ライフサイエンスコーパス: experimental design

1 alculation while controlling FDR for RNA-seq experimental design.

2 ample size while controlling FDR for RNA-seq experimental design.

3 f sequencing depth related questions for the experimental design.

4 cal power and sample size is a key aspect of experimental design.

5 ison, and pre-harvest) in a randomized block experimental design.

6 he extraction step was optimised by using an experimental design.

7 ter lights on to implement a within-subjects experimental design.

8 bilities and make an informed decision about experimental design.

9 otential improvements in model structure and experimental design.

10 diverse cellular characteristics to optimize experimental design.

11 described, including common difficulties in experimental design.

12 yzed with a scoring pipeline specific to its experimental design.

13 lection of the best target DNA sequences for experimental design.

14 0, 150 and 200 degrees C according to a 3(2) experimental design.

15 perimental findings depends on the rigour of experimental design.

16 lank-matching", copes with the blank through experimental design.

17 large sample sizes and impose limitations on experimental design.

18 e most appropriate approach for our data and experimental design.

19 d from these models allow for flexibility in experimental design.

20 ropriate multiplexing can be included in the experimental design.

21 on model (R(2)=0.9486) was obtained from the experimental design.

22 conditions for FIE or FID were chosen in the experimental design.

23 o improve parameter estimation using limited experimental design.

24 60 min, which was obtained by a second order experimental design.

25 en fully optimized by means of a Box-Behnken experimental design.

26 f publication of the results, but during the experimental design.

27 asurement conditions were optimized using an experimental design.

28 the independent, "control" versus "disease" experimental design.

29 e preparations need 1-30 h, depending on the experimental design.

30 ogical outcomes that can be achieved from an experimental design.

31 ns of TEM and issues to be considered during experimental design.

32 h a focus on the considerations required for experimental design.

33 wth curve assays with a fractional factorial experimental design.

34 confident statements, facilitating efficient experimental design.

35 tions that need to be given depending on the experimental design.

36 ata analysis methods that utilize the proper experimental design.

37 hy they are relevant biological variables in experimental design.

38 prospective longitudinal study with a quasi-experimental design.

39 ves the way for model comparison and optimal experimental design.

40 ortant roles in protein function studies and experimental design.

41 temperature) were optimized using factorial experimental design.

42 theoretical and technical considerations for experimental design.

43 ell differentiation and other differences in experimental design.

44 ortant olive varieties with a full factorial experimental design.

45 d without return), despite the absence of an experimental design.

46 zed using the Placket-Burman and Box-Behnken experimental designs.

47 ich can contribute to the development of new experimental designs.

48 the development of functional hypotheses and experimental designs.

49 s were studied and optimized using different experimental designs.

50 efficiently handles complex sample sets and experimental designs.

51 n lead to biologically useful hypotheses and experimental designs.

52 nificance and can be applied to a variety of experimental designs.

53 cross biological replicates for a variety of experimental designs.

54 support the implementation of more rigorous experimental designs.

55 tified with extreme precision and in complex experimental designs.

56 was optimised using a strategy of sequential experimental designs.

57 ess, but too often are limited by dissimilar experimental designs.

58 surrounding early animal evolution in their experimental designs.

59 NA-Seq differential expression under complex experimental designs.

60 studies using rigorous experimental or quasi-experimental designs.

61 Utilizing an embryo transfer experimental design, 2-cell embryos were obtained from o

62 In order to guide experimental design, a kinetic model was built to explor

63 containing food-grade ingredients using two experimental designs: a one-factor-at-a-time method (OFA

64 The proposed method was optimized by experimental design, achieving a limit of detection (LOD

65 Experimental design allowed us to find the optimal condi

66 Such an experimental design allowed us to observe the sequence-i

67 Our experimental design allows us to rigorously distinguish

68 Our experimental design allows us to test whether redistribu

69 combination of regression discontinuity and experimental designs allows us to estimate the effect of

70 Poor experimental design and a failure to engage with experie

71 The knowledge provides new insight into experimental design and a sound basis for further method

72 e appropriate kinetic constants, specialized experimental design and advanced numerical integration o

73 isease (AD) have been proposed to help guide experimental design and aid the interpretation of result

74 ial for additive or synergistic effects, but experimental design and analyses of multimodal therapeut

75 y and use, MOPED includes metadata detailing experimental design and analysis methods.

76 tral composite design (CCD) was employed for experimental design and analysis of the results to obtai

77 We show that proper experimental design and analysis parameters can reduce f

78 at guides the in vivo researcher through the experimental design and analysis process, providing auto

79 l background dependent) bias are excluded by experimental design and analysis.

80 substantially reduced when using an improved experimental design and avoiding confounding factors.

81 udes a conceptual overview and checklist for experimental design and calibration decisions, and is ap

82 es the low incidence of disease and provides experimental design and control that is not possible in

83 This combination of experimental design and data analysis software allows th

84 illustrate the implementation of the assay (experimental design and data analysis), affinities of th

85 Serious problems in the experimental design and data interpretation raise concer

86 icularly in relation to patient variability, experimental design and data interpretation.

87 e analyzed using a simple paired or unpaired experimental design and develop blocking methods to help

88 and translation apply known tenets of sound experimental design and emulation of the clinical disord

89 to simulate RNA-seq data, beginning with an experimental design and ending with collections of RNA-s

90 the trade off between different features of experimental design and estimates of parameter uncertain

91 Our method enables flexibility in experimental design and high-throughput assessment of mi

92 guidelines for development and execution of experimental design and interpretation in animal studies

93 f mimicking facets of the human disease; (2) experimental design and its impact on the interpretation

94 There is growing concern that poor experimental design and lack of transparent reporting co

95 nvestigators proactively address pitfalls of experimental design and methods.

96 Using a novel experimental design and model selection framework for st

97 Chemometric methods were used both at experimental design and multivariate data analysis stage

98 Chemometric tools were used for experimental design and multivariate data analysis.

99 ical trial registries that document a priori experimental design and primary dependent variables, may

100 rocedures for their analysis, we also review experimental design and procedures that affect bioinform

101 required accuracy will guide cost-effective experimental design and promote the routine application

102 elated organisms, and provide heuristics for experimental design and reconstruction of phylogenetic t

103 nd iron was investigated using a Box-Behnken experimental design and response surface methodology (RS

104 t address this complexity through thoughtful experimental design and robust data analysis approaches.

105 y highlighting the possible loopholes in the experimental design and the data analysis procedures.

106 Our previous work has developed a reliable experimental design and the result shows promising resul

107 s is an important finding that confirmed our experimental design and the results produced could guide

108 odel-data interaction as an integral part of experimental design and to address a set of cross-site s

109 s provide greater control and insight during experimental design and troubleshooting.

110 Our analysis also provides insight into experimental design and we find that, for a fixed number

111 lysis, (ii) a variety of tests for different experimental designs and (iii) different enrichment and

112 asurement of social behaviors across diverse experimental designs and also affords the ability to dev

113 Methodological constraints related to experimental designs and analysis methods have so far pr

114 been elusive due to limitations of in vitro experimental designs and animal models.

115 vectors remain elusive, which may complicate experimental designs and data interpretation.

116 contains rich features for handling complex experimental designs and for information borrowing to ov

117 need for new research that uses alternative experimental designs and measuring physiologic, morpholo

118 differential imitation and the links between experimental designs and more or less plausible theoreti

119 A Registered Report detailing the proposed experimental designs and protocols for each subset of ex

120 ng datasets of both longitudinal and spatial experimental designs and to a transplantable metastasis

121 data with environmental metadata to support experimental designs and to gain a mechanistic understan

122 The workshop focused on practical methods, experimental design, and approaches to statistical analy

123 tion was formulated using Taguchi methods of experimental design, and combined with the caspase inhib

124 oextraction technique was optimized using an experimental design, and the analytical performance was

125 de necessary theoretical foundations, inform experimental designs, and guide future research at the i

126 ives that may suit various biological goals, experimental designs, and laboratories' preferences.

127 ods to reduce the number of subjects, refine experimental designs, and replace live animals.

128 ver by lamentable inconsistency in published experimental designs, and so complicates interpretation.

129 ombination of artificial neural network with experimental design (ANN-ED) have demonstrated promise i

130 A chemometric strategy based on combining an experimental design approach and response surface method

131 An experimental design approach was implemented for the opt

132 An experimental design approach was used to obtain calcium-

133 Therefore, precautions for experimental design are warranted to minimize the interf

134 In this article, the Experimental Design Assistant (EDA) is introduced.

135 Experimental design attempts to maximise the information

136 thylated loci from BS-seq data under general experimental design, based on a beta-binomial regression

137 fore, it is imperative to carefully consider experimental design before launching a time-consuming an

138 fore, it is imperative to carefully consider experimental design before launching a time-consuming an

139 We stress the importance of consistent experimental design between research groups to effective

140 ncreasing consciousness of the importance of experimental design, bias removal, accurate quantificati

141 ew guidelines addressing scientific premise, experimental design, biological variables, and authentic

142 rformance of Platypus in clinically relevant experimental designs by comparing with SAMtools and GATK

143 e demonstrate in simulation that the shotgun experimental design can eliminate the biases induced by

144 thousands of human SUMO targets using unique experimental designs can potentially help identify plant

145 Future research employing rigorous experimental designs, careful statistical analysis, and

146 These results may guide researchers in experimental design choices for gut microbiome studies.

147 s all steps, ranging from considerations for experimental design, Co-IP, preparation of the sample fo

148 are a valuable research tool, for example in experimental designs comparing cases with high and low p

149 ted into clinical success due to preclinical experimental design considerations that inadequately pre

150 icrobial data types to human health, several experimental design considerations, data analysis challe

151 We discuss experimental design considerations, including statistica

152 Furthermore, we discuss key experimental design considerations, including the choice

153 genetic diversity in multiple alignments and experimental design constraints given by the user.

154 However, the differences in experimental design, coverage density, and possible resu

155 mporal experimental data that guides further experimental design, data collection and model refinemen

156 cal research and add layers of complexity to experimental design, data integration, and analysis.

157 Scientists face a number of experimental design decisions, including the sample size

158 nature of seeing and thinking, nitty-gritty experimental design details, and everything in between.

159 The experimental design dissociated in space and time the pr

160 Effect sizes were extracted alongside experimental design elements addressing threats to valid

161 cted subgroup analyses based on prespecified experimental design elements associated with internal, c

162 This study highlights the importance of experimental design for downstream results in skin micro

163 resents the application of a Plackett-Burman experimental design for the robust estimation of precisi

164 have advanced the technique identifying key experimental designs for potential POC assays.

165 ll require the development of a standardized experimental design framework that will enable the shari

166 We offer experimental design guidelines and quantify possible sou

167 on the setting, participant characteristics, experimental design, hand hygiene measurement, intervent

168 eatment effects are targeted, this alternate experimental design has similar predictive value as trad

169 Some efforts at harmonizing experimental designs has helped but not entirely removed

170 studies and employing both observational and experimental designs, has documented striking individual

171 t cell signaling networks can lead to better experimental designs, improved allocation of resources a

172 or promiscuity and provides a benchmark for experimental design in assessment of PARP inhibitor effe

173 or the cutaneous research community to guide experimental design in characterizing skin microbiota.

174 ct to fulfillment of fundamental elements of experimental design in current guidelines.

175 Here, we survey current best practices for experimental design in microbiome molecular epidemiology

176 e dilution buffer were optimized by Doehlert experimental design in order to enhance the detection sp

177 of mathematical models poses challenges for experimental design in sloppy models.

178 d SOF were evaluated using a fully factorial experimental design in the BelloCell system.

179 C virus (HCV) in human hepatoma cells in an experimental design in which host cell evolutionary chan

180 power estimation are essential components of experimental designs in biomedical research.

181 hetic biology efforts rely on conceptual and experimental designs in combination with testing of mult

182 ings might be instructive for cost-effective experimental designs in NGS-based research and also prov

183 his enables efficient comparison across many experimental designs in order to maximize signature dive

184 This work proposes a "shotgun" experimental design, in which we observe multiple sub-ne

185 ture seed tissues were investigated using an experimental design including two locations in Algeria a

186 a poor record of adhering to basic tenets of experimental design, including randomization, concealmen

187 dicate the need for better understanding the experimental design, including temporal and spatial alig

188 ld be a valuable research tool complementing experimental designs, including preventative clinical tr

189 h advancing paternal age using several quasi-experimental designs, including the comparison of differ

190 scriptomics data to be realized, a change in experimental design is paramount: effective transcriptom

191 q) experiment, an important consideration in experimental design is the minimum number of sequenced r

192 oxi-mC data sets with arbitrary and complex experimental designs is an open and important problem.

193 s, biological variations and multiple-factor experimental designs is under-developed.

194 In almost all experimental design, it is necessary to compare chromato

195 of (i) a cost efficient and (ii) an optimal experimental design leading to a compromise, e.g. in the

196 by the use of two-electrode cells, but this experimental design makes it hard to distinguish the imp

197 By selecting complementary experiments, experimental design may inadvertently make details that

198 Alternative experimental designs may be needed to better understand

199 ur knowledge, this is the first time that an experimental design methodology has been applied to simu

200 es by using a multivariate strategy based on experimental design methodology.

201 een studied previously using a comprehensive experimental design methodology.

202 The experimental design mimicked these habitats that either

203 of model selection outcomes and the role of experimental design needs to be examined more carefully.

204 Additional analyses using several quasi-experimental designs obtained commensurate results, furt

205 the gating mechanism but also on the general experimental design of any lipid dependence study.

206 Application of the experimental design of genome-wide association studies (

207 of the thiols, are crucial parameters in the experimental design of molecular electronic devices to e

208 tal cluster/support systems, but also assist experimental design of optimal metal cluster/support sys

209 ons and discuss special issues pertaining to experimental design of thiol redox studies.

210 We extensively validated our experimental design on a model cell culture system showi

211 translation, we need to assess the effect of experimental design on disease outcome and model experim

212 ameter estimation/model selection, and (iii) experimental design optimization.

213 dies are flawed, either through questionable experimental design or improper validation methods.

214 We explore the relationship among experimental design, parameter estimation, and systemati

215 Using a novel experimental design, participants (trained actors) perfo

216 d in vivo compound screens using a 1 x 1 x 1 experimental design (PDX clinical trial or PCT) to asses

217 Implementation of new reporting and experimental design principles will improve experimental

218 or steps in RNA-seq data analysis, including experimental design, quality control, read alignment, qu

219 (1) Effect sizes often reflect artifacts of experimental design rather than real-world relevance, an

220 ifferent platforms, including variability in experimental design, reporting of results, and the lack

221 by means of a Box-Behnken and 3(2) composite experimental designs, respectively, for the effective ex

222 to removing of lead were identified for each experimental design response.

223 Current experimental design should be refined to generate cleare

224 This experimental design studied the influence of four parame

225 demonstrate the usefulness of our method in experimental design (such as sample size and sequencing

226 The results raise cautions in experimental design, such as receptor overexpression in

227 iple be ameliorated by exploiting correlated experimental designs, such as time series or dosage resp

228 xperiment of 126 cortical interneurons in an experimental design targeted to co-expression.

229 Our results suggest that new experimental designs targeting a majority of inhibitory

230 cay using a balanced and baseline-referenced experimental design that allowed for direct comparisons

231 approaches need to be coupled with improved experimental design that considers larger sample sizes a

232 e propose a regulatory framework and optimal experimental design that enables transgenerational epige

233 ceptive-field-based models, combined with an experimental design that leaves the retinal stimulus una

234 f 200 passages in human hepatoma cells in an experimental design that precluded coevolution of the ce

235 knowledge, we outline ongoing challenges in experimental design that remain to be overcome in order

236 We introduce an experimental design that renders possible the stringent

237 ors to consider in order to solidify a sound experimental design that will yield clean, interpretable

238 Here, I review the main experimental designs that are suitable for primate field

239 addressed by multiple-factor screening using experimental designs that included both asymmetrical (Ad

240 We describe experimental designs that instead randomly assign indivi

241 ral separation of signals and well-conceived experimental designs that specifically circumvent the hi

242 when using purely observational data without experimental design--that temporal data-driven modeling

243 s study presents the optimisation through an experimental design then the validation of a method to d

244 O sample were optimised by a Plackett-Burman experimental design; then the two extraction techniques

245 m carefully considering essential aspects of experimental design through to accurately defining the e

246 We observe that experimental design thus makes confidence a criterion fo

247 pervised nontargeted analysis based upon the experimental design to aid in the discovery of analytes

248 d limitations of the DFI approach as well as experimental design to best evaluate the commutability o

249 y well, and suggest practical limitations on experimental design to ensure reliable kinetic measureme

250 We used a differences-in-differences, quasi-experimental design to examine spatial variability in th

251 Using fMRI, here we implement a novel experimental design to functionally dissociate the mecha

252 are no methods that explicitly leverage the experimental design to improve isoform quantification.

253 present study, we used a simultaneous PET-MR experimental design to investigate the effects of functi

254 mental parameters and can be used for future experimental design to obtain correct epsilon-values all

255 aluated using a rotational central composite experimental design to optimise the production of beta-g

256 rimental design on disease outcome and model experimental design to resemble the clinical course of M

257 This has implications for future experimental design to study mRNA transport dynamics.

258 tly, we aimed to propose the optimal limited experimental design to the estimation process of paramet

259 In this Review, I discuss experimental designs to detect the contribution of epist

260 thod can be used in conjunction with optimal experimental designs to effectively identify model struc

261 ults offer new targets for developing better experimental designs to investigate regulatory molecular

262 rch is needed, specifically longitudinal and experimental designs, to determine the effectiveness of

263 onmental change is simulated and the type of experimental design used.

264 We review some of the experimental designs used to probe these circuits and su

265 gene-network based approach to a prospective experimental design using whole-transcriptome RNA-Seq ge

266 eq data derived from different antibodies or experimental designs using the same approach.

267 After choosing preliminary conditions, an experimental design was carried out with the variables C

268 This experimental design was chosen to lower the impact of ge

269 A Doehlert experimental design was conducted and surface response m

270 A community-intervention trial with a quasi-experimental design was conducted in East Lombok, West N

271 Assisted by response surface methodology, an experimental design was developed for testing the extrac

272 An experimental design was employed to further optimize the

273 An experimental design was planned to study three factors a

274 A longitudinal experimental design was used to assess the progression o

275 A tailor-made experimental design was used to screen the effect of bea

276 A Doehlert matrix experimental design was used, evaluating the effects of

277 ogy, coupled to a full factorial three-level experimental design, was applied to investigate the comb

278 Using a novel split-colony experimental design we evaluated visual learning perform

279 Using a multi-factorial experimental design we found that growth phase, voltage,

280 Using a quasi-experimental design, we compared patient-level outcomes,

281 Using a 'common-garden' experimental design, we detected significant interspecif

282 Through an experimental design, we investigated the hypothesis of a

283 ease the physiological relevance of in vitro experimental design, we present a new approach and a set

284 Using a longitudinal experimental design, we quantified the ontogenetic profi

285 Using simulated data for three different experimental designs, we compare the power of the method

286 Using yoked experimental designs, we demonstrate that social interac

287 the significant factors, two full factorial experimental designs were built, each containing four of

288 As an analytical tool, experimental designs were used for the optimization.

289 ts and based on an original observational or experimental design, were included.

290 ly foraging pink sundews, and we employed an experimental design where treatments were the presence o

291 y NMR techniques (VT and EXSY) using a novel experimental design whereby a chiral substituent ((s)Bu)

292 eriments and summarizes important aspects of experimental design, which aim to help researchers delib

293 eriments and summarized important aspects of experimental design, which aim to help researchers delib

294 SPME method was developed using multivariate experimental designs, which was conducted in two stages.

295 rewiring of gene and metabolite networks in experimental design with multiple factors.

296 We used a quasi-experimental design with quarterly measures of healthcar

297 Box-Behnken experimental design with response surface methodology wa

298 0 muatm) scenarios, crossed in an orthogonal experimental design with the presence/absence of the cub

299 Two articles used experimental designs with vignettes.

300 ment was carried out following a Box-Behnken experimental design, with three factors, temperature (18