ライフサイエンスコーパス: experimental model

1 ce for further development of Parhyale as an experimental model.

2 way swapping," using yeast glycolysis as the experimental model.

3 n in dendritic cells (DCs) during GVHD in an experimental model.

4 humans and indicates the need to prove in an experimental model.

5 emia-reperfusion sequelae in a human in vivo experimental model.

6 uids (with and without nicotine) on the same experimental model.

7 h improved pathophysiologic properties as an experimental model.

8 image pancreatic inflammation in a relevant experimental model.

9 effects of altered fatty acid metabolism in experimental models.

10 modulation of spinal networks in accessible experimental models.

11 deling after large myocardial infarctions in experimental models.

12 and we suggest guidelines for selecting new experimental models.

13 nary and computational methods and tested in experimental models.

14 ion, and complications of atherosclerosis in experimental models.

15 tion of oncogene expression level in t(8;21) experimental models.

16 human pathogen Trypanosoma brucei and mouse experimental models.

17 ble vascular scaffold [BVS]) using different experimental models.

18 rmance from in vitro to pre-clinical in vivo experimental models.

19 R) loss-of-function leads to fibrogenesis in experimental models.

20 upal thorax closure in Drosophila are useful experimental models.

21 sm of the virus and the paucity of tractable experimental models.

22 properties against liver and colon cancer in experimental models.

23 horts and the functional properties of SN in experimental models.

24 of various modes of cell death in a range of experimental models.

25 ETBF induces colon carcinogenesis in experimental models.

26 rging therapy that regulates inflammation in experimental models.

27 therapies and yet it is poorly reproduced in experimental models.

28 ed informatics or can only be used in single experimental models.

29 valuated for its anti-inflammatory action in experimental models.

30 ecrease mortality and morbidity after ICH in experimental models.

31 nd anti-senescence responses in a variety of experimental models.

32 s on using human tissues and supplemented by experimental models.

33 y have been hampered by a paucity of in vivo experimental models.

34 ide (NO)-dependent vasodilator properties in experimental models.

35 Both aspects are challenging to capture in experimental models.

36 d the functional role of CST was explored in experimental models.

37 , various prion strains can be propagated in experimental models.

38 In experimental models a number of epigenetic mechanisms ha

39 No current experimental models accurately reflect the human disease

40 In this experimental model, Acute Respiratory Distress Syndrome

41 approach is also clearly dependent upon the experimental model and access to skeletal muscle that is

42 ing performance of a metabarrier in a scaled experimental model and demonstrate that surface ground m

43 vation improves pulmonary hemodynamics in an experimental model and in an early clinical trial.

44 By employing a simple coculture experimental model and using single-molecule imaging, we

45 anti-BP180 IgE has been suggested in various experimental models and by the successful use of omalizu

46 ion of HDAC6 improved established PAH in two experimental models and can be safely given in combinati

47 We used experimental models and clinical databases to identify G

48 interference with tumor detection; however, experimental models and clinical studies have shown a co

49 nes the evidence obtained from the different experimental models and considers implications that thes

50 Innovative research with experimental models and exploitation of the geographical

51 uantify occurrence of extracellular traps in experimental models and human samples.

52 culosis (TB) and then provide data from both experimental models and human studies that illustrate ho

53 evidence, which comes from analysis of both experimental models and patient samples.

54 linked to cardiac injury and dysfunction in experimental models and patients with sepsis.

55 as a theoretical framework to bridge between experimental models and scales, with the aim of separati

56 Our results concur with findings from experimental models and the current model of DR pathogen

57 rular endothelial cells (MGECs) were used as experimental models, and GYY4137 as H2S donor.

58 f infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus

59 ducibly shown to prolong lifespan in various experimental model animals.

60 also highlights the strengths of a combined experimental-modeling approach to unambiguously understa

61 l scavenger, and sunlight was assessed by an experimental-modeling approach.

62 Here, we present a coupled experimental/modeling approach to establish an in vitro

63 expression in single cells using a combined experimental/modeling approach.

64 These technologies in experimental models are providing new insights into memo

65 Genetic loss-of-function experimental models, as well as selective TNF blockade b

66 derstood, reflecting the lack of appropriate experimental models both in vivo and in vitro.

67 Adiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of m

68 or vascularization and growth in mouse tumor experimental models, but the molecular basis of their pr

69 These findings were confirmed in the experimental model by showing that only CMR-MaR values f

70 Indeed, planarian flatworms were used as experimental models decades before Caenorhabditis elegan

71 Experimental models demonstrated that therapeutic induct

72 We then developed an experimental model demonstrating that holoHC is transpor

73 Here we demonstrate that a novel experimental model employing thermoneutral housing, as o

74 fects of bile acids on stellate cells in two experimental models: ex vivo (mouse pancreatic lobules)

75 Several experimental models faithfully recapitulate many importa

76 astoid cell lines (LCLs), which represent an experimental model for EBV-associated cancers.

77 Our study presents a new experimental model for exploring cellular mechanisms of

78 ing that CREM transgenic mice are a valuable experimental model for human AF pathophysiology.

79 onhuman primates currently serve as the best experimental model for Lyme disease because of their clo

80 Classical blink conditioning is a popular experimental model for studying neural mechanisms underl

81 udy establishes merotelic kinetochores as an experimental model for studying the mechanical response

82 make this combined approach attractive as an experimental model for the assessment of neuroprotective

83 e data, and mice cannot serve as an adequate experimental model for the distinct regional differences

84 ypodium distachyon has emerged as a powerful experimental model for the grasses.

85 infant rabbit can be used as an alternative experimental model for the study of diarrheagenic Campyl

86 es the discrepancies between theoretical and experimental models for these biochemically ubiquitous c

87 In experimental models, growth factor stimulation and/or on

88 Notably, until now, no experimental model has been described to determine the o

89 Experimental modeling has defined a cooperative role of

90 Evidence, mostly from experimental models, has accumulated, indicating that mo

91 tic agents on the hair follicle, a number of experimental models have been proposed.

92 Experimental models have provided insights into the effe

93 Although experimental models have shown that the human fetal test

94 While many experimental models have tested the in vitro or in vivo

95 iac function has been extensively studied in experimental models; however, its role in human ischemic

96 Using our experimental model, impact of adaptive immunity on S. au

97 Experimental models in mice and human epithelial cells s

98 ultiple developmental contexts, the range of experimental models in which each of the steps can be ex

99 in case reports, clinical trial results and experimental models, include systemic infections, delete

100 luidigm) cytometry, and complex high-content experimental models including slice culture and zebrafis

101 r ameliorated autoimmune diseases in several experimental models, including colitis.

102 Experimental models indicate that PADI4 is critical for

103 t conflicting data regarding its function in experimental models justify a close assessment of its ti

104 As such, this experimental model may be adopted to examine vicarious s

105 idirectional and varies depending on tissue, experimental model, methodological approach, and feature

106 ng in temporal lobe epilepsy patients and in experimental models mimicking this neurological disorder

107 gh eNOS derangement has been demonstrated in experimental models, no studies have directly shown that

108 We apply the modified KCE method to an experimental model of a platelet-derived growth factor (

109 tory Distress Syndrome Network, in a porcine experimental model of acute respiratory distress syndrom

110 nal collapse and aeration distribution in an experimental model of acute respiratory distress syndrom

111 Ten piglets submitted to an experimental model of acute respiratory distress syndrom

112 the renoprotective effects of puerarin in an experimental model of advanced DN and provide a molecula

113 H remission caused by B-cell depletion in an experimental model of AIH.

114 ut genetic and environmental confounders, an experimental model of allergic asthma in mice was used.

115 In this experimental model of allergic asthma, matched bronchoal

116 l asthma in workers, we sought to develop an experimental model of allergic lung inflammation to subt

117 t which clearance is observed in an in vitro experimental model of antibiotic treatment as a criterio

118 In the experimental model of bile duct ligation, silencing of P

119 In an experimental model of cardiac fibrosis, cardiac pressure

120 prepared from human tenocytes), which are an experimental model of cell-mediated collagen fibril form

121 regulated in colonic endothelial cells in an experimental model of colitis and in the inflamed mucosa

122 10 mg/kg daily, o.s.) was tested in a murine experimental model of colitis induced by intracolonic ad

123 rrelated with increased susceptibility to an experimental model of colitis.

124 We developed a murine experimental model of congestive hepatopathy through par

125 l role in limiting functional recovery in an experimental model of diabetes.

126 Using an experimental model of elevated hematocrit in healthy mic

127 eractions by water-soluble CORM-401 using an experimental model of endotoxemia in vitro.

128 Finally, studies of an experimental model of endotoxin shock show that iNOS def

129 onditioning remains the most widely employed experimental model of fear and anxiety, and continues to

130 ability of ld-IL-2 to control allergy in an experimental model of food allergy.

131 To guide investigation, an experimental model of genital tract infection has been d

132 An experimental model of glaucoma has been established by e

133 ighly attenuated in macaque eyes, a relevant experimental model of human trachoma infection.

134 Our aim was to develop an experimental model of hyperfibrinolysis and to study its

135 1 mutations in patient samples as well as an experimental model of inducible expression.

136 We have developed an experimental model of infant infection with EPEC, using

137 were infected with a H1N1 virus (PR8) as an experimental model of influenza infection.

138 ave demonstrated therapeutic potential in an experimental model of liver cancer in vivo.

139 e ability for early metastatic seeding in an experimental model of lung metastasis, indicating that h

140 patients, a finding that we confirmed in the experimental model of lung TLS induction.

141 ung squamous cell carcinoma (LSCC) and in an experimental model of lung TLS induction.

142 Using an experimental model of MI (left anterior descending arter

143 hese observations has been extended using an experimental model of multiple sclerosis [experimental a

144 ent with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly in

145 al of the generated cells was assessed in an experimental model of myocardial infarction.

146 M1 strains recovered from a nonhuman primate experimental model of necrotizing fasciitis.

147 Here, we combined an experimental model of nephron reduction in mice from dif

148 uction, and airway hyperresponsiveness in an experimental model of OVA-induced asthma.

149 In an experimental model of pancreatic injury, we found that V

150 1(-/-) mice developed severe bone loss in an experimental model of periodontitis.

151 78 drive TF-mediated tumor progression in an experimental model of prostate cancer.

152 a survival advantage to photoreceptors in an experimental model of retinal detachment.

153 r required to infect cells offers a powerful experimental model of retroviral entry.

154 terol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome.

155 Using an experimental model of s.c. B. anthracis infection (an en

156 of trametinib in a more clinically relevant experimental model of sepsis.

157 Using an experimental model of skin exposure to NM we observe act

158 In this study, a representative experimental model of skin was developed which was compr

159 adaptation to altered auditory feedback, an experimental model of speech motor learning which like v

160 slice preparation to provide a synchronized experimental model of T-cell selection in situ.

161 The objective was to examine an experimental model of the early multiple sclerosis lesio

162 Here we describe a novel experimental model of the peripheral neuro-cardiac axis

163 Here we present an experimental model of this early learning process, in wh

164 and reduced hemorrhagic transformation in an experimental model of transient focal cerebral ischemia.

165 having been shown to improve outcomes in an experimental model of traumatic brain injury, TSG-6 expr

166 We examined the role of IL-17 in an experimental model of VL caused by infection of C57BL/6

167 n and establish a proof of principle whereby experimental modelling of a disorder can help mechanisti

168 ll prove useful to track C5aR1 expression in experimental models of acute and chronic inflammation an

169 late phases of the inflammatory response in experimental models of acute and chronic renal IRI using

170 lly, compound 6 produces potent analgesia in experimental models of acute and persistent pain.

171 inhibitor of this cascade has been tested in experimental models of addiction, a necessary step towar

172 Experimental models of allergic disease, basic mechanism

173 Experimental models of allergic disease, basic mechanism

174 and prevented Abeta-induced neurotoxicity in experimental models of Alzheimer disease.

175 Studies in experimental models of anti-MPO GN suggest that, after A

176 en shown to act as a successful treatment of experimental models of arthritis, such as collagen-induc

177 rentially target inflammatory macrophages in experimental models of atherosclerosis and obesity, thus

178 tion, and inhibits inflammation in different experimental models of autoimmune diseases.

179 Recent research in experimental models of autoimmunity and in patients with

180 17 cells and that high-salt diets exacerbate experimental models of autoimmunity.

181 MCs exhibit a worsened pathology in various experimental models of bacterial infection.

182 Thus, experimental models of BDV infection may provide new too

183 l role of which has been well established in experimental models of both immune-mediated and non-immu

184 GHRH and its receptors are expressed in experimental models of BPH, in which antagonists of GHRH

185 Here, using two experimental models of breast cancer, we reinforced the

186 mprove myocardial remodeling and function in experimental models of cardiovascular disease.

187 na(i2)(fl/fl)/PF4-Cre mice were subjected to experimental models of cerebral and myocardial ischemia/

188 Liver inflammation in two independent experimental models of chronic liver injury and fibrosis

189 s in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy.

190 ced expression of noncanonical WNT-5A in two experimental models of COPD and increased posttranslatio

191 yperresponsiveness (AHR) and inflammation in experimental models of COPD.

192 lyze the effect of inhibiting necroptosis in experimental models of critical illnesses.

193 characterize failing beta cells from various experimental models of diabetes and report a striking en

194 n may confound understanding alloimmunity in experimental models of diabetes.

195 the inhibition of tubulin polymerization, in experimental models of diffuse malignant peritoneal meso

196 ary motion detectors have served as premiere experimental models of direction selectivity for 60 year

197 ficial effects of GLP-1R analogs reported in experimental models of DR.

198 ore seizures has been described in different experimental models of epilepsy, raising the hypothesis

199 hown to suppress seizures both in humans and experimental models of epilepsy.

200 mole-rat, like other long-lived species and experimental models of extended longevity, is resistant

201 ms of pathology, both clinically and in many experimental models of FGR, impaired uteroplacental vasc

202 odelling for studying relevant behaviours in experimental models of fungal disease.

203 omyocytes also occurred in other genetic and experimental models of heart failure.

204 abetes and developing therapeutics depend on experimental models of hyperglycemia, hyperinsulinemia,

205 accumulation of MDSCs is a characteristic of experimental models of hypertension.

206 Here, we used theoretical considerations and experimental models of immune responses in vitro and in

207 oth toxins cannot be adequately addressed in experimental models of infection because mice are resist

208 and conditionally delete C5aR2 expression in experimental models of inflammation.

209 and conditionally delete C3aR expression in experimental models of inflammation.

210 iogenesis precedes leukocyte infiltration in experimental models of inflammatory bowel disease and ac

211 Using both in vivo and in vitro experimental models of ischemia, we demonstrate a neurop

212 cular targets that have been investigated in experimental models of ischemic AKI and how such models

213 ibition of Top1 protected mice from death in experimental models of lethal inflammation.

214 Here, we use experimental models of liver fibrosis to show that defic

215 ies using partial hepatectomy (PH) and other experimental models of liver regeneration implicate the

216 Ranolazine blocks INaL in experimental models of LQT3 harboring the SCN5A-D1790G m

217 Experimental models of malaria have shown that the regul

218 Although most experimental models of medical device infection draw upo

219 We develop experimental models of metastatic luminal breast cancer

220 d execution, and (ii) phenotype detection in experimental models of movement disorders.

221 d neurorestorative effects across a range of experimental models of neuronal degeneration, and, recen

222 e of IL-33/IL-33 receptor (ST2) signaling in experimental models of neuropathic pain in mice.

223 re, we examined treatment-naive patients and experimental models of PAH and identified a reduction in

224 ation, oxidative damage, and fibrosis in the experimental models of PAH and lung fibrosis.

225 acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial

226 e shown promise in preclinical evaluation in experimental models of PAH.

227 for their antinociceptive activity in acute experimental models of pain showing an effect equal to o

228 , and firing activity of LHb were studied in experimental models of Parkinson's disease and LID.

229 Single-dose AB103 reduces mortality in experimental models of polymicrobial and gram-negative b

230 is frequently targeted by autoantibodies in experimental models of prostatic autoimmunity.

231 potently attenuate inflammation in multiple experimental models of systemic autoimmunity and mucosal

232 Experimental models of thrombotic stroke induced by eith

233 A lack of experimental models of tumor heterogeneity limits our kn

234 roke affects neural and vascular networks in experimental models of type 1 diabetes.

235 microRNA profiles have been demonstrated in experimental models of type 2 diabetes, including in isl

236 the success of a few wild tobacco species as experimental model organisms have resulted in growing kn

237 Herein, a novel integrated experimental-modelling platform is presented whereby exp

238 This experimental-modeling procedure simulates LA-ICPMS imagi

239 80s, avoidance had fallen out of favor as an experimental model relevant to fear and anxiety.

240 ium sulfate (DSS) and azoxymethane (AOM)-DSS experimental models, respectively.

241 On the basis of a number of experimental models, several alternative cell types have

242 w results obtained in the most commonly used experimental models should be interpreted in the develop

243 We propose that RNA methylation studies in experimental models should be validated in primary clini

244 mechanism and may be an artefact of previous experimental models studied.

245 This is the first joint experimental/modeling study that unambiguously elucidate

246 Findings from our experimental model suggest that the offspring of dams ex

247 Experimental models suggest a direct antistaphylococcal

248 Experimental models support dietary LComega3PUFA protect

249 In addition, we establish a tractable experimental model system to investigate the impact and

250 (LCMV), provides investigators with a superb experimental model system to investigate virus-host inte

251 rogeneous Escherichia coli lawn serves as an experimental model system to study population expansions

252 In our experimental model system we control the deformation of

253 ry on a bacterial virus (phage lambda) as an experimental model system, we investigated the thermodyn

254 on has allowed for a wide range of different experimental model systems designed to explore different

255 uding those resulting from viral infections, experimental model systems for evaluating how and why th

256 rating the relevance and importance of mouse experimental model systems for studying human influenza

257 of ovarian cancer is presented as are novel experimental model systems for studying the fallopian tu

258 Experimental model systems have been instrumental in rap

259 Advances in genetics and experimental model systems have illuminated an important

260 Experimental model systems of schizophrenia combined wit

261 alysis of multiple samples, or for non-human experimental model systems with no reliable databases of

262 ating a variety of tissues, tumor types, and experimental model systems, we show that an HA-dependent

263 ling blocks asthmatic responses in human and experimental model systems.

264 iciently high yields to be routinely used as experimental model systems.

265 s of human motor learning, introducing a new experimental model that closely approximates the key fea

266 e sulfonic acid (DNBS)-induced colitis is an experimental model that mimics Crohn's disease.

267 Here, we used an experimental model that reproduces olanzapine-induced hy

268 ephalomyelitis in nonobese diabetic mice, an experimental model that resembles several aspects of SPM

269 However, the number of experimental models that can be used to explore collecti

270 gates in purified properdin preparations and experimental models that do not allow discrimination bet

271 ividual species and endpoints in the various experimental models that may be examined.

272 Vast differences exist between experimental models that mimic these processes, and thei

273 We conclude that in our experimental model the combination of bacteria, chronic

274 However, without a tractable experimental model, the mechanism of human PGC (hPGC) sp

275 ytosing RPE cells, utilizing three different experimental models: the human-derived RPE-like cell lin

276 Here we use the zebrafish experimental model to assess the effects of untreated ru

277 in prostate cancer cells, and in an in vivo experimental model to demonstrate the feasibility of PSM

278 Our goal was to use an experimental model to determine the temporal relationshi

279 which contains imiquimod, and is used as an experimental model to induce psoriasis-like skin lesions

280 P. knowlesi as both a human pathogen and an experimental model to lift the roadblock between malaria

281 equencing analysis of human samples, with an experimental model to show that Th17-related genes are s

282 ation; Dnmt1(Deltaalb) mice provide a unique experimental model to study the role of senescence and t

283 cific populations, and how we have developed experimental models to decipher the interactions between

284 increased risk for CAP, and establish murine experimental models to dissect underlying molecular mech

285 erapy potential are important to decipher in experimental models to pave the way for future developme

286 sights to inform the development of faithful experimental models to test the efficacy of new treatmen

287 subpopulation, and are less virulent in the experimental models used here.

288 way from a healthy human subject, printed an experimental model using a 3D printer, and analyzed the

289 In an experimental model, variable and intermittent contact fo

290 w how information from related and unrelated experimental models was translated to a clinical setting

291 As an experimental model, we designed a task in which human pa

292 Using a clinically valid experimental model, we find that, under anxiety, decisio

293 been shown to produce synergistic effects in experimental models when evaluated in combination with r

294 We have developed an experimental model where genetically identical, co-house

295 Our unique experimental model which incorporates genetic effect, na

296 major obstacle is the lack of an appropriate experimental model which incorporates genetic susceptibi

297 n the ability to reproduce already existing 'experimental models', which in turn, have an unclear acc

298 aptive processes should guide development of experimental models, which could include targeted gene d

299 In pregnant sheep, experimental models with a small, defective placenta tha

300 In experimental models with von Willebrand disease pigs, pl