ライフサイエンスコーパス: explant

1 : 10 of them presented recurrence at imaging/explant.

2 largest viable tumor and number of tumors on explant.

3 ment proteins interacting with the cartilage explant.

4 acuity of 20/25 or better by 3 months after explant.

5 enriched airspaces of a cystic fibrosis lung explant.

6 nonfunction in conjunction with a difficult explant.

7 ect, and some will ultimately have no HCC on explant.

8 umor diameter and number of viable tumors on explant.

9 t did not affect Sox9 mRNA levels in gonadal explants.

10 ns and goldfish, zebrafish and chick retinal explants.

11 n of cytokines from human ulcerative colitis explants.

12 analogs in cystogenesis in embryonic kidney explants.

13 om mouse embryonic day 9.5 trunk neural tube explants.

14 gestation fetal- and maternal-derived tissue explants.

15 educed ZIKV infection in placental cells and explants.

16 types that agree with observations in tissue explants.

17 d by SDS PAGE and by qRT-PCR in ex-vivo bone explants.

18 ted testosterone secretion from adult testis explants.

19 eolae formation was studied in human retinal explants.

20 ooccurrence of apoptosis and necrosis in the explants.

21 n embryonic day 10.5 aorta-gonad-mesonephros explants.

22 , a result confirmed in human term placental explants.

23 ned through culture of sonication fluid from explants.

24 elease from IL-1beta-treated human cartilage explants.

25 her in CTB than in SCT in culture and living explants.

26 microvascular sprouting assay using choroid explants.

27 on and pericyte loss compared to nondiabetic explants.

28 ltured endothelial cells and infarcted heart explants.

29 deficiency decreased synapse density in SGN explants.

30 rformed on nontransplanted aortas and grafts explanted 2 and 4 weeks after transplantation to assess

31 onsumption (healthy 36.4 +/- 10.3 ml/kg/min; explanted 29.8 +/- 5.9 ml/kg/min; implanted 20.5 +/- 4.3

32 ith other patients (healthy 5.35 +/- 0.95 W; explanted 3.45 +/- 0.72 W; LVAD implanted 2.37 +/- 0.68

33 estingly, HCV RNA was detected in most liver explants (67%).

34 t evidence that in developing salivary gland explants, a single posttranslational change in microtubu

35 patients (85%) with residual HCV-RNA in the explant achieved a sustained virologic response after re

36 ivo coculture of gammadelta T cells with RPE explants activated the production of anti-inflammatory c

37 Upon explant analysis, tumors exceeding the Milan criteria, m

38 al between initial placement of the hydrogel explant and removal of the explant was 159 months.

39 al and post-transcriptional rhythms in brain explants and cultured neurons.

40 ed ROS or PGZ (6-6000muM) was mixed with fat explants and cultured.

41 ure approaches, outgrowth from limbal biopsy explants and isolated cell seeded in low calcium medium.

42 Analysis of cultured mesoderm explants and mouse embryonic fibroblasts from null mutan

43 s failure of convergence force generation in explants and of blastopore closure in whole embryos.

44 nd (RANKL) in osteocytes and mouse calvarial explants and preferentially induces apoptosis in preoste

45 as used to infect equine respiratory mucosal explants and primary equine respiratory epithelial cells

46 ibe how to culture adult zebrafish hearts as explants and study the regeneration of epicardial tissue

47 ere avidly to both intact ex vivo peritoneal explants and three-dimensional collagen gels.

48 pt androgen production in human fetal testis explants and to evaluate the importance of mixture effec

49 tion procedure was developed from shoot apex explants and used to downregulate expression of 3 member

50 microscopy, parathyroid culture, whole organ explant, and animal model assays.

51 ost-operative years, the iris prosthesis was explanted, and intravitreal cultures showed P. acnes gro

52 is less inhibitory for RGC axons from retina explants, and because of its low abundance.

53 constructs of Six1 and Eya1 in pre-placodal explants, and blocking protein synthesis before hormone-

54 1 cells, angiogenic sprouting in aortic ring explants, and retinal revascularization in oxygen-induce

55 imarily to leading edge cells in mesendoderm explants, and that these forces are balanced by intercel

56 If explants are prepared from appropriate transgenic lines,

57 Explanted arterial segments underwent either histomorpho

58 primary potential source of bias was use of explant as the reference standard in only 13% of studies

59 sed bacterial survival in CFA-exposed airway explants, ASL, and AMPs.

60 was evaluated using the human in vitro skin explant assay (skin explant assay).

61 the human in vitro skin explant assay (skin explant assay).

62 he mixed lymphocyte reaction and in the skin explant assay.

63 episcleral MIRAgel (MIRA Inc., Waltham, MA) explant at the Radboud University Medical Center from 19

64 Hearts were explanted at 5 h (n = 6) and 24 h (n = 6), and transcrip

65 Eleven (6.7%) of these patients were explanted at a later date.

66 culture media and tissue harvesting sites on explant attachment, growth, and phenotype of OMECs cultu

67 beta3 inhibition in elastin mutant mice and explants attenuates aortic hypermuscularization and sten

68 from goldfish, zebrafish, and chick retinal explants avoided rat M1-4 but freely crossed zebrafish M

69 as 20 months, with 82% of the patients being explanted between 12 and 24 months after the implant.

70 ascular invasion (23.8% [n = 81], P < .001), explant beyond Milan criteria (37.3% [n = 159], P < .001

71 In mouse lung explants, blocking IL-1beta expression, posttranslationa

72 arker content and clonogenic capacity in the explants but also had the opposite effect on the isolate

73 d VEGF-induced caveolae formation in retinal explants but did not rescue VEGF-induced alterations in

74 BCG2) content and clonogenic capacity in the explants but had opposite effects on isolated cells.

75 y studied in osteocytes in vitro and in bone explants, but has yet to be examined in vivo.

76 notypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tissue obt

77 A swollen hydrogel explant can be removed many years after the primary deta

78 explants of murine tumors and clinical tumor explants can be potentiated by combining the uCendR pept

79 Heart explants can be prepared within 2 h, and they can be mai

80 Tissue explants can be used to investigate adipose regulation i

81 Explanted capsular bags from 3 of these patients were co

82 Histologic examination of the explanted capsular bags revealed a paucicellular membran

83 s expression were histologically analyzed in explanted cardiac tissue affected by the DES mutation.

84 s or inhibition of VEGFR2 signaling in organ explants caused an aberrant increase in cells expressing

85 irculating tumour cell (CTC) patient derived explant (CDX) mouse model.

86 re also observed in 9/10 CTC patient-derived explants (CDX), where molecular analysis of fractionated

87 vated to produce infectious virus, following explant cocultivation and that spontaneous reactivation

88 When explant cocultivation of trigeminal ganglia was performe

89 ich was attenuated in mice and dog tracheal, explants compared to CIV H3N8 wild type.

90 Fold outgrowth was superior from LL explants compared to explants from the buccal mucosa (BM

91 ease in IFN-gamma release from infected COPD explants compared with controls (P = 0.04).

92 Through maxillary explant culture assays, we demonstrate that the Golgb1 m

93 labor, term not in labor samples in an organ explant culture in vitro were exposed to cigarette smoke

94 e that addition of hepsin to OA cartilage in explant culture induced significant collagen and aggreca

95 mor tissue, we describe an optimized ex vivo explant culture model that enables concurrent evaluation

96 of primary NSCLC specimens were amenable to explant culture with tissue integrity intact for up to 7

97 f numerous patterning systems in vivo and in explant culture.

98 Here, using mammalian tooth explants cultured in isolation, we investigate self-regu

99 ional modeling of cusp patterning, and tooth explants cultured with small braces show that correct cu

100 Finally, we show in explant cultures ex vivo that Nogo-A-Delta20 promotes th

101 splantation of limbal epithelial sheets from explant cultures is one of the standard treatments of li

102 igh expression of CXCL1 in FFPE samples from explant cultures of CRC patients-derived liver metastase

103 In explant cultures of embryonic kidney rudiments, retinoic

104 e growth factor to Jag1-mutant outflow tract explant cultures rescued the hyperproliferative phenotyp

105 nts of Cl(-)-driven fluid secretion in organ explant cultures show that pharmacological CaSR activati

106 enetic analysis, pharmacological inhibition, explant cultures, and induced pluripotent stem cells (iP

107 pression of ductal markers in ex vivo acinar explant cultures.

108 stem/progenitor cell preservation in limbal explant cultures.

109 n of infectious virus in medium samples from explanted cultures does not occur until extensive spread

110 explanted ganglia by sampling media from the explanted cultures or by homogenization of the ganglia a

111 y the indirect method of sampling media from explanted cultures.

112 KV infects primary human placental cells and explants-cytotrophoblasts, endothelial cells, fibroblast

113 Patients with complete explant data within the Milan criteria for whom a Model

114 LPS exposure in first-trimester explants decreased (P < 0.001) ABCB1 and ABCG2 mRNA and

115 chisin-deficient (Rs1h(-/Y) ) murine retinal explants decreased activation of Src, an initial transmi

116 effects on the growth of axons from retinal explants derived from different quadrants of the retina.

117 Ex vivo mutant aortic ring explants developed significantly fewer and thinner aorti

118 More than 34% of the episcleral hydrogel explants developed symptomatic swelling and required sur

119 Explanted donor hearts (n=8) served as controls.

120 on and in epithelial cells isolated from HFL explants during type II cell differentiation in culture.

121 ltured human keratinocytes in vitro and skin explants ex vivo to examine how IGF-1R activation status

122 rs in mice and clinical peritoneal carcinoma explants express p32 protein accessible from the IP spac

123 visual field loss from baseline than either explanted eyes or sham eyes through 42 months.

124 reated eyes, eyes retaining the implant, and explanted eyes, as was visual acuity and OCT macular vol

125 eal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37).

126 We use embryonic tissue explants, finite element modeling, and 3D cell-patternin

127 stic profile compared with patients who were explanted for recovery (complete recovery).

128 tricular assist device patients who were not explanted for recovery have demonstrated substantial imp

129 .7% had been transplanted, 1.6% had left VAD explanted for recovery, and 20.7% had died on device.

130 as significantly higher in patients who were explanted for recovery.

131 ential of CML cells, including primary cells explanted from 12 CML patients.

132 ermany) with a hydrophobic surface that were explanted from 5 patients because of opacification.

133 Accordingly, cells explanted from miR-34a/b/c-deficient adenomas formed tum

134 ositive T cells was found in diseased livers explanted from patients with chronic hepatitis C infecti

135 Orbital fibroblasts explanted from patients with TED were treated with TGF-b

136 ence of hepatitis C virus (HCV) RNA in liver explants from 39 patients awaiting liver transplantation

137 we made use of organotypic cultures of skin explants from control and mutant embryos at embryonic da

138 s from mid- and late-gestation placentas and explants from first-trimester chorionic villi with the p

139 Explants from healthy and failing human hearts were comp

140 h levels of IL-1beta, IL-6, and IL-17 in VAT explants from lean donors.

141 to the mitochondria (MCAT) and in cartilage explants from MCAT transgenic mice.

142 ntibody and CD8(+) T cells in reactivated TG explants from mice latently infected with (i) the avirul

143 In vitro culture of visceral fat explants from naive dietary restricted mice showed signi

144 th was superior from LL explants compared to explants from the buccal mucosa (BM), HP, and transition

145 ia, and metabolic gene expression in blubber explants from wild grey seals.

146 measuring reactivation in latently infected explanted ganglia by sampling media from the explanted c

147 virus detection by direct homogenization of explanted ganglia correlates with viral protein expressi

148 tumor, liver, lung, and spleen as well as in explanted gel pellets were generated and the behavior of

149 Explanted grafts display physiological strength and stif

150 All evaluable explanted grafts experienced antibody-mediated rejection

151 In the LVAD explanted group, 38% of the patients achieved peak cardi

152 Patients with HCV RNA-positive explants had received shorter courses of treatment, and

153 metabolism was evaluated in human plasma and explanted heart tissue from patients with HF.

154 logically documented focal RV fibrosis in an explanted heart.

155 ein, were associated with marked fibrosis of explanted hearts and gene-specific nucleolar segregation

156 II (Ang II) metabolism was examined in human explanted hearts with dilated cardiomyopathy (n = 25).

157 ms biofilms on the choriodecidual surface of explanted human gestational membranes.

158 raphy using a fresh cardiac thrombus from an explanted human heart.

159 Myocardial Ang II levels in explanted human hearts with dilated cardiomyopathy were

160 out on left ventricular tissue obtained from explanted human hearts.

161 an phosphorylation (pPLB) were determined in explanted human left ventricular myocardium (pediatric n

162 , an AAV serotype evaluation in human cornea explants identified an AAV8 and 9 chimeric capsid (8G9)

163 Ex vivo transduction of mouse organotypic explants identified Anc80L65 from a set of other adeno-a

164 acids-treated trophoblast cells and villous explant in vitro.

165 Further, culturing rat lens explants in FGF increased their expression of Prox1, and

166 erentially project axons towards limb muscle explants in vitro and distal limb muscles in vivo upon t

167 RETREAT was superior to Milan criteria (explant) in predicting HCC recurrence by the net reclass

168 ce of HCC (viable or nonviable) found in the explant?" in patients with T2 MELD exceptions.

169 PTH secretion in explants increased in response to leptin and decreased w

170 Glycolysis was higher in explants incubated in 25 mM glucose (HG) for 24 h compar

171 cues the HF phenotypes in Lhx2 knockout skin explants, indicating that it operates downstream of LHX2

172 -cAMP addition to wild-type embryonic kidney explants induced proximal tubular cystogenesis and p-Cre

173 ssed by part of the mononuclear cells in the explant.Isolated graft cells were mostly CCR7-CD45RO+ ef

174 denced in the mesangia of a transplanted and explanted kidney from a German patient with a CFHR2-CFHR

175 mortality, or the rate of reactivation from explanted latently infected ganglia.

176 The explanted lenses were submitted to our laboratory and we

177 82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence int

178 ial cells, the swine were euthanized and the explanted liver underwent quantitative pathologic examin

179 he histopathological findings for HCC in the explanted liver.

180 Confocal microscopy of lung explants localized the increase in HMGA1 consistently to

181 cro-CT studies of tissue cores obtained from explant lungs were examined and were correlated 1:1 with

182 micro-CT were applied to 11 air-inflated CF explanted lungs and 7 control lungs to measure, count, a

183 On MDCT, CF explanted lungs showed an increased median (interquartil

184 significantly higher in healthy controls and explanted LVAD patients compared with other patients (he

185 le hydrogen peroxide (H2O2) concentration in explant media was measured by using microelectrodes.

186 recurrence risk classification compared with explant Milan criteria (net reclassification index, 0.40

187 Here we used an ex vivo testicular explant model and in vivo exposure to determine the conc

188 methods for detecting reactivation using the explant model are compared.

189 vered at sea level or above 3100 m, using an explant model of hypoxia-reoxygenation to assess the imp

190 ts in phagosome maturation using a mouse RPE explant model.

191 Tissue was cultured in a short-term explant model.

192 n vitro human graft-versus-host disease skin explant model.

193 Experiments using inhibitors in explant models and genetic knock-downs in vivo reveal an

194 hese observations to cell culture and tissue explant models and show that in nagZ mutants, the biofil

195 e xenograft and patient-derived breast tumor explant models.

196 ays might be quantitatively characterized in explant models.

197 In intestinal explants, modulation of Bmp signaling alters the spatial

198 Using distal colon explants mounted in a horizontal perfusion chamber we de

199 RAS(G12D) mouse model or in a patient tumour explant mouse model of KRAS-mutant lung cancer suppresse

200 sent a method to target microRNA function in explanted mouse embryonic organs.

201 68), and 22.1% were beyond Milan criteria on explant (n = 159) owing to understaging by pretransplant

202 Using intact tissue explants, Ncad+ MCAs were also shown to efficiently rupt

203 ists abrogated ex vivo fibrotic responses in explanted normal and SSc fibroblasts and in 3D human ski

204 l redetachment related to the removal of the explant occurred in 11% of patients.

205 Primary AmEpCs and explants of amniochorionic membranes from mid-gestation

206 ystem composed of neurons grown ex vivo from explants of embryonic mouse olfactory epithelia, we obse

207 enerated in cultures from central and limbal explants of murine cornea.

208 cultured cancer cells and its penetration in explants of murine tumors and clinical tumor explants ca

209 Intact explants of SKs were also sensitive to Akt inhibition.

210 Explants of this epiblast grown in the absence of furthe

211 Primary TNBC tumor explants or cell lines treated with the GR ligand dexame

212 sease were twice as likely to have no HCC on explant (OR, 2.12; 95% CI, 1.18-3.83) and had a predicte

213 In brain slice explants, oxygen deprivation (OD) activated apoptotic pa

214 n compared to patients with HCV RNA-negative explants (P = .014 and P = .013, respectively).

215 e for precision medicine screening of tumour explants, particularly in hard-to-treat cancer types suc

216 a retrospective cohort study using national explant pathology data from 2012 to 2015.

217 Data of the explanted patients were compared with those with the dev

218 onstitutively active Akt (Akt-CA) in retinal explants phenocopies the reduction in amacrine cell prod

219 enhancing dermal accumulation of the ATRA in explant pig skin.

220 We exposed pig and human airway explants, pig and human ASL, and the human cationic AMPs

221 Fat explants placed perivascular to the external jugular vei

222 her materials dislodged from the surfaces of explanted prosthetic joints using sonication.

223 In this context, embryonic organ explants provide a reliable and reproducible system that

224 ponses to TcdA and TcdB in cells and colonic explants provides the opportunity to unify a large body

225 with and without ulcerative colitis (UC) and explanted PSC livers.

226 Device explant rates for myocardial recovery were 0.9% at 1-yea

227 cells, LAT, and CD8alpha(+) DCs in blocking explant reactivation in TG of mice latently infected wit

228 Based on an explant reactivation model, it has been proposed that CD

229 The time to explant reactivation of avirulent strains of HSV-1 was s

230 s reactivation on day 28 p.i. as measured by explant reactivation were calculated.

231 affected the level of viral DNA and time to explant reactivation.

232 continuous-flow LVAD, 16 patients with LVAD explanted (recovered patients), and 24 heart transplant

233 ely 50% of cases responding ex vivo Notably, explant responses to cisplatin correlated significantly

234 Diabetic human myocardial explants revealed capillary rarefaction and pericyte los

235 Confocal live imaging of tissue explants revealed that although these cells reorganize d

236 nockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regu

237 The explant showed a vascular rejection (Banff ACR grade III

238 Ex-vivo FRET imaging of mouse cartilage explants showed that intermediate level of interstitial

239 as CD28-negative T cells were present in the explant, showing a great IFN-gamma production capacity a

240 Aortic tissue and explanted smooth muscle cells from Acta2(-/-) aortas sho

241 plant spent medium, compared with uninfected-explant spent media (1,351-fold and 58-fold, respectivel

242 nhibitory factor accumulated in the infected-explant spent medium, compared with uninfected-explant s

243 Explanted stenotic tricuspid aortic valves were weighed,

244 In explant studies, the levels of beta-HB released were tem

245 ta-hydroxysteroid dehydrogenase 1 mRNA in HG explants suggests glucose involvement in blubber cortiso

246 lly active dose of KAFAK to bovine cartilage explants, suppressing pro-inflammatory interleukin-6 (IL

247 Using an ex vivo human FM explant system and an in vivo mouse model of pregnancy,

248 n of cell-specific markers revealed that the explant system maintained structural and functional inte

249 We explanted testis tissue at postnatal day (P)5.5 and cult

250 how rapidly the virus reactivated following explant TG-induced reactivation.

251 The percentage of explants that ultimately develop symptomatic swelling is

252 outcomes in 24 patients either retaining or explanting the device at 24 months relative to sham-trea

253 In explant tissue, cisplatin-resistant tumors excluded plat

254 ohistochemistry were performed on biopsy and explant tissue.

255 osterone synthesis in human fetal testicular explants to an extent greater than that seen with indivi

256 harvesting site impacted the ability of the explants to attach to the culture well.

257 Such analysis requires explants to be imaged under conditions that maintain bot

258 We utilized Spag6-deficient mice and SGN explants to define the role of SPAG6.

259 ogenesis can be induced in vitro by exposing explants to growth regulators and/or stress treatments.

260 ed in vitro by subjecting stem villus artery explants to hypoxia-reoxygenation, or inhibiting CSE.

261 nal state in seals, and highlight the use of explants to study fat tissue function in wildlife.

262 established organotypic cell cultures of AT explants to study the impact of cytokine treatment on lo

263 We used ex vivo aortic explants to test monocyte adhesion and in vitro cocultur

264 We exposed the P5.5 to -11.5 explants to various concentrations (40-160 microg/ml) of

265 samples) and in six SCLC patient-derived CTC explant tumors.

266 the dynamics of DENV infection in human skin explants using quantitative in situ imaging.

267 Picrosirius red staining of explanted valves showed greater amount of collagen fiber

268 al cell outgrowth from infarcted mouse heart explants via p38 MAPK-MK2.

269 t of the hydrogel explant and removal of the explant was 159 months.

270 EHV1 binding to and infection of mucosal explants was greatly enhanced upon destruction of the re

271 The callus culture for stem and leaf explants was initiated in modified Murashige and Skoog (

272 itors and siRNA knockdown in embryonic organ explants, we determined that VEGFR2-dependent signaling

273 notypic human midgestation chorionic villous explants, we show that syncytiotrophoblasts isolated fro

274 Organotypic culture and human tumour explants were allowed to grow long-term (14-35 days) and

275 enotype was methodically altered when neuron explants were cocultured with microisolates from dispara

276 Colonic explants were cultured and preserved ex vivo for 35 days

277 Bovine cartilage explants were cultured with IL-1alpha to induce cartilag

278 Human ex vivo lung explants were infected with a clinical strain of NTHi.

279 stance and FD4 permeability of nasal mucosal explants were measured.

280 Tissue explants were mechanically minced into 1 mm(3) pieces to

281 Corneal limbal explants were obtained from 2 sites, the harvested area

282 e of 3.43 transgenic events per 100 infected explants were recovered as opposed to only 0.41% recover

283 Levels of HCV RNA in explants were significantly higher in patients with a re

284 kt-CA activates Tgfbeta signaling in retinal explants, which is a negative feedback pathway for amacr

285 delivery of glutamate into the subsurface of explanted wild-type rat retinas elicits highly localized

286 ns of 20E support prolonged proliferation in explanted wing discs in the absence of insulin, incident

287 Stimulation of normal-weight bone explant with recombinant resistin increased the Type I c

288 Treatment of colon explants with 8Br-cGMP also activated FoxO target gene e

289 n studied at the cellular level using tissue explants with conflicting results.

290 Treatment of mandibular explants with exogenous EDN1 peptides partially rescued

291 reatment of mouse chondrocytes and rat tibia explants with IL-1beta, an inflammatory mediator thought

292 Treatment of Id cDKO cardiac explants with LSKL, a peptide antagonist of TSP1 activat

293 Comparing the transcriptome of explants with non-induced controls, we identified hundre

294 of neuronal morphology, we cocultured neuron explants with peripheral target tissues removed from dis

295 Treatment of human lung airway explants with recombinant NPY increased airway contracti

296 assays and electroporation of mouse retinal explants with reporter constructs of wild-type and varia

297 Treatment of NSCLC explants with the targeted agent TRAIL revealed differen

298 nhibitors or activators into embryonic organ explants, with a microRNA pulldown assay that allows dir

299 were recovered from over 40% of the starting explants, with most producing healthy, fertile plants.

300 ) lead may have the lead either abandoned or explanted; yet there are limited data on the comparative