ライフサイエンスコーパス: exporter

1 ere it functions as a metabolite and protein exporter.

2 of ferroportin, the only known cellular iron exporter.

3 y characterized, mammalian, basolateral iron exporter.

4 n detail or investigated in the MsbA lipid A exporter.

5 luding ndvA, which encodes the cyclic glucan exporter.

6 of ferroportin, the sole known cellular iron exporter.

7 nd independent of fpn1's function as an iron exporter.

8 resulting in a permanently "turned on" iron exporter.

9 ed to allow the production of this potential exporter.

10 o that caused by overproduction of the AcrEF exporter.

11 hat conferred by overproduction of the MdtEF exporter.

12 ac, that is a candidate for the elusive iron exporter.

13 p PCC 6803 and named this protein Mnx for Mn exporter.

14 ables substrate transfer in a eukaryotic ABC exporter.

15 es as previously proposed for multi-drug ABC exporters.

16 e flexible than other structurally known ABC exporters.

17 ains in the conformational transition of ABC exporters.

18 on in the same epithelium of other bile acid exporters.

19 er folds, namely large ABC importers and ABC exporters.

20 erent substrate recognition profile from the exporters.

21 h current structural models of bacterial ABC exporters.

22 rs with a high degree of similarity to lipid exporters.

23 hormone by inhibiting membrane-based steroid exporters.

24 dependent uptake systems and 13 are presumed exporters.

25 rity to the HlyB family of bacterial protein exporters.

26 entiating heterodimeric from homodimeric ABC exporters.

27 n a refined model of solute transport by ABC exporters.

28 d extended the X loop, which is found in ABC exporters.

29 s that Mmt1/2 function as mitochondrial iron exporters.

30 ard-open and inward-open conformation of ABC exporters.

31 drolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding o

32 cription studies indicate that the alcaligin exporter activity of AlcS is required to maintain approp

33 ating access models for ATP-binding cassette exporter activity suggest that ATP binding at the two cy

34 FLVCR expression in cell lines suggest this exporter also impacts heme trafficking in intestine and

35 of sialin (SLC17A5), a lysosomal sialic acid exporter also recently implicated in exocytotic release

36 P1B4-type ATPase that functions as an Fe(II) exporter and aids GAS defenses against iron intoxication

37 (Arabidopsis thaliana) PHOSPHATE1 (PHO1) Pi exporter and defined the functions of its different doma

38 s reports, we show that ABCB10 is not a heme exporter and instead is required for the early mitochond

39 l of ColV is specific for the CvaA-CvaB-TolC exporter and is processed concomitant with secretion.

40 FrvA is a high affinity Fe(II) exporter and its induction imposes severe iron limitatio

41 paratus functions as a proton-driven protein exporter and that ATP hydrolysis is not essential for ty

42 ablish that CUA-1 is a key intestinal copper exporter and that its trafficking is regulated to mainta

43 rence in the transport mechanism between ABC exporters and ABC importers.

44 We identified key exporters and importers from the number of shipments a c

45 orters, suggesting that ATP-binding cassette exporters and importers may use similar mechanisms to ac

46 Cs), KCC2 and NKCC1, which serve as chloride exporters and importers, respectively.

47 eported high NBD fluctuations in several ABC exporters and possibly represents a fundamental differen

48 e-bound, outward-facing conformations of ABC exporters and which binds ATP.

49 tion-chloride cotransporter KCC2 (K(+)/Cl(-) exporter) and a reduced KCC2/NKCC1 (Na(+)/K(+)/Cl(-) imp

50 SR-B1 (a CE influx protein), ABCA1 (a FC exporter), and HMG CoA reductase protein/mRNA levels wer

51 porter), a short yeast MRP (Yor1p oligomycin exporter), and human CFTR channels.

52 of ferroportin, the presumed intestinal iron exporter, and have evaluated its potential role in regul

53 ore synthetase subunits, a integral membrane exporter, and three genes with no obvious role in sidero

54 pH, (2) adequate expression of the key HCO3- exporter, anion exchanger 2 (AE2), and (3) an intact cho

55 ABC exporters are present both in prokaryotes and eukaryotes

56 Main virtual water exporters are the South and Central agrarian regions: An

57 Multidrug ATP binding cassette (ABC) exporters are ubiquitous ABC transporters that extrude c

58 e regulator (CFTR) (ABCC7), unique among ABC exporters as an ion channel, regulates ion and fluid tra

59 and express lower levels of the cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) in

60 copper transporter 1) but also by the copper exporter ATP7A (Menkes ATPase), whose function is achiev

61 on and appear to downregulate the K(+)-Cl(-) exporter channel KCC2 following peripheral nerve damage,

62 BMY, which is mediated by binding to nuclear exporter chromosome region maintenance 1 and further enr

63 P binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in t

64 us is the ATP-binding-cassette subunit of an exporter complex required for cytochrome c biogenesis.

65 ducts of these three genes form a single ABC exporter complex, in which pilI is an integral membrane

66 tant with conformational change in all three exporter components.

67 hat the cue pathway, which includes a copper exporter, CopA, and a periplasmic oxidase, CueO, is the

68 Deletion of the S Typhimurium copper exporters, CopA and GolT, was found to decrease infectio

69 centrated orange juice and, unlike the other exporter countries, the domestic consumption is mainly b

70 Inhibition of the nuclear exporter CRM1 by leptomycin B did not interfere with NEM

71 target of the beta-karyopherin-like nuclear exporter, Crm1p.

72 ally similar to the Escherichia coli amyloid exporter CsgG; however, unlike CsgG, PelC does not posse

73 is via characterization of a putative copper exporter, CtpV.

74 in the margin that utilize a PIN-based auxin exporter/CUC2 transcription factor system to define regi

75 d in S. pneumoniae by expression of the zinc exporter CzcD, whose expression is activated by the nove

76 Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member

77 in the DMT superfamily, the drug/metabolite exporter (DME) family, consists of over 100 sequenced me

78 The existence of multiple tRNA exporters, each with different tRNA preferences, may ind

79 further demonstrated that loss of the copper exporter encoded by copA led to decreased virulence in p

80 Deletion of either the exporter, encoded by copA, or the chaperone, encoded by

81 In particular, heterodimeric ABC exporters exhibit pronounced allosteric coupling between

82 MacB is a founding member of the Macrolide Exporter family of transporters belonging to the ATP-Bin

83 encodes a member of the ATP-binding cassette exporter family.

84 also related to mRNA expression of the heme exporter feline leukemia virus subgroup C receptor 1 (be

85 on between the hormone hepcidin and the iron exporter ferroportin (Fpn) regulates plasma iron concent

86 Mutations in the iron exporter ferroportin (Fpn) result in iron overload in ma

87 The macrophage iron exporter ferroportin (FPN) was up-regulated in the Hfe(-

88 mporter DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been clo

89 tigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracel

90 is is tightly regulated by the membrane iron exporter ferroportin and its regulatory peptide hormone

91 such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macro

92 imarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of

93 Adipocyte-specific loss of the iron exporter ferroportin resulted in iron loading and decrea

94 tide hormone that binds to the cellular iron exporter ferroportin, causing its internalization and de

95 creasing cell surface expression of the iron exporter ferroportin, hepcidin decreases iron absorption

96 Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus

97 ates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and d

98 ates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and d

99 It acts by binding to the iron exporter ferroportin, inducing its internalization and d

100 copper status affects expression of the iron exporter ferroportin-1 (FPN1), J774 macrophage cells wer

101 ve increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake

102 levels by promoting degradation of the iron exporter ferroportin.

103 gered a TLR4-dependent reduction in the iron exporter ferroportin.

104 nduces the degradation of the exclusive iron exporter ferroportin.

105 on of the only known mammalian cellular iron exporter ferroportin.

106 Loss of the cellular iron exporter, ferroportin, had no apparent consequences.

107 ession of iron importers as well as the iron exporter, ferroportin, suggesting an impaired ability to

108 Mice lacking the heme exporter FLVCR1 have a severe macrocytic anemia; however

109 stal structure of apo-ABCB10 shows a classic exporter fold ABC transporter structure, in an open-inwa

110 sults demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role i

111 Ts function both as maturation proteases and exporters for quorum-sensing or antimicrobial polypeptid

112 r-stimulated trafficking of the ATP7A copper exporter from the Golgi to vesicles that partially overl

113 TmrAB is a heterodimeric ABC exporter from the thermophilic Gram-negative eubacterium

114 he resistance nodulation cell division (RND) exporters from Gram-negative bacteria.

115 been achieved in the structural analysis of exporters from the superfamily of adenosine triphosphate

116 t eukaryotic homologs [renamed FEX (fluoride exporter)] function in fluoride export.

117 a dimer in solution, implying that the MbfA exporter functions as a dimer.

118 to derepression of the acrEF and mdtEF drug exporter genes.

119 ce by regulating the expression of multidrug exporter genes.

120 ion in the membrane component of an ABC drug exporter have been biochemically characterized.

121 ms likely that the TMDs of ABC importers and exporters have evolved different mechanisms to couple to

122 n1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane hel

123 ferroportin 1 (Fpn1), the sole cellular iron exporter identified to date.

124 st molecular characterization of a polyamine exporter in animal cells and indicate that the diamine p

125 ggesting that this protein serves as an iron exporter in cells that recycle iron from senescent red b

126 tightly to TmrAB, and imply a role for this exporter in glycolipid translocation.

127 17) has been characterized as a vacuolar Fru exporter in leaves, its expression in leaves is low.

128 Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell-specific function and

129 pass membrane protein that serves as an iron exporter in many vertebrate cell types.

130 nt genetic model to explore the role of this exporter in Mn homeostasis.

131 )/Ca(2+) exchanger 1 (NCX1), a major calcium exporter in renal epithelial cells, regulates epithelial

132 otransporter 2 (KCC2), the predominant Cl(-) exporter in the adult brain.

133 Ferroportin (Fpn) is the only known iron exporter in vertebrate cells and plays a critical role i

134 Ferroportin (Fpn) is the only known iron exporter in vertebrates.

135 We also analyzed the levels of Zn-exporters in a panel of PCa cells derived from EA and AA

136 egarded as a model system for asymmetric ABC exporters in general, and for TAP in particular.

137 urther explored the expression profile of Zn-exporters in PCa using Oncomine database.

138 Our study provides an insight regarding Zn-exporters in PCa, which may open new avenues for future

139 highlight the unexpected flexibility of ABC exporters in the resting state and underline the power o

140 United States is one of the largest soybean exporters in the world.

141 xpression is in contrast to many other toxin exporters in yeast, and this, along with the fact that t

142 use (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.

143 erroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.

144 Physiological substrates for this exporter include putrescine, cadaverine, and monoacetyl

145 Current alternating access models for ABC exporters including the multidrug and Lipid A transporte

146 tructures of three full-length ABC multidrug exporters (including MsbA) have been published recently

147 n by sequence analysis to be also present in exporters, including MDR1.

148 We find that all of the newly identified exporters indeed fall into one of the two above-mentione

149 They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR)

150 ty increases, and the independent cus copper exporter is also necessary for full copper tolerance.

151 It is concluded that the cGMP exporter is distinct from MRP1 and has properties simila

152 of ZntR rises, and transcription of the zntA exporter is increased.

153 ose that the motif present in DrrB and other exporters is actually a modified version of the EAA moti

154 P1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticulo

155 transport mechanism, especially of human ABC exporters, is scarce.

156 y member Los1 (Exportin-t) has been the only exporter known to execute nuclear export of newly transc

157 g the Mn importer, and mntE, encoding the Mn exporter, lead to Mn sensitivity during aerobiosis.

158 In addition to auxin exporters, leaves also express auxin importers, notably

159 ce ferroportin, the only known cellular iron exporter, limit the intracellular growth of these bacter

160 because it is essential, but the known tRNA exporters (Los1 [exportin-t] and Msn5 [exportin-5]) are

161 nction, yet the one known yeast tRNA nuclear exporter, Los1, is nonessential.

162 Transnational exporters market fruit of the Cavendish cultivars, which

163 s secreted by the ATP-binding cassette (ABC) exporter McjD, which ensures self-immunity of the produc

164 bundle interactions in ATP-binding cassette exporters might offer a potent strategy to alter their t

165 r, ntcp, and the multispecific organic anion exporter, mrp2.

166 ies on the homodimeric multidrug/lipid A ABC exporter MsbA from Escherichia coli, we performed cystei

167 study the prototypical ATP-binding cassette exporter MsbA reconstituted in nanodiscs at 37 degrees C

168 on bacterial K+ channels, while the lipid-A exporter, MsbA, provides a template for the MDR-like cor

169 a previously unrecognized class of fluoride exporter necessary for survival in standard environmenta

170 duit for surfactant export and the other the exporter of a molecule that is required for induction or

171 The Na(+)/Ca(2+) exchanger is the major exporter of Ca(2+) across the cell membrane of cardiomyo

172 Brazil is currently the largest exporter of concentrated orange juice and, unlike the ot

173 cluding ndvA, which encodes an ATP-dependent exporter of cyclic beta glucans.

174 rter ABCC4 is recognized as an ATP-dependent exporter of endogenous substances as well as an increasi

175 cilitator Superfamily pump EntS is the major exporter of enterobactin and the ABC transporter IroC ex

176 protein-1 (MRP1) and use this as their major exporter of GSSG.

177 nsporter that has been proposed to act as an exporter of heme to the periplasm.

178 largest swine population but is not a major exporter of live swine, and is not an important source o

179 and protein levels of RSB1, which encodes an exporter of long chain bases dihydrosphingosine (DHS) an

180 tivation domain-binding protein 1 (JAB1), an exporter of p27, into the cytoplasm, thereby facilitatin

181 SUR4 were decreased, and expression of YOR1 (exporter of PHS-1P) and DPL1 (lyase that degrades DHS-1P

182 s) mobilized the exocyst complex, a powerful exporter of subcellular vesicles, to rapidly expel intra

183 Pseudomonas aeruginosa is a prolific exporter of virulence factors and contains three of the

184 2 and Ypq1-3 proteins are lysosomal/vacuolar exporters of CAAs and suggest that small-molecule transp

185 ant displacer overall, while the largest net exporters of embodied environmental pressures were Polan

186 ntinental margins and North Atlantic are key exporters of organic carbon.

187 In addition to these exporters, one importer, Pseudomonas aeruginosa Q9I147,

188 chanistic insight into how heterodimeric ABC exporters operate.

189 ng the potential for Cca1p to function as an exporter or an adapter in this tRNA nuclear export pathw

190 and can be adapted to specific cases of data exporters or data converters that need to be implemented

191 range conformational couplings, e.g., in ABC exporters or other ATP-driven molecular machines.

192 (orfs 13, 19, 32 and 33) and three putative exporters or self-resistance genes (orfs 14, 20 and 30).

193 out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.

194 low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of Ctr1 activity, but its funct

195 the body may be influenced by the multi-drug exporter P-glycoprotein.

196 t of rapamycin activity and net hydrogen ion exporters, particularly sodium bicarbonate co-transporte

197 the raspberries could be traced to a single exporter per event.

198 eraction partners and identified the calcium exporter plasma membrane calcium ATPase isoform 4 (PMCA4

199 Ferroportin is an iron exporter present on the surface of absorptive enterocyte

200 rst time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromos

201 response to SL is the removal of PIN1 auxin exporter proteins from the plasma membrane in vascular-a

202 nts use a recently discovered family of F(-) exporter proteins to lower cytoplasmic F(-) levels to co

203 pport the structural homology of MurJ to MOP exporter proteins, suggesting that MurJ might function a

204 ABC exporters pump substrates across the membrane by couplin

205 s the transcription of the Co(II) and Ni(II) exporter, RcnAB, by binding to DNA as an apoprotein and

206 s the transcription of the Co(II) and Ni(II) exporter, RcnAB.

207 Others were exotic and/or invasive in exporters' regions.

208 val in vivo depended on CaxP, the first Ca2+ exporter reported in bacteria.

209 stent with a role for Abc3 as vacuolar hemin exporter, results with hemin-agarose pulldown assays sho

210 Analysis of the proposed exporter role of AbcA in cell mixing experiments showed

211 esting the increased expression of some drug exporter(s) in this mutant.

212 s as an adaptor or coactivator of amino acid exporter(s).

213 ported structures of the bacterial multidrug exporter Sav1866 suggest a domain architecture in which

214 istent with the hypothesis that these copper exporters sequester the platinum drugs into subcellular

215 Only two, ZnT1 and ZnT2 (both cellular Zn exporters), show a progressive down-regulation under Zn-

216 in and the exporting activity of the nuclear exporter signal (NES) near the N terminus.

217 suggest that lrgA encodes a murein hydrolase exporter similar to bacteriophage holin proteins while l

218 s study, we determined the involvement of Zn-exporters, SLC30A 1-10 in PCa, in the context of racial

219 GM-CSF upregulated expression of Zn exporters, Slc30a4 and Slc30a7; the metal was shuttled a

220 ery of a selective nuclear androgen receptor exporter (SNARE) that functions to exclude AR from the n

221 In contrast to other ABC exporter structures, the nucleotide binding domains (NBD

222 richia coli is a member of the bacterial ABC exporter subfamily and is essential for the export of th

223 In a homodimeric ABC exporter such as MsbA responsible for lipid A transport

224 al structures of bacterial and mammalian ABC exporters suggest a common alternating access mechanism

225 ily members Tbx3 and Brachyury with the CRM1 exporter, suggesting general significance.

226 /oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily (TC #2.A.66) consists of four previ

227 /oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily member MurJ.

228 drug/oligo-saccharidyl-lipid/polysaccharide) exporter superfamily, which includes flippases that tran

229 Our data also show that tRNA exporters surprisingly exhibit differential tRNA substra

230 Escherichia coli is mediated by a dedicated exporter system consisting of host TolC protein and the

231 At least eight drug exporter systems require TolC for their functions.

232 Using silencing RNAs to the bulk mRNA exporter Tap/NXF1, we observed a significantly increased

233 eceptor 1a (FLVCR1a) is plasma membrane heme exporter that is ubiquitously expressed and controls int

234 receptor 1 (FLVCR1) is a cell membrane heme exporter that maintains the balance between heme levels

235 resentative of the heterodimer family of ABC exporters that have an intrinsically impaired nucleotide

236 rexpression of mutant derivatives of the ABC exporters that lacked the peptides also resulted in impa

237 pose a novel mechanism for toxic peptide ABC exporters that only requires the transient opening of th

238 of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and

239 nificant economic loss to both producers and exporters, the seed export industry urgently requires ra

240 t the apo structure of the heterodimeric ABC exporter TM287/288 and compare it to the previously solv

241 DEER measurements on the heterodimeric ABC exporter TM287/288 from Thermotoga maritima, which conta

242 hina, have shifted from being a net emission exporter to being a net emission importer.

243 al pathogens use the ESAT-6 system 1 (Esx-1) exporter to promote virulence.

244 ing of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages.

245 meostasis is maintained by intestinal copper exporter trafficking that is coordinated with extraintes

246 The mycobacterial Esx-1 (ESAT-6 system 1) exporter translocates virulence factors across the cytop

247 n) is the only known mammalian cellular iron exporter, understanding its localization and regulation

248 ATP-binding cassette exporters use the energy of ATP hydrolysis to transport

249 whereas MCT4 is a well-characterized lactate exporter, we found that both intracellular and extracell

250 Zn-exporters were found to be differentially expressed at t

251 nes were lower and levels of major bile acid exporters were similar, which therefore could not explai

252 to the circulation and functions as an iron exporter when expressed in Xenopus oocytes.

253 , we demonstrated that SpoIIIE acts as a DNA exporter: When SpoIIIE was synthesized in the larger of

254 both the degradation pathway and a chloride exporter, which preempted the adaptive process and direc

255 redicted that SMu0836 and SMu0837 encode ABC exporters, which we designated rcrPQ (rel competence-rel

256 mational transition of MsbA, a bacterial ABC exporter whose structure has been solved in multiple fun

257 analysis revealed several interactions of Zn-exporters with certain tumor suppressor and promoter pro

258 ite highlights the articulated design of ABC exporters, with ligands and nucleotides spanning structu

259 urreducens GSU1501, part of an ATP-dependent exporter within an operon of polysaccharide biosynthesis

260 ncoding the nucleoporin Nup82 and in the NES exporter Xpo1/Crm1 also caused the nucleoplasmic accumul

261 nvolving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and ZnT-4).