.

207 mple of latent viral infection in humans and experimental animal models.

208 regs) to achieve this have been promising in experimental animal models.

209 brain injury and adversely affect outcome in experimental animal models.

210 d DC, and from analyses of their function in experimental animal models.

211 en studied extensively both in humans and in experimental animal models.

212 ions have also been identified in humans and experimental animal models.

213 ment and its disruption in human infants and experimental animal models.

214 tal programming can be modeled in a range of experimental animal models.

215 genetic mutations, and the complexity of the experimental animal models.

216 erum and many extraintestinal tissues in all experimental animal models.

217 inflammation in both human hypertension and experimental animal models.

218 inflammation in both human hypertension and experimental animal models.

219 is rare in animals and poorly reproduced in experimental animal models.

220 dance with several studies done in different experimental animal models.

221 is infection in both humans and unvaccinated experimental animal models.

222 s of CD4(+) regulatory T cells in humans and experimental animal models.

223 omparing brain function between patients and experimental animal models; however, the relationship be

224 DNase I injected into experimental animals, moreover, results in significant i

225 Experimental animals (n = 45) were subjected to bending

226 st setting and (ii) it reduces the number of experimental animals needed.

227 , their use will also lead to a reduction in experimental animal numbers.

228 Clinical, in vitro, and experimental animal observations indicate that antineutr

229 that SPS increases fecal potassium losses in experimental animals or humans and no evidence that addi

230 osure of murine macrophages/human monocytes, experimental animals, or people to TLR ligands.

231 ls and decreased by 537.9 pg/dL +/- 209.6 in experimental animals (P = .004).

232 ticosterone levels dropped to 149.0 ng/mL in experimental animals (P = 0.0001).

233 In experimental animals, PFAAs cause toxicity to the liver,

234 eNOS-/-) mice and their wild-type control as experimental animals, platelet-activating factor (PAF) a

235 ent evidence from studies in both humans and experimental animals point to the involvement of TCE exp

236 for careful analysis of visual thresholds of experimental animals prior to therapeutic intervention.

237 Data from experimental animals provided crucial information on pla

238 This experimental animal (rats and mice) study shows that ast

239 Experimental animals received daily triple-drug immunosu

240 For each pair, experimental animals received islets cultured with 20 mi

241 the initial training period, the contingent (experimental) animal received a siphon shock each time i

242 s a control group, we compared outcomes with experimental animals receiving the same regimen with the

243 alamic sensitivity to brief gaps in noise in experimental animals relative to controls.

244 g on the development and task performance of experimental animals remains unclear.

245 , we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SE

246 Experimental animals' seizures are often defined arbitra

247 Observations in thyroid patients and experimental animals show that the skin is an important

248 In humans and experimental animals, structural and functional changes

249 ies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in huma

250 Experimental animal studies and limited epidemiologic ev

251 oproteins bind and neutralize endotoxin, and experimental animal studies demonstrate protection from

252 Both clinical trials and experimental animal studies demonstrate that chronic hyp

253 Experimental animal studies document an association of d

254 Results from experimental animal studies have suggested that an assoc

255 -term impact of cannabis exposure, for which experimental animal studies have validated causal relati

256 Systematic consideration of experimental animal studies of oral biphenyl exposure to

257 nic process or cortical hyperexcitability in experimental animal studies or those that can aggravate

258 d up to 8 March 2012 for epidemiological and experimental animal studies related to maternal smoking

259 Experimental animal studies revealed that only those ant

260 widely used in human clinical studies and in experimental animal studies to evoke allergic contact de

261 Clinical reports, experimental animal studies, and computational modeling

262 rgely due to advances in cell biology and to experimental animal studies, emphasis has been switched

263 Recently completed experimental animal studies, human biomarker data, and v

264 shown to adversely affect health outcomes in experimental animal studies, particularly following feta

265 reduce levels of free and total thyroxine in experimental animal studies, the direction of associatio

266 his hypothesis in clinical observational and experimental animal studies.

267 s are not well understood and rely mainly on experimental animal studies.

268 Experimental animal study.

269 Interventional controlled experimental animal study.

270 Prospective, randomized, controlled, experimental animal study.

271 e sensitive to endotoxins when compared with experimental animals such as mice.

272 Overall, studies in human infants and experimental animals suggest that iron homeostasis is ab

273 ence, the need to model these diseases in an experimental animal system.

274 However, it is clear from studies in experimental animals that rejection can be prevented thr

275 In the experimental animals that were subjected to extended per

276 ors have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of

277 slow down heart failure progression, and in experimental animals, the development of atherosclerosis

278 In experimental animals, the presence of brain-derived cons

279 eurons have been observed in PD patients and experimental animals, there is limited evidence linking

280 with the type A strains can be prevented in experimental animals through vaccination with the attenu

281 uch studies, however, physically tethers the experimental animal to an external light source, limitin

282 arious end points necessitating sacrifice of experimental animals to assess histological damage, thus

283 Exposure of experimental animals to purified recombinant CARDS toxin

284 We exposed experimental animals to stable isotope-labeled formaldeh

285 The ability to estimate absorbed doses in experimental animals to which radiolabeled material has

286 nt of chemical hazards away from traditional experimental animal toxicology studies to one based on t

287 Whether findings in the experimental animal translate into true benefit for pati

288 of HCC associated with EGFR was confirmed in experimental animals using the SB transposon system in a

289 significant impairment of renal function in experimental animals versus controls, with significant c

290 The average postprocedure weight gain in experimental animals was significantly lower than that i

291 al immunodominance hierarchies in humans and experimental animals, we defined the immunodominance hie

292 Two of the experimental animals were euthanized with nonviable lung

293 Experimental animals were inoculated intraperitoneally w

294 ered intranasally on multiple occasions, and experimental animals were sacrificed on day 8 for experi

295 hich are commonly found in many patients and experimental animals with cancer and are potent suppress

296 rrow and at tumor sites in most patients and experimental animals with cancer and inhibit both adapti

297 xpressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF)

298 Experimental animals with myelin disorders can be treate

299 he bioactivity of vitreous from patients and experimental animals with PVR, and protected rabbits fro

300 are abundant in the vitreous of patients and experimental animals with PVR, they make only a minor co